Abstract Laparoscopic Sleeve Gastrectomy (LSG) is the commonest bariatric procedure done worldwide for morbid obesity. LSG benefits extend beyond it being just a restrictive procedure. Hormonal effects after LSG are well documented in literature. Calcitonin has been ascribed to induction of satiety in mammals. We studied calcium homeostasis in patients(N=21) suffering with morbid obesity who underwent LSG and compared them with non-obese candidates (N=15) who were age and sex matched. Blood samples were collected from patients on day before LSG (day-0), day-180, and day-360 after LSG. Blood sample was collected from non-obese group for comparison. We found that there was no significant difference of calcium in the patients compared to non-obese candidates. We observed that mean serum vitamin D increased on day-180 (M=55.33nM, SD=34.72, p=0.059) and day-360 (M=58.24nM, SD=36.19, p=0.038) from values on day-0 (M=29.48nM, SD=21.03, p=0.423) compared to non-obese candidates (M=35.4nM, SD=22.36). Decrease in mean parathyroid hormone (PTH) on day-180 (M=4.19pM, SD=1.8, p=0.83) and on day-360 (M=4.9pM, SD=2, p=0.31) from day-0 (M=6.19pM, SD=3.53, p=0.06) was observed, compared to non-obese candidates (M=4.31pM, SD=1.2). However, normalization of mean calcitonin was noted on day-180 (M=0.4pM, SD=0.8, p=0.22) and day-360 (M=0.8pM, SD=1.1, p=0.74) from day-0 (M=0.34pM, SD=0.4, p=0.02) compared to non-obese candidates (M=0.7pM, SD=0.41). Results of this study showed normalization of calcitonin, which may have role in satiety after LSG. Larger study is recommended to ascertain the trend of calcitonin after LSG.