Role Of Psychological Stress Research Articles

The Role of Lifestyle Factors, Psychological Stress and Interventions in Type 2 Diabetes Mellitus: A Comprehensive Review, Challenges and Future Direction

Type 2 diabetes mellitus (T2DM) is a multifaceted chronic condition characterized by insulin resistance and hyperglycemia. This review synthesizes evidence on the influence of lifestyle factors such as diet, physical activity, and stress on the development and progression of T2DM. It highlights the intricate relationship between obesity, insulin resistance, and β-cell dysfunction, with a particular focus on the role of psychological stress in exacerbating disease outcomes. Through the analysis of recent studies, the review explores how lifestyle interventions, including dietary changes, exercise, and stress management, can improve glycemic control and reduce complications. This comprehensive review underscores the need for integrated, personalized management strategies in T2DM care, emphasizing the importance of addressing both physiological and psychological factors to optimize outcomes and prevent complications.

Tobacco Use and Perceived Stress Among Male College Students in Bangalore, India

BACKGROUND: More than 250 million individuals use tobacco in some form on a daily basis in India and adolescents make up a significant proportion of that number. The period of adolescence is critical in the initiation of smoking or tobacco use as well as its progression from experimentation to dependency. In this study, the role of psychological stress was explored with respect to cigarette consumption and level of addiction or dependence. METHODS: A total of 183 male college students (mean age= 19.8 years) from Bangalore, India completed the questionnaire booklet which included a Cigarette use screening form, the Perceived Stress Scale and the Autonomy over Smoking Scale. Of the 183 participants, there were 85 (46.2%) current smokers and 98 (53.7%) nonsmokers, and their scores on the perceived stress scale were compared using analysis of variance and independent samples _t_ tests. The relationship between levels of stress and dependence on tobacco (loss of autonomy) was also explored using Pearson’s product moment correlation (_r_). RESULTS: There was no significant difference between current smokers and nonsmokers on perceived stress (_t_[181] = -1.26, _p_ >0.05), The same result was extended when the group of nonsmokers was divided into three (Never smokers, experimental smokers and former regular smokers) and the differences in scores were tested again between all four groups (_F_[3, 179]=.642, _p_ >0.05). There was, however, a significant positive correlation between level of dependence on tobacco and perceived stress (_r_=.743, _p_ <0.01). CONCLUSION: The study found that there was no difference in perceived stress levels between smokers and nonsmokers, although there was a positive relationship between the level of perceived stress and level of tobacco dependence (loss of autonomy) among the current smokers.

Explore how perception of emotional blackmail affects users to withdraw from online communities: a role of psychological stress

Explore how perception of emotional blackmail affects users to withdraw from online communities: a role of psychological stress

Explore how perception of emotional blackmail affects users to withdraw from online communities: a role of psychological stress

Explore how perception of emotional blackmail affects users to withdraw from online communities: a role of psychological stress

Modulatory role of intra-accumbal dopamine receptors in the restraint stress-induced antinociceptive responses

Stress contributes to pain sensation by affecting several neural pathways, including mesolimbic-cortical dopamine neurons. Nucleus accumbens, an essential element of the mesolimbic dopaminergic pathway, plays a fundamental role in modulating pain and is differentially influenced by stressful events. Since we previously demonstrated the marked association of intra-NAc dopamine receptors with forced swim stress-evoked analgesia in acute pain state, this research was conducted to consider the contribution of intra-accumbal D1- and D2-like dopamine receptors to modulating effects of exposure to restraint stress in pain-related behaviors during the tail-flick test. Stereotaxic surgery was executed to implant a guide cannula within the NAc in male Wistar rats. On the test day, different concentrations of SCH23390 and Sulpiride as D1- and D2-like dopamine receptor antagonists, respectively, were unilaterally microinjected within the NAc. The vehicle animals received saline or 12 % DMSO (0.5 µl) instead of SCH23390 or Sulpiride into the NAc, respectively. Five minutes following receiving drug or vehicle, animals were restrained for 3 h and then their acute nociceptive threshold was measured for a 60-min period by the tail-flick test. Our data revealed that RS considerably enhanced antinociceptive reaction in acute pain states. The analgesia evoked by RS dramatically declined following blocking either D1- or D2-like dopamine receptors in the NAc, an effect was more noticeable by D1-like dopamine receptor antagonist. These findings indicated that intra-NAc dopamine receptors are considerably mediated in the RS-produced analgesia in acute pain states, suggesting their possible role in psychological stress and disease.

