Benefitting from the similar microstructure morphology and macroscopic equivalent mechanical properties to the human bone, the Ti6Al4V gyroid lattice is widely applied in implant. Incompatibility of the elastic modulus between the bone and the implant results in the stress shielding. The anisotropy of lattice intensifies the uncontrollability the stress shielding. The anisotropy of lattice is reproduced experimentally and numerically in this work. A method for determining material parameters of representative volume unit is proposed, which successfully weakens the stress shielding in multiple directions. From the numerical results, the following findings are obtained. A method to increase the lattice elastic modulus without changing the volume fraction is proposed. The mechanical properties of the model with certain angle describing the rotated gyroid lattice is closer to isotropy. Several models with volume fractions of 20%–50% are more compatible with the elastic/shear modulus of human bone.
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