Risk Factor For Psychotic Experiences Research Articles

2.75 Longitudinal Associations Between Digital Media Use and Psychotic Experiences in Youth From the Community

Digital media use has been associated with adverse mental health outcomes in youth. Whether it is a risk factor for psychotic experiences is unclear. We aimed to examine longitudinal associations between digital media use and psychotic experiences in a community sample of youth.

Psychotic experiences in the general population, a review; definition, risk factors, outcomes and interventions.

Psychotic experiences (PE) are common in the general population, in particular in childhood, adolescence and young adulthood. PE have been shown to be associated with an increased risk for later psychotic disorders, mental disorders, and poorer functioning. Recent findings have highlighted the relevance of PE to many fields of healthcare, including treatment response in clinical services for anxiety & depression treatment, healthcare costs and service use. Despite PE relevance to many areas of mental health, and healthcare research, there remains a gap of information between PE researchers and experts in other fields. With this review, we aim to bridge this gap by providing a broad overview of the current state of PE research, and future directions. This narrative review aims to provide an broad overview of the literature on psychotic experiences, under the following headings: (1) Definition and Measurement of PE; (2) Risk Factors for PE; (3) PE and Health; (4) PE and Psychosocial Functioning; (5) Interventions for PE, (6) Future Directions.

Childhood adversity increases risk of psychotic experiences in patients with substance use disorder

IntroductionAdverse childhood experiences (ACEs) increase the risk of psychotic experiences (PE), but little is known about heterogeneities of this association in different developmental stages, dimensions, or whether they are affected by substance use disorder (SUD). This study examines the association between different types of ACEs at various developmental stages and lifetime PE in patients with SUD in Chile. MethodsWe included 399 consenting adults in outpatient or residential SUD treatment programs. Sociodemographic data and information about PE and ACEs were obtained by trained clinical psychologists. ResultsPatients reporting PE experienced more ACEs compared to patients without PE (4.2 versus 3.4). They also experienced more complex adversities (41.8% versus 25.1%), had more psychiatric comorbidities (85% versus 70.4%), and reported using more substances (mean 4.5 versus 3.9). Adjusted association between ACEs and PE showed the highest OR for arrests (1.88), sexual abuse (1.81), alcohol abuse by parents (1.48), school exclusion (1.39), foster or residential care (18.3). ConclusionEarly exposure to ACEs is a risk factor for later PE among patients with SUD. Type of ACE and the period when they occurred is important, suggesting the existence of critical periods where the individual is more susceptible to adverse environmental stimuli.

Childhood adversity and recurrence of psychotic experiences during adolescence: the role of mediation in an analysis of a population-based longitudinal cohort study.

Psychotic experiences (PEs) are relatively common in childhood and adolescence and are associated with increased risk of functional issues and psychiatric illness in young adulthood, and PEs that recur are associated with increased risk of poorer psychiatric and functional outcomes. Childhood adversity is a well-established risk factor for PEs. The aim of this study was to investigate (1) the relationship between childhood adversity and recurring PEs in adolescence and (2) candidate mediators of that relationship. We used data from Cohort '98 of the Growing Up in Ireland study (n = 6039) at three time points (ages 9, 13 and 17) to investigate the relationship between childhood adversity (parent-reported at age 9), recurring PEs (measured using a subset of the Adolescent Psychotic-like Symptoms Screener at ages 13 and 17). The mediating roles of parent-child relationship, internalising and externalising difficulties, self-concept, physical activity, dietary quality, perceived neighbourhood safety and friendship quantity were investigated using the KHB path decomposition method. Childhood adversity was associated with an increased risk of recurring PEs with a population attributable fraction of 23%. Internalising difficulties and self-concept explained 13% of the relationship between childhood adversity and PEs suggesting a partial mediation. A significant direct effect remained between childhood adversity and recurring PEs. The established relationship between childhood adversity and PEs may be mainly driven by the relationship between childhood adversity and recurring PEs. Internalising difficulties and self-concept together mediate part of the relationship between childhood adversity and recurring PEs.