Psoriasis and Vitiligo Co-Occurrence: When Inflammatory Disease Meets Autoimmune Pathology

Vitiligo and psoriasis are common inflammatory skin diseases, although, their association in the same patient is rare. We report the cases of two diabetic women (59 and 61-year-old). The first patient had extensive vitiligo evolving since infancy; she consulted for a moderate pruritus in the vitiligo lesions followed by erythematosquamous lesions at the same sites. The second patient consulted for the same lesions but in this case psoriasis appeared first followed by achromic lesions in the same sites and beyond. A medical atopic history was reported in the two cases. Few publications reported the association of vitiligo-psoriasis in the literature. The majority of case reports illustrated patients diagnosed with vitiligo who developed psoriasis later. Current data on the pathophysiology of these two conditions are still unclear; however, the two diseases share a common locus in the major histocompatibility complex. Dendritic cells may also participate in the genesis of both skin diseases via autoimmune inflammation mediated by the Th1 and Th17 pathways. In addition, pro-inflammatory cytokines IFNα has been recognised as a potential inducer of both psoriasis and vitiligo. The presence of atopic medical history in our cases can be explained by the high activity of IL- 2 witch is raised in psoriasis, atopic dermatitis and vitiligo, furthermore, locus PSORS4 and atopic dermatitis locus ATOD2 are co-localizated on chromosome 1q21, it leads to suggest that, probably, a vitiligo locus overlaps on the same chromosome1q21. The role of psychological stress and Koebner’s phenomenon is often emphasized in the genesis of the two diseases.

The Role of Psychological Stress in Psoriasis: A Narrative Literature Review

Psoriasis is a chronic, persistent skin disease characterized by characteristic lesions in the form of well-defined erythematous patches covered by thick white, shiny scales resembling wax droplets. Psoriasis has a psychological, social, and emotional impact. Psychological stress has also been shown to influence the disease and course of psoriasis. Therapy in psoriasis patients with psychological stress can be given pharmacologically and psychologically. Patients with moderate to severe psoriasis using the Goeckerman regimen for psoriasis showed significant improvements in anxiety and depression scores. Psychological therapies such as relaxation therapy and meditation are able to control the emotions that trigger stress and reduce the appearance and severity of psoriasis. This literature review aims to describe the impact of psychological stress on psoriasis patients so as to increase awareness to detect psychological stress and provide appropriate treatment.

Systematic review: the role of psychological stress in inflammatory bowel disease.

Psychological stress is a possible factor in the disease course and poor psychosocial outcomes in inflammatory bowel disease (IBD). Understanding the exact relationship between stress and health has been hampered by methodological issues and how stress has been defined and measured. To explore the association between stress and disease outcomes, investigate the impact of stress on psychosocial outcomes, and evaluate the efficacy of interventions in reducing stress for people with IBD METHODS: We performed a systematic review, searching Medline, CINAHL, Embase and PsycInfo databases on 21 January 2021. We included prospective studies that recruited people with IBD who were aged 16 or over and that measured psychological stress or distress. Analyses included Critical Appraisal Skills Programme quality assessments of included studies and narrative analyses against each research question. We reviewed 38 studies with 4757 people with IBD, and included 23 observational and 15 interventional studies using 36 different instruments to measure stress. Perceived stress was the most frequently studied concept and preceded IBD exacerbation. Only three studies examined the relationship between stress and psychosocial factors. Cognitive behavioural interventions may reduce stress and other interventions with disease-specific stress, but more studies are needed where groups have comparable baseline characteristics and potential harms are considered alongside benefits. Psychological stress appears to precede IBD exacerbation, although what role it plays in psychosocial outcomes and how it is best managed is unclear. Further research needs to examine the differential effects of stress on disease subtypes and IBD in flare and remission.

N12 Systematic Review: The role of psychological stress in Inflammatory Bowel Disease

Abstract Background Psychological stress is a possible factor in the disease course and poor psychosocial outcomes in Inflammatory Bowel Disease (IBD). Understanding the exact relationship between stress and health has been hampered by methodological issues and how stress has been defined and measured. This study aims to explore the association between stress and disease outcomes, investigate the impact of stress on psychosocial outcomes, and evaluate the efficacy of interventions in reducing stress for people with IBD. Methods A systematic review was performed. Medline, CINAHL, Embase, and PsycInfo databases were searched. Prospective studies recruiting people with IBD 16 years old or over and measuring psychological stress or distress were included. Results Thirty-eight studies, from 41 reports, with 4757 people with IBD were included in the review. Studies used thirty-six different instruments to measure stress. Perceived stress was the most frequently studied concept and was found to precede IBD disease exacerbation. Depression and helplessness were positively associated with perceived stress, while social support, resilience, and quality of life were negatively associated. Cognitive-behavioural group programmes may reduce stress and education, stress management, and exercise and other group programmes may reduce disease-specific stress, but more studies are needed where groups have comparable baseline characteristics and potential harms are considered alongside benefits. Conclusion Psychological stress appears to precede IBD disease exacerbation, though what role it plays in psychosocial outcomes and how it is best managed is unclear. Further research is needed to examine the differential effects of stress on disease subtypes and IBD in flare and remission.

