Role Of Adverse Childhood Experiences Research Articles

Professional Help-Seeking Attitudes Among College Students: The Role of ACEs, Resilience, and Mental Health

ABSTRACT Adverse Childhood Experiences (ACEs) are associated with poorer physical and mental health outcomes, which have been shown to negatively impact resilience. The prevalence of mental health diagnoses among college students is increasing in frequency and severity. Further, research shows that college students often have unmet mental health needs and underutilize professional help for mental health disorders. The purpose of this study was to better understand the relationship between ACES, resilience, mental health diagnosis, mental health treatment, and attitudes toward help-seeking. Specifically, we wanted to understand what contributes to college students seeking professional help. Nine hundred and forty-one college students from a large Southwest university completed a series of measures via a Qualtrics link. There was a significant relationship between ACE scores and previous/current mental health diagnosis (p = .001) and between ACE scores and previous/current psychological treatment (p = .001). When considering all factors together, a four-way ANOVA indicated the overall model was significant, but only current/recent mental health treatment had a significant effect on attitude toward seeking professional help (p=.001). ACEs, resiliency, and mental health diagnosis did not impact attitudes toward seeking help. This study adds to the growing body of literature on understanding what contributes to college students seeking help.

Understanding adverse childhood experiences and the call for trauma-informed healthcare system in Turkey: a review

Over the past four decades, research has underscored the significance of approaching and preventing trauma from a systemic standpoint. Trauma-informed care (TIC) methodologies offer a structure for healthcare practices, striving to convert organizations into trauma-informed systems that employ trauma-specific interventions. This review employs epidemiological and household data from Turkey to underscore the importance of integrating trauma-informed care as a means of prevention and intervention. Through a desk review, the study examines the role of adverse childhood experiences (ACEs), delving into their origin from family dynamics, migration, violence, exposure to violence, juvenile delinquency, and child maltreatment. The research highlights innovative healthcare approaches that leverage data to address complex patient health issues while considering mental health needs. In contemporary times, healthcare organizations acknowledge the value of a data-driven approach to make informed clinical decisions, enhance treatment procedures, and improve overall healthcare outcomes. The reviewed research and empirical data furnish proof of the importance of effective and efficient treatment methods that prioritize trauma prevention and treatment, integrating the role of ACEs. This paper seeks to contribute to discussions on transforming the healthcare system to meet the healthcare needs of Turkish households, all the while taking into account the evolving sociopolitical factors that shape Turkey's population characteristics.

Neural correlates of stress-reactive rumination in depression – The role of childhood trauma and social anxiety

Recent work showed an association of prefrontal dysfunctions in patients with Major Depressive Disorder (MDD) and social stress induced rumination. However, up to date it is unclear which etiological features of MDD might cause prefrontal dysfunctions. In the study at hand, we aimed to replicate recent findings, that showed prefrontal activation alterations during the Trier Social Stress Test (TSST) and subsequently increased stress-reactive rumination in MDD compared to healthy controls. Moreover, we aimed to explore the role of adverse childhood experiences and other clinical variables in this relationship. N = 55 patients currently suffering from MDD and n = 42 healthy controls (HC) underwent the TSST, while cortical activity in areas of the Cognitive Control Network (CCN) was measured via functional near-infrared spectroscopy (fNIRS). The TSST successfully induced a stress reaction (physiologically, as well as indicated by subjective stress ratings) and state rumination in all subjects with moderate to large effect sizes. In comparison to HC, MDD patients showed elevated levels of state rumination with large effect sizes, as well as a typical pattern of reduced cortical oxygenation during stress in the CCN with moderate effect sizes. Self-reported emotional abuse and social anxiety were moderately positively associated with increased stress-reactive rumination. Within the MDD sample, emotional abuse was negatively and social anxiety positively associated with cortical oxygenation within the CCN with moderate to large effect sizes. In conclusion, our results replicate previous findings on MDD-associated prefrontal hypoactivity during stress and extends the research toward specific subtypes of depression.

Adverse Childhood Experiences

This paper examines the role of Adverse Childhood Experiences on adolescent development. Adverse Childhood Experiences are significant early traumas that affect brain development and can lead to serious physical, mental and emotional issues if left unaddressed. Incorporating evidence from literature reviews, this study demonstrates that these issues can be addressed by nurturing resilience into the lives of children and adults.

