Consideration In Risk Assessment Research Articles

Nitrogen modulates the ozone response of Mediterranean wheat: Considerations for ozone risk assessment

The experiment was conducted in an Open Top Chamber facility located in the Mediterranean basin to investigate how nitrogen (N) fertilization affects the response of wheat to ozone (O3) exposure. The study considered the response of Artur Nick, a modern wheat cultivar commonly used in the area, to three O3 exposure levels (ambient and elevated ambient, +20 and +40 nL L−1 O3), and two N fertilization doses (100 and 200 kg ha−1). Measurements included leaf gas exchange, leaf chlorophyll content, leaf and grain N content, plant growth and yield parameters. Ozone × N interactive effects were studied and quantified based on accumulated O3 concentrations above a 40 nL L−1 threshold (AOT40) and phytotoxic O3 dose (POD) indices, which are used in O3-risk assessments, from which critical levels (CL) for a 5 % effect were derived.Results revealed that O3 impacts on growth and yield parameters were stronger under the highest N fertilization dose. In consequence, O3 Critical Levels (CL) were as much as 3–4 times lower for grain yield in the high-N compared to the low-N treatment. Interestingly, O3 limited the fertilizer stimulus, strongly reducing the N use efficiency for grain yield and the agronomic efficiency of N for protein yield. Another important aspect was that 71 % of the POD was accumulated before anthesis, stressing the potential importance of O3 exposure during the vegetative phase of wheat under Mediterranean conditions, which is usually considered less important than post-anthesis exposure.In conclusion, this study suggests the need to consider crop N management in the derivation of O3 CLs, due to its effect on dose-response relationships used for CL derivation, including the potential O3 effects in N use efficiency. Therefore, N modulation could be considered in the O3-risk assessment methodology to be applied in risk exercises when negotiating air pollution abatement policies.

Quantification of additives in beached plastic debris from Aotearoa New Zealand

Plastics have become an essential part of modern society. Their properties can be easily manipulated by incorporating additives to impart desirable attributes, such as colour, flexibility, or stability. However, many additives are classified as hazardous substances. To better understand the risk of plastic pollution within marine ecosystems, the type and concentration of additives in plastic debris needs to be established. We report the quantification of thirty-one common plastic additives (including plasticisers, antioxidants, and UV stabilisers) in beached plastic debris collected across Aotearoa New Zealand. Additives were isolated from the plastic debris by solvent extraction and quantified using high-resolution liquid chromatography-mass spectrometry. Twenty-five of the target additives were detected across 200 items of debris, with plasticisers detected at the highest frequency (99 % detection frequency). Additives were detected in all samples, with a median of four additives per debris item. A significantly higher number of additives were detected per debris item for polyvinyl chloride (median = 7) than polyethylene or polypropylene (median = 4). The additives bis(2-ethylhexyl) phthalate, diisononyl phthalate, diisodecyl phthalate, and antioxidant 702 were detected at the highest concentrations (up to 196,930 μg/g). The sum concentration of additives per debris item (up to 320,325 μg/g) was significantly higher in polyvinyl chloride plastics (median 94,716 μg/g) compared to other plastic types, primarily due to the presence of phthalate plasticisers. Non-target analysis was consistent with the targeted analysis, indicating a higher number and concentration of additives in polyvinyl chloride debris items compared to all other polymer types. Feature identification indicated the presence of more additives than previously detected in the targeted analysis, including plasticisers (phthalate and non-phthalate), processing aids, and nucleating agents. This study highlights phthalates and polyvinyl chloride as key targets for consideration in ecotoxicology and risk assessments, and the development of policies to reduce the impacts of plastic pollution.

PM2.5 and heavy metals in urban and agro-industrial areas: health risk assessment considerations

The study investigated PM2.5 and heavy metal pollutant concentrations in Seoul and Wonju, South Korea, emphasizing the importance of considering PM2.5 chemical constituents for health impact assessments. While PM2.5 concentrations were similar between the two cities with slight variations, heavy metal concentrations differed significantly. Regional sources, PM2.5 composition, and meteorological conditions influenced these variations. Exposure to Fe was highest in all areas, with some heavy metals exceeding permissible levels, stressing the need to consider regional characteristics in assessments. Different heavy metals influence health risks differently in each city. When examining the HI (the summation of the hazard quotient for heavy metals), Seoul remained below an HI value of 1, while Wonju exceeded this threshold when exposed to CTE concentrations. In Seoul, As had a significant health impact of PM2.5, while in Wonju, Mn was more influential. Source apportionment confirmed different pollution sources in Seoul and Wonju, affecting the distribution of PM2.5 constituents in the atmosphere. Effective PM2.5 management requires a comprehensive approach considering chemical constituents and health impacts not just mass-based PM2.5 management, emphasizing regional-specific assessments and policy considerations to mitigate health risks. Therefore, tailored management strategies based on regional characteristics are necessary.Graphical

