Risk Of Carpal Tunnel Syndrome Research Articles

A cross-sectional study to assess the risk of carpal tunnel syndrome among middle age group

Carpal tunnel syndrome (CTS) is a syndrome begins with pain, numbness, and paraesthesia’s in the first three digits and the lateral half of the fourth digit with symptoms of pain at the wrist, spreading across the hand to forearm or extending beyond the elbow which progresses to hand weakness, impaired fine motor coordination, clumsiness, and eventually atrophy of the thenar muscles. Aim: The present study aims to assess the risk of carpel tunnel syndrome among middle age group. Methods: In this study Non-Experimental Research study design and random sampling technique is used and a total of 601 samples were assessed. Questionnaire and physical examination related carpel tunnel syndrome are assessed. Results: The age were grouped into 25-35 yrs (60.7%) and 36-45 yrs (38.2%). The occupation was categorised as sedentary (23%), moderate workers (50%) and heavy workers (25.8%0. The mean risk score is 10(78.5%). There is a significant association between moderate workers and overweight category fall into the high risk of carpel tunnel syndrome. Conclusion: The study concluded that people who work moderately in the fields of IT. Teaching. Administrative Staff. Tailoring associated with overweight showed high risk for carpel tunnel syndrome.

Carpal tunnel syndrome and occupational hand exposures: a Danish nationwide cohort study

ObjectivesThe aim was to examine exposure–response relations between occupational hand exposures and carpal tunnel syndrome (CTS) and to compare the relation between surgery-treated and non-surgery-treated CTS. The secondary aim was...

The association of bariatric surgery and carpal tunnel syndrome: A propensity score-matched cohort study

ObjectivesTo test the hypothesis that weight loss following bariatric surgery is associated with a reduced risk of developing carpal tunnel syndrome (CTS) when compared to obese patients who do not undergo bariatric surgery. MethodsWe performed a cohort study using data from Swedish nationwide healthcare registries. Patients aged 18-79 years who underwent bariatric surgery 2006-2019 were propensity score (PS)-matched to up to 2 obese bariatric surgery-free patients (“unexposed patients”). Cox proportional hazard regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CIs) to compare the incidence of CTS among bariatric surgery patients to obese unexposed patients both overall and divided by subgroups of age, sex, bariatric surgery type, and duration of follow-up. Results40,619 bariatric surgery patients were PS-matched to 63,540 obese unexposed patients who did not undergo surgery. Bariatric surgery was not associated overall with CTS (HR 0.98, 95% CI 0.91-1.05). There was a 23% decreased risk of CTS incidence observed within >1-3 years after bariatric surgery (HR 0.77, 95% CI 0.68-0.88). Decreased CTS risks were observed among bariatric surgery patients aged 18-34 years (HR 0.87, 95% CI 0.74-1.01) and those who underwent sleeve gastrectomy (HR 0.81, 95% CI 0.63-1.03), but these risks did not reach significance compared to obese unexposed patients. However, there was a 20% increased CTS risk after 6 years (HR 1.20, 95% CI 1.05-1.36). ConclusionOur results suggest that marked weight does not have a lasting impact in the reduction of CTS incidence.

Risk of carpal tunnel syndrome among patients with osteoarthritis: a US population-based study

BackgroundCarpal tunnel syndrome (CTS), an entrapment neuropathy caused by pressure of the median nerve, is a progressive condition that can lead to a decreased quality of life. Studies suggest an association between CTS and arthritis; however, previous studies examining osteoarthritis (OA) and CTS are limited in number, scope and study design. This study estimated the incidence and risk of CTS among patients with OA, both overall and by specific joints, in a large population-based cohort in the United States.MethodsPatients from the Optum claims database aged ≥ 45 years and diagnosed with OA between January 1, 2018, and December 31, 2022, were eligible for the OA cohort. The non-OA cohort included those without a diagnosis of OA at the index date and no history of OA for 12 months pre-index. Baseline characteristics were balanced using propensity score matching. The risk of CTS in the OA and non-OA cohort were evaluated using incidence rates and adjusted hazard ratios that were estimated using Cox regression.ResultsAfter applying the inclusion/exclusion criteria, 3,610,240 of the 6,023,384 adults with a diagnosis of OA remained in the OA cohort. After propensity-score matching, each cohort included 1,033,439 individuals. The incidence rates for CTS per 1000 person-years were 7.35 (95% confidence interval [CI] 7.21–7.49) in the OA cohort and 1.44 (95% CI 1.38–1.50) in the non-OA cohort. The risk of developing CTS in patients with OA was ~ 4 times that of patients without (hazard ratio = 3.80; 95% CI 3.54–4.07). This increased risk was found across all OA joint types, with OA of the hand/wrist having the highest risk for CTS. Additionally, multiple OA joints presented a higher risk compared with a single affected joint.ConclusionsOA increases the risk of CTS, but this is not limited to patients with hand/wrist OA, suggesting a systemic impact of OA on CTS. While the risk appears highest for patients with hand/wrist OA, patients with more distant affected joints like knee or hip also have an increased risk of CTS.

