Aimed at the stability problem of quadrotor Unmanned Aerial Vehicle (UAV) flight attitudes under random airflow disturbance conditions, a robust H-infinity-based dual cascade Model Predictive Control (MPC) attitude control method is proposed. Model Predictive Control itself has the capability to minimize the deviation between the prediction error and the control target by optimizing the control algorithm. The robust H-infinity controller can maintain stability in the face of system model uncertainty and external disturbances. The controller designed in this paper divides the attitude control loop into the following two parts: the angle loop and the angular velocity loop. The angle loop, serving as the main control loop of the attitude control, employs the robust H-infinity controller to process the angle of the quadrotor UAV and then transmits the processed value to the MPC controller. This approach reduces the computational load of the MPC controller. Simultaneously, by optimizing the algorithm, MPC minimizes the prediction error and the deviation from the control target. Simulation experiments confirm that the proposed algorithm improves the stability of the UAV attitude under random airflow disturbance conditions, while also achieving accurate tracking of the UAV’s position.