Mating type and microsatellite genotyping indicate that the Tunisian population of Phyllosticta citricarpa is clonal and thrives only asexually

Citrus black spot (CBS) caused by Phyllosticta citricarpa was reported for the first time in Tunisia in 2019. This was also the first reported occurrence of the disease in a Mediterranean climate. In Tunisia, CBS is mainly found in lemon (Citrus limon) orchards, and is seldom observed on sweet orange (Citrus × sinensis). This recent finding in North Africa raises questions about how the disease has been able to spread under Mediterranean climatic conditions. In this work, 216 Phyllosticta strains collected from lemon orchards in 2021, 2022 and 2023 throughout the country's main citrus-growing provinces were characterised by species morphological and molecular identification, mating type and Simple Sequence Repeats (SSR) microsatellite genotyping (MLG). P. citricarpa was the only species found to be associated with CBS in Tunisia. Although P. citricarpa is a heterothallic fungal species, potentially able to reproduce both sexually and asexually, a single mating type (MAT 1-1-1) idiomorph was found in the population. In addition, three MLGs were observed, across ten microsatellite loci, one of which was massively represented (93 %), indicating a clonal population. The clonality observed suggests a single recent introduction of the pathogen into the country. These findings support the idea that in Tunisia, P. citricarpa only reproduces asexually by pycniospores, with a relatively limited dispersal potential. This is consistent with the absence of pseudothecia on the leaf litter. These results show that CBS is able to thrive under Mediterranean conditions, even in the absence of sexual reproduction. This should be taken into consideration for CBS risk assessment and management.

Climate risk assessment in insurance: A USA and Africa Review

Climate risk assessment in insurance is a critical component of understanding and mitigating the impacts of climate change on the insurance industry. This paper provides a comprehensive review of climate risk assessment practices in the insurance sector, focusing on both the United States (USA) and Africa. The study explores the unique challenges and opportunities each region faces in the context of climate-related risks. In the USA, a mature and well-established insurance market grapples with the increasing frequency and severity of climate-related events. Hurricanes, wildfires, and floods have become more prevalent, necessitating a thorough evaluation of risk models and actuarial practices. The paper delves into how American insurers are adapting to these challenges through advancements in technology, data analytics, and collaboration with climate scientists. The role of regulatory frameworks and government initiatives in shaping the industry's response is also explored. Contrastingly, the African insurance landscape faces its own set of challenges in the wake of climate change. The continent is particularly vulnerable to extreme weather events, such as droughts and storms, impacting both agriculture and infrastructure. The paper investigates the unique considerations in climate risk assessment for African insurers, including the need for localized data, community-based resilience initiatives, and the potential for innovative insurance products that cater to the specific needs of the population. A comparative analysis highlights the disparities in resources, infrastructure, and regulatory frameworks between the two regions. It also underscores the importance of international collaboration in sharing best practices and facilitating the transfer of knowledge and technology. The paper emphasizes the role of insurers not only as financial risk mitigators but also as key stakeholders in promoting climate resilience and sustainability. This paper provides valuable insights into the evolving landscape of climate risk assessment in insurance, offering a nuanced understanding of the challenges faced by the USA and Africa. The findings aim to inform policymakers, insurers, and other stakeholders, fostering a proactive approach to climate resilience in the global insurance industry.

Microplastic Contamination in Sediments of Xiamen Bay: Investigating Ecological Consequences

Microplastic contamination in aquatic ecosystems poses a global environmental challenge, with local variations requiring focused investigations. This study examines the prevalence, characteristics, and ecological implications of microplastics in Xiamen Bay sediments, providing insights into the potential risks for both the environment and human health. The analysis encompasses spatial and temporal distribution patterns, ecological impacts on sediment biota, and pathways of human exposure. Key considerations for human health risk assessment are identified, considering particle characteristics, exposure levels, and vulnerable populations. The study concludes by emphasizing the importance of interdisciplinary collaboration in addressing these challenges and proposes strategies for mitigating the impact of microplastic contamination in Xiamen Bay.