Migration and psychotic experiences in the Tokyo Teen Cohort

BackgroundImmigration has been shown to be associated with an increased risk for psychotic experiences, with similar effect sizes for first-generation and second-generation migration (i.e., children whose parents had migrated). However, this association varies by country, and by ethnic group at the within-country level, such that risk is greatest among migrants facing substantial social exclusion and disadvantage. This is the first study to our knowledge to examine migration as a potential risk factor for psychotic experiences in Japan. MethodUsing data from the Tokyo Teen Cohort (N=3052), we tested whether migrant status was associated with the lifetime prevalence of psychotic experiences at age 10. ResultsOnly 2.2% of the sample (n=68) had at least one migrant parent. Psychotic experiences were more common among children with at least one migrant parent, odds ratio (95% CI) = 2.06(1.26–3.35). This association appeared to be driven primarily by visual hallucinations and thought broadcasting, and specific to children with lower IQ at age 10. DiscussionThe findings suggest that migrant status is associated with increased likelihood of psychotic experiences at age 10 in Tokyo, Japan. Future prospective research should explore social exclusion as a potential underlying mechanism and can further clarify the protective role of IQ and related factors.

Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank

Cannabis is known to produce acute, transient psychotic-like experiences. However, it is unclear whether cannabis disproportionately increases the risk of specific types of psychotic experiences and whether genetic predisposition influences the relationship between cannabis use and psychotic experiences. In this cross-sectional study of 109,308 UK Biobank participants, we examined how schizophrenia polygenic risk modulates the association between self-reported cannabis use and four types of self-reported psychotic experiences (auditory hallucinations, visual hallucinations, persecutory delusions, and delusions of reference). Cohort-wide, we found a strong, dose-dependent relationship between cannabis use and all four types of psychotic experiences, especially persecutory delusions. Cannabis users’ psychotic experiences tended to be earlier-onset and cause greater distress than non-users’, but were not more likely to lead to help-seeking. Participants with high schizophrenia polygenic risk scores showed stronger associations between cannabis use and auditory hallucinations, visual hallucinations, and delusions of reference, as well as psychotic experiences overall. For instance, cannabis ever-use was associated with 67% greater adjusted odds of delusions of reference among individuals in the top fifth of polygenic risk, but only 7% greater adjusted odds among the bottom fifth. Our results suggest that cannabis use is a predictive risk factor for psychotic experiences, including early-onset and distressing experiences. Individuals genetically predisposed to schizophrenia may be especially vulnerable to psychotic experiences as a result of using cannabis, supporting a long-postulated hypothesis. This study exemplifies the utility of population-scale biobanks for elucidating gene-by-environment interactions relating substance use to neuropsychiatric outcomes and points to the translational potential of using polygenic risk scores to inform personalized harm reduction interventions.

Lifetime and Momentary Psychotic Experiences in Adult Males and Females With an Autism Spectrum Disorder.

BackgroundExisting research shows that adults with an autism spectrum disorder (ASD) are more vulnerable to develop overt psychosis. However, studies investigating (subclinical) psychotic experiences (PE) in ASD are scarce, and it is unknown if PE are accompanied with more distress in adults with ASD compared to the general population. This study examined lifetime PE and accompanying distress, momentary PE levels, and the impact of daily life stress and negative affect (NA) on momentary PE in males and females with ASD compared to controls.MethodsIn 50 adults with ASD (males N= 26, females N= 24) and 51 adults without ASD (males N= 26, females N= 25), the Community Assessment of Psychic Experiences (CAPE) was used to analyze group differences in frequency and distress of lifetime subclinical positive, negative, and depressive symptoms. The Experience Sampling Method (ESM) was used to measure momentary PE, NA, and stress (activity-related, event-related, and social stress) for 10 days. Multilevel analyses were conducted to test whether stress and NA were associated with momentary PE and whether these associations were modified by group or sex.ResultsAdults with ASD reported more lifetime CAPE negative and depressive symptoms, but similar levels of PE, than controls. Higher levels of accompanying distress were found in participants with ASD for each subscale. With respect to ESM momentary PE, higher levels were reported by adults with ASD and a stronger association between event-related stress and momentary PE was found compared to controls. This was not the case for NA, activity-related, and social stress. Overall, no significant differences between male and female outcomes were found.ConclusionAdults with ASD are more prone to encounter lifetime subclinical negative and depressive symptoms and accompanying distress compared to adults without ASD. Similar levels of lifetime PE in both groups were still accompanied with more distress in the ASD group. Furthermore, higher levels of ESM momentary PE were found in participants with ASD. Additionally, event-related stress may act as a risk factor for PE in both females and males with ASD, with a stronger risk-increasing effect than in their control counterparts.