Risks of carpal tunnel syndrome and carpal tunnel release surgery in users of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists: A target trial emulation study

AimPreclinical studies have shown that sodium-glucose cotransporter 2 inhibitors (SGLT2is) have a neuroprotective effect. This study compared the risks of carpal tunnel syndrome and carpal tunnel release surgery between new users of SGLT2is and new users of glucagon-like peptide-1 receptor agonists (GLP-1RAs). MethodsA retrospective new-user active comparator cohort study with a target trial design was conducted by using the TriNetX platform. Patients with type 2 diabetes mellitus prescribed SGLT2is or GLP-1RAs were identified. Covariates were balanced using propensity score matching to form 2 homogenous treatment groups. Outcomes were the risk of carpal tunnel syndrome and the risk of carpal tunnel release surgery. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using the TriNetX platform. ResultsThe crude cohort included 86,188 and 100,244 patients in the SGLT2is group and GLP-1RAs group, respectively. After matching, each group included 65,464 patients. The SGLT2is group had an average age of 59.6 years, and 46 % were women. The GLP-1RAs group had an average age of 59.5 years, and 45.9 % were women. The incidences of carpal tunnel syndrome (HR: 0.928; 95 % CI: 0.869 to 0.991) and carpal tunnel release surgery (HR: 0.840; 95 % CI: 0.726 to 0.971) were significantly lower in the SGLT2is group than in the GLP-1RAs group. ConclusionIn patients with type 2 diabetes mellitus, SGLT2is seem to decrease the risk of carpal tunnel syndrome and the need for carpal tunnel release surgery. Prospective studies are required to confirm our results.

Association of carpal tunnel syndrome risk factors with treatment modality selection focusing on corticosteroid injection and surgery: A nationwide population-based study.

Several studies have revealed the risk factors for carpal tunnel syndrome (CTS). However, no studies have evaluated the influence of these risk factors on the selection of treatment modalities for CTS. This study aimed to determine the influence of CTS risk factors on the selection of CTS treatment modalities with a focus on corticosteroid injection (CI) and surgery. We conducted a retrospective cohort study of patients aged ≥20 years with newly diagnosed CTS in the Korean health insurance review and assessment service between 2010 and 2019. We evaluated the demographic information, the existence of CTS risk factors, and the applied treatment modalities for CTS, including CI and operation. The CTS risk factors include age, sex, diabetes mellitus, osteoarthritis of the hand or wrist, rheumatoid arthritis, hypothyroidism, gout, chronic kidney disease (CKD) on dialysis, antiestrogen or aromatase inhibitor medication, and a history of distal radius fracture (DRF). Multivariable logistic regression analyses were conducted. Age over 80 years was the most significantly associated factor for the selection of CI in CTS (odd ratio [OR], 2.149; 95% confidence interval [CI], 2.092 to 2.209; P < .001). Among underlying diseases or medications, CKD on dialysis (OR, 4.001; 95% CI, 3.819-4.193; P < .001) was the most significant associated factor for the selection of operation for CTS, followed by a history of DRF (OR, 1.803; 95% CI, 1.749-1.860; P < .001). Old age was the most significantly related factor for selecting CI. Among underlying diseases or medications, CKD on dialysis and the history of DRF were the most significantly related factors for selecting operative treatment. For these patients, clinicians should proactively consider an operation to reduce the long-term discomfort and economic burdens.

Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements

Carpal tunnel syndrome (CTS) is a common disorder caused by compression of the median nerve in the wrist, resulting in pain and numbness throughout the hand and forearm. While multiple behavioural and physiological factors influence CTS risk, a growing body of evidence supports a strong genetic contribution. Recent genome-wide association study (GWAS) efforts have reported 53 independent signals associated with CTS. While GWAS can identify genetic loci conferring risk, it does not determine which cell types drive the genetic aetiology of the trait, which variants are "causal" at a given signal, and which effector genes correspond to these non-coding variants. These obstacles limit interpretation of potential disease mechanisms. We analysed CTS GWAS findings in the context of chromatin conformation between gene promoters and accessible chromatin regions across cellular models of bone, skeletal muscle, adipocytes and neurons. We identified proxy variants in high LD with the lead CTS sentinel SNPs residing in promoter connected open chromatin in the skeletal muscle and bone contexts. We detected significant enrichment for heritability in skeletal muscle myotubes, as well as a weaker correlation in human mesenchymal stem cell-derived osteoblasts. In myotubes, our approach implicated 117 genes contacting 60 proxy variants corresponding to 20 of the 53 GWAS signals. In the osteoblast context we implicated 30 genes contacting 24 proxy variants coinciding with 12 signals, of which 19 genes shared. We subsequently prioritized BZW2 as a candidate effector gene in CTS and implicated it as novel gene that perturbs myocyte differentiation invitro. Taken together our results suggest that the CTS genetic component influences the size, integrity, and organization of multiple tissues surrounding the carpal tunnel, in particular muscle and bone, to predispose the nerve to being compressed in this disease setting. This work was supported by NIH Grant UM1 DK126194 (SFAG and WY), R01AG072705 (SFAG & KDH) and the Center for Spatial and Functional Genomics at CHOP (SFAG & ADW). SFAG is supported by the Daniel B. Burke Endowed Chair for Diabetes Research. WY is supported by the Perelman School of Medicine of the University of Pennsylvania.

Prevalence of Carpal Tunnel Syndrome During Pregnancy

Background: Carpal Tunnel Syndrome (CTS) is a common condition during pregnancy, associated with symptoms like tingling, numbness, and pain in the hand and arm due to median nerve compression. The prevalence and severity of CTS can increase due to physiological changes during pregnancy, such as fluid retention and hormonal fluctuations. Objective: This study aimed to determine the prevalence of CTS in pregnant women, identify the trimester with the highest occurrence, and assess the effectiveness of Phalen's and Durkan compression tests in diagnosing CTS during pregnancy. Methods: A cross-sectional study was conducted over six months at Akhtar Saeed Trust Teaching Hospital and Farooq Hospital, Lahore, involving 121 pregnant women. Participants were selected using non-probability convenience sampling and were divided by trimester. The diagnosis of CTS was confirmed through Phalen's and Durkan compression tests. Data analysis was performed using SPSS version 25, with a chi-square test to evaluate the association between CTS prevalence and pregnancy trimester. Results: The prevalence of CTS among the participants was identified as 33.1% with Phalen's test and 55.4% with Durkan's compression test. The third trimester showed the highest occurrence of CTS symptoms, with a significant increase in prevalence (p=0.005 for Phalen’s test and p=0.394 for Durkan compression test). The frequency of CTS symptoms was 28.9% in the first trimester, 32.2% in the second trimester, and 38.8% in the third trimester. Conclusion: The study confirms that CTS is prevalent among pregnant women, particularly in the third trimester. The findings emphasize the need for healthcare providers to be aware of the increased risk of CTS during pregnancy and the importance of early diagnosis and management to alleviate symptoms.

Association between the digit ratio (2D:4D), handgrip strength, wrist ratio, and body fat distribution in women with different carpal tunnel syndrome severity

BackgroundTo evaluate the relationship of the second to fourth digit ratio (2D:4D), a biomarker of prenatal sex hormone exposure, with wrist ratio (WR), wrist-palm ratio (WPR), body mass index (BMI), waist-hip ratio (WHR), and handgrip strength (HGS) in different carpal tunnel syndrome (CTS) severity. MethodThis study involved 90 female participants (aged 18 to 83) with CTS. According to CTS severity, the participants were divided into four groups: normal, mild, moderate, and severe. All parameters of hand anthropometry and body fat distribution were measured, and the mean 2D:4D, WR, WPR, HGS, BMI, and WHR values were compared based on CTS severity. Data were collected with a visual analog scale (VAS) for pain and a Likert (LS) scale for numbness severity. ResultsThe mean age, 2D:4D, WD, WW, WR, WPR, BMI, and HGS values showed a significant differences between CTS severity groups. We found that lower 2D:4D and higher WPR and BMI were associated with increased risk of CTS (AUC = 0.728) after removing the effect of age. Bilateral hands were affected in 38.9 % (70/180) of participants. Regression analysis showed that lower HGS can be used as independent variable for predicting the females having bilateral affected hands. The LS score was considerably higher in the severe and moderate groups. Also, the VAS score was significantly higher in the severe group. ConclusionThe findings of the study demonstrated an association between 2D:4D, WPR, and BMI among women, emphasizing the effect of intrauterine sex hormone exposure on late life CTS severity.

