Cascade decays of single K to O vacancies in an isolated iodine atom are simulated by straightforward construction of the cascade decay trees. Cascade-emitted electron and photon spectra are calculated and analyzed to determine the portions of energies (a) absorbed by the iodine atom after ionization and complete cascade relaxation, (b) emitted by cascade electrons, (c) emitted by cascade photons. These quantities are calculated as functions of incident photon energy following photoionization of the iodine atom in the 0.01–100 keV energy range. Cascade electrons and photoelectrons are shown to be principal energy transmitters from an ionized iodine atom to the environment. Presented data are relevant for developing the strategies of photon activation radiation therapy when iodine is used as a radiosensitizing agent.