ResilienCity: Resilience and Psychotic-Like Experiences 10 Years After L'Aquila Earthquake.

An earthquake hit the city of L’Aquila in central Italy in 2009, leaving the city completely destroyed and 309 casualties. Unexpectedly, lower rates of psychotic experiences in persons affected by the earthquake compared to non-affected persons were found 10 months after the earthquake. The very long-term impact of a natural disaster on the prevalence of psychotic experiences deserves more in-depth detailing. The Authors examined resilience and psychotic experiences in a university student sample of 494. No effect of direct exposure to the earthquake (odds ratio = 0.64, 95%CI [0.37, 1.11]), material damages (odds ratio = 0.86, 95%CI [0.60, 1.23]), psychological suffering (odds ratio = 1.06, 95% CI [0.83, 1.36]), or global impact severity (odds ratio = 0.92, 95%CI [0.76, 1.12]) on psychotic experiences was detected. Resilience levels did not differ between affected and non-affected persons. Resilience showed a strong protective effect on psychotic experiences (odds ratio=0.38, 95% CI [0.28, 0.51]. The protective effect of the RSA factor “Perception of Self” was significantly stronger in individuals affected by the earthquake compared to non-affected subjects. Being affected by an earthquake is not a risk factor for psychotic experiences in a university student sample, as no direct effect of the earthquake was detected after 10 years after the event. Resilience is confirmed as a strong protective factor for psychotic experiences irrespectively of large collective traumatic events. Extension of these results to a general population sample could provide interesting insights into recovery from natural disasters.

Neighborhood change and psychotic experiences in a general population sample

Social stress caused by the neighborhood environment may be a risk factor for psychotic experiences (PEs). However, little information is available on the effect of the perception of the neighborhood in relation to PEs. In a general population study in the United States (N = 974), we examined the relationship between PEs and neighborhood disruption/gentrification. When adjusted for age, sex, race, income, nativity, city, marital status, and common mental disorders, higher disruption scores were significantly associated with higher odds for any PE (odds ratio = 1.09, 95% CI = 1.05–1.12). The same pattern of associations was observed for individual PEs including delusional mood, delusion of reference and persecution, delusion of control, and hallucination. This study suggests that subjectively perceived neighborhood change may be a factor contributing to the occurrence of PEs. There was no significant relationship between PE and gentrification. Having a low income and racial minority status did not modify this association. Future studies can employ comparative longitudinal analyses of individuals/neighborhoods/cities, geographical information systems, and ethnography, to examine the impact of neighborhood change on mental health.

Rural birth/upbringing and childhood adversities are associated with psychotic experiences in university students in China

BackgroundUrbanicity has been reported to associate with an increased risk of psychotic experiences (PEs) in developed countries but less is known about the situation in developing countries. The present study aimed to investigate the effects of birth/upbringing place and other environmental factors on PEs in Chinese university students. MethodsA computer-assisted cross-sectional survey was conducted on 4620 second-year undergraduates, using a stratified cluster sampling. Birth places and residential mobility before 16 years old were recorded. PEs were measured using the subscales of psychoticism and paranoid ideation in the Symptom Checklist-90-R (SCL-90-R). Six questions extracted from the childhood section of the World Mental Health Composite International Diagnostic Interview (WMH-CIDI) were used to assess childhood trauma. ResultsGeneralized ordered logit model of multiple regression analysis revealed that participants with rural birth/upbringing (e.g. rural upbringing, on graded factor score of psychoticism and paranoid ideation [GFSPPI], 0 versus 1 & 2, odds ratio [OR] 1.409, 95% CI 1.219–1.628, p < 0.00001; 0 & 1 versus 2, OR 1.584, 95% CI 1.179–2.128, p < 0.00001) and those who reported childhood trauma (e.g. on GFSPPI, 0 versus 1 & 2, OR 1.737, 95% CI 1.498–2.014, p < 0.00001; 0 & 1 versus 2, OR 1.618, 95% CI 1.224–2.140, p < 0.00001) were apt to present more severe PEs. While upbringing places and childhood trauma affected both the presence and the severity of PEs, gender affected the presence or absence of PEs only (e.g. females, on GFSPPI, 0 versus 1 & 2, OR 1.887, 95% CI 1.631–2.183, p < 0.00001; 0 & 1 versus 2, OR 0.927, 95% CI 0.702–1.223, p = 0.593). Besides, the number of risk factors was associated with the severity of PEs in the cumulative odds logistic regression analysis (e.g. 3 risk factors versus 0 risk factor, on GFSPPI, OR 4.126, 95% CI 3.075–5.537, p < 0.00001). ConclusionsFemale, rural birth/upbringing and childhood trauma are risk factors of PEs in university students in China. The discrepancy in the findings between developed countries and China has important implications for urbanicity as a risk factor for PEs.

