Role Of Diet Composition Research Articles

The Metabolic Syndrome, a Human Disease.

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of related but rather independent pathologies. The human nature of MS (its exceptionality in Nature and its close interdependence with human action and evolution) is presented and discussed. The text also describes the close interdependence of its components, with special emphasis on the description of their interrelations (including their syndromic development and recruitment), as well as their consequences upon energy handling and partition. The main theories on MS's origin and development are presented in relation to hepatic steatosis, type 2 diabetes, and obesity, but encompass most of the MS components described so far. The differential effects of sex and its biological consequences are considered under the light of human social needs and evolution, which are also directly related to MS epidemiology, severity, and relations with senescence. The triggering and maintenance factors of MS are discussed, with especial emphasis on inflammation, a complex process affecting different levels of organization and which is a critical element for MS development. Inflammation is also related to the operation of connective tissue (including the adipose organ) and the widely studied and acknowledged influence of diet. The role of diet composition, including the transcendence of the anaplerotic maintenance of the Krebs cycle from dietary amino acid supply (and its timing), is developed in the context of testosterone and β-estradiol control of the insulin-glycaemia hepatic core system of carbohydrate-triacylglycerol energy handling. The high probability of MS acting as a unique complex biological control system (essentially monophyletic) is presented, together with additional perspectives/considerations on the treatment of this 'very' human disease.

Ramadan during pregnancy and neonatal health-Fasting, dietary composition and sleep patterns.

Large shares of pregnant Muslims worldwide observe the Ramadan fast. Previous research showed that Ramadan during pregnancy is associated with adverse offspring health outcomes lasting throughout the life-course. Evidence on effects on birth outcomes is inconclusive, however, and previous research did not consider the role of dietary composition and sleep patterns during Ramadan. This study systematically documents maternal lifestyle during Ramadan and assesses if diet and sleep adaptations to Ramadan, independent of and in addition to maternal fasting, are associated with neonatal health outcomes. This study reports a survey of 326 Muslims who delivered their baby in Mainz, Germany, linked to maternal & infant hospital records. Participants reported on fasting, dietary composition and sleep schedules while pregnant during Ramadan. Fasting during pregnancy was associated with reduced birthweight, in particular for fasting during the first trimester (-352ˑ92g, 95% CI: -537ˑ38; -168ˑ46). Neither dietary composition nor altered sleep were directly associated with birthweight. However, dietary composition during Ramadan outside of fasting hours seems to moderate the fasting-birthweight association, which disappeared for women switching to high-fat diets. The finding that dietary intake during Ramadan potentially moderates the fasting-birthweight association is of high relevance to pregnant Muslims who wish to fast and their healthcare professionals, since dietary choices outside of fasting hours are often relatively easily modifiable. This is the first study to include information on maternal diet and sleep during Ramadan, and additional research is needed to assess the roles of specific (macro)nutrients and food groups.

587 The role of diet composition fed during residual feed intake determinations and the impact of the diet on the gene sets associated with efficiency as determined by a gene set enrichment analysis

587 The role of diet composition fed during residual feed intake determinations and the impact of the diet on the gene sets associated with efficiency as determined by a gene set enrichment analysis

Look Action for Health in Diabetes trial: What we have learned in terms of real world practice and clinical trials.

Look Action for Health in Diabetes trial: What we have learned in terms of real world practice and clinical trials.

Have new guidelines overlooked the role of diet composition?

New US guidelines for the management of overweight and obesity have disregarded robust evidence from intervention trials demonstrating the importance of dietary factors for weight control and disease prevention. This omission implies that diet composition does not matter, a stance that is potentially counterproductive for prevention and treatment strategies.