The trajectory of anxiety in therapy: The role of ACEs.

The connection between adverse childhood experiences (ACEs) and anxiety disorders is well-documented. Additionally, therapy has been shown to be effective at reducing anxiety symptoms. Yet more needs to be known about how ACEs may shape the process of therapy and the trajectory of anxiety symptoms. This study was designed to compare the trajectory of improvement in anxiety symptoms over the course of 12 sessions of therapy in adults (N = 472), who reported more (greater than four) and fewer (fewer than four) ACEs using a multigroup latent growth curve analysis. Data were drawn from the Marriage and Family Therapy Practice Research Networkdatabase. Results suggested that the rate of improvement in those with more and fewer ACEs was not significantly different; however, those with more ACEs had a significantly higher average starting point of anxiety symptoms.

The role of negative childhood experiences and internal stigma in the formation of motivation for the treatment of patients with mental disorders

Background: Motivation for treatment is an important component of patients' compliance to treatment of mental disorders, and its formation can be affected by different factors. The aim of the study: To analyze relationship between adverse childhood experiences, internal stigma and the intensity and structure of motivation to pharmaco-psychotherapy in patients with mental disorders. Materials and methods: The study involved 102 patients treated at the V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, the Kashchenko Hospital, and the City Psychiatric Hospital No. 6. The study used the Adverse Childhood Experience (ACE) questionnaire, the Internalized Stigma of Mental Illness (ISMI) questionnaire, and the Treatment Motivation Assessment Questionnaire (TIMQ). Statistical analysis was performed using the SPSS 26.0 software package. Results: According to the results of multiple regression analysis, patients with higher education determined the improvement of patients' motivation for treatment, increasing the probability of its high intensity by 5.92 times. The presence of each additional type of adverse experience in childhood also 1.4-fold increase the odds of intensive motivation of patients. Among individual variants of negative experience, emotional abuse was associated with a tenfold decrease in odds, while observing violence against a mother or stepmother in childhood was conversely associated with a fifteenfold increase in the odds of forming an intense motivation for treatment. Conclusion: Integrative role of adverse childhood experiences is important, but, unlike the internal stigma of mental disorder, it can be equally associated with both less adaptive motivational patterns during treatment. to both more and less adaptive motivational patterns in patients in the process of their treatment.

COVID-19 post-traumatic stress disorder: the role of ACEs, alexithymia, and attachment in the Italian population.

The COVID-19 pandemic is considered a collective traumatic event. Several studies have highlighted high levels of post-traumatic stress disorder (PTSD) symptoms among the general population during the pandemic. The general aim of this research is to explore the role of adverse childhood experiences (ACEs), alexithymia, and anxiety and avoidance attachment dimensions as risk factors that are making individuals more vulnerable to PTSD-COVID-related symptoms. The COVID-19-PTSD Questionnaire, 20-Item Toronto Alexithymia Scale (TAS-20), Adverse Childhood Experiences Questionnaire, and the Experiences in Close Relationships-Revised Form (ECR-R) were administered to 224 participants who were between 18 and 65 years of age, and residents of Italy. Socio-demographic variables were also collected. The data was collected between October 2021 and March 2022. The findings of the Spearman correlation analysis showed several significant associations between alexithymia, attachment dimensions, and PTSD symptoms related to COVID-19 diagnosis and age. A multivariable logistic regression model was performed using the COVID-19-PTSD total scores over/under the clinical cut-off as dependent variables and age, gender, anxiety and avoidance attachment scores, ACEs, and total alexithymia as independent variables, with alexithymia total score (B = .071; p = .001), ECR-R Anxiety (B = .034; p = .001) and ECR-R Avoidance (B = -.033; p = .024) showing to respectively increase and reduce the possibility of reporting clinical symptomatology. Emotional regulation and attachment have been shown to be risk factors for COVID-19 PTSD symptomatology. Focused intervention programs and emotional education can be useful tools for developing protective factors in the general population.

Associations between adverse childhood experiences and history of weight cycling.

