Rotating Magnetic Field Research Articles

Multimodal Locomotion and Dynamic Interaction of Hydrogel Microdisks at the Air-Water Interface under Magnetic and Light Stimuli.

The potential applications of hydrogel microrobots in biomedicine and environmental exploration have sparked significant interest in understanding their behavior under multiphysical fields. This study explores the multimodal locomotion and dynamic interaction of hydrogel microrobots at the air-water interface under magnetic and light stimuli. A pair of hydrogel microrobots at the air-water interface exhibits a transition from cooperative, combined rotation to interactive behavior, involving both rotation and revolution under the influence of a rotating magnetic field (RMF), and a shift from attraction to separation under near-infrared (NIR) light, demonstrating the dynamic modulation of their behaviors in response to different stimuli. Notably, the behavioral patterns of multiple hydrogel microrobots under multiphysical fields indicate that NIR light can enhance interactive motion behaviors under RMFs and extend the range of motion trajectories. Dynamic models for each condition are established and analyzed based on dynamic equilibrium, and their behavior can be modulated by parameters such as magnetic particle concentration, magnetic field frequency, and NIR light intensity. This work introduces a novel strategy for regulating and controlling the dynamic behaviors of hydrogel microrobots, offering new insights into their multiphysical field locomotion.

Determining the Axial Orientations of a Large Number of Flux Transfer Events Sequentially Observed by Cluster during a High-Latitude Magnetopause Crossing

Flux transfer events (FTEs) are magnetic structures generally believed to originate from time-varying magnetic reconnection at the Earth’s magnetopause. Despite years of research, the mechanism of how FTEs are formed through reconnection remains controversial. In various models, FTEs exhibit different global configurations. Studying the FTE axial orientation can provide insights into their global shape, thereby helping to distinguish the generation mechanisms. In this paper, taking advantage of the orbital characteristics of the four Cluster spacecraft, we devised a multi-spacecraft timing method to determine the axes of a total of 57 FTEs observed sequentially by Cluster during a high-latitude duskside magnetopause crossing. During the nearly five-hour observation, the interplanetary magnetic field (IMF) experienced a large rotation, leading to a substantial rotation of the magnetosheath magnetic field. The analysis results show two new features of the FTE axis that have not been reported before: (1) the axes of the FTEs gradually rotate in response to the turning of the IMF and the magnetosheath magnetic field; (2) the axes of the FTEs vary between the direction of the magnetosheath magnetic field and the direction of the reconnection X-line. These features indicate that FTEs may have a more complex global configuration than depicted by traditional FTE models.

Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway

Alzheimer's disease (AD) is a geriatric disorder that can be roughly classified into sporadic AD and hereditary AD. The latter is strongly associated with genetic factors, and its treatment poses greater challenges compared to sporadic AD. Rotating magnetic fields (RMF) is a non-invasive treatment known to have diverse biological effects, including the modulation of the central nervous system and aging. However, the impact of RMF on hereditary AD and its underlying mechanism remain unexplored. In this study, we exposed APP/PS1 mice to RMF (2 h/day, 0.2 T, 4 Hz) for a duration of 6 months. The results demonstrated that RMF treatment significantly ameliorated their cognitive and memory impairments, attenuated neuronal damage, and reduced amyloid deposition. Furthermore, RNA-sequencing analysis revealed a significant enrichment of autophagy-related genes and the PI3K/AKT-mTOR signaling pathway. Western blotting further confirmed that RMF activated autophagy and suppressed the phosphorylation of proteins associated with the PI3K/AKT/mTOR signaling pathway in APP/PS1 mice. These protective effects and the underlying mechanism were also observed in Aβ25–35-exposed HT22 cells. Collectively, our findings indicate that RMF improves cognitive and memory dysfunction in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway, thus highlighting the potential of RMF as a clinical treatment for hereditary AD.

Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic field.

