Role Of Executive Control Research Articles

The cortical connectome of primate lateral prefrontal cortex

The lateral prefrontal cortex (LPFC) of primates plays an important role in executive control, but how it interacts with the rest of the cortex remains unclear. To address this, we densely mapped the cortical connectome of LPFC, using electrical microstimulation combined with functional MRI (EM-fMRI). We found isomorphic mappings between LPFC and five major processing domains composing most of the cerebral cortex except early sensory and motor areas. An LPFC grid of ∼200 stimulation sites topographically mapped to separate grids of activation sites in the five domains, coarsely resembling how the visual cortex maps the retina. The temporal and parietal maps largely overlapped in LPFC, suggesting topographically organized convergence of the ventral and dorsal streams, and the other maps overlapped at least partially. Thus, the LPFC contains overlapping, millimeter-scale maps that mirror the organization of major cortical processing domains, supporting LPFC's role in coordinating activity within and across these domains.

Impaired Spatial Inhibition Processes for Interhemispheric Anti-saccades following Dorsal Posterior Parietal Lesions.

Anti-saccades are eye movements that require inhibition to stop the automatic saccade to the visual target and to perform instead a saccade in the opposite direction. The inhibitory processes underlying anti-saccades have been primarily associated with frontal cortex areas for their role in executive control. Impaired performance in anti-saccades has also been associated with the parietal cortex, but its role in inhibitory processes remains unclear. Here, we tested the assumption that the dorsal parietal cortex contributes to spatial inhibition processes of contralateral visual target. We measured anti-saccade performance in 2 unilateral optic ataxia patients and 15 age-matched controls. Participants performed 90 degree (across and within visual fields) and 180 degree inversion anti-saccades, as well as pro-saccades. The main result was that our patients took longer to inhibit visually guided saccades when the visual target was presented in the ataxic hemifield and the task required a saccade across hemifields. This was observed through anti-saccades latencies and error rates. These deficits show the crucial role of the dorsal posterior parietal cortex in spatial inhibition of contralateral visual target representations to plan an accurate anti-saccade toward the ipsilesional side.

Magnetic Resonance Imaging Texture of Medial Pulvinar in Dementia with Lewy Bodies

Introduction: Executive dysfunction is common in dementia with Lewy bodies (DLB). The pulvinar nucleus plays a role in executive control and synchronizes with cortical regions in the salience network that are vulnerable to Lewy pathology. Objective: We investigated the pulvinar subregions in patients with mild DLB and their associations with executive function. Methods: The sample consisted of 38 DLB patients and 38 age- and sex-matched normal controls. We evaluated cognitive function using the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. We obtained four pulvinar nuclei using preprocessed T1-weighted magnetic resonance images. We compared volumes and textures of the DLB patients and the normal controls for each nucleus. We used a linear regression to determine the association of textures and neuropsychological test scores. Results: The DLB patients showed comparable volumes to the normal controls in all pulvinar nuclei. However, the DLB patients showed different texture of the left medial pulvinar (PuM) from the normal controls. The entropy, contrast, and cluster shade were lower but autocorrelation of left PuM was higher in the DLB patients compared to the normal controls. These texture features of the left PuM were associated with the set-shifting performance measured by the Trail Making Test. Conclusions: In DLB, the left PuM may be altered from early stage, which may contribute to the development of executive dysfunction.

Dynamics of attentional bias for food in Dutch and Chinese children and the role of executive control

The current study examined the relationships among dynamics of attentional bias for food, executive control and adjusted BMI% among children. 106 Dutch (8-12 years old, 56.60% female) and 99 Chinese children (9-13 years old, 44.44% female) participated in the study. All participants first completed a self-report hunger questionnaire, and then the food dot-probe task and attention network task were administered. Both mean attentional bias and the variability of attentional bias were computed as people often experience the opposite goals to approach and avoid palatable food. We hypothesized that only the variability of attentional bias for food would be positively related to adjusted BMI%. In addition, such association would be moderated by the executive control, which would be also negatively related to adjusted BMI%. The results showed that adjusted BMI% was only positively associated with the variability of attentional bias for food in Dutch children. However, such association did not exist in Chinese children and executive control was not a significant moderator of the relation between the variability of attentional bias for food and adjusted BMI% in both Dutch and Chinese children. Unexpected, compared with Dutch children, Chinese children had stronger executive control, which was directly related to a lower adjusted BMI%. This study emphasized both TL-BS variability for food and executive control might have an effect on adjusted BMI%, in addition, culture possibly serve as a reason for the inconsistent results between Dutch and Chinese children.