Report of the Workshop on Hector’s and Māui Dolphins in New Zealand: Consideration of Spatial Risk Assessment of Threats (Bled, Slovenia, 22-23 April 2023)

How to cite: International Whaling Commission, 2023. Report of the Scientific Committee: Report of the Workshop on Hector’s and Māui Dolphins in New Zealand: Consideration of Spatial Risk Assessment of Threats. J. Ceatcean Res. Manage. (Suppl.) 25: 211-287.

Crystallinity: A Complex Critical Quality Attribute of Amorphous Solid Dispersions.

Does the performance of an amorphous solid dispersion rely on having 100% amorphous content? What specifications are appropriate for crystalline content within an amorphous solid dispersion (ASD) drug product? In this Perspective, the origin and significance of crystallinity within amorphous solid dispersions will be considered. Crystallinity can be found within an ASD from one of two pathways: (1) incomplete amorphization, or (2) crystal creation (nucleation and crystal growth). While nucleation and crystal growth is the more commonly considered pathway, where crystals originate as a physical stability failure upon accelerated or prolonged storage, manufacturing-based origins of crystallinity are possible as well. Detecting trace levels of crystallinity is a significant analytical challenge, and orthogonal methods should be employed to develop a holistic assessment of sample properties. Probing the impact of crystallinity on release performance which may translate to meaningful clinical significance is inherently challenging, requiring optimization of dissolution test variables to address the complexity of ASD formulations, in terms of drug physicochemical properties (e.g., crystallization tendency), level of crystallinity, crystal reference material selection, and formulation characteristics. The complexity of risk presented by crystallinity to product performance will be illuminated through several case studies, highlighting that a one-size-fits-all approach cannot be used to set specification limits, as the risk of crystallinity can vary widely based on a multitude of factors. Risk assessment considerations surrounding drug physicochemical properties, formulation fundamentals, physical stability, dissolution, and crystal micromeritic properties will be discussed.

Temporal trends of lipophilic organic contaminants in blue mussel (1994–2017) and eelpout (1994–2017) from the southern Baltic Sea

A time-trend study was carried out for two important Baltic Sea species, blue mussel (1994–2017, 11 samples) and eelpout (1994–2017, 11 samples), to track the changes in levels of regulated persistent organic pollutants (POPs) and show potential increases in the levels of the contaminants of emerging concern (CECs). It was carried out utilizing gas chromatography–high-resolution mass spectrometry (GC-HRMS) based non-target screening (NTS). Data were acquired in two modes – electron ionization (EI) and electron capture negative ion chemical ionization (ECNI) – to widen the contaminant coverage, and treated using a fast semi-automated NTS data processing workflow. The study revealed that >250 tentatively identified compounds show statistically significant temporal trends in Baltic blue mussel and eelpout. A large number of regulated substances, including but not limited to PCBs, DDTs and other organochlorine pesticides (OCPs), chlorobenzenes, and many polybrominated diphenyl ethers (PBDEs), showed significant declining trends, as was expected. Their rates of decline were in good agreement with previously reported data. In contrast, increasing trends were observed for many CECs, some polycyclic aromatic compounds (PAHs), and hydrocarbons. The CEC group included, among others, four compounds, namely, one personal care product ingredient, 2-ethylhexyl stearate, one brominated compound 1,2,3,5-tetrabromobenzene and two intermediates 4-isopropoxyaniline and bilobol dimethyl ether, that were reported in marine biota for the first time to the best of our knowledge. Several compounds, including four CECs and two unknown brominated compounds, showed levels considerably higher than the common legacy pollutants (CB-153 and BDE-99), which might be taken into consideration for future monitoring and risk assessment. In addition, this work revealed the presence of a plethora of organoiodinated compounds that exhibited statistically significant temporal trends in the samples under study, which could be of future interest.

Evaluation of toxicity and mutagenicity of oxaliplatin on germ cells in an alternative in vivo model Caenorhabditis elegans.