Nonalcoholic Fatty Liver Disease (NAFLD), a Manifestation of the Metabolic Syndrome: New Perspectives on the Nutritional Therapy

Nonalcoholic fatty liver disease (NAFLD) is a multifactorial hepatic disease that develops through complex mechanisms that may be strongly influenced by dietary composition. NAFLD treatment is based on multidisciplinary intervention, which includes nutritional aspects. The objective of this review was to elucidate the influence and role of dietary composition, including fatty acid types, antioxidant nutrients, pre and probiotics and vitamin D in the nutritional treatment and prevention of NAFLD. Increased intake of Monounsaturated fatty acids (MUFAs) and omega-3 polyunsaturated fatty acid (PUFA), particularly as replacements for saturated fat and in a higher proportion than carbohydrates, is beneficial to NAFLD patients, improving insulin resistance; increasing plasma levels of adiponectin and its synthesis by the adipose tissue; and restoring the expression of hepatic peroxisome proliferator-activated receptor alpha (PPAR-I±), which in turn reduces cholesterol levels and triacylglycerol accumulation. n-3 PUFAs can reduce lipotoxicity caused by excessive saturated and trans fatty acid ingestion and exert a protective role in inflammatory pathways, promoting resolvins and protectins. Several mechanisms linking gut flora to NAFLD have been proposed, such as inflammation and energy extraction. Studies are often designed to explore the beneficial effects of probiotics, prebiotics and vitamin D in these pathways. The results of this review reveal that the strong positive influence bioactive compounds have on these inflammatory processes must be considered when developing treatment and prevention plans for NAFLD patients.

Factors that influence mercury concentrations in nestling Eagle Owls (Bubo bubo)

Mercury (Hg) is a global pollutant that bioaccumulates and biomagnifies in food chains, and is associated with adverse effects in both humans and wildlife. The Hg levels detected in blood obtained from Eagle Owl (Bubo bubo) chicks in Southeast Spain (Murcia) can be considered low (mean Hg concentration in blood from 2006 to 2012 was 36.83±145.58μg/l wet weigh, n=600), and it is therefore unlikely that Hg pollution can negatively affect their breeding. Positive correlation (r=0.339, p<0.001, n=229) was found to exist between the Hg concentrations in the blood and back feathers of the chicks. We provide a regression equation that could be helpful to estimate blood Hg levels when analyzing Hg concentrations in back feathers. Blood Hg concentrations in Eagle Owls have shown positive correlations with Hg levels in rabbit muscles, more evident in nests from the Northern area (r=0.600, p=0.014, n=16), where rabbits are the main prey of Eagle Owls. The best Linear Mixed Model to explain variations in blood Hg concentrations in nestling Eagle Owls includes year and location within the mining area as variables. The variable year is assigned the largest value of relative importance, followed by the location in the ancient mining sites and then the zone. Rainfalls may have an effect on the temporal differences in the blood Hg concentrations of nestling Eagle Owls. Although the studied region is not considered Hg polluted, the Hg levels were higher in Eagle Owls and European Rabbits from areas within the ancient mining sites as compared to those in the entire region. This result shows that spatial differences in Hg concentrations in Eagle Owls may be affected by local contamination, and that the role of diet composition may be less significant.

Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating

The role of diet composition in response to overeating and energy dissipation in humans is unclear. To evaluate the effects of overconsumption of low, normal, and high protein diets on weight gain, energy expenditure, and body composition. A single-blind, randomized controlled trial of 25 US healthy, weight-stable male and female volunteers, aged 18 to 35 years with a body mass index between 19 and 30. The first participant was admitted to the inpatient metabolic unit in June 2005 and the last in October 2007. After consuming a weight-stabilizing diet for 13 to 25 days, participants were randomized to diets containing 5% of energy from protein (low protein), 15% (normal protein), or 25% (high protein), which they were overfed during the last 8 weeks of their 10- to 12-week stay in the inpatient metabolic unit. Compared with energy intake during the weight stabilization period, the protein diets provided approximately 40% more energy intake, which corresponds to 954 kcal/d (95% CI, 884-1022 kcal/d). Body composition was measured by dual-energy x-ray absorptiometry biweekly, resting energy expenditure was measured weekly by ventilated hood, and total energy expenditure by doubly labeled water prior to the overeating and weight stabilization periods and at weeks 7 to 8. Overeating produced significantly less weight gain in the low protein diet group (3.16 kg; 95% CI, 1.88-4.44 kg) compared with the normal protein diet group (6.05 kg; 95% CI, 4.84-7.26 kg) or the high protein diet group (6.51 kg; 95% CI, 5.23-7.79 kg) (P = .002). Body fat increased similarly in all 3 protein diet groups and represented 50% to more than 90% of the excess stored calories. Resting energy expenditure, total energy expenditure, and body protein did not increase during overfeeding with the low protein diet. In contrast, resting energy expenditure (normal protein diet: 160 kcal/d [95% CI, 102-218 kcal/d]; high protein diet: 227 kcal/d [95% CI, 165-289 kcal/d]) and body protein (lean body mass) (normal protein diet: 2.87 kg [95% CI, 2.11-3.62 kg]; high protein diet: 3.18 kg [95% CI, 2.37-3.98 kg]) increased significantly with the normal and high protein diets. Among persons living in a controlled setting, calories alone account for the increase in fat; protein affected energy expenditure and storage of lean body mass, but not body fat storage. clinicaltrials.gov Identifier: NCT00565149.