The role of executive control in post-stroke aphasia treatment

ABSTRACT Executive control (EC) ability is increasingly emerging as an important predictor of post-stroke aphasia recovery. This study examined whether EC predicted immediate treatment gains, treatment maintenance and generalization after naming therapy in ten adults with mild to severe chronic post-stroke aphasia. Performance on multiple EC tasks allowed for the creation of composite scores for common EC, and the EC processes of shifting, inhibition and working memory (WM) updating. Participants were treated three times a week for five weeks with a phonological naming therapy; difference scores in naming accuracy of treated and untreated words (assessed pre, post, four- and eight-weeks after therapy) served as the primary outcome measures. Results from simple and multiple linear regressions indicate that individuals with better shifting and WM updating abilities demonstrated better maintenance of treated words at four-week follow-up, and those with better common EC demonstrated better maintenance of treated words at both four- and eight-week follow-ups. Better shifting ability also predicted better generalization to untreated words post-therapy. Measures of EC were not indicative of improvements on treated words immediately post-treatment, nor of generalization to untreated words at follow-up. Findings suggest that immediate treatment gains, maintenance and generalization may be supported by different underlying mechanisms.

Executive Control and Adolescent Health: Toward A Conceptual Framework.

Executive control is a set of cognitive abilities that may impact a variety of adolescent health behaviors and outcomes; however, research on executive control as a contributor to the physical health of youth is relatively limited. Therefore, the current article explores the possible role of executive control in adolescent health by reviewing relevant literature and proposing a conceptual framework to guide future research in this area. The development of executive control from preschool through adolescence is described, with particular attention to executive control in the unique health context of adolescence. A new conceptual model is proposed, focusing on how executive control may play a critical role in supporting health in adolescence and beyond through the mechanisms of attentional, behavioral, and emotional control. Literature exploring associations between youth executive control and key health behaviors (including diet, physical activity, sleep and substance use) is reviewed. Researchers and clinicians are encouraged to consider executive control as an important cross-cutting contributor to health during adolescence and beyond and to incorporate this construct into longitudinal studies of health.

Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks

The frontoparietal control network (FPCN) plays a central role in executive control. It has been predominantly viewed as a unitary domain general system. Here, we examined patterns of FPCN functional connectivity (FC) across multiple conditions of varying cognitive demands, to test for FPCN heterogeneity. We identified two distinct subsystems within the FPCN based on hierarchical clustering and machine learning classification analyses of within-FPCN FC patterns. These two FPCN subsystems exhibited distinct patterns of FC with the default network (DN) and the dorsal attention network (DAN). FPCNA exhibited stronger connectivity with the DN than the DAN, whereas FPCNB exhibited the opposite pattern. This twofold FPCN differentiation was observed across four independent datasets, across nine different conditions (rest and eight tasks), at the level of individual-participant data, as well as in meta-analytic coactivation patterns. Notably, the extent of FPCN differentiation varied across conditions, suggesting flexible adaptation to task demands. Finally, we used meta-analytic tools to identify several functional domains associated with the DN and DAN that differentially predict activation in the FPCN subsystems. These findings reveal a flexible and heterogeneous FPCN organization that may in part emerge from separable DN and DAN processing streams. We propose that FPCNA may be preferentially involved in the regulation of introspective processes, whereas FPCNB may be preferentially involved in the regulation of visuospatial perceptual attention.

The role of executive control in resolving grammatical number conflict in sentence comprehension.

In sentences with a complex subject noun phrase, like "The key to the cabinets is lost", the grammatical number of the head noun (key) may be the same or different from that of the modifier noun phrase (cabinets). When the number is the same, comprehension is usually easier than when it is different. Grammatical number computation may occur while processing the modifier noun (integration phase) or while processing the verb (checking phase). We investigated at which phase number conflict and plausibility of the modifier noun as subject for the verb affect processing, and we imposed a gaze-contingent tone discrimination task in either phase to test whether number computation involves executive control. At both phases, gaze durations were longer when a concurrent tone task was present. Additionally, at the integration phase, gaze durations were longer under number conflict, and this effect was enhanced by the presence of a tone task, whereas no effects of plausibility of the modifier were observed. The finding that the effect of number match was larger under load shows that computation of the grammatical number of the complex noun phrase requires executive control in the integration phase, but not in the checking phase.

