Role Of Narrow Band Imaging Research Articles

Role of narrow band imaging in detecting recurrence in patients of squamous cell carcinoma larynx and hypopharynx who underwent radiotherapy/chemo-radiotherapy

BackgroundNarrow band imaging (NBI) is an emerging modality that enhances the accuracy of detection of head and neck malignancies by visualisation of aberrant neoangiogenesis in malignant tissue using narrow bandwidth light in blue and green spectrum. The purpose of this study was to assess the role of NBI in detecting recurrence in patients with Squamous cell carcinoma larynx and hypopharynx who have undergone Radiotherapy/Chemoradiotherapy (RT/CTRT). The aim of the study was to (a) determine the role of NBI in follow-up of patients with carcinoma of larynx and hypopharynx previously treated with radiotherapy or chemotherapy, (b) determine the role of NBI as the initial investigatory tool of choice in detecting local recurrence and compare with other modalities like fibreoptic laryngoscopy (FOL), Magnetic Resonance Imaging (MRI) and Positron Emission Tomography- Computed Tomography (PETCT). MethodsProspective multicentric study at ENT departments of tertiary care centres in Delhi, Bangalore and Pune in India was conducted from Jan 2019 to Sep 2022. Thirty-four consecutive patients diagnosed as squamous cell carcinoma (SCC) larynx/hypopharynx who underwent chemo/radiotherapy were scheduled for NBI 12 weeks after completion of therapy with FOL and PETCT/MRI and followed up 03 monthly for 02 years. NBI/FOL/PETCT or MRI and Histopathological Examination (HPE) were compared. ResultsNBI was found to be 100% sensitive and 96% specific with a positive predictive value of 85% and negative predictive value of 100% respectively with a diagnostic accuracy of 97%. ConclusionNBI along with FOL increases the sensitivity of detection of recurrence in patients of laryngeal/hypopharyngeal cancer post-chemo/radiotherapy.

Current role of narrow band imaging in diagnosing gastric intestinal metaplasia: a systematic review and meta-analysis of its diagnostic accuracy.

Gastric intestinal metaplasia (GIM) can be missed by random gastric biopsies taken during white light endoscopy. Narrow band imaging (NBI) may potentially improve the detection of GIM. However, pooled estimates from prospective studies are lacking and the diagnostic accuracy of NBI in detecting GIM needs to be more precisely defined. The aim of this systematic review and meta-analysis was to study the diagnostic performance of NBI in detecting GIM. PubMed/Medline and EMBASE were screened for studies examining GIM in relation to NBI. Data from each study were extracted and calculations of pooled sensitivity, specificity, likelihood ratios, diagnostic odds ratios (DORs), and areas under the curve (AUCs) were performed. Fixed or random effects models, were used as appropriate, depending on the presence of significant heterogeneity. We included 11 eligible studies in the meta-analysis, comprising 1672 patients. NBI showed a pooled sensitivity of 80% (95% confidence interval [CI] 69-87), specificity of 93% (95%CI 85-97), DOR 48 (95%CI 20-121), and AUC of 0.93 (95%CI 0.91-0.95) in detecting GIM. This meta-analysis showed that NBI is a reliable endoscopic means of detecting GIM. NBI with magnification performed better than NBI without magnification. However, better designed prospective studies are needed to precisely determine the diagnostic role of NBI, especially in high-risk populations where early detection of GIM can impact gastric cancer prevention and survival.

Role of Narrow-band Imaging in Visualizing the Vascularity of Tympanic Membrane in Otitis Media Using Vascular Otoendoscopy Score: A Pilot Study

Introduction: The victorious healing of the tympanic membrane (TM) primarily depends upon the adequate blood supply to the affected part of the TM. Magnifying narrow-band imaging (NBI) is a new technique used to improve the visualization of the vascularity status of perforated TM. However, search of peer-reviewed Indian literature revealed a lack of consensus on this. To improve the understanding of this subject in this study, magnifying NBI and conventional white light were compared using Vascular Otoendoscopy Score (VOS) which is a subjective scoring system used for evaluation of the degree of vascularization. Materials and Methods: The study was conducted using NBI and white light videoendoscopy to visualize TM vascularity in 100 otitis media (OM) and 100 normal TMs. Grading of vascularity was done using VOS in both arms and compared. Results: Our study revealed a score of 1.4 ± 0.71 on white light and 1.72 ± 0.45 on NBI as a reference in cases with OM and a score of 1.68 ± 0.46 on white light and 1.96 ± 0.19 on NBI can be taken as a reference for a normal TM. Conclusion: NBI has the advantage of better visualization of the vascularity status of TM and thus can potentially complement the white light examination for the prediction of better surgical outcomes.

