Risk Factors For HCV Infection Research Articles

Epidemiological characteristics of hepatitis c infection in Nizhny Novgorod at the first stage of infection control program (2016–2021)

Objective. To characterize the peculiarities of the epidemic process of viral hepatitis C in Nizhny Novgorod at the first stage of the infection control program (2016–2021).
 Materials and Methods. A retrospective analysis of the incidence of registered forms of HCV infection in Nizhny Novgorod was carried out using information of statistical and analytical materials. A total of 78 883 blood serum samples were collected from individuals undergoing pre-hospital screening and admitted to non-infectious hospitals from 2016 to 2021. Laboratory testing included the determination of HCV infection markers: anti-HCV IgM and IgG, antibodies to structural and non-structural proteins (n = 2953). Seropositive samples were tested for the presence of HCV RNA (n = 467) using the Real Time PCR method.
 Results. A trend towards a decrease in the incidence of registered forms of HCV infection was observed in Nizhny Novgorod from 2016 to 2021. It was found that among the various suspected transmission routes and risk factors for HCV infection, the predominant ones were a history of injected drug used and sexual transmission. The seroprevalence of anti-HCV was 3.6 ± 0.1 % and the prevalence of HCV RNA among the adult population was 1.8 ± 0.1 %. The highest prevalence of active HCV infection was observed in the age groups of 30–39 years (3.3 ± 0.3 %) and 40–49 years (5.7 ± 0.5 %).
 Conclusions. To achieve the goals of the HCV elimination program, targeted and dynamic seroepidemiological studies are necessary to increase the number of individuals screened for HCV infection markers, with subsequent expansion of access to effective antiviral therapy for those with active infection.

Prevalence and predictors of hepatitis C infection among antenatal attendees in a tertiary hospital in Southern Nigeria.

Hepatitis C virus infection as it specifically relates to pregnancy has been a neglected condition, thus its recognition and treatment in pregnancy is relevant because of the risks of the long-term complications of the infection in the mother, potential effects of the infection on the pregnancy and risk of vertical transmission to the newborn. To determine the proportion of pregnant women with serologic markers of hepatitis C infection, identify risk factors as well as factors that predict the occurrence of the infection in them. Over a 3-week period, blood samples from 456 pregnant women were assessed for antibodies to hepatitis C virus, while a pre-tested questionnaire was used to obtain socio-demographic data and the presence of risk factors in the University of Uyo Teaching Hospital, Nigeria. The prevalence of HCV infection in pregnancy was 4.6%. No known risk factors for HCV infection in pregnancy were identified. Only increasing gestational age was a predictor of HCV infection in pregnancy in the study. The prevalence of hepatitis virus infection among the study population was high. Second trimester and increasing gravidity were protective of the infection in pregnancy. There is therefore need for introduction of general routine screening of all pregnant women presenting for antenatal care.

Prevalence and Associated Risk Factors of HCV Infection Among Children in Lahore, Pakistan

Background: Pakistan has second highest prevalence of HCV in the world. The epidemiology and burden of HCV infection varies in people of different ages. Objective: Present study was designed to measure the prevalence of HCV among children in selected public
 and private hospitals of Lahore Methods: Children in the study were screened for anti-HCV test through ELISA (third generation ELISA Kit
 and Qaigen kit) for detecting the viral load from June 2018 to May 2019. Results: Children in the study were screened for anti-HCV test through ELISA (third generation ELISA Kit and Qaigen kit) for detecting the viral load. The average age of non-reactive and reactive children was 7.28±3.36 and 5.50±3.8 years respectively. Socio-economic status was found associated with anti-HCV. An association was found significant for birthplace, delivery assisted by, and type of milk given to the child. Conclusion: This study shows that the prevalence of HCV is 3.85% in children in lahore city of Pakistan, which is alarming situation for healthcare providers, researchers and policy makers.

