To determine whether youth, family, and neighborhood factors and minoritized status are associated with youth-reported sexual victimization from childhood through young adulthood. We analyzed longitudinal data from 2 population-based samples of Puerto Rican youth living in the South Bronx (as a minoritized group) and Puerto Rico (as a nonminoritized group). Waves 1 to 3 were collected annually beginning in 2000 (youth age 5-13). Wave 4 was collected 2013 to 2017 (youth age 15-29). We estimated multivariable associations between youth, family, and neighborhood factors and minoritized status at Wave 1 (independent variables); and youth-reported sexual victimization at Waves 1 to 4 (dependent variables). None of the factors was associated with youth-reported sexual victimization at Wave 1 (N=1911). Among youth reporting no previous history of sexual victimization at Wave 1 (n=1823), youth in the South Bronx vs Puerto Rico were more likely to report sexual victimization at Waves 2 or 3 (odds ratio (OR) [95% confidence interval (CI)]=3.62 [1.46-8.97]). Older youth were less likely to report sexual victimization (OR [95% CI]=0.77 [0.65-0.91]) (all P < .01). Among youth reporting no history of sexual victimization at Waves 1 to 3 (n=1782), youth in the South Bronx (OR [95% CI]=2.53 [1.52-4.22]), female youth (OR [95% CI]=2.81 [1.83-4.30]), and youth whose parents had more than a high school degree (OR [95% CI]=2.25 [1.38-3.67]) were more likely to report sexual victimization at Wave 4 than their counterparts (all P ≤ .001). Future research should investigate how living as a minoritized youth may contribute to an increased risk of sexual victimization.