Is Carpal Tunnel Release Necessary in High-Energy Distal Fractures of the Radius?

Purpose This study aimed to compare the clinical outcomes of patients who underwent volar plate osteosynthesis for high-energy distal radius fracture (DRFx) and carpal tunnel release (CTR) for acute or subacute carpal tunnel syndrome (CTS) with patients who did not undergo CTR. Methods This study is a retrospective evaluation of all high-energy DRFx treated with volar plate osteosynthesis in a regional hospital between January 2021 and January 2023. All adult patients (≥18 years) who underwent open reduction and internal fixation were included in the study after obtaining approval from the internal review board of our institution. Only patients who underwent plate osteosynthesis of the volar aspect through a modified Henry incision and patients who underwent CTR through a classic separate incision were included in the study. Clinical results includehand dynamometry, visual analog scale (VAS) scores, and physical examination findings of patients who underwent volar plate osteosynthesis because of high-energy DRFx and CTR due to CTS in the acute and subacute periods were retrospectively examined. Results Among the patients who underwent volar plate osteosynthesis because of high-energy DRFx, no statistically significant difference was detected between the hand grip strength and VAS scores of patients who underwent CTR because of acute CTS and subacute CTS at the sixth postoperative week (p>0.05). Conclusion Prophylactic CTR may be performed in the same session in selected cases, such as DRFx caused by a high-energy injury, to establish a scale for DRFx at a high risk of CTS and avoid delays in treatment. CTR for transient CTS detected in the subacute period during outpatient follow-up does not improve clinical outcomes.

Carpal tunnel syndrome among Manitoba workers: Results from the Manitoba Occupational Disease Surveillance System.

Carpal tunnel syndrome (CTS) is associated with occupational high-force repetitive tasks and vibration. This project examines the relationship between CTS and work to: (1) identify jobs and industries with increased CTS risk; (2) explore whether there is a sex difference in the risk of CTS after controlling for occupation; and (3) determine whether any observed relationships persist after excluding Workers Compensation Board (WCB) accepted time-loss CTS claims. We linked 95.5% of time-loss WCB claims from 2006 to 2019 to provincial administrative health data. The cohort included 143,001 unique person-occupation combinations. CTS cases were defined as at least two medical claims for (ICD-9 354) within a 12-month period or a surgical claim for CTS from 2 years before the WCB claim to 3 years after. WCB accepted CTS time-loss claims not identified by the medical claims were also included. A total of 4302 individuals (3.0%) met the CTS definition. Analysis revealed that the hazard ratios (HRs) of CTS vary considerably with occupation. Sex-based differences in CTS risks were observed, both in low- and high-risk occupations. In many occupations with increased HR, the HR remained elevated after excluding accepted time-loss WCB cases. The risk of developing CTS varied with occupation. Job titles with ergonomic risk factors had higher risks than those with lower exposures. This finding remained after eliminating time-loss compensated WCB cases, suggesting that all cases of CTS in high risk jobs are not identified in WCB statistics. Female workers in some job titles had excess CTS cases compared to male workers within the same job title.

External wrist ratio is not a proxy for internal carpal tunnel shape: Implications for evaluating carpal tunnel syndrome risk.