Hepatitis C Virus Prevalence in Hemodialysis Patients in Karbala Province

Purpose: The study aimed to evaluate HCV infection rates are widespread in hemodialysis patients and identify any potential HCV infection risk factors in this cohort. Methods: Hepatitis C virus statistical information was collected from the publicly accessible Karbala province/ Iraq. Results: All told, 236 dialysis patients, 150 (63.6%) male and 86 (36.4%) female, they are between the ages of 15 and 78 (44.39 + 15.06 S.D.) years. Sampling lasted from May to October 2019-2021. Each HD treatment required three to four hours, and depending on their haemodialysis facility, patients were divided into two shifts for each of their two or three weekly dialyses. Dialysis membranes were single-use, disposable devices. Conclusions: The information in this study indicated that HCV is prevalent in hemodialysis centers are comparatively high and also demonstrated that the greatest risk factor for developing HCV seems to be the duration of time undergoing hemodialysis therapy, which raises the possibility of nosocomial transmission.

Prevalence, diagnosis, treatment, and associated factors of hepatitis C in the United States from 1999 to 2018: A population-based cross-sectional study

Background and aimHepatitis C virus (HCV) infection is one of the major global health challenges, leading to a significant increase in rates of hepatic fibrosis, cirrhosis and hepatocellular carcinoma. A comprehensive nationwide survey of trends in prevalence and associated factors could facilitate preventive behavioral interventions. Herein, we sought to determine prevalence, diagnosis, treatment, and risk factors for HCV infection in the general United States (US) population. MethodsThis was a secondary analysis of the publicly available data from the US National Health and Nutrition Examination Survey (NHANES). The prevalence of HCV-RNA-positive (HCV-RNA+) was weighted using patient serum sample data collected from 1999 to 2018. A propensity score matching model was used due to the imbalance in the number of HCV-RNA+ and HCV-RNA-negative (HCV-RNA−) patients. Matched variables included gender, age, educational level, marital status, language, household size, alcohol consumption, smoking, number of family members and family income to poverty ratio. ResultsThe weighted prevalence of HCV-RNA+ was 1.11% (95% confidence interval (CI): 1.02–1.20), 1.58% (95% CI: 1.42–1.74) for men and 0.67% (95% CI: 0.57–0.77) for women aged 20 years or older in the US from 1999 to 2018. The weighted prevalence of HCV-RNA+ increased from 0.87% (95% CI: 0.62–1.12) in 2013–2014, 0.95% (95% CI: 0.68–1.22) in 2015–2016 to 1.00% (95% CI: 0.72–1.28) in 2017–2018, respectively. In propensity-matched analysis, patients with HCV-RNA+ were more likely to be non-Hispanic black, and have had drug use and blood transfusions. Meanwhile, the weighted diagnostic and treatment rates were 56.27% (95% CI: 50.90–61.64) and 35.40% (95% CI: 27.64–43.16) from 1999 to 2018, respectively. ConclusionsActive HCV infection rate increased between 2013 and 2018, varied by demographic and risk variables. In the direct-acting antiviral era, affordable treatment and universal screening have the potential to improve overall national health.

Prevalence and Risk Factors of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Infections among Prisoners Admitted to DMCH