Adverse childhood experiences (ACEs) predict obesity onset; however, the relationship between ACEs and history of weight cycling has not been adequately explored. This gap is problematic given the difficulty in weight loss maintenance and the impact of ACEs on obesity development, chronicity, and associated weight stigma. The objective of this study was to examine associations between self-reported history of ACEs and weight cycling in a sample of weight loss treatment-seeking adults with overweight/obesity. The number of participants in the analyzed sample was 78, mostly white educated adult women (80% female, 81% Caucasian, 75%≥bachelor's degree) with excess adiposity enrolled in the Cognitive and Self-regulatory Mechanisms of Obesity Study. ACEs were measured at baseline using the ACEs Scale. History of weight cycling was measured using the Weight and Lifestyle Inventory that documented weight loss(es) of 10 or more pounds. Higher ACE scores were associated with a greater likelihood of reporting a history of weight cycling. Participants with four or more ACEs had 8 times higher odds (OR=8.301, 95% CI=2.271-54.209, p=0.027) of reporting weight cycling compared with participants with no ACEs. The association of weight cycling for those who endorsed one to three ACEs was not significant (OR=2.3, 95% CI=0.771-6.857, p=0.135) in this sample. The role of ACEs in health may be related to associations with weight cycling. Results indicated that those who reported four or more ACEs had significantly higher odds of reporting weight cycling compared with those with no ACEs. Further research is needed to further explore how ACEs predict the likelihood of weight cycling, which may be prognostic for sustained weight loss treatment response and weight stigma impacts.

The role of adverse childhood experiences in predicting child abuse perpetration among married mothers in Alexandria, Egypt: a cross-sectional study

BackgroundAdverse childhood experiences (ACEs) are receiving increased amounts of attention as a critical public health issue. ACEs have a massive impact on future violence victimization and perpetration. They are also associated with lifelong mental and physical health consequences as well as premature mortality. The present study aimed to investigate the role of different ACEs among married mothers in predicting the risk of child abuse perpetration in offspring.MethodsA cross-sectional study was conducted on 350 mothers of children aged 2–12 years attending family health centres in Alexandria. The mothers completed a predesigned interview questionnaire on sociodemographic data and data related to ACEs, spousal violence, and child abuse perpetration. Suitable bivariate and multivariate statistical tests were used to analyse the collected data using version 20.0 of the Statistical Package for Social Sciences (SPSS).ResultsTwo-thirds of mothers (66.3%) reported ever having been exposed to any ACE, and 18.6% of them had experienced 3 or more ACEs. Psychological abuse (46%) and witnessing domestic violence (17%) were the most common. Psychological aggression (95.4%), minor physical assault (79%), and neglect (52%) were the most common forms of child abuse perpetrated by the mothers. The number of ACEs experienced by mothers showed a moderate positive significant correlation with the 5 forms of child abuse examined. Different ACEs, mother’s age, socioeconomic status, and current exposure to spousal violence were found to be independent predictors of different forms of child abuse (psychological aggression, neglect, minor physical assault, and severe physical assault).ConclusionDifferent practices of family violence are strongly connected throughout different stages of an individual’s life and across generations. Further understanding of the interconnections among forms of violence and addressing them should be prioritized. Additionally, concerted national strategies across all levels and sectors are needed to address this complex problem.

Beyond tears: The predictive role of adverse childhood experiences and complex trauma in male depression within the Chinese cultural context.

Beyond tears: The predictive role of adverse childhood experiences and complex trauma in male depression within the Chinese cultural context.

Medical trauma in young adults with inflammatory bowel disease: The role of trauma-informed care

Medical trauma is a profound concern for those with chronic conditions like inflammatory bowel disease (IBD), especially young adults. This trauma, arising from both the disease itself and necessary medical interventions, manifests as an accumulation of traumatic experiences impacting a patient’s physical and psychological well-being. The Crohn’s and Colitis Young Adults Network (CCYAN) conducted a roundtable discussion involving young adult IBD patients and healthcare professionals focused on medical trauma and its implications in the treatment of young adults with IBD. This article summarizes the key insights from this discussion, including medical trauma in IBD as an accumulation of ‘micro-traumas,’ the impacts of such trauma and disruptions in care regardless of post-traumatic stress diagnosis, the role of adverse childhood experiences and trauma-informed care, practical strategies to cultivate trust during individual patient encounters, and recommendations for providing trauma-informed care within the clinical setting.