Cancer invasion and migration play a pivotal role in tumor malignancy, which is a major cause of most cancer deaths. Rotating magnetic field (RMF), one of the typical dynamic magnetic fields, can exert substantial mechanical influence on cells. However, studying the effects of RMF on cell is challenging due to its complex parameters, such as variation of magnetic field intensity and direction. Here, we developed a systematic simulation method to explore the influence of RMF on tumor invasion and migration, including a finite element method (FEM) model and a cell-based hybrid numerical model. Coupling with the data of magnetic field from FEM, the cell-based hybrid numerical model was established to simulate the tumor cell invasion and migration. This model employed partial differential equations (PDEs) and finite difference method to depict cellular activities and solve these equations in a discrete system. PDEs were used to depict cell activities, and finite difference method was used to solve the equations in discrete system. As a result, this study provides valuable insights into the potential applications of RMF in tumor treatment, and a series of in vitro experiments were performed to verify the simulation results, demonstrating the model's reliability and its capacity to predict experimental outcomes and identify pertinent factors. Furthermore, these findings shed new light on the mechanical and chemical interplay between cells and the ECM, offering new insights and providing a novel foundation for both experimental and theoretical advancements in tumor treatment by using RMF.

Effect of noninertial acceleration on heat transfer by Rayleigh–Bénard magnetoconvection: Exploring nonlinear dynamics

AbstractBuoyancy‐driven Rayleigh–Bénard convection in the presence of a magnetic field, rotation, and temperature‐dependent viscosity has applications in the field of crystal growth, space laboratory experiments, and atmospheric convection. It also has potential applications in heat transfer and magnetohydrodynamics, which can occur in planetary and stellar interiors. The present work aims to study the combined effect of magnetic fields and rotation on the onset of Rayleigh–Bénard convection in temperature‐dependent viscosity Newtonian liquids with internal heat sources/sinks. Both linear and weak nonlinear stability analyses of convection are performed in the problem. The minimal representation of the Fourier series for the stream function and the magnetic potential allows us to derive the analytical expression for the thermal Rayleigh number () and the generalized Lorenz model. In linear theory, the critical Rayleigh number and the wave number are tabulated for different values of the Chandrasekhar number (), the Taylor number (), and the thermorheological parameter (), and the onset of stability is analyzed. It is found that the instability manifests at when for stress‐free and isothermal boundaries. In nonlinear theory, the generalized Lorenz model obtained is not amenable to analytical treatment; therefore, the classical fourth‐order Runge–Kutta method is applied to solve the Lorenz model. It is found that the internal Rayleigh number, the thermorheological parameter, and the Taylor number influence the onset of convection and heat transfer coefficient. It is also demonstrated that the joint increase in rotational force and magnetic field strength stabilizes the system strongly, thereby reducing heat transfer. However, increasing the heat source and the variable viscosity parameter have antagonistic influences.

Diffraction of quasi-nondiffracting Bessel beam by an impedance disc in an anisotropic plasma

The diffraction of the so-called nondiffracting Bessel beam by an impedance disc immersed in an anisotropic medium is examined. The external uniform magnetic field, which makes the plasma anisotropic, is taken to be rotational as opposed to being parallel to the edge of the problem geometries in the literature. Thus, the appropriate dielectric matrix that models the anisotropic region under the rotational dc external magnetic field is derived for the first time, to the best of our knowledge. Upon considering the geometric optics waves, the total scattered waves are obtained with the diffracted waves by using the definition of high-frequency asymptotic expressions associated with the scattered waves at the transition regions. The results are expressed in terms of the Fresnel functions so that the wave behaviors in the transition regions are uniform. The solutions are compared numerically with existing studies in the literature, including limit values.

Numerical analysis of stacked HTS tapes in rotating magnetic fields using H and T-A formulations

Superconducting windings in rotating electrical machines and multi-phase transformers are subject to rotating magnetic fields. Most existing studies on the electromagnetic characteristics of stacked high-temperature superconducting (HTS) tapes focus on the influence of vertical magnetic field (VMF) and the transport current. The numerical study on characteristics of HTS stacked tapes in rotating magnetic fields (RMFs) has received less research attention. This paper presents two-dimensional models of stacked HTS tapes in RMF based on H and T-A formulations. AC losses obtained by the two formulations agree well in a single tape configuration but significantly differ in a stack configuration. The discrepancy increases as the number of stack layers and the stack interval increase. Under the same magnetic field amplitude, the RMF penetration depth in stacked tapes is higher than those of VMF and parallel magnetic field (PMF), and the parallel component of RMF causes higher AC loss in the end tapes of a stack. While the applied current increases the overall AC loss, it can significantly decrease the AC loss of the end tape. It is found that reducing the stack interval and replacing end tapes with tapes of higher critical current can significantly reduce the overall AC loss of stacked tapes in an RMF. These results are crucial for modeling superconducting machines and offer valuable insights into characterizing superconducting tapes in RMFs using numerical methods.