Longitudinal associations between psychotic experiences and disordered eating behaviours in adolescence: a UK population-based study

SummaryBackgroundPsychotic experiences might represent non-specific markers of poor mental health in adolescence. However, only a few predominantly cross-sectional studies have tested their association with disordered eating behaviours in adolescent and adult populations. The aim of this study was to explore the association between psychotic experiences at age 13 years, and disordered eating behaviours and body-mass index (BMI) at age 18 years.MethodsWe used data from the Avon Longitudinal Study of Parents and Children, a longitudinal birth cohort based in Avon (England, UK) including mothers with an expected delivery date between April 1, 1991, and Dec 31, 1992, and their children. Psychotic experiences (such as delusions and hallucinations) and BMI were measured at clinical assessments when children were nearly aged 13 years, and data on disordered eating behaviours (ie, presence of binge eating, purging, fasting, or excessive exercise for weight loss; any of these behaviours [included to increase statistical power]; and number of behaviours [included to investigate severity]) were obtained via a postal questionnaire that used adapted questions from the Youth Risk Behaviour Surveillance System questionnaire at approximately age 18 years. For each outcome, we ran a univariable model and four multivariable models (logistic, linear [for BMI], or negative binomial [for the number of behaviours] regression), progressively adjusting for child and maternal sociodemographic, physical, and mental health characteristics (including child's sex, and maternal age, marital status, and highest academic qualification); autistic traits at age 7 years (measured with the Social and Communication Disorder Checklist); baseline BMI at age 13 years, and depressive symptoms at baseline (ie, at age 13 years when psychotic experiences were measured: childs' symptoms measured with the Moods and feelings Questionnaire, and maternal symptoms measured at 32 weeks' gestation with the Edinburgh Postnatal Depression Scale). We imputed missing outcome and covariate data.FindingsOur sample included 6361 children, of whom 734 (12%) reported psychotic experiences at age 13 years. In univariable models, psychotic experiences were associated with greater odds of reporting any disordered eating behaviours (odds ratio [OR] 1·92, 95% CI 1·46–2·52; p<0·0001), and more severe symptoms (as measured by the number of disordered eating behaviours: 0·58, 0·32–0·84; p<0·0001) at age 18 years. These associations were slightly attenuated by adjustment for maternal and child characteristics (any disordered eating behaviours OR 1·82, 95% CI 1·35–2·44, p<0·0001; number of disordered eating behaviours 0·49, 95% CI 0·23–0·75, p<0·00001), autistic traits at age 7 years (any disordered eating behaviours OR 1·80, 95% CI 1·34–2·41, p<0·0001; number of disordered eating behaviours 0·48, 95% CI 0·22–0·74, p<0·00001), and BMI (any disordered-eating behaviours OR 1·83, 95% CI 1·36–2·46, p<0·0001; number of disordered-eating behaviours 0·32, 95% CI 0·06–0·57, p<0·00001) Adjusting for baseline depressive symptoms attenuated, but not removed, these associations (any disordered eating OR 1·50, 95% CI 1·10–2·03, p=0·010; more severe symptoms 0·32, 0·06–0·57, p=0·017). Psychotic experiences were also associated with greater binge eating, purging, and fasting behaviours, although some associations weakened after controlling for depressive symptoms. We noted no associations between psychotic experiences and excessive exercise or BMI in any of the models.InterpretationOur findings suggested that psychotic experiences are markers of increased risk for several disordered eating behaviours in late adolescence, possibly by indicating more severe psychopathology in early adolescence. More research investigating shared risk factors for psychotic experiences and eating disorders is warranted to elucidate shared and specific causal pathways.FundingWellcome Trust, the Royal Society, University College London Hospitals National Institute for Health Research Biomedical Research Centre, UK Medical Research Council, and the University of Bristol.