To trust or not to trust in the thrall of the COVID-19 pandemic: Conspiracy endorsement and the role of adverse childhood experiences, epistemic trust, and personality functioning

RationaleConspiracy endorsement is a public health challenge for the successful containment of the COVID-19 pandemic. While usually considered a societal phenomenon, little is known about the equally important developmental backdrops and personality characteristics like mistrust that render an individual prone to conspiracy endorsement. There is a growing body of evidence implying a detrimental role of adverse childhood experiences (ACEs) – a highly prevalent developmental burden – in the development of epistemic trust and personality functioning. This study aimed to investigate the association between ACEs and conspiracy endorsement in the general population, specifically questioning a mediating role of epistemic trust and personality functioning. MethodsBased on cross-sectional data from a representative German survey collected during the COVID-19 pandemic (N = 2501), we conducted structural equation modelling (SEM) where personality functioning (OPD-SQS) and epistemic trust (ETMCQ) were included as mediators of the association between ACEs and conspiracy endorsement. Bootstrapped confidence intervals (5000 samples, 95%-CI) are presented for all paths. ResultsACEs were significantly associated with conspiracy endorsement (β = 0.25, p < 0.001) and explained 6% of its variance. Adding epistemic trust and personality functioning as mediators increased the explained variance of conspiracy endorsement to 19% while the direct association between ACEs and conspiracy endorsement was diminished (β = 0.12, p < 0.001), indicating an indirect effect of personality functioning and epistemic trust in the association between ACEs and conspiracy endorsement. Fit indices confirmed good model fit. ConclusionsEstablishing an association between ACEs and conspiracy endorsement further increases the evidence for early childhood adversities' far-reaching and detrimental effects. By including epistemic trust and personality functioning, these findings contribute to a deeper understanding of the underlying mechanisms in the way that ACEs may be associated with conspiracy endorsement.

Linking Adverse Childhood Experiences and Other Risk Factors to Subjective Cognitive Decline in an Aging Population.

The Centers for Disease Control and Prevention's Healthy Brain Initiative (HBI) encourages an interdisciplinary approach to addressing the burden of subjective cognitive decline (SCD) among the aging US population as that population continues to increase. Our study is one of the first to evaluate associations between SCD and adverse childhood experiences (ACEs) and other modifiable risk factors to support implementation of the initiative. We used multivariate logistic regression to assess data from the 2020 Behavioral Risk Factor Surveillance System survey to evaluate associations between SCD and ACEs scores and sociodemographic, behavioral, and clinical risk factors. Models were weighted to account for the complex survey design. Approximately 8.1% of survey respondents reported experiencing SCD within the past 12 months. Adjusted regression analysis showed that conditions such as depression (AOR, 2.85; 95% CI, 2.29-3.55), arthritis (AOR, 1.30; 95% CI, 1.05-1.60), and diabetes (AOR, 1.33; 95% CI, 1.05-1.68) were significantly associated with SCD. SCD was also associated with experiencing more than 3 falls per year (AOR, 2.95; 95% CI, 2.13-4.09), sleeping more than 9 hours per night (AOR, 2.06; 95% CI, 1.37-3.09), and physical inactivity (AOR, 1.32; 95% CI, 1.03-1.68). Two or more ACEs also significantly increased the odds of SCD (AOR, 1.69; 95% CI, 1.36-2.10). Findings from our study can be used to inform policy, environment, and systems change efforts aimed at addressing modifiable risk factors to support healthy aging. The role of ACEs as determinants of brain health across the life course should also be considered in the design of clinical and community-based interventions.

The effect of smoking initiation in adolescence on the subsequent smoking trajectories of people who smoke, and the role of adverse childhood experiences: Results from the 1958 British cohort study.

To examine the association between smoking initiation in adolescence and subsequent different smoking trajectories of people who smoke, and to examine the combined effect of adverse childhood experiences (ACEs) and smoking initiation in adolescence on smoking trajectories of people who smoke. Data are from 8757 individuals in Great Britain from the birth cohort National Child Development Study and who reported being smokers or former smokers by age 23. Smoking initiation in adolescence was measured at 16 y and smoking trajectories were derived from smoking variables from ages 23 to 55. We modelled the relationship between smoking initiation in adolescence with or without ACEs and smoking trajectories. Individuals who initiated smoking in adolescence were more likely to quit later than quitting in twenties (RRR quitting in thirties =3.43 [2.40; 4.89] p<.001; RRR quitting in forties =5.25 [3.38; 8.14] p<.001; RRR quitting in fifties =4.48 [2.95; 6.79] p<.001), to relapse (RRR Relapse =3.66 [2.82; 4.76] p<.001) and to be persistent smokers (RRR persistent =5.25 [3.81; 7.25] p<.001) compared to those who had initiated smoking in young adulthood. These effects were particularly pronounced in case of ACEs. Smoking prevention programs aimed at reducing smoking initiation should be promoted to adolescents to limit the burden of smoking, especially for people who have suffered adversity during childhood.