Multi-physics analysis of squeezing fluid flow with rotational, magnetic field, and heat transfer interactions

This research paper presents a comprehensive study on the intricate interplay of rotational, magnetic field and heat transfer effects in squeezing fluid flow, utilizing the foundational framework of Navier–Stokes equations. Fluid flow in confined geometries has significant applications in various industrial processes, including lubrication systems, microfluidics, and heat exchangers. The integration of rotational motion, magnetic fields, and heat transfer phenomena into this context holds immense potential for optimizing performance and efficiency. The study commences with the derivation and analysis of the coupled Navier–Stokes equations, incorporating the Coriolis force due to rotational motion, the Lorentz force arising from magnetic fields, and the energy equation for heat transfer. This comprehensive model accounts for the complex interactions between these physical phenomena, offering a holistic perspective on squeezing fluid flow dynamics. Numerical analysis are conducted to investigate the behavior of fluids under the influence of rotational, magnetic field, and heat transfer effects. The results reveal intricate flow patterns, including vortex formation and heat transfer enhancement. Furthermore, the impact of key parameters such as rotational speed, magnetic field strength, and temperature gradients on flow characteristics is systematically analyzed. The Dufour effect pertains to the transfer of energy resulting from a gradient in mass concentration, occurring as a correlated consequence of irreversible processes. It functions as the inverse of the Soret effect. The temperature changes due to the concentration gradient, amplifying as the Dufour number increases. The most significant temperature rise is observed at the midpoint of the fluid domain. Conversely, the Soret number behaves in a similar but opposite manner. Tables 4–10 has been created to offer a comprehensive analysis of the optimal alignment between Homotopy Analysis Method (HAM) and BVP4c. Specifically, it demonstrates a continuous decrease in skin friction for ξSo, ξRd, and ξR2, while showing an increase for ξSc, ξDo, and ξRem. Meanwhile, the skin friction remains constant for ξPr. The research centers on analyzing heat and mass transfer properties within an incompressible fluid confined between two rotating and stretching disks amidst an unpredictable flow pattern. The study employs a blend of analytical and numerical approaches to solve the governing equations, delving into the intricate fluid dynamics and the intricate processes of heat and mass transfer within this intricate system.

Magnetically Powered Microrobotic Swarm for Integrated Mechanical/Photothermal/Photodynamic Thrombolysis.

Current thrombolytic drugs exhibit suboptimal therapeutic outcomes and potential bleeding risks due to their limited circulation time, inadequate thrombus penetration, and off-target biodistribution. Herein, a photosensitizer-loaded, red cell membrane-encapsuled multiple magnetic nanoparticles aggregate is successfully developed for integrated mechanical/photothermal/photodynamic thrombolysis. Red cell membrane coating endows magnetic particles with prolonged blood circulation and superior biocompatibility. Under a preset rotating magnetic field (RMF), the aggregate with asymmetric magnetic distribution initiates rolling motion toward the blood clot interface, and because of magnetic dipole-dipole interactions, the aggregate tends to self-assemble into longer, flexible chain-like microrobotic swarm with powerful mechanical stir forces, thereby facilitating thrombus penetration and mechanical thrombolysis. Moreover, precise magnetic control enables targeted photosensitizer accumulation, allowing effective conversion of near-infrared (NIR) light into heat and reactive oxygen species (ROS) for thrombus phototherapy. In thrombolysis assays, the weight of thrombi is massively reduced by ≈90%. The work presents a safer and more promising combination of magnetic microrobotic technology and phototherapy for multi-modality thrombolysis.