Background: There are approximately 66 thousand prisoners remained in 68 prisons in Bangladesh. (source: Kara Adhidoptar, Bangladesh). So these number of prisoners suffers from different diseases. Prisoners are associates with various high risk of infectious diseases, as a result of the possibility of transmission of infections in prisons surroundings. A high prevalence of blood borne hepatitis viruses and HIV carried out in correctional facilities around the world by investigations have shown. There are limited data on medical disorders among prison inmates in Bangladesh. The study was aimed at confirming prevalence of HIV, hepatitis B and hepatitis C as well to assess knowledge and attitudes related to HIV, HBV and HCV infections among prisoners admitted to DMCH who referred to medicine department and/ or attended out-patient department in DMCH. Objective: To determine the prevalence and risk factors of HIV, HBV and HCV infection among prisoners referred to tertiary care hospital. Methods: This cross sectional study was done with a total number of 100 inmates over a period of one year. Prisoners, imprisonment for more than six months and who gave consent voluntarily were included in the study. After taking consent from the patient’s/guardians history was taken and physical examination was done. Sample was selected from the population by purposive sampling technique. Data were analysis was done using SPSS version 22.0. Result was expressed in tables and graphs. Results: The results showed a significantly higher seroprevalence of HBV (6%) and HCV (4%) though no prisoner was found to be HIV positive compared to the seroprevalence of these virus infections reported in the general Bangladeshi population (5.8% for HBV and 0.3% for HCV). Exposure of risk factors estimated H/O foreign travels 12%, IV drug abuse 14%, extramarital sexual exposure 16%, sharing of needle 10%, H/O blood transfusion 08%, family H/O diseases 05%, immunization of hepatitis B only 8% and homo sexuality 0%. Risk factors for HBV infection was estimated-family h/o disease 20%, IV drug abuse 7.10%, sharing of needles & syringes 10%, sexual exposue12.50%, blood transfusion 12.50%. Risk factors for HCV infection was estimated -IV drug abuse 7.10%, sexual exposue6.25%, sharing of needles & syringes 20%. Risk factors for HIV infection 0% for all risk factors as no one was HIV infected. Among the IDUs 14% was HBV positive and 30% was HCV positive. Conclusion: The results indicate higher prevalence of HBV and HCV infections among prisoners which has proven that HBV and HCV are the emerging public health problem in a developing country like Bangladesh. Various risk factors contribute to raise prevalence of hepatitis B, hepatitis C and HIV in prisoners. So avoidance from these risk factors is essential to prevent transmission of infection in prison. So health education and dissemination of message about the moods of transmission of these diseases is very important in prison.

S1210 Catching Hepatitis C: Universal Hepatitis C Screening in a Primary Care Setting in California’s Central Valley

Introduction: An estimated 2.4 million people in the United States are living with chronic hepatitis C (HCV). Approximately 40% of HCV patients are unaware of their diagnosis. Socioeconomic status and the ongoing opioid crisis are important risk factors for HCV infection. The rates of intravenous and intranasal drug use in California’s Central Valley are among the highest in the nation and many are socioeconomically disadvantaged, creating a perfect scenario for HCV propagation. Identification and treatment of HCV is imperative to prevent morbidity and mortality as well as the spread of infection. Methods: A universal HCV screening program was implemented in the internal and family medicine teaching clinics at a large federally qualified health center in the Central Valley. The electronic medical record identifies eligible patients based on current CDC guidelines. Once identified, an automatic prompt alerts the provider and HCV labs (HCV antibody test with reflex to genotype and RNA level) are auto-populated and available to be signed at the end of the visit. Patients with active HCV infection (positive RNA level) are contacted by the designed project coordinator, who facilitates linkage to care to a primary care provider as well as to the provider experienced in treating HCV. Linkage to care is defined as, completion of the first medical appointment. Results: Universal screening was implemented on July 1, 2021. The data here was collected between July 1, 2021 and November 30, 2021. A total of 1152 patients were eligible for screening and 1084 patients completed the screening. Twenty-three patients tested positive for HCV Ab and 11 patients (9 male and 2 female) tested positive for HCV RNA. Most HCV RNA positive patients were Hispanic (36%) and African American (27%). The most common genotype was 1a (45%). Fifty-four percent of HCV RNA positive patients were linked to care. Conclusion: Prior to the implementation of universal screening, only 54% eligible patients were screened in a 12-month period. Based on preliminary data, we screened 94% eligible patients within a 5-month period. In addition, only 31% of HCV patients prior to universal screening were linked to care compared to the 54% linked to care through our initiative. Our project encouraged providers to screen patients which helped identify HCV in the community. Although data collection is ongoing, we suspect this initiative will surpass the total number of patients screened and linked to care compared to previous practices.