O12.2. STICKS AND STONES MAY BREAK MY BONES BUT WORDS INCREASE THE RISK OF PSYCHOTIC EXPERIENCES

BackgroundThere has been a surge of interest into the relationship between psychotic experiences (PEs) and bullying. However, the methods of bullying and impact of bullying varies across individuals and the prevalence may also vary by respondent (parent or children). For this reason, a thorough investigation into this relationship is warranted.MethodsA longitudinal analysis was conducted on waves 1 and 2 (ages 9 and 13) of the nationally representative Growing Up in Ireland study. Data from n=7163 families were included in this study. Information regarding bullying, being a bully, bullying type, reasons for the bullying, the impact of the bullying was collected from the participating child and their primary care giver (PCG) at both waves. Psychotic experiences were reported by the child at the second wave using the Adolescent Psychotic Symptoms Screener.Results13.12% of children met validated criteria for psychotic experiences. Based on the PCG’s account, 32.89% of those with PEs at age 13 were bullied at age 9 and this was independently associated with PEs even after accounting for bullying at 13 (OR: 1.40, CI: 1.19–1.65). Physical, verbal, electronic bullying and bullying by exclusion were associated with an increased risk of PE. However, in a multivariate analysis only verbal bullying was independently associated with an increased risk of psychotic experiences (OR: 1.56, CI: 1.27–1.93; adjusted for bullying at 13: OR: 1.47, CI: 1.19–1.82). There was a linear relationship between the number of different methods of bullying experienced at 9 and the risk of PEs at 13 (continuous OR: 1.24, CI: 1.14–1.34). Of the reasons for bullying given by the PCG, only ethnicity (OR: 2.36, CI: 1.46–3.80), being a teacher’s pet (OR: 2.09, CI: 1.17–3.73) and jealously (OR: 2.28, CI: 1.5–3.39) were significantly associated with PEs. Persistent bullying was associated with a higher risk of PEs relative to their peers (never bullied OR: 2.31, CI: 1.73–3.08; and bullied at one-time point: OR: 1.49, CI: 1.10–2.03).Based on the child’s account, the vast majority of those who report being a bully (13.87%) at age 9 were also bullied (76.48%, OR: 7.04, 5.97–8.31). Both being a bully and being bullied at age 9 were associated with an increased risk of PEs (16.91%, OR: 1.34, CI: 1.09–1.64; and 50.48% OR: 1.71, CI: 1.48–1.98, respectively). In a multivariate analysis only being bullied was independently associated with PEs (OR: 1.68, CI: 1.44–1.96; adjusted for bullying at 13: OR: 1.57, CI: 1.34–1.83). Verbally bullying another was the only method of bullying associated with an increased risk of PEs at 13 (OR: 1.59, CI: 1.06–2.39). Of those reporting being bullied, verbal and written bullying at age 9 were associated with an increased risk of PEs at age 13 (OR: 1.25, CI: 0.97–1.6; and OR: 1.44, CI: 1.05–1.97, respectively). In a multivariate analysis only written bullying was associated with an increased risk of PEs (OR: 1.47, CI: 1.05–2.06; adjusted for bullying at 13: OR: 1.41, CI: 1.01–1.99). The impact of the bullying on well-being was also associated with an increased risk of PEs at 13 (OR: 1.36, CI: 1.09–1.72; adjusted for bullying at 13: OR: 1.30, CI: 1.04–1.63). Persistent bullying was associated with a vastly higher risk of PEs relative to their peers (never bullied: OR: 4.42, CI: 3.44–5.69; and bullied at one time point OR: 2.71, CI: 2.10–3.50).DiscussionBullying is pervasive in the childhood of those who subsequent report PE. Bullying at age 9, particularly verbal and written bullying methods are risk factors for PEs in adolescence even when controlling for adolescent bullying. Persistent bullying was associated with a vastly higher risk of PEs. Reducing the rates of bullying in childhood may moderate the likelihood of PEs in adolescents.