Enhancing understanding of the rotating magnetic field in electric machines through active learning and visualization

AbstractThis paper presents a method aimed at improving comprehension of AC electric machine principles by facilitating the learning of the Rotating Magnetic Field (RMF) through visualization tools provided by Finite Element Method (FEM) software. First, traditional methods used in textbooks to explain RMF in electric machines are reviewed, with an analysis of various instructional strategies. Acknowledging the limitations of these conventional approaches and the inherent complexity of RMF comprehension, a novel visualization method is proposed. Understanding RMFs in electric machines is fundamental for electrical engineers due to their crucial role in electric machine design and optimization. While textbooks typically rely on mathematical explanations and simple sketches, advancements in computer and software technology offer opportunities to utilize finite element tools for enhanced comprehension. Through dynamic animations and interactive simulations, emphasis is placed on prioritizing conceptual understanding over mathematical descriptions. Furthermore, this paper explores the development of pre‐simulation models in FEM tools to facilitate RMF learning in AC electric machines, and the process of creating a model to teach rotating magnetic fields in electric machines is carefully outlined. This approach holds promise for engineers seeking a deeper understanding of electric machines and can also be utilized by educators to enhance their teaching methodologies.

Numerical simulations on the AC loss of REBCO stacks under rotating magnetic fields

AC loss presents a significant challenge for high-temperature superconducting (HTS) rotating machines. To date, the behaviour of total AC loss (Qtol) (with current) and magnetization loss (Qm) (without current) in a single HTS tape under rotating magnetic fields (RF) have been explored. However, a research gap remains in understanding how these findings translate to the more complex HTS windings of rotating machines. Further exploration is needed to understand the loss behaviour of more complex HTS structures, such as HTS stacks. In this work, Qtol and Qm, in the HTS stacks under RF and a perpendicular AC standing wave magnetic field are numerically investigated. Two different RF models are considered: one is the Uni-RF model, characterized by a uniform field with equal field amplitudes and phases at each position, and the other is a non-uniform field created by a rotating Halbach array, referred to as the Hal-RF model. The dependence of AC loss on parameters such as the number of tapes in the stacks, tape width (2a), and the inclination angle (α) of tapes, which refers to the angle between the normal direction of the stack and the vertical direction, have been explored. The number of tapes in the stacks ranges from 1 to 16, α ranges from 0° to 90°, and the tape width includes 4 mm and 40 mm. Additionally, different rotating field directions are also considered. Interestingly, the analytical values from Brandt and Indenbom equation for Qm of a superconducting strip (BI-strip) are close to Qm results of the stacks under the standing wave at high fields, while they are over twice as high as those in the Hal-RF model at 1 T. This suggests the BI-strip equation is not reliable for predicting Qm under RF at high fields. We also show in the Hal-RF model that different rotation directions of the field lead to varying Qm and Qtol when asymmetric Jc (B, θ) data are applied. Moreover, it has been observed that the inclination angle has no impact on Qm under uniform RF while significantly impacts both Qm and Qtol in the Hal-RF model.

Enhanced ofloxacin degradation in water by a novel integrated photocatalysis and rotating magnetic field system

In this work, a novel integrated Fe3O4/g-C3N4 (FC) composite and rotating magnetic field (RMF) system was developed to enhance the photodegradation of ofloxacin (OFX) in water. The RMF was excited by three-phase alternating current, providing great flexibility on the magnetic field and avoiding mechanical transmission. By integrating RMF, the OFX degradation by FC photocatalysis was greatly enhanced. With the optimal FC composition of 20 % (wt) Fe3O4 (FC20), >87 % OFX degradation could be achieved with 1 g/L FC20, an RMF-excited current of 2 A, and a reaction time of 300 min, compared to OFX decomposition of ∼65 % by FC20 photocatalysis alone. The magnetic induction intensity, solution pH, and water matrices all affected OFX degradation by the integrated FC-RMF system. The FC20 was reliable for OFX degradation in water with minimal efficacy reduction after four consecutive reuses. In the integrated FC-RMF system, reactive species' contribution to OFX degradation was in the order of holes > superoxide anions > hydroxyl radicals. The electron transfer mechanisms during OFX degradation and five potential degradation pathways were proposed. In summary, the integrated FC-RMF system demonstrated a potential route for enhancing the removal of OFX and possibly other antibiotic contaminants from water.