Racial differences in psychological stress and insulin sensitivity in non-Hispanic Black and White adolescents with overweight/obesity

Introduction: Racial differences in type 2 diabetes risk persist among non-Hispanic Black and non-Hispanic White adolescents with overweight/obesity; however, the role of psychological stress in this disparity is less clear. Purpose: To examine racial differences in the association between psychological stress, insulin sensitivity (Si), acute insulin response to glucose (AIRg), and disposition index (DI) among non-Hispanic Black and non-Hispanic White adolescents with overweight/obesity. Methods: Ninety-six adolescents (60% female; 51% non-Hispanic Black; 16.6 ± 1.8 years of age) with overweight/obesity (BMI percentile ≥ 85th percentile) were included in this analysis. Psychological stress was assessed using the 14-item Perceived Stress Scale. Glucose and insulin data from an intravenous glucose tolerance test was modeled to obtain Si, AIRg, and DI. Multivariable linear regression models were used to examine the association between race, psychological stress and metabolic outcomes (Si, AIRg, and DI). Results: Race was a significant predictor of log-AIRg and log-DI (ps < 0.05) independent of all covariates in the main effect models. Lower Si (pinteraction = 0.014) and DI (pinteraction = 0.012) was also observed among Black adolescents who reported higher stress levels, whereas higher Si and DI was observed among non-Hispanic White adolescents reporting higher stress in the race interaction models. Race however, did not moderate the association between psychological stress and AIRg (p > 0.05), nor was stress associated with Si, AIRg, or DI ("p" "s" > 0.05) across all other models. Conclusions: Psychological stress may play an important and distinct role in shaping racial differences in type 2 diabetes risk among adolescents with overweight/obesity. Additional research is needed to understand the long-term effects of psychological stress on metabolic health among non-Hispanic Black and non-Hispanic White adolescents with overweight/obesity.

Psychological Stresses in Children Trigger Cytokine- and Kynurenine Metabolite-Mediated Abdominal Pain and Proinflammatory Changes.

Recurrent abdominal pain (RAP) is a common medically unexplained symptom among children worldwide. However, the biological mechanisms behind the development of functional and behavioral symptoms and changes in blood markers have not been well explored. This study aimed to assess changes in the concentrations of inflammatory markers, including cytokines and tryptophan catabolites, in the serum of children with RAP compared to those with subclinical infections. Children with RAP but without organic diseases were included, and those with asymptomatic intestinal parasitic infections were used as a subclinical infection cohort. Blood samples were collected and used to measure the cytokine profile using Multiplex Immunoassay and tryptophan catabolites using high performance liquid chromatography. Children with RAP showed significantly higher concentrations of serum tumor necrotic factor-α, p<0.05, but lower concentrations of IL-10, p<0.001, IL-6, p<0.001 and brain-derived neurotrophic factors (BDNF) p<0.01. In addition, a significant increase in the metabolite of the kynurenine pathway, 3-hydroxyanthranilic acid (3-HAA) p<0.01, a significant decrease in the concentrations of anthranilic acid (AA) p<0.001, together with an increased ratio of serum 3-HAA to AA (3-HAA/AA) p<0.001, was found in this cohort. These findings indicate the significant activation of the immune system and presence of inflammation in children with RAP than those with subclinical parasitic infections. Moreover, children with RAP tested with the Strengths and Difficulties Questionnaire (SDQ), displayed high psychological problems though these SDQ scores were not statistically associated with measured cytokines and kynurenine metabolites. We however could hypothesize that the pro-inflammatory state together with concomitant low concentrations of BDNF in those children with RAP could play a role in psychological stress and experiencing medically unexplained symptoms.

Prevalence and Prognostic Value of Psychological Stress Events in Patients with First Myocardial Infarction-Long-Term Follow-Up Study.

