ABSTRACT High pressure grinding rolls has been widely used in mineral industries as energy-efficient equipment. During the working life of an HPGR mill, the rolls’ surface wears out, and a concave wear profile (maximum wear in the middle) occurs on the rolls. As a result, a difference between HPGR discharge particle size from the middle and edges is also expected that has yet to be quantified. On the other hand, many operational variables affect the HPGR performance; however, there is an interaction between the operational variables and worn rolls. This work studied the effect of operational variables such as hydraulic pressure, rolls’ rotation speed, level of material in the hopper, and operational gap on the HPGR performance on an industrial scale. In addition, the particle size of HPGR discharge from the middle and edges of the rolls is also investigated. Results indicated that HPGR discharge from the middle of the rolls is always finer than discharge from the edges, while the difference between the discharge size from the middle and edges depended on the other variables. Furthermore, it was concluded that deeper material levels in the hopper and lower rotation speed of the rolls resulted in a finer HPGR discharge. This finding is crucial in optimising the HPGR performance and modifying the design of HPGRs to regulate the distribution of material on the rolls.