Refueling of field-reversed configuration core via axial plasmoids injection

This study successfully developed a refueling technique for a field-reversed configuration (FRC) via axial plasmoid injection and demonstrated it on the FAT-CM device at Nihon University. The target FRC is generated using the collisional-merging formation technique combined with conical theta-pinch formation. Plasmoids with an FRC-like configuration are coaxially injected from both ends of the FAT-CM device toward the preexisting target FRC. Postinjection, the system achieves equilibrium, resulting in increases by factors of 1.8 and 2.4 in the total inventory and plasma energy, respectively, compared to cases without injection. This method effectively accomplishes FRC refueling while preserving the intrinsic characteristics of a simply connected, axisymmetric configuration and a high beta value approaching unity. Therefore, this approach offers potential for repetitive refueling in the reactor stage having a FRC plasma core. Experimental outcomes are compared with magnetohydrodynamic simulation results. In the collisional merging process, the characteristics of the pre-collision plasmoids, such as the strong toroidal rotation and coherent FRC-like magnetic field structures of the FRC, are not preserved. Experimental environments have been constructed to investigate such unique properties of the resulting FRCs.

Angular Dependence of Hump‐Shape Hall Effects for Distinguishing between Karplus–Luttinger and Geometrical Origins

AbstractAmong the vast magnetic heterostructures explored in Condensed Matter Physics, two contrasting interpretations of the hump‐shaped Hall Effects remain ambiguous and debated, namely, the overlap of two opposite‐signed Karplus–Luttinger Hall loops associated with inhomogeneous collinear domains with perpendicular anisotropy, or the Geometrical/Topological Hall Effect emanated from hexagonal close‐packed lattice of Skyrmion ground state with smoothly varying non‐collinear moments. Their similarity in topology implies difficulty in discrimination via magnetic imaging. Here, this ambiguity is overcome and clarified by the divergence exponent of hump peak fields extracted from Hall measurements with magnetic field rotation on several heterostructures. Their difference in sensitivity to in‐plane fields reveals that the former mechanism involves higher uniaxial anisotropy than the latter, departing from the Skyrmion ground state regime by the Ginzburg–Landau framework of triple‐q spin‐wave superposition. Numerous material systems can be summarized into a single curve of divergence exponent versus the collinear quality factor, bridging the crossover of the two mentioned mechanisms.

Influence of rotating magnetic field on thermal field and entropy generation of a tube containing the nanofluid using mixture model

The thermo-fluidic properties and entropy generation in a tube comprising nanofluid under variable rotational magnetic field have not been studied earlier. In the current study, the influence of a rotating magnetic field is evaluated by using mixture model at four different pump power for three cases. A steady-state, Newtonian Ag/water nanofluid, incompressible, and 3D model have been supposed. The influence of pump power variation and using nanofluid are studied. Results indicated that by raising the pump power for three cases, the Nusselt number enhances, and Bejan number, the friction factor, and dimensionless temperature decreases. The rotating magnetic field for the Case III in comparison to the Case Ⅰ and Case Ⅱ at 60 W and 0.5 % volume fraction of nanofluid, enhanced the Nusselt number by 356.3 % and 12.42 %, respectively. In the presence of 0.5 % nanofluid at 60 W pump power, the friction factor increases by 103.5 % compared to Case Ⅰ, with the same fluctuations observed in Cases Ⅱ and Ⅲ. The maximum dimensionless temperature reached 0.575 for Case Ⅲ at a power of 30 W using water. A rotating magnetic field of 60 W raised PEC by 219.44 % and 261.11 % for Cases Ⅱ and Ⅲ, respectively, compared to Case Ⅰ.