While there is good evidence that symptoms of depression determine prognosis of patients with coronary heart disease (CHD), the role of psychological stress is less clear. We evaluated the prognostic value of stressful events in patients with initial myocardial infarction (MI) with respect to subsequent cardiovascular events. The KAROLA-study included patients with CHD who participated in an in-patient rehabilitation program. A total of 577 patients with initial MI were included and self-reported psychological stressful events before their MI was assessed by a structured questionnaire. Hazard ratios were used to evaluate the long-term association of stressful events with secondary cardiovascular events. Additionally, associations of stressful events with depression, anxiety and other cardiovascular risk factors were investigated. Unusual stress at work (26.5%) and sleep disorder (23.4%) were the most frequently reported stressful events that occurred in the last 4 weeks before MI. However, only death of a family member showed a statistically significant increase in risk for subsequent cardiovascular events (HR: 1.59; 95%-CI: 1.01–2.50) and this result was not corrected for multiple testing. Notably, we found higher symptom scores of anxiety and depression associated with all single stressful event items. In conclusion, we found no clear patterns that psychological stressful events before MI would increase the long-term risk of subsequent adverse CHD events directly. However, we saw increased symptom scores of anxiety and depression in persons with stressful events.

Impact of Exploitative Leadership on Workplace Incivility: Role of Psychological Distress -Evidence from Banking Sector

Aim: The present study investigated the effect of exploitative leadership on workplace incivility banking Sector employee with the role of psychological stress as a moderator Background: Destructive leadership, the mostly exploitative leadership, had been less thoughtful earlier in banking research. Additionally, fundamental mechanisms and boundary conditions that occur between exploitative leadership and employee outcomes such as workplace incivility were also missing in the banking literature with the context of psychological distress. Methods: This present research quantitative nature in which data had collected from the banking Sector (N = 310) working in the Pakistani banking sector through self-administrative questionnaires. Results: psychological distress moderate the relationship between exploitative leadership and workplace incivility among banking sector employees when psychological distress was high. Conclusions: Exploitative leadership had a significant impact on outcomes in the form of workplace incivility and psychological distress significantly moderating between exploitative leadership and workplace incivility when psychological distress was high at the banking sector in Pakistan Implications for Banking Sector Management: It is among the pioneer studies to unveil the exploitative side of leadership and its negative consequences for banking sector employees. Psychological distress in the banking sector can be reduced by discouraging leader exploitative behavior. Banking can utilize workplace incivility from work as a tool to reduce destructive outcomes of leader exploitative behavior.

A Review of the State of Purinergic Signaling and Psychological Stress

Purinergic signaling is involved in multiple physiological and pathological processes. Psychological stress, as an inharmonious state in response to stressors, is closely related to the function or dysfunction of purinergic signaling. Abnormal expression of ATP interceptors caused by stress leads to psychological stress-related diseases, such as anxiety, depression, post-traumatic stress disorder and schizophrenia. Recent studies demonstrate that a complex network of purinergic signaling (such as ATP, adenosine and P2X2R, P2X3R, P2X4R, P2X7R, A1R, A2AR) plays a key role in psychological stress, but the specific mechanism remains to be further studied. And few studies focus on the application of ATP real-time detecting to psychological stress animal models, so the specific biological role of ATP in the process of stress is still unknown. This review will summarize the relationship between purinergic signaling and psychological stress and propose to apply the duplicate ATP real-time detection technology and purinergic compounds on psychological stress research in order to provide novel potential targets for the treatment of stress-related diseases.

The Role of Psychological Stress on the Performance of the Social Workers Working in the Hope Complexes of Mental Health in Northern Borders

The study aimed to know the role of psychological stress in the performance of social workers in Al-Amal mental health complexes in the northern border region. In order to achieve this goal, a two-part questionnaire was designed. The first part included demographic and social information, while the second part formed of five axes (anxiety Depression, mental health, handicaps and the role of mental health management). The sample consisted of eighty-five subjects. The results of the study showed the following: - There are statistically significant differences according to the effect of social pressures, according to the family's support among social workers at Al-Amal Complex for Mental Health in the northern region. - There are statistically significant differences according to the effect of economic pressures according to the income level of the social workers in Al-Amal Complex for Mental Health in the northern region. - There are statistically significant differences according to the effect of psychological stress on social workers in Al-Amal Complex for Mental Health in the northern region, according to psychological rigidity. Keywords: social pressure, social workers. DOI: 10.7176/JEP/11-21-06 Publication date: July 31 st 2020

Risk factors for cardiovascular disease among railway locomotive drivers

Cardiovascular diseases in locomotive drivers are a factor limiting their working activity, as they can potentially increase the risks of accidents and disasters in rail transport. Working conditions of drivers are associated with occupational hazards that have a negative impact on the cardiovascular system. A review of clinical studies examining the risk factors for cardiovascular disease indicates the significant role of psychological stress on the health status of drivers. It was revealed that the negative effects of stress on the cardiovascular system depend on work stress, work schedule, and also on social factors: job satisfaction, salary, quality of rest and sleep. The studies revealed a correlation between the development of cardiac rhythm disturbances of high gradations with psychoemotional stress and sleep apnea in locomotive drivers.