Carpal tunnel syndrome (CTS) is highly prevalent, resulting in decreased function and increased need for costly healthcare services. External wrist ratio (depth/width >0.70) is a strong predictor of the development of CTS and has been suggested to be a proxy for internal carpal tunnel (CT) shape. Conversely, sonography can more directly evaluate CT shape. The purpose of our study was to explore the relationship between wrist ratio and sonographic CT measurements to (1) evaluate the reliability of sonographic CT measurements and (2) explore how external wrist measures relate to anthropometric features of the CT. We used sonographic imaging on a sample of healthy participants (n = 226) to measure CT cross-sectional area, depth, width, and depth/width ratio. We conducted exploratory correlation and regression analyses to identify relationships of these measures with external wrist ratio. Reliability for dominant and nondominant sonographic CT measures ranged from good to excellent (0.79-0.95). Despite a moderate correlation between CT width and depth and their external wrist counterparts (0.33-0.41, p < 0.001), wrist ratio and CT ratio demonstrated weak to no correlation (dominant: r = 0.12, p = 0.053; nondominant: r = 0.20, p = 0.002) and the mean CT ratio was far lower than the mean wrist ratio (0.45 vs. 0.71 bilaterally). Supporting this, we observed several key differences in the relationship between external wrist measures compared to corresponding CT measures. Additionally, regression analyses combining participant factors and CT measurements produced models accounting for less than 15% of the variability in external wrist ratio (linear models) or correctly predicting less than 68% of wrist ratio-based risk categorization (logistic models). Overall, among healthy young adults, wrist shape is not an adequate proxy for CT shape.

The Carpal Tunnel Syndrome and Ergonomic Risk Factor Profile in Online Motorcycle Taxi Drivers (ojol) in Jakarta

Introduction: The increasing need for online motorcycle taxi driver (ojol) transportation continues to increase in Jakarta. This increases the activity of motorcycle taxi drivers, which can cause Carpal tunnel syndrome risks due to the awkward posture of the wrist while riding the motorcycle (the wrist posture is too long on the motorcycle handlebars with repetitive motion), which will affect the nerves and blood supply to the wrist and hand. This study aims to determine the risk of the motorcycle taxi driver’s upper limb using Rapid Upper Limb Assessment (RULA) and Carpal tunnel syndrome risk factor using the Boston Carpal Tunnel Syndrome Questionnaire (BTCSQ). Method: This research used a cross-sectional study approach with 97 respondents online motorcycle taxi drivers. The respondents were collected based on the activity of online motorcycle taxi drivers who were in or passing through the data collection location and willing to take part in the Rapid Upper Limb Assessment (RULA) and the Boston Carpal Tunnel Syndrome Questionnaire (BTCSQ). The RULA assessment and analysis were performed and supported by video (recording from a cycle of the activity while the respondents were riding the motorcycles). The respondents’ criteria were an online motorcycle taxi driver with a minimum of 1 year of working experience, at least 3 hours working duration per day, and not clinically suffering from rheumatoid arthritis and wrist problems. This study has been approved by Universitas Kristen Krida Wacana ethical committee. Result: The results of BCTSQ and RULA in online motorcycle taxi drivers have found that there’s mild–moderate risk respectively in Jakarta. In RULA, it was found that there were 87.6% of respondents were reported at moderate risk which had an impact on musculoskeletal problems, especially the upper limb. In the BCTSQ, the result showed that there were mild complaints in 38.1% of respondents regarding the wrist which was at risk of developing carpal tunnel syndrome. Discussion: With RULA results, in the form of moderate risk, Further ergonomics investigation and assessment are needed to find out further risk factors, mitigation plans, and best improvements to reduce the risks. The occurrence of mild complaints in the wrist based on BCTSQ requires further clinical examination of carpal tunnel syndrome to reduce the incidence of CTS cases in online motorcycle taxi drivers. Conclusion: This research’s result has found mild-moderate risk factors from the activity and working posture among online motorcycle taxi drivers in Jakarta. Further investigation and research ergonomically are needed.

Risk of Upper Limb Diseases in Osteoarthritis Patients: A Propensity-score-matched Cohort Study.

Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts quality of life, particularly when affecting the hands. However, whether patients with OA are associated with higher risk of developing upper limb disorders, specifically trigger finger (TF) and carpal tunnel syndrome (CTS), remains unclear. This study aimed to evaluate the risk of upper limb disease in OA patients. Using the US Collaborative Network, a subset of the TriNetX research network, we identified patients diagnosed with OA and matched them 1:1 with non-OA controls based on propensity scores. Matching covariates included age, sex, race, and comorbidities. The cohort consisted of 1,554,182 patients in each group. The hazard ratio of TF and CTS, as well as related surgical interventions, was assessed over a 5-year follow-up period. Patients with OA had a 1.30-fold increased risk of TF [95% confidence interval (CI)=1.27-1.33] and a 1.50-fold increased risk of CTS (95%CI=1.48-1.53) compared to controls. The hazard ratios for undergoing surgical interventions were 1.61 for TF (95%CI=1.51-1.71) and 1.97 for CTS (95%CI=1.78-2.19). These risks remained significant across various sensitivity analyses and stratifications according to age and sex. OA significantly increases the risk of TF and CTS. These findings highlight the need for vigilant monitoring and management of upper limb disorders in OA patients to improve overall patient care and outcomes. Future research is warranted to focus on pathological mechanisms of OA and their impact on upper limb health to develop targeted interventions.