Role of Narrow Band Imaging in Laryngeal Lesions: A Prospective Study from Southern India.

To assess the utility of Narrow Band Imaging (NBI) as a diagnostic tool in evaluating laryngeal pathology in patients presenting with hoarseness. Study design: Prospective cross sectional diagnostic study. Methods: 200 patients with voice change were recruited and laryngeal findings documented with high definition flexible endoscopy with both white light and narrow band light and the representative still images recorded for analysis. The NBI intraepithelial papillary capillary loop (IPCL) patterns was compared with the histopathology report. Of the 200 patients evaluated, 84 lesions were biopsied which included both benign and malignant lesions. The sensitivity obtained was 73.3% [54.1-87.7% with 95% CI] and the specificity was 87% [75.1-94.6% with 95% CI] for detecting malignant lesions. NBI can be considered as a useful diagnostic tool in evaluating laryngeal pathology and can be used to detect early premalignant and malignant lesions.

The role of NBI with flexible video-endoscope in the follow-up of head and neck cancer patients: a prospective study.

Narrow band imaging (NBI) enhances mucosal vasculature and could help in the identification of recurrences. We assessed the effectiveness of NBI with flexible video-endoscope in the early detection of recurrence after treatment of head and neck squamous cell carcinoma, its diagnostic advantage over high-definition white-light (HD WL) endoscopy, also in relation to recurrence site, and the influence of previous radiotherapy (RT) or chemotherapy (CT). Moreover, we investigated the association between index tumor site and the risk of developing recurrence, and the relation between index tumor site and recurrence site. From January 2018 to November 2020, 160 patients previously treated with surgery and/or RT ± CT were evaluated using NBI with flexible video-endoscope. Sensitivity, specificity, positive/negative predictive value, and accuracy were calculated for NBI and HD WL, and compared using the McNemar test. The Fisher exact test was used to compare the other associations investigated. The difference between NBI and HD WL sensitivity was statistically significant (p < 0.001). The NBI diagnostic advantage was 62.5%, highest in the hypopharynx (p = 0.05), and was not influenced by previous RT or CT (p = 0.49). Index tumor site statistically related with recurrence site (p < 0.001), but not with the risk of developing recurrence (p = 0.81). NBI with flexible video-endoscope could represent a valid option to detect recurrence early during the follow-up, especially in a difficult-to-visualize site such as the hypopharynx.

Role of narrow band imaging in the detection of mucosal lesions of head and neck

&lt;p class="abstract"&gt;&lt;strong&gt;Background: &lt;/strong&gt;Head and neck mucosal lesions are difficult to diagnose at early stage; therefore, they usually present at an advance phase. Narrow Band imaging (NBI) first came to use around 2005 and became one of the most used technologies for image enhanced endoscopy.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Material and method: &lt;/strong&gt;In order to identify best method for early detection of mucosal lesion of head and neck, we examined patients with suspected lesions first under white light endoscopy then under NBI endoscopy. Patients under-went biopsy thereafter, and results were compared. Our aim was to evaluate the role of NBI as a screening tool in the early detection of mucosal lesions of head and neck.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Result:&lt;/strong&gt; It was observed that NBI is useful tool in identifying mucosal lesions of head and neck early. 71 patients were included in our study and it was observed that NBI endoscopy shows 100% sensitivity, 96.36% specificity and 97.18% accuracy in identifying benign lesions. It shows 100% sensitivity, 94.74% specificity and 98.59% accuracy in identifying malignant lesions.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; In our study we came to conclusion that NBI is very promising tool for early screening purposes of mucosal lesions of head and neck which were missed in routine examination.&lt;/p&gt;

A Prospective Study to Evaluate the Role of Narrow Band Imaging and Toludine Blue in the Screening of Premalignant and Malignant Lesions of the Oral Cavity in a Tertiary Referral Centre.

