Cardiovascular disease is widespread at the present time, causing the disability of the population. The main risk factors are hyperlipoproteinemia, hypertension, hyperglycemia, etc. Blood-red hawthorn Crataegus sanguinea, a species of the genus Hawthorn (Crataegus) of the Rose family (Rosaceae) is a universal remedy for the prevention of diseases of the cardiovascular system. Hawthorn medications have antihypertensive, cardioprotective, cardiotonic, antiarrhythmic, mild diuretic, antispasmodic and sedative effects. At the same time, biologically active substances of hawthorn are non-toxic and do not have pronounced side effects with prolonged use. In this regard, it is important to study the mechanisms of pharmacological action of drugs based on this plant in order to prolong and improve the quality of life of the population.