The role of adverse childhood experiences in obesity among adolescents with autism spectrum disorder: National survey of Children’s health 2018-2019

BackgroundAdolescents with autism spectrum disorder (ASD) are at an increased risk of overweight/obesity and adverse childhood experiences (ACEs). ObjectiveThis study examined whether ACEs increased the odds of overweight/obesity in adolescents with ASD. MethodsThis cross-sectional study used National Survey of Children's Health (NSCH) 2018-2019 data (N = 31,533 children ages 10–17 years, including n = 480 children with mild ASD and n = 423 children with moderate/severe ASD with normal or overweight/obese BMI). Parent-reported body mass index (BMI) was coded as overweight/obesity vs. normal weight. The independent variable was the count of nine ACEs. Binary logistic regression was conducted, controlling for social ecological factors. ResultsThe odds of overweight/obesity in adolescents with ASD with 1–2 ACEs (OR 1.3, CI 1.1-1.4) and 3+ ACEs (OR 1.6, CI 1.3-2.0) were higher than those with 0 ACEs; odds increased with higher counts of ACEs. Household income level was the most significant sociodemographic influence on odds of obesity in adolescents with ASD (0–99 % Federal Poverty Level: OR 1.9, CI 1.6-2.3). Adolescents with moderate/severe ASD (OR 1.7, CI 1.2-2.5) and mild ASD (OR 1.6, CI 1.0-2.4) had higher odds of overweight/obesity after accounting for ACEs, race/ethnicity, sex, household income, and physical activity. ConclusionFindings indicated ACEs are associated with ASD, which calls for integration of ACEs information within trauma-informed care practices for obesity prevention and intervention for adolescents with ASD. Persistent disparities of overweight/obesity exist by race/ethnicity, sex, and household income within this population, which indicates the need for tailoring trauma-informed approaches to the unique needs of this population.

The Role of Adverse Childhood Experiences in the Trajectories to Adulthood of Chinese Youth: A Retrospective Study

This study uses data from a retrospective survey of the life history of participants from five cohorts born between 1930 and 1979, to analyze the role of adverse childhood experiences (ACEs). We found that ACEs have significant effects on the transition of young Chinese people into adulthood. Young people who have experienced more ACEs were more likely to transition to adulthood earlier, and accelerate their acceptance of adult social roles, and young adults with a high incidence of ACEs also have an increasing probability of falling into the disadvantaged or least successful trajectory to adulthood. More ACEs are associated with a decreased probability of being classified into the delayed and advantaged trajectories into adulthood characterized by high education and stable work, and an increased probability of being classified into the early and disadvantaged trajectories into adulthood characterized by unemployment, early marriage, and more children.

Moving From Adverse Childhood Experiences to Celebrating Supportive Nurturing Relationships.

The editors of the Section on Pediatric Trainees feature in Pediatrics are deeply pleased to share the winning submission from the feature's seventh annual essay competition. This year's competition was informed by the 2022-2023 Section on Pediatric Trainees Advocacy Campaign: "Races against ACEs," which encouraged trainees to understand, witness, and act upon the role of adverse childhood experiences (ACEs) in pediatric medicine, and youth welfare more broadly. In the essay competition, we asked writers to reflect not only on the effects of ACEs on the well-being of young people, but also on how pediatricians can address these issues in venues ranging from patient encounters to training programs to public policy. We were impressed by, and grateful for, the thoughtfulness and vulnerability of trainees in sharing their experiences related to this critically important topic. This winning essay, by Dr Chelemedos, weaves the author's lived experiences with childhood trauma alongside clinical experiences caring for patients facing similar, though distinct, challenges. In doing so, Chelemedos' work sheds light on the ubiquity, and long-term impacts, of ACEs across the life span in a deeply human way; simultaneously, it exemplifies the critical role physicians play in combatting social malaise, one full set of swings at a time. The runner-up essay, by Dr Alessandra Angelino, will appear in next month's issue.

