Introduction: The use of prostaglandin preparations with or without oxytocin infusion is widely recognized and accepted as a standard method of induction of labor. It has been shown to reduce induction time and the risk of failed induction. But the use of prostaglandin E2 is quite expensive and is not available in many developing countries. In such cases, misoprostol can also be used as an induction agent. The aim of the study was to assess the rate of successful induction of labor following intra-vaginal administration of misoprostol. Methods: This open clinical trial study was conducted at the Department of Obstetrics and Gynaecology, North East Medical College Hospital, Sylhet, Bangladesh. The study duration was 1 year and was conducted with a total of 100 patients who were admitted with term pregnancy and unfavorable cervix in the study hospital, fulfilling the inclusion and exclusion criteria. Result: Bishop’s score was significantly raised after 6 hours vaginal misoprostol [4.63 (SD ± 1.17) VS 5.82 (SD ± 1.60); p<0.001]. The mean induction to vaginal delivery time was 14.6 (SD ± 4.6) hours (range 6 to 23 hours); the induction to vaginal delivery time was<12 hours in 44.3% and 12-24 hours in 55.7% cases. The mode of delivery was vaginal in most of the cases (70.0%) and cesarean section was in 30.0% of cases. Fetal distress was the most frequent indication of cesarean section (63.3%), followed by arrested labor (20.0%) and failed induction (16.7%). The maternal obstetric complication was postpartum hemorrhage (3.0%) without any ruptured uterus, tachysystole, hypertonus uterus, or hyperstimulation. The maternal side-effects were nausea or vomiting (5.0%), diarrhea (2.0%), and fever (1.0%). Fetal outcomes were, normal baby (65.0%), APGAR score <7 at 1 min (27.0%), resuscitation needed (27.0%), neonatal unit admission (13.0%), meconium passage (8.0%) and intrauterine Fetal death (diagnosed before induction) (8.0%). Conclusion: Vaginal misoprostol seems to be a promising drug for labor induction with a high rate of success. Possible advantages of misoprostol may be the availability, ease of administration, well tolerability, and most notably its dual action in cervical ripening and labor induction. However, future studies focusing on dosing regimens and routes of application are needed.