The polarization-angle flip in GRB prompt emission

Context. In recent years, some polarization measurements of gamma-ray bursts (GRBs) have been reported, and the polarization-angle (PA) rotation in the prompt emission phase has been found in several bursts. The physical mechanism of the PA evolution is still unclear. In this work, we studied the origin of the PA rotation in a toroidal magnetic field. Aims. We aim to provide an explanation for the PA rotation in GRBs and find the physical conditions that lead to the rotation by 90 degrees in the toroidal magnetic-field (MF) model. Moreover, we present some observable polarization properties in the MF model that can be tested in the future. Methods. We calculated the instantaneous polarization degree (PD) from a top-hat jet with different normalized viewing angles (q = θv/θj), jet opening angles (θj), and jet Lorentz factors (Γ) in three wavebands. When the PD changes between positive and negative values, it means that the PA flips by 90 degrees. On these grounds, we can summarize the range of parameters required for these PA flips. Considering these parameter conditions, we can further estimate the observed rate of the GRBs exhibiting such PA rotations. Results. We find that the PA rotation in the toroidal MF is primarily related to three critical factors: the viewing angle, the jet opening angle, and the jet Lorentz factor. Additionally, the PA can experience flips of 90 degrees twice. The conditions for the flips are q ≳ 0.5 (except for q ≃ 1) and yj = (Γθj)2 ≳ 4. However, the two flips in the PA might not be concurrently observable due to the constraint of flux. Taking these conditions into account and assuming a random orientation between the jet axis and the line of sight (LOS), we obtain a theoretical upper limit (without any constraints) for the observed rate of GRBs in the X-ray or γ-ray band displaying the flips in PA as Rch ≲ 80%. We further constrain the observed rate as Rch ∼ 16% according to the maximal post-flip polarized flux level, where the observed rate of single and double flips each account for ∼8%. It should be noted that the observed rates are different in various wavebands. The observed rate of the second PA flip in the optical bands should be higher than that in the X-ray or γ-ray band since the flux in the optical band declines much slower than that in the X-ray or γ-ray band. Moreover, when the LOS is close to the jet edge (q → 1), it is the easiest case in which to observe the 90-degree PA flip due to the relatively high post-flip polarized flux level. The first and second PA flips in a GRB pulse are most likely to occur at the observed times of tobs ∼ [2 − 3]tpeak and ∼[3 − 4]tpeak, respectively, where tpeak is the peak time of the pulse. It is also noted that the PA flip would not happen before the peak time.

White dwarf magnetospheres: Shielding volatile content of icy objects and implications for volatile pollution scarcity

Context. About 25–50% of white dwarfs are found to be contaminated by heavy elements, which are believed to originate from external sources such as planetary materials. Elemental abundances suggest that most of the pollutants are rocky objects and only a small fraction of white dwarfs bear traces of volatile accretion. Aims. In order to account for the scarcity of volatile pollution, we investigate the role of the white dwarfs’ magnetospheres in shielding the volatile content of icy objects. Methods. We estimated the volatile sublimation of inward drifting exocomets. We assume the orbits of the exocomets are circularized by the Alfvén wing drag that is effective for long-period comets. Results. Volatile material can sublimate outside the corotation radius and be shielded by the magnetic field. The two conditions for this volatile-shielded mechanism are that the magnetosphere radius must be larger than the corotation radius and that the volatiles are depleted outside the corotation radius, which requires a sufficiently slow orbital circularization process. We applied our model to nine white dwarfs with known rotational periods, magnetic fields, and atmosphere compositions. Our volatile-shielded model may explain the excess of volatile elements such as C and S in the disk relative to the white dwarf atmosphere in WD2326+049 (G29-38). Nevertheless, given the sensitivity of our model to the circularization process and material properties of icy objects, there remains considerable uncertainty in our results. Conclusions. We emphasize the importance of white dwarfs’ magnetic fields in preventing the accretion of volatile gas onto them. Our work suggests a possible explanation for the scarcity of volatile-accretion signatures among white dwarfs. We also identify a correlation between the magnetic field strength, the spin period, and the composition of pollutants in white dwarf atmospheres. However, given the uncertainties in our model, more observations are necessary to establish more precise constraints on the relevant parameters.

Safety of Exposure to 0.2 T and 4 Hz Rotating Magnetic Field: A Ten-Month Study on C57BL/6 Mice.

