Introduction: To evaluate the incidence rate, patient profile, and risk factors of penile cancer patients. Material & method: We reviewed the medical records of incidence rate, patient profile, and risk factors patients of penile cancer in Arifin Achmad Hospital Regional General of Riau Province in January 2013 to December 2017. The data collected were age, histopathology types, smoking history, ethnic/tribes, circumcision history and city/district origin. Approval on the study was obtained from the Ethical Review Board for Medicine and Health Research, Medical Faculty, University of Riau. Result: There were 20 penile cancer patients. Penile cancer was frequently (40%) diagnosed in the 46-55 age group. Most patients came from Pekanbaru city in 25% and most (60%) patients were Batak tribes followed by Malay tribes (15%). Sixty percent of patients had risk factors for smoking history and 75% were not circumcised. All penile cancer patients had histopathology results in the form of squamous cell carcinoma. Conclusion : Risks factors of penile cancer patients in our hospital were Pekanbaru city origin, Batak tribe, smoking history, and not circumcised.