The role of psychological stress in atopic dermatitis through an increase of IL-31

AbstractIntroduction: Atopic dermatitis occurs due to multifactorial interactions such as genetic, environmental, impaired skin barrier function, immunological factors, infection and post-psychological stress. Th1 cells and some proinflammatory cytokines such as IL-6, IL-10 and others play a role in the pathogenesis of atopic dermatitis, also IL-31. IL-31, including cytokines of the IL-6 family expressed mainly on CD4 T cells. Many researchers also associate stress with the occurrence of atopic dermatitis, stress will trigger the release of these cytokines from immune cells (e.g. IL-6, TNF α). The aim of the study is determine correlation between stress and increase in IL-31 level in person with atopic dermatitisMethod: We designed a case-control study including 58 patient, range from 14-65 years old. Diagnosis of atopic dermatitis is established based on Hanifin and Rajka criteria, and the severity based on SCORAD. Venous blood was collected for IL-31 examination, stress index was measured by interview according to the Holmes-Rahe stress scale test method.Result: In this study, the stress index in atopic dermatitis was 102.26 + 11.71, and in control 61.35 + 19.87 there was a significant difference with p &lt;0.005. IL-31 levels in atopic dermatitis were 274.44 + 95.35, higher than controls 129.44 + 85.45, significantly with p&lt;0.005. The results of linear regression between stress index and severity of dermatitis (SCORAD), appeared to have a moderate positive correlation with r = 0.04. OR 4.56 (95% CI 2.78-11.56).Conclusions: From this study it can be concluded that stress increases IL-31 levels and positively correlates with the severity of atopic dermatitis.

Considering the Role of Psychological Stress on Sleep Quality in Individuals with Subclinical Hypothyroidism [Letter

Considering the Role of Psychological Stress on Sleep Quality in Individuals with Subclinical Hypothyroidism [Letter

Does psychological stress trigger or exacerbate vitiligo: More data are needed

Background: Vitiligo is a common disorder characterized by depigmentation due to autoimmune destruction of melanocytes. The role of psychological stress in causing vitiligo is not well characterized. Purpose: This article aims at reviewing the role of stress in triggering and/or exacerbating vitiligo. Methods: Seven relevant studies were found in the literature search. Results: Most of the studies support the theory that stressful life events may trigger the onset or the progression of vitiligo. Conclusion: Studies depended mainly on retrospective reporting of stressful events could be a major source of bias.

Воспалительные заболевания кишечника в стадии ремиссии с СРК - подобными симптомами

The remaining disorders of stool, supposedly of a functional nature, similar to the symptoms of irritable bowel syndrome (IBS), in patients with inflammatory bowel disease (IBD) in remission during the last 16 years are actively discussed in the literature. A great similarity in the clinical manifestations and mechanisms of the formation of true IBS and IBD-IBS was revealed. As the combining factors of these two pathological conditions, occult inflammation in the intestinal wall, intestinal motility disorders, visceral hypersensitivity, intestinal microbiome disorder and increased permeability of the mucosa are considered. The role of psychological stress in the formation of the IBD-IBS remains underestimated and insufficiently investigated. In patients with true IBS and IBD-IBS, the indices of depression, actual and personal anxiety, alexithymia are statistically significantly higher than in healthy individuals and do not differ among themselves. An additional confirmation of similar changes in the psychovegetative status in patients with IBS and IBD-IBS is the study of one of the relatively new psychometric indicators, the Visceral Sensitivity Index (VSI), which characterizes specific anxiety with respect to gastroenterological symptoms of the disease. An integrative index of all psycho-vegetative changes in patients is an indicator of the quality of life. As in patients with true IBS, and with IBD-IBS, according to the literature, Noah decrease in both physical and mental QOL component. The article deals with modern information about similarities and differences mechanisms of IBS and IBD in remission with IBS-like symptoms, which indicate large differential diagnostic difficulties in distinguishing these disorders.