The Role of Adverse Childhood Experiences on People in Opiate Agonist Treatment: The Importance of Feeling Unloved

Introduction: Adults in opiate agonist treatment (OAT) often have a background of adverse childhood experiences (ACEs) and are more likely to be exposed to a variety of risks that may trigger post-traumatic stress disorder (PTSD). Summative ACE scores are often used to identify individuals at risk of PTSD and continued substance use. What has not been addressed is whether specific ACE factors are exerting a greater influence on the individual. This study investigated whether specific ACEs predicted PTSD, and current continued substance use among adults in long-term OAT. Methods: An analysis of data that were collected at the follow-up stage of a study among 131 adults who attended OAT was conducted. Participants attended one of six OAT settings, covering 45% (n = 890) of clients in a defined area of Dublin, Ireland in 2017. Interviews were conducted with 104 participants, 66 males (63%) and 38 females (37%), with an average age of 43 years (SD = 7.4). The Adverse Childhood Questionnaire (ACQ); PTSD checklist (PCL-5); heroin; tranquilliser; cannabis; alcohol; and cocaine used in the previous 28 days were measured using the quantity used score within the Opiate Treatment Index. Socio‐demographics and age of first use of these four substances were also collected. The analysis has focussed on relating ACEs to PTSD, age of first drugs use, and current drug use of the participants. Results: Bivariate analysis showed that the summative ACQ score was significantly correlated with age of first opiate use (p = 0.004). Multiple regression analysis showed that the summative ACQ score and tranquilliser use predicted higher levels of PTSD (R2 = 0.50). Four specific ACEs predicted 54% of the variance in PTSD, these were feeling unloved (β = 0.328) living with a household member who had a problem with alcohol or used illicit street drugs (β = 0.280); verbal abuse (β = 0.219); and living with a person who had a mental illness (β = 0.197). Conclusions: While a summation of all ten ACEs predicted higher levels of PTSD, the factor “feeling unloved” as a child provided the single strongest predictor and may represent an overarching risk of PTSD and continued substance use in later life among adults in treatment for an opiate use disorder.

Burnout and secondary traumatic stress in staff working with people with intellectual disabilities: The role of adverse childhood experiences, resilience and trauma-informed organisational climate.

There has been extensive research into adverse childhood experiences (ACEs), however, less consideration has been given to the prevalence and impact of ACEs for staff working with people with intellectual disabilities. Participants were staff employed by agencies that care for people with intellectual disabilities. An online survey collected demographic information and measures of ACEs, resilience, trauma-informed organisational climate, burnout and secondary traumatic stress. Correlation, regression, mediation and moderation analyses were used. 81.7% of 109 participants had experienced at least one ACE. Burnout, secondary traumatic stress and resilience were greater in the present study than in comparable samples. Trauma-informed organisational climate significantly predicted burnout and secondary traumatic stress. Resilience significantly predicted burnout. Staff working with people with intellectual disabilities are likely to have experienced ACEs. Working in a trauma-informed organisational climate and resilience may be effective avenues for reducing burnout and secondary traumatic stress.

Severe or chronic disease in childhood predicts suicidality and links to anxiety in young adulthood

Purpose Suicide prevention needs measures, and further understanding of the role of adverse childhood experiences may elucidate the suicide process and ease the identification of suicide risk. Materials and methods A random sample of adults, aged 18–28 years and representative of the general population living in Finland, participated in a nationwide health examination survey. Of them (n = 793) we analyzed whether severe or chronic disease in childhood before the age of 16 years contributed to suicidality (suicidal ideation and/or suicide attempts), and whether severe or chronic disease in childhood was associated with mental disorders, current psychological distress, current usage of prescription medicines, or current work capacity. Results Having severe or chronic disease in childhood contributed independently to suicidality, with the odds ratio of 5.41 (95% confidence interval of 2.98–9.82, p < .001), but the significance of this association was lost after controlling for mental disorders. Having severe or chronic disease during childhood, as compared not having such condition, was associated with having more frequently anxiety (p < .001), greater psychological distress (p < .001), more frequently usage of psychotropic medicines (p < .001), and poorer work capacity (p < .001). Conclusion Having severe or chronic disease in childhood not only increased the odds for suicidality, but also associated with anxiety, current psychological distress, current usage of psychotropic medication, and current work capacity in young adulthood.