We review recent progress in our understanding of the role of strange quarks in the structure of the nucleon. For the contribution to its mass the result is remarkably small, an order of magnitude smaller than commonly assumed. This has profound consequences for the searches for dark matter which are currently underway. There has also been remarkable progress in the understanding of hypernuclei. In particular, there is a very natural explanation at the quark level of why Λ-hypernuclei are bound whereas Σ-hypernuclei are not. The consequences for dense matter, for example in neutron stars, are not yet fully understood but we know they are significant.