In India cancer patients come at a very advanced stage with many of them being crossed the stage of resection. A wide range of non invasive techniques like toludine blue staining, methylene blue staining, Narrow band imaging have been developed for the early detection of malignant and premalignant lesions in the mucosa including oral cavity and gastrointestinal tract. However it is difficult for the clinicians to decide which diagnostic tool is most appropriate and useful for screening, resulting in failure to pick up the lesions at an early stage. Various online journals have been reviewed and no journal was found to support this point. This study here by describes Toludine blue and narrow-band imaging (NBI), diagnostic tools already proven independently as a useful screening method in many fields, and demonstrate its usefulness in the early detection of premalignant and malignant lesions of the oral cavity, as reported by previous studies in the otolaryngologic literature and compare both screening tools which has not been done till now. This study was done in a tertiary referral centre in middle India from March 2018 to August 2019 in order to evaluate the role of different screening tools (NBI and Toludine blue).44 patients with suspicious oral cavity lesions (premalignant and malignant) who had given consent for both NBI and toludine blue screening techniques were selected from the suspected (premalignant and malignant lesions) who had visited the OPD during the study period. Patients with proven malignancy were excluded from the study. A detailed history of the patient taken and standard Ear, nose, throat, oral cavity and neck examination of patient carried out. After subjecting the patients to screening tools like NBI and toludine blue, the efficacy of these techniques in helping us to take a representative biopsy was evaluated. In present study the sensitivity (to correctly identify all patients with disease), specificity (to correctly reject healthy patients without disease) of older technique toludine blue in detecting premalignant lesion was 66.6%, 87.8% while for NBI was 66.6%, 95%. For malignant lesion sensitivity and specificity of toludine blue was 94.3%, 100%, while the same for NBI was 100%, 88.8% respectively. Both NBI and toludine blue staining can be adopted for screening and the accurate detection of biopsy site and in the follow up of premalignant lesions to look for malignant transformation. Time tested is Toludine blue which is cheap and easily available. But being a better tool and having an upper hand in evaluating the lesions, NBI should be made available in all the secondary and tertiary care centres as a screening method.

The role of Narrow Band Imaging (NBI) in the diagnosis of sinonasal diseases.

Narrow band imaging (NBI) endoscopy is an optical method that helps to characterise tissue vasculature. Its appli- cation in sinonasal pathology remains scarce and a systematic study of its application to rhinology is lacking. The aim of this study is to analyse and describe the normal sinonasal mucosa under NBI light and to characterise the microvascular features of various sinonasal pathologies. We also want to suggest a classification of the patterns, peculiar to this district, and to evaluate whether they can be indicative of a specific physiological or pathological condition. Digital videos and images under white light and NBI of 103 patients (82 evaluated) with 29 sinonasal pathologies and 55 controls (33 evaluated). were independently analysed by three otolaryngologists and the final pattern was then arranged for each image, reaching an agreement between the individual evaluations. Once the appearance of normal sinonasal (SN) mucosa was established (SN1), four patterns for the pathological mucosa were described and a working classification was proposed (SN2, SN3, SN4, SN5). We calculated specificity (80.6% vs 90.6%), sensi- tivity (20% vs 38.5%), PPV (46.1% vs 50%), NPV (54.7% vs 85.7%) and accuracy (53% vs 80.3%) of the ability of SN4 and SN5 pattern to discriminate between benign and malignant nasal neoformations. This is the first study to propose a systematic NBI description and a classification of the vasculature of healthy and pathological mucosa in the sinonasal tract. Our preliminary results show that this technique can help in the workup of several rhinologic conditions and especially in distinguishing benign from malignant tumors.

Role of narrow band imaging in the diagnosis of premalignant and malignant lesions of oral cavity

Objective: To investigate the role of narrow band imaging (NBI) endoscopy in diagnosing oral premalignant and malignant lesions. Methods: NBI and white light (WLI) endoscopy were performed on 85 patients (47 females, 38 males, aged from 12 to 83 years old, the medium age was 58 years) with 144 oral lesions from July 2016 to October 2017 in the First Affiliated Hospital of Xiamen University. NBI findings were classified into 5 types according to the Ni's classification and compared with histopathological results. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of NBI and WLI were calculated. Accuracy of NBI on premalignant and malignant lesions were compared with that of WLI. The connection between NBI findings and pathological results were investigated. SPSS 22.0 software was used to analyze the data. Results: Sensitivity, specificity, PPV, and NPV of NBI vs WLI were 96.5% vs 81.2%, 98.3% vs 98.3%, 98.8% vs 98.6%, and 95.1% vs 78.4%, respectively. NBI findings showed high accordance with the phathological results (kappa=0.943,P<0.01). However, consistency between WLI findings and the phathological results was relatively low (kappa=0.765, P<0.01). NBI was more accurate in diagnosing both premalignant (P<0.01) and malignant lesions (especially for high-grade intraepithelial neoplasia, P<0.01) than WLI. There was remarkable correlation between NBI findings and the phathological results (r=0.836, P<0.01). Conclusions: NBI shows high accuracy in detecting premalignant and malignant lesions of oral cavity. Ni's NBI classification is helpful to diagnose the premalignant and early malignant lesions as well as to evaluate tumor invasion. Thus, NBI can contribute more to early diagnosis and therapy of premalignant and malignant lesions of oral cavity.