Amidst the burgeoning interest in rotating magnetic fields (RMF) within biological research, there remains a notable gap in the scientific evidence concerning the long-term safety of RMF. Thus, this study aimed to investigate the safety of protracted exposure to a 0.2 T, 4 Hz RMF over 10 months in mice. Two-month-old female C57BL/6 mice were randomly allocated to either the RMF group (exposed to 0.2 T, 4 Hz real RMF) or the SHAM group (exposed to 0 T, 4 Hz sham RMF). Throughout the experiment, the murine weekly body weights were recorded, and their behavioral traits were assessed via open field tests. In the final month, a comprehensive evaluation of the murine overall health was conducted, encompassing analyses of blood parameters, histomorphological examination of major organs, and skeletal assessments using X-ray and micro-CT imaging. The murine immune system and lipid metabolism were evaluated through immunochip analysis and metabolomics. Notably, no discernible adverse effects with RMF exposure were observed. Murine body weight, locomotor behavior, organ histomorphology, and skeletal health remained unaffected by RMF. Blood analysis revealed subtle changes in hormone and lipid levels between the SHAM and RMF groups, yet these differences did not reach statistical significance. Moreover, RMF led to elevated serum interleukin-28 (IL-28) levels, albeit within the normal range, and modest alterations in serum lipid metabolites. Conclusively, mice exposed to the 0.2 T, 4 Hz RMF for 10 months displayed no significant signs of chronic toxicity, indicating its potential clinical application as a physical therapy.

Palliative effect of rotating magnetic field on glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating osteoblast differentiation

With the substantial increase in the overuse of glucocorticoids (GCs) in clinical medicine, the prevalence of glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) continues to rise in recent years. However, the optimal treatment for GC-ONFH remains elusive. Rotating magnetic field (RMF), considered as a non-invasive, safe and effective approach, has been proved to have multiple beneficial biological effects including improving bone diseases. To verify the effects of RMF on GC-ONFH, a lipopolysaccharide (LPS) and methylprednisolone (MPS)-induced invivo rat model, and an MPS-induced invitro cell model have been employed. The results demonstrate that RMF alleviated bone mineral loss and femoral head collapse in GC-ONFH rats. Meanwhile, RMF reduced serum lipid levels, attenuated cystic lesions, raised the expression of anti-apoptotic proteins and osteoprotegerin (OPG), while suppressed the expression of pro-apoptotic proteins and nuclear factor receptor activator-κB (RANK) in GC-ONFH rats. Besides, RMF also facilitated the generation of ALP, attenuated apoptosis and inhibits the expression of pro-apoptotic proteins, facilitated the expression of OPG, and inhibited the expression of RANK in MPS-stimulated MC3T3-E1 cells. Thus, this study indicates that RMF can improve GC-ONFH in rat and cell models, suggesting that RMF have the potential in the treatment of clinical GC-ONFH.

Kinetic‐Scale Current Sheets in the Solar Wind at 5 AU

AbstractWe present statistical analysis of 16,903 current sheets (CSs) observed over 641 days aboard Ulysses spacecraft at 5 AU. We show that the magnetic field rotates across CSs through some shear angle, while only weakly varies in magnitude. The CSs are typically asymmetric with statistically different, though only by a few percent, magnetic field magnitudes at the CS boundaries. The data set is classified into about 90.6% non‐bifurcated and 9.4% bifurcated CSs. Most of the CSs are proton kinetic‐scale structures with the half‐thickness of non‐bifurcated and bifurcated CSs within respectively 200–2,000 km and 500–5,000 km or 0.5–5λp and 0.7–15λp in units of local proton inertial length. The amplitude of the current density, mostly parallel to magnetic field, is typically within 0.05–0.5 nA/m2 or 0.04–0.4JA in units of local Alfvén current density. The CSs demonstrate approximate scale‐invariance with the shear angle and current density amplitude scaling with the half‐thickness, and . The matching of the magnetic field rotation and compressibility observed within the CSs against those in ambient solar wind indicate that the CSs are produced by turbulence, inheriting its scale‐invariance and compressibility. The estimated asymmetry in plasma beta between the CS boundaries is shown to be insufficient to suppress magnetic reconnection through the diamagnetic drift of X‐line. The presented results will be of value for future comparative analysis of CSs observed at different distances from the Sun.