Risk factors for hepatitis C virus infection at a large urban emergency department.

In 2020, Centers for Disease Control and Prevention (CDC) released guidelines recommending HCV screening in all adults 18 years and older. In the current study, we aimed to identify risk factors for HCV infection in an ED population. We performed a retrospective analysis of ED patients ≥ 18 years who were screened for HCV between 28 November 2018, and 27 November 2019, at a single urban, quaternary referral academic hospital. An HCV-antibody immunoassay (HCV-Ab) was used for screening; positive results were confirmed by measuring HCV ribonucleic acid (RNA). The outcome of interest was the number of new HCV diagnoses (presence of viremia by HCV RNA testing). Multiple logistic regression models were used to identify risk factors associated with a new HCV diagnosis. 16,722 adult patients were screened for HCV (mean age: 46 ± 15 years; 51% female). HCV seroprevalence was 5%. Independent risk factors for HCV included increasing age [10-year aOR 1.26 (95% CI 1.23, 1.30)], male sex [aOR 1.25 (95% CI 1.03, 1.51)], undomiciled housing status [aOR 2.8 (95% CI 2.3, 3.5)], history of tobacco use [aOR 3.0 (95% CI 2.3, 3.9)], history of illicit drug use [aOR 3.6 (95% CI 2.9, 4.5)], Medicaid insurance status [aOR 4.0 (95% CI 2.9, 5.5)] and Medicare insurance status [aOR 1.6 (95% CI 1.1, 2.2)].The ED services a high-risk population with regards to HCV infection. These data support universal screening of ED patients for HCV. Risk factor profiles could improve targeted screening at institutions without universal testing protocols.

Epidemiology of Hepatitis C virus infection among incarcerated populations in North Dakota.

This retrospective cohort study was conducted to determine the prevalence of HCV infections among individuals incarcerated in a state prison system and identify potential contributing factors to HCV infection. North Dakota Department of Corrections and Rehabilitation (NDDOCR) data from 2009 to 2018 was used and period prevalence was calculated for this 10-year time period. The period prevalence of HCV infection was (15.13% (95% CI 14.39-15.90) with a marginally significant (p-value: 0.0542) increasing linear trend in annual prevalence over this period. Multivariate logistic regression analysis was used to identify risk factors associated with HCV infection. The main significant independent risk factors for HCV infection in this incarcerated population were age >40 years [OR: 1.78 (1.37-2.32)]; sex [OR: 1.21 (1.03-1.43)]; race/ethnicity [OR: 1.97 (1.69-2.29)]; history of intravenous drug use (IVDU) [OR: 7.36 (6.41-8.44)]; history of needle or syringe sharing [OR: 7.57 (6.62-8.67)]; and alcohol use [OR: 0.87 (0.77-0.99)]. Study limitations include uncollected information on sexual history, frequency or duration of injection drug use and blood transfusion history of the incarcerated population. Considering the high prevalence of HCV infection and its associated risk factors, it is important to implement prevention programs such as syringe/needle exchanges and counsel with imprisoned IVD users.

Injecting drug users, MSM and people at the older age should be routinely tested for HCV in Poland - data derived from a post-exposure prophylaxis population.