P254 Virtual chromoendoscopy with Narrow Band Imaging (NBI) for the classification of polypoid and non-polypoid lesions in ulcerative colitis: A prospective study using different endoscopic classifications

Abstract Background In ulcerative colitis (UC), the diagnostic accuracy of virtual chromoendoscopy with non-magnified Narrow Band Imaging (NBI) was disappointing in the detection and differential diagnosis of neoplastic lesions in most trials performed according to unclear diagnostic criteria. The Kudo and NICE criteria are validated in the general population, but controversial in UC. Recently, a modified Kudo classification specific for the inflammatory setting of UC has been developed using virtual chromoendoscopy with Fuji Intelligence Color Enhancement (FICE). The performance of NBI according to these three classifications for optical diagnosis of neoplastic and non-neoplastic lesions in UC has never been analysed. Methods All visible, polypoid and non-polypoid, lesions found during consecutive surveillance colonoscopies with non-magnified NBI (Exera II CV180) for long-standing UC (&amp;gt;8 years from disease onset) were included in a prospective, single-centre study, and classified as suspected or not suspected for neoplasia according to the NICE, Kudo and Kudo-modified criteria. The primary endpoint was to compare the sensitivity (SE), specificity (SP), negative (-LR) and positive (+LR) likelihood ratios of the three classifications, using histology as the reference standard. Results 394 lesions (mean size 6 mm, range 2–40 mm; type 0-Is 83%) from 84 patients (males 62%; mean age 57 y, range 30–79 y; mean disease duration 20 y) were found: 21 (5%) were neoplastic, 49 (12%) hyperplastic and 324 (82%) inflammatory lesions. The diagnostic accuracy of the NICE, Kudo and modified-Kudo classifications were, respectively: SE 76% vs. 71% vs. 86% (p = not significant); SP 55% vs. 69% vs. 79% (p &amp;lt; 0.05 Kudo-mod vs. both Kudo and NICE); +LR 1.69 vs. 2.34 vs. 4.15 (p &amp;lt; 0.05 Kudo-mod vs. both Kudo and NICE); -LR 0.43 vs. 0.41 vs. 0.18 (p = not significant). Conclusion The diagnostic accuracy of NBI for the differentiation of neoplastic and non-neoplastic lesions in UC is low if used with the conventional classifications validated in the general population, but it is significantly better with the modified Kudo classification specific for UC. The role of NBI in UC surveillance for neoplasia should be re-evaluated according to more accurate diagnostic criteria.

The role of narrow-band imaging in parathyroid surgery: a preliminary evaluation in five parathyroid adenoma cases.

Narrow-band imaging uses selective haemoglobin light absorption to emphasise vascular visualisation and capillary networks. This study aimed to evaluate the application of this technique to parathyroid surgery. This preliminary evaluation was carried out on five consecutive patients with single parathyroid adenoma being considered for minimally invasive video-assisted parathyroidectomy. The adenomas were checked for narrow-band imaging vascular patterns. Minimally invasive video-assisted parathyroidectomy was then carried out in accordance with our standard protocol. In four out of the five cases, narrow-band imaging integrated the white endoscopic light and direct vision, but in one case narrow-band imaging allowed distinction between the hidden neoplastic tissue and the surrounding structures thanks to the different vascular patterns. Narrow-band imaging was helpful in properly identifying adenoma. It is suggested that this technique be considered as a means for surgeons to improve their confidence in selected surgical treatments and to improve treatment quality.