The platinum compound oxaliplatin is a widely used chemotherapeutic drug that shows a broad spectrum of activity in various human tumors. While the treatment-related side effects of oxaliplatin on directly treated individuals have been well-documented, little is known about the influence of oxaliplatin on germ cells and non-exposed progenies. Here we investigated the reproductive toxicity of oxaliplatin in a 3R-compliant in vivo model Caenorhabditis elegans, and evaluated the germ cell mutagenicity of oxaliplatin by using whole genome sequencing. Our results indicated that oxaliplatin treatment significantly disrupts development of spermatids and oocytes. By treating parental worms with oxaliplatin for three successive generations, sequencing data unveiled the mutagenic effects of oxaliplatin on germ cells. Analysis of genome-wide mutation spectra showed the preferentially induction of indels by oxaliplatin. In addition, we uncovered the involvement of translesion synthesis polymerase ζ in modulating mutagenic effects of oxaliplatin. These findings suggest that germ cell mutagenicity is worthy of consideration for the health risk assessment of chemotherapeutic drugs, while the combined use of alternative in vivo models and next generation sequencing technology appears to be a promising way for the preliminary safety assessment of various drugs.

Safety and Monitoring of Inflammatory Bowel Disease Advanced Therapies.

The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing therapies has changed the treatment landscape of inflammatory bowel disease (IBD). These advances led to unique adverse effect profiles and identification of new safety signals, resulting in the evolution of the safety, monitoring, and positioning of IBD therapies. In this updated review, we (1) examine the existing and updated safety data of monoclonal antibodies and small molecules for IBD, with a focus on recently Food and Drug Administration (FDA)-approved therapies, and (2) propose risk stratification and assessment considerations prior to and during IBD treatment.

Phthalate esters and their metabolites in paired soil-crop systems from farmland in major provinces of eastern China: Pollution characteristics and implications for human exposure

The extensive application of phthalate esters (PAEs) as plasticizers has raised considerable concern regarding their environmental load, but the associated occurrence of PAE metabolites has often been ignored. The soil–plant system is a vital source of human exposure to PAEs via crop intake. Here, paired soil–plant samples were collected from eastern China to investigate the occurrence characteristics of seven PAE congeners and two primary monoester phthalate metabolites (mPAEs) in farmland. The detection frequencies of PAEs and mPAEs in the investigated soil–plant systems were 100 %. The total concentrations of PAEs in the collected soil and plant samples ranged from 0.07 to 1.83 mg/kg (dw) and from 3.9 to 24 mg/kg (dw), respectively. Moreover, di-(2-ethylhexyl) phthalate, diisobutyl phthalate and di-n-butyl phthalate were the predominant PAE congeners in the farmlands of eastern China, collectively accounting for >90 % of the total concentration of PAEs. In addition, the total concentrations of the two mPAEs were markedly higher in plant samples (49 ng/g dw to 549 ng/g dw) than in soil samples (3 ng/g dw to 22 ng/g dw), indicating that PAEs are readily metabolized in plants. The hazard index (HI) values of all PAEs in all crops were <1, demonstrating that the risks of PAEs in the crops were acceptable. However, the daily intake of mPAEs from the consumption of cabbage was higher than or comparable to that of some PAEs (such as di-n-octyl phthalate). This highlights the importance of taking metabolites into consideration in further environmental investigations and risk assessments of PAEs.

Applications of the hormesis concept in soil and environmental health research

Hormesis refers to positive biological effects caused by exposure to low doses of a stressor known to be toxic at higher doses. These effects include an enhanced defense system and stimulated plant/microorganism growth and reproduction. Hormesis has emerged as a fundamental concept with broad relevance to the field of soil and environmental health. Its utilization in evaluating environmental effects and ecotoxicity can reduce uncertainties introduced by extrapolating from high to low doses of pollutants. Similarly, its consideration in risk assessment can help tackle toxicity risks imposed by chemical mixtures. Further, it can maximize the effectiveness of novel agrochemicals applied at the lowest possible concentration, thus reducing their ecological and human risks. Hormesis-based interventions, such as plant priming and stimulation of beneficial insects and waste-degrading microbes, can further reduce agrochemical loads into the environment, thereby enhancing plant and soil health. Inclusion of hormesis in strategies to control harmful organisms, such as pests, pathogenic microbes and harmful algal bloom organisms, can aid in combating chemical resistance. Hormesis-inclusive studies also provide useful information regarding suitable pollutant tolerance levels for microorganisms and plants during bioremediation and phytoremediation, thus enhancing environmental remediation. In sum, hormesis is highly relevant and offers numerous potential applications in soil and environmental health research.

Prepregnancy Migraine, Migraine Phenotype, and Risk of Adverse Pregnancy Outcomes.