The aim of the study was to identify risk factors for HCV infection and thus identify groups for routine HCV testing in the group of people consulted for post-exposure prophylaxis (PEP). A retrospective analysis was performed of cross-sectional data available from consultations due to post-exposure prophylaxis in HIV Out-patient Clinic and Emergency Department (ED) of Hospital for Infectious Diseases in Warsaw, Poland. Data were obtained from the electronic database, from 2008-o 2016. For statistical analysis, χ2 and t-tests were used for group comparisons, as appropriate. A total of 3,593 persons were included in the study, 60 (1.7%) were anti-HCV positive. In the first step, univariate models were estimated for each of predictors separately. The results showed that odds of infection are significantly higher in males (OR = 1.92), people after non-professional exposure (OR = 3.82), and increase with age (OR = 1.03). In the next step, a multivariate logistic model was fitted in the group of participants after non-professional exposure with gender, age, and route of exposure as predictors. Obtained results revealed significantly higher odds of infection, both in IDU (OR = 162.6) and gender exposure (OR = 3.59) groups. After including routes of exposure, effects of age remained significant (OR = 1.05), while the effects of gender did not (OR = 1.12). Based on the study results, it is recommended that routine testing for HCV should be provided for people at older age, and for individual with behavioural risk factors, such as history of injecting drus use or sexual exposure, particularly among men having sex with men (MSM).

Prevalence of HCV infection and related risk factors in drug users in Wenzhou, Zhejiang, 2011–2020

Objective To understand the prevalence of hepatitis C and related risk factors in drug users under sentinel surveillance in Wenzhou during 2011–2020 and provide evidence for the prevention and control of hepatitis C in this population. Methods A consecutive cross-sectional survey with standard questionnaire was conducted in about 400 drug users randomly selected in compulsory detoxification settings for the annual sentinel surveillance between April and July during 2011–2020, and basic demographic information and blood samples were collected from them. Multivariate logistic regression model was used to analyze the related risk factors of HIV infection. Results A total of 4052 drug users were included in the analysis, the prevalence rate of HCV infection was 41.91%. The average positive rate of HCV antibody was 54.10% during 2011–2013, and 36.65% during 2014–2020. However, the positive rate of HCV antibody increased from 30.00% in 2014 to 41.50% in 2020. Multivariate logistic regression analysis indicated HCV infection risk factors included age ≥30 years, living in Zhejiang, low education level, being traditional drug user or mixed drug user and injecting drug use. Among them, age ≥30 years, living in Zhejiang, being traditional drug user or mixed drug user and injecting drug use can explain the rise of HCV antibody positive rate from 2014 to 2020. Conclusion In the past 10 years, the prevalence of HCV infection in drug users in Wenzhou remained at a high level, showing a significant decline firstly and then a gradual rise. It is speculated that the early decrease of HCV infection level might be related to the improvement of the diagnosis and treatment of Hepatitis C, but the recent increase of HCV infection level is caused by the changes in the characteristics of drug users and the types or modes of drug use.

Analysis of integrated HCV surveillance in Shanghai, 2014-2019

Objective: The purpose of this study is to analyze the surveillance data of the Integrated HCV surveillance in Shanghai and provide a scientific basis for HCV's elimination strategies. Methods: Descriptive statistical analysis and multivariate logistic regression analysis were performed using the multi-dimension results of the Integrated HCV surveillance in Shanghai from 2014 to 2019. Data related to reported HCV cases, HCV gene subtypes surveillance, HCV behavioral risk factors surveillance and HCV-antibody testing results of the community-based general population and high-risk/key populations. Results: The reported incidence rate of acute hepatitis C in Shanghai decreased from 2014 to 2019 (Z=-4.07, P<0.01); meanwhile, the reported incidence rate of chronic hepatitis C met an upward trend (Z=10.26,P<0.01), with an annual average, reported incidence rates of 0.18 per 100 000 and 8.60 per 100 000, respectively. Seven hundred forty-four blood samples were subtyped with 16 subtypes from 4 genotypes (GT1, GT2, GT3, and GT6). Among above, 1b (324 cases, 43.55%), 3a (121 cases, 16.26%), 3b (111 cases, 14.92%) and 6a (47 cases, 6.32%) were the principal subtypes. The composition of genotypes varied with decreased 1b and increased 3b and 6a. The major risk factors for HCV infection were blood transfusion (OR=4.18, 95%CI: 2.79-6.27), surgery (OR=1.63, 95%CI: 1.26-2.12), sharing syringe (OR=4.18, 95%CI: 2.75-6.34), pedicure (OR=2.01, 95%CI: 1.54-2.62), sharing razors (OR=4.09, 95%CI:1.24-13.51), and unsafe beauty practices (OR=3.15, 95%CI: 2.13-4.65). HCV antibody screening of 11 groups of high-risk/key populations showed that drug users had the highest HCV-antibody positive rate of 18.81% (1 008/5 358). The anti-HCV positive rate of the general population was 0.16% (7/4 268), which was significantly lower than that of high-risk/key populations from the same year, 2.50%(501/20 002) (χ2=94.04, P<0.01). Conclusions: Shanghai is a low-endemic area of HCV. Constantly carrying out integrated surveillance and analysis is of great value for early identification of HCV infected people and its risk factors, timely adjustment of prevention and control strategies, and eliminating the public health threat of HCV.