Narrow Band Imaging for Surveillance in Inflammatory Bowel Disease

The role of narrow band imaging (NBI) for surveillance colonoscopy in patients with inflammatory bowel disease (IBD) is debatable. We aim to compare NBI versus other endoscopic techniques in surveillance of IBD basing on current evidences. A systematic search of PubMed, Embase, and the Cochrane Library databases was conducted for relevant studies. To assess the detection efficacy, we estimated risk ratios (RRs) for dichotomous outcomes and mean differences (MDs) for continuous outcomes. To assess the differentiation efficacy, we estimated sensitivity and specificity of NBI with reference to histology. All outcome variables were pooled using a random-effects model. Heterogeneity was tested by the Q statistic and I statistic. A total of 10 studies involving 938 participants were included. Statistically significant differences were not found in the likelihood of detecting patients with dysplastic lesions [RR, 1.11; 95% confidence interval (CI), 0.83-1.48] nor in the likelihood of detecting dysplastic lesions by targeted biopsies (RR, 0.76; 95% CI, 0.51-1.12) between NBI and other techniques, and there was also no difference in the likelihood of detecting dysplastic subtypes. NBI required shorter procedural time compared with other techniques (MD, -10.23; 95% CI, -11.53 to -8.92). The sensitivity and specificity of NBI to differentiate neoplastic lesions from non-neoplastic lesions were 0.64 (95% CI, 0.50-0.77) and 0.74 (95% CI, 0.69-0.79), respectively, and the area under the curve (AUC) was 0.7626. Although a shorter procedural time is needed, the clinical application of NBI for both dysplasia detection and neoplasia differentiation in IBD is not superior to other endoscopic techniques.

The role of narrow band imaging for the postoperative follow-up of malignant laryngeal tumor

The role of narrow band imaging for the postoperative follow-up of malignant laryngeal tumor

36 - Role of narrow band imaging in diagnostics of concurrent bladder carcinoma in situ

36 - Role of narrow band imaging in diagnostics of concurrent bladder carcinoma in situ

Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up.

Clinicians have recognised the role of narrow band imaging (NBI) in the management of head and neck cancer in several studies. However, a recent systematic review was unable to pool the data on diagnostic efficacy in this setting owing to the heterogeneity in the published data. Secondary analysis of data, utilising Bayes' theorem, from meta-analyses and randomised trials. In patients with a histological diagnosis of mild dysplasia who show no abnormalities on NBI, the post-test probability of malignancy is estimated to be 2.3%, compared to 10.3% with conventional white light imaging (WLI). For severe dysplasia, similar post-test probabilities after NBI and WLI are estimated to be 8.0% and 29.7%, respectively. Post-test probabilities in this setting indicate the chance of missing malignancy following a negative NBI or WLI in patients who undergo no further intervention. This study also provides a nomogram designed for use in this setting. This study identifies the evidence base for use of NBI in the follow-up for laryngeal dysplasia.

Role of narrow band imaging in the detection of malignant lesions of the oropharynx and the laryngopharynx

Objective:To explore the role of narrow band imaging (NBI) endoscopy in the diagnosis of oropharyngeal and laryngopharyngeal lesions. Method:NBI and white light (WLI) endoscopy were performed on 90 patients with oropharyngeal and laryngopharyngeal lesions from August 2016 to May 2017. NBI findings were classified into 5 types according to the Ni classification and were compared with histopathological results. Accuracy of NBI on premalignant and malignant lesions were compared with WLI. The connection between NBI findings and phathological results were explored. Result:Sensitivity, specificity, PPV, and NPV of NBI vs WLI were 988% vs 83.7%, 89.2% vs 86.5%, 95.5% vs 93.5%, and 97.1% vs 69.6%, respectively NBI findings were highly consistent with the phathological results (kappa=0.901,P<0.01). However, consistency between WLI findings and the phathological results was relatively low (kappa=0.657,P<0.01). NBI was more accurate in diagnosing both premalignant (P<0.01) and malignant lesions (especially for high-grade intraepithelial neoplasia, (P<0.01) than WLI. NBI findings correlated with the phathological results (r=0.820, P<0.01). Conclusion:NBI shows high accuracy in detecting premalignant and malignant lesions of oropharynx and laryngopharynx; Ni's NBI classification helps to diagnose the premalignant and early malignant lesions and evaluate tumor invasion. Thus, NBI can contribute more in the diagnosis and minimally invasive treatment of premalignant and malignant lesions of oropharynx and laryngopharynx.

Prospective diagnostic study on the use of narrow-band imaging on suspicious lesions during colonoscopy examination.