Associations of body mass index and waist circumference with: energy intake and percentage energy from macronutrients, in a cohort of australian children

BackgroundIt is evident from previous research that the role of dietary composition in relation to the development of childhood obesity remains inconclusive. Several studies investigating the relationship between body mass index (BMI), waist circumference (WC) and/or skin fold measurements with energy intake have suggested that the macronutrient composition of the diet (protein, carbohydrate, fat) may play an important contributing role to obesity in childhood as it does in adults. This study investigated the possible relationship between BMI and WC with energy intake and percentage energy intake from macronutrients in Australian children and adolescents.MethodsHeight, weight and WC measurements, along with 24 h food and drink records (FDR) intake data were collected from 2460 boys and girls aged 5-17 years living in the state of Queensland, Australia.ResultsStatistically significant, yet weak correlations between BMI z-score and WC with total energy intake were observed in grades 1, 5 and 10, with only 55% of subjects having a physiologically plausible 24 hr FDR. Using Pearson correlations to examine the relationship between BMI and WC with energy intake and percentage macronutrient intake, no significant correlations were observed between BMI z-score or WC and percentage energy intake from protein, carbohydrate or fat. One way ANOVAs showed that although those with a higher BMI z-score or WC consumed significantly more energy than their lean counterparts.ConclusionNo evidence of an association between percentage macronutrient intake and BMI or WC was found. Evidently, more robust longitudinal studies are needed to elucidate the relationship linking obesity and dietary intake.

Probiotics in Preterm Infants: A Controversial Issue

Current research is directed toward innovative dietary compositions that exert specific effects on health promotion and reducing the risk of diseases. For example, the demonstration that the gut microbiota is an important constituent in the intestine's mucosal barrier has led to new therapeutic strategies for infections as well as allergic and inflammatory conditions. Specific probiotic bacteria have been shown to stabilize the gut microbial environment and the intestine's permeability barrier, and to enhance systemic and mucosal IgA responses. These comprise important targets in the preterm infant, who is particularly susceptible to infection and inflammation and in whom the immature enterocyte responds to intraluminal antigens with proinflammatory cytokines. Recent data point to differences in immunomodulatory effects between candidate probiotic bacteria. Each probiotic strain is a unique component itself, and each strain has specific properties that cannot be extrapolated from other, even closely related, strains. Therefore, these properties of probiotic bacteria should be characterized during preclinical and clinical evaluations. Furthermore, because probiotics are a tool with which to modify the gut barrier and microbiota, the strains used must be obtained from acceptable sources with a proven safety record and efficacy to guarantee their future clinical applications. The approach of supplementation with single components, however, overlooks the role of dietary composition, with its range of nutrients and other potentially active components, and also the conceivable combined effects. Consequently, research now focuses both on characterizing specific probiotic strains and on how the food matrix and the dietary content interact with the most efficient probiotic strains.

The Influence of Dietary Composition on Energy Intake and Body Weight

We review evidence regarding the influence of dietary fat, fiber, the glycemic index and sugar on energy intake and body weight. Although data from comprehensive long-term studies are lacking, published investigations suggest that the previous focus on lowering dietary fat as a means for promoting negative energy balance has led to an underestimation of the potential role of dietary composition in promoting reductions in energy intake and weight loss. More randomized clinical trials are needed to examine the relative utility of different putative dietary factors in the treatment of obesity.