Significant amelioration of hepatitis C virus infection in a hyperendemic area: longitudinal evidence from the COMPACT Study in Taiwan

ObjectivesHepatitis C virus (HCV) infection is the leading cause of cirrhosis and hepatocellular carcinoma worldwide. Tzukuan, located in the southwestern area of Taiwan, is an HCV hyperendemic area (>30%). This...

Demographic Characteristics and Risk Factors for HIV and Hepatitis C Virus Co-infection in Pregnancy at a Tertiary Hospital in Northern Nigeria

Hepatitis and TB co-infection in PLWHA is now a major source of co-morbidity and of public health concern. HIV and Hepatitis are two viruses with overlapping epidemics and shared routes of transmission. The clinical course of HCV is accelerated in patients with HIV with resultant end-stage Liver disease as a major cause of death. Most studies in my environment failed to identify significant risk factors for HCV infection thus making intervention difficult. The study was a descriptive cross-sectional study carried out among consecutive consenting HIV positive pregnant women attending the antenatal clinic of ABUTH-Zaria Nigeria. Relevant information was obtained using a structurally administered questionnaire while Enzyme Linked Immunosorbent assay Biotech Laboratories UK was used for anti Hepatitis C antibodies assay. Twenty four of the 285 samples tested positive for anti HCV antibodies giving a co-infection rate of 8.4%. Lack of formal education was associated with HCV-HIV co-infection (p &lt;0.05), odds ratio (OR) 2.5; 95%CI 0.97-6.97. The possible risk factors analyzed including previous blood transfusion and injecting drug use were not associated with HIV- HCV co-infection (p&gt;0.05). This study revealed a high HCV co-infection with significant association with non-formal educational status. Improving female education may be one important strategy for its prevention.

Demographic Characteristics and Risk Factors for HIV and Hepatitis C Virus Co-infection in Pregnancy at a Tertiary Hospital in Northern Nigeria

Hepatitis and TB co-infection in PLWHA is now a major source of co-morbidity and of public health concern. HIV and Hepatitis are two viruses with overlapping epidemics and shared routes of transmission. The clinical course of HCV is accelerated in patients with HIV with resultant end-stage Liver disease as a major cause of death. Most studies in my environment failed to identify significant risk factors for HCV infection thus making intervention difficult. The study was a descriptive cross-sectional study carried out among consecutive consenting HIV positive pregnant women attending the antenatal clinic of ABUTH-Zaria Nigeria. Relevant information was obtained using a structurally administered questionnaire while Enzyme Linked Immunosorbent assay Biotech Laboratories UK was used for anti Hepatitis C antibodies assay. Twenty four of the 285 samples tested positive for anti HCV antibodies giving a co-infection rate of 8.4%. Lack of formal education was associated with HCV-HIV co-infection (p &lt;0.05), odds ratio (OR) 2.5; 95%CI 0.97-6.97. The possible risk factors analyzed including previous blood transfusion and injecting drug use were not associated with HIV- HCV co-infection (p&gt;0.05). This study revealed a high HCV co-infection with significant association with non-formal educational status. Improving female education may be one important strategy for its prevention.

