Objective To investigate the risk factors for contact dermatitis in patients with peripherally inserted central catheter (PICC) catheterization. Methods A total of 244 patients with PICC catheterization admitted in the Venous Catheter Nursing Outpatient of Affiliated Hospital of Nanjing University of TCM from June to August 2016 were selected using convenience sampling. A prospective study was performed on those patients for general information, PICC catheter information, PICC care information and contact dermatitis development information. SPSS 21.0 was used to analyze the date. Results A number of 24 patients were observed to have contact dermatitis with an incidence of 9.84%. Single factor analysis showed that gender, age, allergy, dressing type and catheter material correlated to the development of contact dermatitis with PICC. The differences were statistically significant (P<0.05) . Multiple factor logistic regression analysis showed that the gender[OR=2.721, 95%CI (1.059-6.994) , P=0.038], allergy[OR=5.846, 95%CI (2.030-16.833) , P=0.001]and dressing type[OR=4.055, 95%CI (1.472-11.169) , P=0.007]were risk factors of contact dermatitis in patients with PICC catheterization. Conclusions For PICC catheterization patients, effective preventive measures aiming at risk factors can reduce the occurrence of contact dermatitis with PICC. Key words: Contact dermatitis; Peripherally inserted central catheter; Influencing factor