Intimate partner violence and psychotic experiences in four U.S. cities

BackgroundA large body of research has established a relationship between trauma exposure, particularly during childhood, and psychotic experiences. Yet, there remains a general lack of research on adult trauma exposure, including intimate partner violence (IPV), as a risk factor for psychotic experiences. The purpose of this study is to investigate the association between IPV and psychotic experiences in U.S. cities. MethodsData were collected from 1615 participants in four U.S. cities. Psychotic experiences were assessed through the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) psychosis screen along with adapted IPV measures. ResultsFindings revealed that experiencing at least one form of IPV was significantly associated with each of the four psychotic experiences assessed for both men and women. The strongest associations were found for threatening and sexual IPV; physical IPV was not significantly associated with psychotic experiences. Exposure to IPV was associated with more than a tripling of the odds of reporting at least one psychotic experience as opposed to none. Among those exposed to IPV there was between three- to five times the odds of reporting specific subtypes of psychotic experiences. ConclusionThe results expand on prior findings linking psychotic experiences and childhood trauma exposure to include intimate adult exposures. Emotional and sexual IPV appear to be associated with elevated risk for psychotic experiences in adulthood. Even though IPV is more commonly reported by women in the U.S., such victimization appears to have similar associations with psychotic experiences regardless of gender.

Psychotic Experiences in the Context of Police Victimization: Data From the Survey of Police-Public Encounters.

Social defeat has been proposed as the common mechanism underlying several well-replicated risk factors for sub-threshold psychotic experiences (PEs) identified in epidemiological research. Victimization by the police may likewise be socially defeating among vulnerable individuals and, therefore, may be associated with elevated risk for PEs. However, no prior studies have examined the relation between police victimization and PEs. We tested the hypothesis that exposure to police victimization (ie, physical, sexual, psychological, and neglect) would be associated with increased odds for PEs in the Survey of Police-Public Encounters data (N = 1615), a general population sample of adults from 4 US cities. Respondents who reported each type of police victimization were more likely to report PEs in logistic regression analyses (all P < .01), most of which were significant even when adjusting for demographic variables, psychological distress, and self-reported crime involvement (adjusted OR range: 1.30 to 7.16). Furthermore, the prevalence of PEs increased with greater exposure to police victimization in a linear dose-response relation, OR (95% CI) = 1.44 (1.24-1.66). These findings suggest that police victimization is a clinically important and previously unreported risk factor for PEs in the urban US population. These findings support the need for community-based outreach efforts and greater police training to reduce the prevalence of this exposure, particularly in socially disadvantaged urban communities.

Young for one׳s grade: A risk factor for psychotic experiences among adults in the National Comorbidity Survey-Replication

School-related difficulties have received relatively little attention as environmental risk factors for psychotic experiences (PEs), despite being characterized by marginalization and social defeat during critical periods of psychological development. This study examined both childhood age relative to one׳s classmates and school mobility as risk factors for adult psychotic experiences in the National Comorbidity Survey-Replication (NCS-R). Weighted logistic regression models were used to explore the hypotheses that lifetime psychotic experiences reported on the World Health Organization psychosis screen would be more prevalent among those younger than their classmates during childhood and for those with frequent school mobility. Younger perceived relative age (odds ratio (OR)=2.05, 95% confidence interval=1.43–2.95) was independently associated with psychotic experiences in the fully adjusted model, but school mobility was not. School-related risk factors for psychosis provide promising points for community-level intervention, and support the claim that environmental factors characterized by disadvantage and marginalization contribute to psychosis etiology.

Common versus psychopathology-specific risk factors for psychotic experiences and depression during adolescence.

An argument often used to support the view that psychotic experiences (PEs) in general population samples are a valid phenotype for studying the aetiology of schizophrenia is that risk factors for schizophrenia show similar patterns of association with PEs. However, PEs often co-occur with depression, and no study has explicitly tested whether risk factors for schizophrenia are shared between PEs and depression, or are psychopathology specific, while jointly modelling both outcomes. We used data from 7030 subjects from a birth cohort study. Depression and PEs at age 18 years were assessed using self-report questionnaires and semi-structured interviews. We compared the extent to which risk factors for schizophrenia across sociodemographic, familial, neurodevelopmental, stress-adversity, emotional-behavioural and substance use domains showed different associations with PEs and depression within bivariate models that allowed for their correlation. Most of the exposures examined were associated, to a similar degree, with an increased risk of both outcomes. However, whereas female sex and family history of depression showed some discrimination as potential risk factors for depression and PEs, with stronger associations in the former, markers of abnormal neurodevelopment showed stronger associations with PEs. The argument that PEs are valid markers for studying the aetiology of schizophrenia, made simply on the basis that they share risk factors in common, is not well supported. PEs seem to be a weak index of genetic and environmental risk for schizophrenia; however, studies disentangling aetiological pathways to PEs from those impacting upon co-morbid psychopathology might provide important insights into the aetiology of psychotic disorders.