Towards understanding the process of intestinal adaptation.

When bowel is lost due to disease or surgery, the residual bowel increases its functional capacity in order to compensate for the loss of absorptive capacity. The success and extent of this adaptive process is critical to recovery. This article reviews the current understanding of the intestinal adaptation. Adaptation is a complex process which as yet is poorly understood and thus it is difficult to develop strategies to enhance the out-come of the adaptation phase. Extensive loss of bowel brings about functional as well as morphologic changes in the remaining intestine. The exact relationship between histologic changes and function is still unknown and some studies show that histologic changes may precede functional changes. Both nonnutritive and nutritive factors have been identified as major stimuli to the adaptive process. The importance of oral intake as a positive stimulus has been demonstrated and the role of diet composition rather than diet complexity being recognized. Recent studies attempt to understand the molecular basis of intestinal adaptation by seeking to characterize the nature of humoral factors involved and to establish alterations in the patterns of gene expression. These new approaches may facilitate the identification of both nutritional and pharmacological methods to manipulate the intestinal adaptation process.

The pyruvate dehydrogenase complex: nutrient control and the pathogenesis of insulin resistance.

This review examines the molecular mechanisms underlying substrate competition between glucose and lipid in starvation and in insulin-resistant states. We demonstrate that lipid-derived substrates are oxidized in preference to glucose by skeletal muscle in vivo during prolonged starvation. An accelerated and exaggerated lipolytic and ketogenic response to starvation in late pregnancy is associated with more rapid suppression of glucose oxidation by the maternal skeletal-muscle mass. These benign adaptations to changes in lipid availability (which occur secondarily to changes in carbohydrate supply and demand) contrast with the well-documented detrimental effects to health of an inappropriately high supply of dietary lipid. We present results that indicate that the prolonged consumption of a diet high in saturated fat is associated with a stable enhancement of pyruvate dehydrogenase (PDH) kinase activity at least in two oxidative tissues--liver and heart. This long-term enhancement of PDH kinase activity is concomitant with the development of whole-body insulin resistance and adds a new dimension to the potential role of dietary composition in the pathogenesis of insulin resistance.

Role of diet composition on bacterial translocation (BT) after small bowel transplantation (SBT) in rats

Role of diet composition on bacterial translocation (BT) after small bowel transplantation (SBT) in rats

NUTRITION IN THE PATHOGENESIS OF ALCOHOLIC LIVER DISEASE

The data and experimental results reviewed here allow the construction of the following hypothesis: alcohol-induced liver disease results from a combination of two phenomena. The first is the induction of the maximum activity of CYP 2E1 by several dietary factors, i.e. (1) low carbohydrate-high fat diet; and (2) the dietary fats composed of PUFA (Yang et al., 1992). The second is the production of lipid peroxidation induced by CYP 2E1 oxidation of ethanol maintained at high blood alcohol levels (> 200 mg %) with the availability of PUFA as substrate (Ekstrom and Ingelman-Sundberg, 1988; Koop, 1992). Thus, lipid peroxidation may be the final common pathway which supports the induction of ALD. Further, it may provide the common denominator which links ALD pathogenesis to non-alcoholic steato-hepatitis (NASH) (French et al., 1989b), where CYP 2E1 is induced by high fat diet and/or diabetes (Dong et al., 1988).

Effects of Dietary Protein Levels on Reproduction and Food Consumption in the German Cockroach (Dictyoptera: Blattellidae)

The effects of four diets (commercial rat food, 5, 25, and 65% protein) on reproduction and daily food consumption of male and female German cockroaches were investigated. Females compensate for low dietary protein levels by elevating consumption rates and reproduce normally. Conversely, a high-protein diet significantly delayed mating in females and resulted in smaller oöthecae. Percentage hatch of oöthecae and male sexual maturation were unaffected by dietary protein content. Males that were allowed to copulate twice a week, ate more, and died sooner than males allowed to mate only once. The role of diet composition in regulating feeding behavior is discussed.