Reducing alcohol-related interpretation biases in young hazardous drinkers by Cognitive Bias Modification–Interpretation Training

Abstract. Aims: This study examined whether alcohol-related interpretation biases (IBs) can be reduced by means of cognitive bias modification – interpretation (CBM-I) training. Also, the training’s generalization effects and the moderating role of executive control (EC) were examined. Methods: Participants were 98 young hazardous drinkers. Half of the participants were trained to interpret ambiguous alcohol-related scenarios in an alcohol-unrelated way (neutral CBM-I), the other half completed alcohol-related ambiguous open-ended scenarios (control CBM-I). Alcohol-related IBs were assessed with open-ended ambiguous alcohol-related scenarios, completed by participants. The completions were coded by participants (self-coding) and by two independent coders (conservatively and liberally). Results: Neutral CBM-I, compared to control CBM-I, did not decrease alcohol-related IBs for the conservative and self-coding. For the liberal coding, both groups showed a decrease in alcohol-related IBs pre to post training. Moreover, there were no group differences in interpreting ambiguous, alcohol-related pictures during a signal-detection task. At the behavioral level, there was no reduction in alcohol use for either group at one week follow-up. Finally, EC did not moderate training effects. Conclusions: Although CBM-I effects were largely absent; the findings emphasize that more research into the working mechanisms of alcohol CBM-I is needed to test its potential in the context of hazardous drinking.

Reinforcement sensitivity and restrained eating: the moderating role of executive control

PurposeAs the prevalence of overweight and obesity are still increasing, it is important to help individuals who encounter difficulty with losing weight. The current study was set out to further investigate characteristics of individuals who are highly motivated to restrict their food intake to lose weight, but fail to do so (i.e., restrained eaters). The motivation to lose weight might stem from high punishment sensitivity, whereas the failure to succeed in restricting food intake might be the result of high reward sensitivity. Thus, it was examined whether restrained eaters are characterized by both high reward sensitivity and high punishment sensitivity. Additionally, this is the first study to examine executive control as a potential moderator of this relationship.MethodsFemale undergraduates (N = 60) performed a behavioral measure of executive control, and completed the Restraint Scale to index level of restrained eating as well as two questionnaires on reinforcement sensitivity; the Behavioral Inhibition Scale/Behavioral Activation Scale, and the Sensitivity to Punishment and Sensitivity to Reward Questionnaire.ResultsThere was a positive relationship between restrained eating and punishment sensitivity as indexed by both questionnaires. Reward sensitivity as measured by both indices was not directly related to restrained eating. Executive control moderated the relation between reward responsivity (but not reward-drive) and restrained eating; specifically in women with relatively weak executive control there was a positive relationship between reward responsivity and restrained eating behavior.ConclusionIn women with low executive control, restrained eating is associated with both heightened sensitivity to punishment and heightened responsivity to reward.

Executive control in spoken noun-phrase production: Contributions of updating, inhibiting, and shifting.

The present study examined how the updating, inhibiting, and shifting abilities underlying executive control influence spoken noun-phrase production. Previous studies provided evidence that updating and inhibiting, but not shifting, influence picture-naming response time (RT). However, little is known about the role of executive control in more complex forms of language production like generating phrases. We assessed noun-phrase production using picture description and a picture-word interference procedure. We measured picture description RT to assess length, distractor, and switch effects, which were assumed to reflect, respectively, the updating, inhibiting, and shifting abilities of adult participants. Moreover, for each participant we obtained scores on executive control tasks that measured verbal and nonverbal updating, nonverbal inhibiting, and nonverbal shifting. We found that both verbal and nonverbal updating scores correlated with the overall mean picture description RTs. Furthermore, the length effect in the RTs correlated with verbal but not nonverbal updating scores, while the distractor effect correlated with inhibiting scores. We did not find a correlation between the switch effect in the mean RTs and the shifting scores. However, the shifting scores correlated with the switch effect in the normal part of the underlying RT distribution. These results suggest that updating, inhibiting, and shifting each influence the speed of phrase production, thereby demonstrating a contribution of all three executive control abilities to language production.

The role of executive control in rhythmic timing at different tempi.

