Role Of Venous Pressure Research Articles

The Role of Venous Pressure in Regulation of Output from the Heart of the Octopus, Eledone Cirrhosa (Lam.)

ABSTRACT The influence of perfusion pressure on stroke volume and heart rate was examined in the isolated ventricle. Input pressure, within the physiological range (10–20 cm of water), had a direct effect upon stroke volume and heart rate. Output back pressure had an inverse effect upon stroke volume and no effect upon heart rate. Sites that could vary input pressure were investigated by selective denervation in the whole animal. The results indicated that the efferent branchial vessel and auricle may be involved, as well as the branchial hearts and lateral venae cavae. It is proposed that the pressure of venous blood has a limited effect upon ventricular output in vivo.

Altered liver function of chronic congestive heart failure

C HRONIC congestive heart failure is characterized by widespread, complex and interrelated changes in various functions of the human body. That the liver is involved in these changes has been shown by numerous anatomic and physiologic studies.1-‘0 There is, however, little agreement among investigators as to the basic mechanisms producing the hepatic alterations. Anoxia, venous hypertension, malnutrition and infection, acting singly or in combination, have all been suggested as factors in the pathogenesis of the process. The possibility that the hepatic disturbance may secondarily modify the heart failure state remains a matter for speculation. In an attempt to appraise responsible mechanisms and possible functional interrelationships between the liver and the cardiocirculatory system, in patients with chronic congestive heart failure, a series of studies has been undertaken. The present report considers the nature and severity of liver impairment in the presence of cardiac decompensation and as compensation is restored. It also provides information concerning the role of venous pressure and arterial or hepatic hypoxia in determining or influencing the hepatic impairment.