Deep mine rock mass is in high static stress and dynamic disturbance coupling conditions, its mechanical properties and failure mode is different from the shallow rock mass, which leads to low rock blasting efficiency and engineering geology hazards. In-depth research on the dynamic response of rock blasting under in-situ stress will help to optimize the blasting design, improve the blasting efficiency and safety of blasting operations, and provide theoretical support for rock blasting in deep mines. In this study, the blasting experiment was conducted on granite specimens under different biaxial static stress conditions. Meanwhile, the dynamic response of rock blasting was monitored, collected, and analyzed using a high-speed digital image correlation (DIC) measurement system, a strain wave acquisition system, and an acoustic emission (AE) system. The results show that small and medium pre-static loads inhibit blast crack propagation, at which time the cumulative AE hits from dynamic loads (CAECd) are more than those from pre-static loads (CAECs), but large pre-static loads promote crack propagation, at which time CAECs are more than CAECd. Secondly, as pre-static load increases, the specimen's maximum strain (εmax) decreases first and then increases, but as lateral pressure coefficient (K) increases, the εmax in the direction of lower static stress decreases gradually and the εmax in the direction of higher static stress remains constant. In addition, the confining pressure magnitude and K affect the area and shape of the failure zone of the specimen, as well as the size and propagation direction of the radial crack. Especially when the confining pressure is high, the specimen will undergo shear failure, and the smaller K is the more serious the shear failure. Finally, the failure criterion of rock under dynamic-static coupling conditions is proposed based on the energy index, and different failure types of rock are discussed.