We investigated the role of attention and executive control in rhythmic timing, using a dual-task paradigm. The main task was a finger tapping task in which participants were asked to tap their index finger in time with metronome sequences. The tempo of the sequences ranged from 600 ms to 3000 ms between each beat. The distractor task, chosen so as to engage executive control processes, was a novel covert n-back task. When the tempo was slow, simultaneous performance of the tapping and n-back tasks resulted in significant performance degradation in both tasks. There was also some dual-task interference at the fast tempo levels, however, the magnitude of the interference was much smaller in comparison. The results suggests that, when the tempo is sufficiently slow, performing rhythmic timing demands attentional resources and executive control. This accords with models of time perception that assume that different timing mechanisms are recruited at different time scales. It also accords with models that assume a dedicated mechanism for rhythm perception and where rhythm perception is assumed to have a slower limit.

Age-related changes in strategic variations during arithmetic problem solving: The role of executive control.

In this review, we provide an overview of how age-related changes in executive control influence aging effects in arithmetic processing. More specifically, we consider the role of executive control in strategic variations with age during arithmetic problem solving. Previous studies found that age-related differences in arithmetic performance are associated with strategic variations. That is, when they accomplish arithmetic problem-solving tasks, older adults use fewer strategies than young adults, use strategies in different proportions, and select and execute strategies less efficiently. Here, we review recent evidence, suggesting that age-related changes in inhibition, cognitive flexibility, and working memory processes underlie age-related changes in strategic variations during arithmetic problem solving. We discuss both behavioral and neural mechanisms underlying age-related changes in these executive control processes.

Attentional bias and executive control in treatment-seeking substance-dependent adolescents: A cross-sectional and follow-up study

BackgroundResearch in adults shows that substance dependent individuals demonstrate attentional bias (AB) for substance-related stimuli. This study investigated the role of AB in adolescents diagnosed with alcohol, cannabis, amphetamine or GHB dependency on entering therapy and six months later, and the role of executive control (EC) as a moderator of the relationship between problem severity and AB. MethodsSeventy-eight young substance-dependent (SD) patients (mean age=19.5), and 64 healthy controls (HC; mean age=19.0) were tested. Thirty-eight SD patients took part at 6-month follow-up (FU). AB was indexed by a visual probe task, EC by the attention network task, problem severity by the short alcohol (or drug) use disorder identification test and the severity of dependence questionnaire. ResultsSD patients demonstrated an AB for substance stimuli presented for 500ms and 1250ms, with the latter related to severity of dependence. There was a nonsignificant tendency indicating that EC was higher in HC than SD participants, but EC did not moderate the relationship between AB and dependency. Substance use, dependency, EC and AB remained unchanged in the 6 month FU period. ConclusionsYoung SD patients showed a stronger relatively early as well as maintained AB toward substance cues. A stronger maintained attention was related to higher severity of dependence. Further, there were some indications that EC might play a role in adolescent substance use. The finding that at FU AB and problem severity were not decreased, and EC was not increased underlines the persistent character of addiction.

Executive control suppresses pupillary responses to aversive stimuli

Adaptive behavior depends on the ability to effectively regulate emotional responses. Continuous failure in the regulation of emotions can lead to heightened physiological reactions and to various psychopathologies. Recently, several behavioral and neuroimaging studies showed that exertion of executive control modulates emotion. Executive control is a high-order operation involved in goal-directed behavior, especially in the face of distractors or temptations. However, the role of executive control in regulating emotion-related physiological reactions is unknown. Here we show that exercise of executive control modulates reactivity of both the sympathetic and the parasympathetic components of the autonomic nervous system. Specifically, we demonstrate that both pupillary light reflex and pupil dilation for aversive stimuli are attenuated following recruitment of executive control. These findings offer new insights into the very basic mechanisms of emotion processing and regulation, and can lead to novel interventions for people suffering from emotion dysregulation psychopathologies.

Dopamine and glutamate release in the anterior default system during rest: A monkey microdialysis study

Human neuroimaging studies have demonstrated the presence of a default system in the brain, which shows a default mode of brain activity, i.e., greater activity during rest than during an attention-demanding cognitive task. Our previous study on monkeys has revealed a default mode of brain activity in medial cortical areas. We have observed an increase in dopamine (DA) release during a working memory (WM) task compared with that during rest in the monkey lateral prefrontal cortex (LPFC). However, no previous study has examined DA release related to the default mode of brain activity. We used a microdialysis technique to investigate changes in DA release in the medial prefrontal cortex (MPFC), which constitutes the anterior default system, during the WM task and rest. Because DA and glutamate (Glu) release in the LPFC is interrelated, we also examined Glu release in the MPFC. We observed a significant increase in DA release, but no significant change in Glu release during rest compared with that during the WM task. We also observed an inhibitory relationship between the two transmitters in the MPFC. Considering that human default brain activity is related to internal thought processes and increased DA release in the LPFC plays an important role in executive control, increase in DA release during rest in the monkey anterior default system may be related to some form of internal thought process.