Demographic Characteristics and Risk Factors for HIV and Hepatitis C Virus Co-infection in Pregnancy at a Tertiary Hospital in Northern Nigeria

Hepatitis and TB co-infection in PLWHA is now a major source of co-morbidity and of public health concern. HIV and Hepatitis are two viruses with overlapping epidemics and shared routes of transmission. The clinical course of HCV is accelerated in patients with HIV with resultant end-stage Liver disease as a major cause of death. Most studies in my environment failed to identify significant risk factors for HCV infection thus making intervention difficult. The study was a descriptive cross-sectional study carried out among consecutive consenting HIV positive pregnant women attending the antenatal clinic of ABUTH-Zaria Nigeria. Relevant information was obtained using a structurally administered questionnaire while Enzyme Linked Immunosorbent assay Biotech Laboratories UK was used for anti Hepatitis C antibodies assay. Twenty four of the 285 samples tested positive for anti HCV antibodies giving a co-infection rate of 8.4%. Lack of formal education was associated with HCV-HIV co-infection (p &lt;0.05), odds ratio (OR) 2.5; 95%CI 0.97-6.97. The possible risk factors analyzed including previous blood transfusion and injecting drug use were not associated with HIV- HCV co-infection (p&gt;0.05). This study revealed a high HCV co-infection with significant association with non-formal educational status. Improving female education may be one important strategy for its prevention.

Demographic Characteristics and Risk Factors for HIV and Hepatitis C Virus Co-infection in Pregnancy at a Tertiary Hospital in Northern Nigeria

Hepatitis and TB co-infection in PLWHA is now a major source of co-morbidity and of public health concern. HIV and Hepatitis are two viruses with overlapping epidemics and shared routes of transmission. The clinical course of HCV is accelerated in patients with HIV with resultant end-stage Liver disease as a major cause of death. Most studies in my environment failed to identify significant risk factors for HCV infection thus making intervention difficult. The study was a descriptive cross-sectional study carried out among consecutive consenting HIV positive pregnant women attending the antenatal clinic of ABUTH-Zaria Nigeria. Relevant information was obtained using a structurally administered questionnaire while Enzyme Linked Immunosorbent assay Biotech Laboratories UK was used for anti Hepatitis C antibodies assay. Twenty four of the 285 samples tested positive for anti HCV antibodies giving a co-infection rate of 8.4%. Lack of formal education was associated with HCV-HIV co-infection (p &lt;0.05), odds ratio (OR) 2.5; 95%CI 0.97-6.97. The possible risk factors analyzed including previous blood transfusion and injecting drug use were not associated with HIV- HCV co-infection (p&gt;0.05). This study revealed a high HCV co-infection with significant association with non-formal educational status. Improving female education may be one important strategy for its prevention.

Demographic Characteristics and Risk Factors for HIV and Hepatitis C Virus Co-infection in Pregnancy at a Tertiary Hospital in Northern Nigeria

Hepatitis and TB co-infection in PLWHA is now a major source of co-morbidity and of public health concern. HIV and Hepatitis are two viruses with overlapping epidemics and shared routes of transmission. The clinical course of HCV is accelerated in patients with HIV with resultant end-stage Liver disease as a major cause of death. Most studies in my environment failed to identify significant risk factors for HCV infection thus making intervention difficult. The study was a descriptive cross-sectional study carried out among consecutive consenting HIV positive pregnant women attending the antenatal clinic of ABUTH-Zaria Nigeria. Relevant information was obtained using a structurally administered questionnaire while Enzyme Linked Immunosorbent assay Biotech Laboratories UK was used for anti Hepatitis C antibodies assay. Twenty four of the 285 samples tested positive for anti HCV antibodies giving a co-infection rate of 8.4%. Lack of formal education was associated with HCV-HIV co-infection (p &lt;0.05), odds ratio (OR) 2.5; 95%CI 0.97-6.97. The possible risk factors analyzed including previous blood transfusion and injecting drug use were not associated with HIV- HCV co-infection (p&gt;0.05). This study revealed a high HCV co-infection with significant association with non-formal educational status. Improving female education may be one important strategy for its prevention.