Carpal Tunnel Syndrome as a Complication of Surgical Scaphoid Reconstruction in Nonunion and Secondary Fracture Dislocation

AbstractThe purpose of this study was to identify risk factors for postoperative carpal tunnel syndrome (CTS) in operative management for scaphoid nonunion and secondary fracture dislocation, treated surgically with takedown and bone grafting. We reviewed medical records of all our patients that underwent carpal tunnel release after scaphoid reconstruction surgery from August 2002 to December 2020. We identified a total of 7 out of 191 patients (3.7%). We investigated surgical parameters, pre- to postoperative changes, in three-dimensional measurements of the scaphoid and carpal tunnel morphometry. We found the preoperative intrascaphoid angle (ISA) and the postoperative change in ISA to correlate with an increased risk of postoperative CTS. Patients undergoing operative scaphoid reconstruction that require a high degree of geometric correction can be at risk to develop postoperative CTS, hence they should be subject to a lower threshold decision for prophylactic carpal tunnel release. Level of Evidence Level III.

A systematic review Risk Factors of Carpal Tunnel Syndrome in Food Industry Workers

Carpal Tunnel Syndrome (CTS) is a health disorder that occurs due to compression of the median nerve in the carpal tunnel with the main symptoms being tingling and pain in the fingers and hands which are innervated by the median nerve. CTS is a multifactorial disease, involving various risk factors (occupational, non-occupational). CTS is at risk of occurring in various industrial sectors, especially workers in the clothing industry, food and beverage industry, and agriculture who cause repetitive movements or maintain unergonomic work postures. CTS has become the center of attention of researchers because it can cause disability in workers, disrupting work productivity. This study aims to analyze the risk factors for CTS in food industry workers. This type of research is a systematic review that was searched via Google Scholars, PubMed, Cochrane Library, ResearchGate and Science Direct with a publication deadline of the last 5 years. The research results showed that 33 journals contained the topic of CTS risk factors in food industry workers. Based on 33 journals, it was found that the factors that cause Carpal Tunnel Syndrome are divided into occupational and non-occupational risk factors. Occupational risk factors include work duration, non-ergonomic workplace, work experience, repetitive wrist movements, hand position and body posture, and exposure to vibration. Apart from that, non-occupational factors include underlying disease, age, female gender, obesity, smoking. The conclusion of this research is that the risk factors for Carpal Tunnel Syndrome (CTS) in food industry workers are caused by various things. In general, it consists of occupational and non-occupational risk factors.

Prevalence of Carpel Tunnel Syndrome among Dentists, A Cross-Sectional Study

Background: Carpal Tunnel Syndrome (CTS) is a neuromuscular disorder predominantly seen in professions demanding repetitive and forceful hand movements, notably among dentists. This study aimed to assess the prevalence of CTS among dentists and its impact on their professional activities. Objective: To determine the prevalence of CTS in dentists and understand how it affects their daily professional tasks. Methods: This cross-sectional study utilized the Boston Carpal Tunnel Questionnaire to evaluate sensory and functional impairments in a sample of 50 dentists. The questionnaire encompassed demographic details, the Functional Status Scale (FSS), and the Symptom Severity Scale (SSS). Data analysis was conducted using SPSS version 28.0. Results: The study sample comprised 38% female and 62% male dentists, primarily aged between 20-30 years (48%), followed by 31-40 years (30%), and 41-50 years (22%). It was found that female dentists exhibited a higher prevalence of CTS compared to male counterparts. Regarding symptoms, 40% of the participants reported mild hand or wrist pain during the day, while 10% experienced moderate pain. Furthermore, 30% of the dentists reported experiencing wrist pain 1-2 times per day. A notable 40% felt slight weakness in the hands, and 6% reported moderate weakness. Conclusion: The study concludes that CTS is highly prevalent among dentists, with a more significant impact observed in female practitioners. These findings highlight the need for targeted preventive measures and ergonomic interventions in dental practice to reduce the risk and burden of CTS.