The role of LIFG-based executive control in sentence comprehension

Prior research has shown that patients with damage to the left inferior frontal gyrus (LIFG) can have difficulties in executive control as well as understanding syntactic garden-paths, that is, sentences with a temporary syntactic ambiguity that resolve towards a less preferred interpretation. The present study tested two LIFG patients on object/subject garden path and matched syntactically unambiguous sentences. Besides syntactic ambiguity, support for the preferred but ultimately inappropriate interpretation was manipulated via verb bias, using verbs that were neutral between alternative analyses and verbs that were biased towards the context-inappropriate option. The LIFG patients, a non-LIFG patient, and healthy controls were tested on a sentence interpretation task (Experiment 1) and grammaticality judgement (Experiment 2). In contrast to the non-LIFG patient and controls, the LIFG patients showed impaired thematic role assignment across garden-path as well as unambiguous sentences, which tended to be worse with biased verbs. The results argue for a role of executive control in overcoming verb bias across diverse sentence processing situations, including, but not limited to, garden-path revision.

Dopamine and the development of executive dysfunction in autism spectrum disorders.

Persons with autism regularly exhibit executive dysfunction (ED), including problems with deliberate goal-directed behavior, planning, and flexible responding in changing environments. Indeed, this array of deficits is sufficiently prominent to have prompted a theory that executive dysfunction is at the heart of these disorders. A more detailed examination of these behaviors reveals, however, that some aspects of executive function remain developmentaly appropriate. In particular, while people with autism often have difficulty with tasks requiring cognitive flexibility, their fundamental cognitive control capabilities, such as those involved in inhibiting an inappropriate but relatively automatic response, show no significant impairment on many tasks. In this article, an existing computational model of the prefrontal cortex and its role in executive control is shown to explain this dichotomous pattern of behavior by positing abnormalities in the dopamine-based modulation of frontal systems in individuals with autism. This model offers excellent qualitative and quantitative fits to performance on standard tests of cognitive control and cognitive flexibility in this clinical population. By simulating the development of the prefrontal cortex, the computational model also offers a potential explanation for an observed lack of executive dysfunction early in life.

The role of executive control in bilingual language production: A study with Parkinson's disease individuals

The basal ganglia are critically involved in language control (LC) processes, allowing a bilingual to utter correctly in one language without interference from the non-requested language. It has been hypothesized that the neural mechanism of LC closely resembles domain-general executive control (EC). The purpose of the present study is to investigate the integrity of bilingual LC and its overlap with domain-general EC in a clinical population such as individuals with Parkinson's disease (PD), notoriously associated with structural damage in the basal ganglia.We approach these issues in two ways. First, we employed a language switching task to investigate the integrity of LC in a group of Catalan–Spanish bilingual individuals with PD, as compared to a group of matched healthy controls. Second, to test the relationship between domain-general EC and LC we compared the performances of individuals with PD and healthy controls also in a non-linguistic switching task. We highlight that, compared to controls, individuals with PD report decreased processing speed, less accuracy and larger switching costs in terms of RT and errors in the language switching task, whereas in the non-linguistic switching task PD patients showed only increased switching cost in terms of errors. However, we report a positive correlation between the magnitudes of linguistic and non-linguistic mixing costs in individuals with PD. Taken together, these results support the notion of a critical role of the basal ganglia and connected structures in LC, and suggest a possible link between LC and domain-general EC.

Two routes to closure: Time pressure and goal activation effects on executive control

Abstract In the present study the impact of need for cognitive closure (NFC) manipulations via time pressure and explicit closure goal activation on executive control was investigated. Although there is some evidence that NFC, measured as an individual variable, is related to better performing in attentional tasks involving executive control, these results have never been validated across different manipulations of NFC. Thus, in the present study we induced NFC via internal and external time pressure and tested the impact of these manipulations on the performance in tasks that measure executive control, i.e., the Stroop and switching tasks. The results revealed that induced high (vs. low) NFC, indeed boosted performance in executive control tasks. Moreover, there was no difference in the effect of both NFC manipulations on task performance. The implications regarding the role of executive control and specific NFC manipulations in social cognition are discussed.