Childhood abuse as a risk factor for psychotic experiences.

To examine the hypothesis that individuals from the general population who report childhood abuse are at increased risk of developing positive psychotic symptoms. Data were derived from a general population sample of 4045 subjects aged 18-64 years. First ever onset of positive psychotic symptoms at 2-year follow-up were assessed using the Composite International Diagnostic Interview and additional clinical interviews if necessary. Childhood abuse was assessed at baseline. Baseline reported childhood abuse predicted development of positive psychotic symptoms associated with need for care [odds ratio (OR) = 11.5, 95% CI 2.6-51.6]. This association remained after adjustment for demographic variables, reported risk factors and presence of any lifetime psychiatric diagnosis at baseline (OR = 7.3, 95% CI 1.1-49.0). The results suggest that early childhood trauma increases the risk for positive psychotic symptoms. This finding fits well with recent models that suggest that early adversities may lead to psychological and biological changes that increase psychosis vulnerability.

Childhood abuse as a risk factor for psychotic experiences

OBJECTIVE: To examine the hypothesis that individuals from the general population who report childhood abuse are at increased risk of developing positive psychotic symptoms. METHOD: Data were derived from a general population sample of 4045 subjects aged 18-64 years. First ever onset of positive psychotic symptoms at 2-year follow-up were assessed using the Composite International Diagnostic Interview and additional clinical interviews if necessary. Childhood abuse was assessed at baseline. RESULTS: Baseline reported childhood abuse predicted development of positive psychotic symptoms associated with need for care [odds ratio (OR) = 11.5, 95% CI 2.6-51.6]. This association remained after adjustment for demographic variables, reported risk factors and presence of any lifetime psychiatric diagnosis at baseline (OR = 7.3, 95% CI 1.1-49.0). CONCLUSION: The results suggest that early childhood trauma increases the risk for positive psychotic symptoms. This finding fits well with recent models that suggest that early adversities may lead to psychological and biological changes that increase psychosis vulnerability. Language: en

Epidemiological Analysis of Alcohol and Drug Use as Risk Factors for Psychotic Experiences

Clinical and laboratory studies link alcohol and other drug use to the occurrence of psychotic experiences, but epidemiologic evidence has been lacking. In this study, the quantitative relationships between alcohol or other drug use and psychotic experiences were examined by analysis of prospective data from 4994 adult household residents sampled in a multisite survey of mental disorders in the population, the NIMH Epidemiologic Catchment Area Program. After control for sociodemographic factors and preexisting psychiatric conditions, the risk for onset of self-reported delusions or hallucinations was observed to be greater for daily users of marijuana or cocaine and for users of anxiolytics or sympathomimetics compared with nonusers. After control for daily cocaine use and alcohol disorder, the risk of onset of psychotic experiences for daily users of marijuana was double that for nonusers. Alcohol disorder in men was associated with eightfold risk and in women with threefold risk. Baseline depressive episodes, manic episodes, agoraphobia, and obsessive-compulsive disorder also were associated with increased risk of onset of psychotic experiences.

Epidemiological Analysis of Alcohol and Drug Use as Risk Factors for Psychotic Experiences

Clinical and laboratory studies link alcohol and other drug use to the occurrence of psychotic experiences, but epidemiologic evidence has been lacking. In this study, the quantitative relationships between alcohol or other drug use and psychotic experiences were examined by analysis of prospective data from 4994 adult household residents sampled in a multisite survey of mental disorders in the population, the NIMH Epidemiologic Catchment Area Program. After control for sociodemographic factors and preexisting psychiatric conditions, the risk for onset of self-reported delusions or hallucinations was observed to be greater for daily users of marijuana or cocaine and for users of anxiolytics or sympathomimetics compared with nonusers. After control for daily cocaine use and alcohol disorder, the risk of onset of psychotic experiences for daily users of marijuana was double that for nonusers. Alcohol disorder in men was associated with eightfold risk and in women with threefold risk. Baseline depressive episodes, manic episodes, agoraphobia, and obsessive-compulsive disorder also were associated with increased risk of onset of psychotic experiences. — J Nerv Ment Dis 178:473-480, 1990