Colonoscopy is the gold standard to detect colorectal neoplasm. Narrow-band imaging (NBI) has a good diagnostic accuracy to differentiate between neoplastic and non-neoplastic colorectal lesions. This study explores the diagnostic validity of NBI colonoscopy as well as its associated factors related to neoplastic and non-neoplastic colorectal lesions. This study enrolled 100 patients in a single-center tertiary teaching hospital. Patients presented for screening colonoscopy, and those with suspicious colorectal lesions were included in this study. During colonoscopy, the most suspicious lesion in each patient was analyzed using the NBI system based on Sano's classification. Each lesion was biopsied for histopathological analysis, the gold standard. Endoscopic images were captured electronically. The sensitivity, specificity, and diagnostic accuracy of NBI colonoscopy were assessed. Other associated factors related to neoplastic and non-neoplastic lesions were analyzed accordingly. The sensitivity and specificity of the NBI were 88.2% and 71.9%, respectively. The area under the receiver-operator curve was 0.801, indicating that NBI has a good ability to differentiate between disease and non-disease. There are significant associations between histopathological examination outcomes and both presenting symptoms, especially weight loss, and lesion site, even after other variables were controlled (P < 0.05). The NBI system in colonoscopy was capable of distinguishing neoplastic from non-neoplastic colorectal lesions. It indicates an acceptable level of agreement with histopathology, the gold standard. However, the role of NBI in screening and surveillance in Malaysia still needs further evaluation and exploration.

The role of narrow band imaging for the early diagnosis of nasopharyngeal carcinoma

The role of narrow band imaging for the early diagnosis of nasopharyngeal carcinoma

Role of narrow band imaging in the diagnosis of laryngeal lesions: Pilot study from India.

Narrow band imaging (NBI) is a new imaging technique developed to improve the diagnostic accuracy of head and neck cancers by depiction of tumor-specific neo-angiogenesis. The purpose of this study was to assess the value of NBI in the diagnosis of laryngeal lesions. To assess the sensitivity and specificity of combined white light endoscopy (WLE) and NBI compared with WLE alone in the diagnosis of laryngeal lesions. Prospective study. Thirty consecutive patients with various laryngeal lesions scheduled for microlaryngoscopic evaluation underwent WLE followed by NBI. Endoscopic NBI findings were classified into five types (I-V) according to the intraepithelial papillary capillary loop features. Types I-IV are considered benign, whereas type V is considered malignant. The observations were compared with histopathology. Sensitivity, specificity, and positive and negative predictive values for the diagnosis of malignancy (i.e., invasive carcinoma and carcinoma in situ) by means of NBI with WLE were calculated. The sensitivity of WLE combined with NBI (100%) was higher than WLE alone (82.6%) in detecting laryngeal cancers. NBI helped in identifying four malignant lesions missed by WLE alone. Two children with respiratory papillomatosis also demonstrated type V pattern, a potential pitfall, leading to an overall positive predictive value of 92% and a negative predictive value of 100%. Combining NBI with WLE increases the sensitivity of detection of laryngeal cancer and its precursor lesions. NBI is also useful in some benign lesions as well as in post-radiotherapy patients.

Application of narrow band imaging in the detection of premalignant and malignant lesions of the larynx

Objective: To evaluate the role of narrow band imaging (NBI) endoscopy in the diagnosis of laryngeal lesions. Methods: A total of 136 patients with laryngeal lesions were examined by NBI and white light (WLI) endoscopy from July 2016 to May 2017. Sensitivity, specificity, accuracy, and positive predictive value (PPV) and negative predictive value (NPV) of NBI and WLI were calculated. SPSS 20.0 software was used to analyze the data. Results: Compared to WLI, NBI showed higher sensitivity (94.9% vs 83.3%), specificity (95.6% vs 84.4%), PPV (94.9% vs 82.3%), and NPV (95.6% vs 85.4%). There was high consistency of the results etween NBI and pathology (kappa=0.904, P<0.01). However, consistency of the findings between WLI and pathology was relatively weak (kappa=0.677, P<0.01). NBI showed the higher accuracy in diagnoses of both benign lesions (especially for premalignant lesions, P<0.01) and malignant lesions (especially for high-grade intraepithelial neoplasia, P<0.05) than WLI. NBI findings correlated with the pathological results (r=0.739, P<0.01). Conclusions: NBI demonstrates higher accuracy in the detection of premalignant and malignant lesions of the larynx.