Increasing uptake of hepatitis C virus infection case-finding, testing, and treatment in primary care: evaluation of the HepCATT (Hepatitis C Assessment Through to Treatment) trial

BackgroundHepatitis C virus (HCV) infection is a key cause of liver disease but can be cured in more than 95% of patients. Around 70 000 people in England may have undiagnosed HCV infection and many more will not have been treated. Interventions to increase case-finding in primary care are likely to be cost-effective; however, evidence of effective interventions is lacking. The Hepatitis C Assessment Through to Treatment (HepCATT) trial assessed whether a complex intervention in primary care could increase case-finding, testing, and treatment of HCV.AimTo investigate the feasibility and acceptability of the HepCATT intervention.Design and settingA qualitative study with primary care practice staff from practices in the south west of England taking part in the HepCATT trial.MethodSemi-structured interviews were carried out with GPs, nurses, and practice staff to ascertain their views of the HepCATT intervention at least 1 month after implementing the intervention in their practice. Normalisation process theory, which outlines the social processes involved in intervention implementation, informed thematic data analysis.ResultsParticipants appreciated the HepCATT intervention for increasing knowledge and awareness of HCV. Although some initial technical difficulties were reported, participants saw the benefits of using the audit tool to systematically identify patients with HCV infection risk factors and found it straightforward to use. Participants valued the opportunity to discuss HCV testing with patients, especially those who may not have been previously aware of HCV risk. Future implementation should consider fully integrating software systems and additional resources to screen patient lists and conduct tests.ConclusionWhen supported by a complex intervention, primary care can play a crucial role in identifying and caring for patients with HCV infection, to help stem the HCV epidemic, and prevent HCV-related illness.

Prevention and factors associated with anti-HCV carriage in pregnant women living in Cotonou

Introductionl´hépatite C est une infection dont la transmission mère-enfant est possible. L´objectif de ce travail était d´étudier la prévalence du portage des anticorps anti-VHC chez des femmes enceintes à Cotonou et d´identifier les facteurs qui y sont associés.Méthodesil s´est agi d´une étude transversale menée du 01/06/2018 au 01/09/2018 auprès de 253 gestantes reçues pour des soins prénatals dans quatre grandes maternités de Cotonou (Bénin). Les anticorps anti-VHC avaient été détectés par des tests rapides d´orientation diagnostique. Un échantillon de sang veineux avait été prélevé chez les gestantes avec anti-VHC positifs en vue de tests sérologiques de confirmation et d´un dépistage du diabète gestationnel.Résultatsla prévalence des anticorps anti-VHC était de 1,2% (3/253 gestantes). Les facteurs associés au portage du VHC n´avaient pu être identifiés compte tenu du faible nombre de cas positifs. Cependant, les gestantes porteuses des anticorps anti-VHC avaient une moyenne d´âge élevée (32 ± 3) comparativement au reste de la population (29,58 ± 5,5). Les facteurs de risque potentiels d´infection par le VHC retrouvés étaient les scarifications, le piercing, le tatouage, le partage du matériel de manucure, un antécédent d´intervention chirurgicale et de transfusion sanguine. La prévalence du diabète gestationnel dans notre étude était de 7,9% (20/253). Aucune association n´était trouvée entre le diabète gestationnel et l´hépatite C.Conclusionla prévalence des anticorps anti-VHC chez les gestantes à Cotonou était faible. Une étude d´envergure nationale s´avère nécessaire afin d´identifier les facteurs associés à cette infection.