Carpal Tunnel Syndrome in Motorbike Riders: Prevalence, Severity, and Implications for Occupational Health

The clinical diagnosis of Carpal Tunnel Syndrome (CTS) is based on a collection of symptoms and indicators that point to compression of the median nerve within the carpal tunnel. Objective: To find out the severity, functional status, and pain of carpal tunnel syndrome in motorbike riders using BCTQ and NPRS. Methods: A cross-sectional study was conducted in 4 months on 169 motorbike riders in Faisalabad based on inclusion and exclusion criteria after obtaining consent. Phalen test was used to see carpal tunnel syndrome. Pain identification was done by using BCTQ in the selected subjects. Data were evaluated by SPSS version 22. Pearson Chi-Square test was applied for BCTQ symptom severity and functional limitation. Results: Data showed that all 169 participants were men. It also demonstrated that 42% fall in the category of 20-24 years, 33.1% fall in the 25-29 years category, and 24.9% fall in the age category of 30-34 years. The distribution showed that the prevalence of carpal tunnel syndrome by the Phalen test was 13% (22) among motorbike riders (169). Conclusions: Bike riding is an occupational hazard for CTS. To lower the risk of CTS in occupations involving motorbike riders, programs utilizing ergonomic and industrial hygiene improvement must be developed and implemented. The study showed that the prevalence of CTS among motorbike riders was 13% and the mean ± S.D was 1.869 ± .3375.

Occupational Risk Factors of Carpal Tunnel Syndrome on Workers: A Literature Review

The median nerve at the wrist becomes crushed in a condition known as carpal tunnel syndrome (CTS), which causes pain, numbness, and tingling in the worker's hand's palm. Risk elements for CTS include things like uncomfortable body posture at work, repetitive hand motions, and vibration exposure. Reviewing prior research on the connection between CTS and potential risk factors such worker hand posture, exposure to hand-arm vibrations, and repetitive hand movements is the goal of this study. The research approach involves searching for relevant articles using the terms carpal tunnel syndrome AND (occupational risk factors OR uncomfortable posture OR hand-arm vibrations OR repeated hand movements) in databases like ScienceDirect, PubMed, ResearchGate, and Scopus. The study indicates that Carpal Tunnel Syndrome is related to repetitive hand movements, hand-arm vibrations, and awkward hand posture during work. This research implies the importance of awareness about occupational safety. Additionally, the study suggests that job designs considering repetitive hand movements, vibrations, and incorrect posture can reduce the risk of Carpal Tunnel Syndrome. Therefore, it is hoped that organizations and workers can collaborate to create a safer, healthier, and more productive work environment.

Screening Plasma Proteins for the Putative Drug Targets for Carpal Tunnel Syndrome.

Carpal tunnel syndrome (CTS) is one of the most common work-related musculoskeletal disorders. The present study sought to identify putative causal proteins for CTS. We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the causal association between 2859 plasma proteins (N = 35,559) and CTS (N = 1,239,680) based on the published GWAS summary statistics. Then we replicated the significant associations using an independent plasma proteome GWAS (N = 10,708). Sensitivity analyses were conducted to validate the robustness of MR results. Multivariate MR and mediation analyses were conducted to evaluate the mediation effects of body mass index (BMI), type 2 diabetes (T2D), and arm tissue composition on the association between putative causal proteins and CTS. Colocalization analysis was used to examine whether the identified proteins and CTS shared causal variant(s). Finally, we evaluated druggability of the identified proteins. Ten plasma proteins were identified as putative causal markers for CTS, including sCD14, PVR, LTOR3, CTSS, SIGIRR, IFNL3, ASPN, TM11D, ASIP, and ITIH1. Sensitivity analyses and reverse MR analysis validated the robustness of their causal effects. Arm tissue composition, BMI, and T2D may play a fully/partial mediating role in the causal relationships of ASIP, TM11D, IFNL3, PVR, and LTOR3 with CTS. The association of ASPN and sCD14with CTS were supported by colocalization analysis. Druggability assessment demonstrated that sCD14, CTSS, TM11D, and IFNL3 were potential drug therapeutic targets. The present study identified several potential plasma proteins that were causally associated with CTS risk, providing new insights into the pathogenesis of protein-mediated CTS and offering potential targets for new therapies.