Migraine is a highly prevalent neurovascular disorder among reproductive-aged women. Whether migraine history and migraine phenotype might serve as clinically useful markers of obstetric risk is not clear. The primary objective of this study was to examine associations of prepregnancy migraine and migraine phenotype with risks of adverse pregnancy outcomes. We estimated associations of self-reported physician-diagnosed migraine and migraine phenotype with adverse pregnancy outcomes in the prospective Nurses' Health Study II (1989-2009). Log-binomial and log-Poisson models with generalized estimating equations were used to estimate relative risks (RRs) and 95% CIs for gestational diabetes mellitus (GDM), preeclampsia, gestational hypertension, preterm delivery, and low birthweight. The analysis included 30,555 incident pregnancies after cohort enrollment among 19,694 participants without a history of cardiovascular disease, diabetes, or cancer. After adjusting for age, adiposity, and other health and behavioral factors, prepregnancy migraine (11%) was associated with higher risks of preterm delivery (RR = 1.17; 95% CI = 1.05-1.30), gestational hypertension (RR = 1.28; 95% CI = 1.11-1.48), and preeclampsia (RR = 1.40; 95% CI = 1.19-1.65) compared with no migraine. Migraine was not associated with low birthweight (RR = 0.99; 95% CI = 0.85-1.16) or GDM (RR = 1.05; 95% CI = 0.91-1.22). Risk of preeclampsia was somewhat higher among participants with migraine with aura (RR vs no migraine = 1.51; 95% CI = 1.22-1.88) than migraine without aura (RR vs no migraine = 1.30; 95% CI = 1.04-1.61; p-heterogeneity = 0.32), whereas other outcomes were similar by migraine phenotype. Participants with migraine who reported regular prepregnancy aspirin use had lower risks of preterm delivery (<2×/week RR = 1.24; 95% CI = 1.11-1.38; ≥2×/week RR = 0.55; 95% CI = 0.35-0.86; p-interaction < 0.01) and preeclampsia (<2×/week RR = 1.48; 95% CI = 1.25-1.75; ≥2×/week RR = 1.10; 95% CI = 0.62-1.96; p-interaction = 0.39); however, power for these stratified analyses was limited. Migraine history, and to a lesser extent migraine phenotype, appear to be important considerations in obstetric risk assessment and management. Future research should determine whether aspirin prophylaxis may be beneficial for preventing adverse pregnancy outcomes among pregnant individuals with a history of migraine.

Multiple generation exposure to ZnO nanoparticles induces loss of genomic integrity in Caenorhabditis elegans

Zinc oxide nanoparticles (ZnO NPs) are commonly used in industrial and household applications, prompting the assessment of their associated health risks. Previous studies indicated that ZnO NPs can induce somatic cell mutations, while the aging process appears to increase the mutagenicity of ZnO NPs. However, little is known about the influence of ZnO NPs on genome stability of germ cells, and non-exposed progeny. Here we show that 20 nm ZnO NPs exposure disrupts germ cell development, and elevates the overall mutation frequency of germ cells in Caenorhabditis elegans (C. elegans). We observed that pristine ZnO NPs elicit germ cell apoptosis to a greater extent than the 60-day aged ZnO NPs. By treating parental worms with ZnO NPs for seven successive generations, whole-genome sequencing data revealed that, although the frequency of point mutations is kept unchanged, large deletions are significantly increased in F8 worms. Furthermore, we found that the mutagenicity of ZnO NPs might be partially attributed to the release of Zn2+ ions. Together, our results demonstrate the genotoxic effects of ZnO NPs on germ cells, and the possible underlying mechanism. These findings suggest that germ cell mutagenicity is worthy of consideration for the health risk assessment of engineered NPs.

Ecological risk assessment based on soil adsorption capacity for heavy metals in Taihu basin, China

Due to the toxicity, bioaccumulation, non-biodegradability and perseverance of heavy metals, their risk assessment is essential for soil quality management. The Hakanson potential ecological risk index (RI), which considers the effects of heavy metal concentration and toxicity, has been widely used in soil ecological risk assessment. However, RI overlooks the influence of soil properties on the mobility and availability of heavy metals in risk assessment. To fill this gap, this study sought to develop an improved ecological risk index (IRI), which incorporates soil adsorption into RI, and applied it to evaluate the ecological risk of heavy metals in the soil of the Taihu basin, China. The soil adsorption models based on the Gradient Boosting Decision Tree (GBDT) was used to predict the soil adsorption capacity of five heavy metals (i.e. cadmium, chromium, copper, lead, zinc). The soil adsorption capacity in 1446 sites in the Taihu basin was predicted by the GBDT models and was assigned as the weight of IRI. The risk assessment results of the five metals in the Taihu basin showed that 40% of the sites were at a moderate risk level and 60% of the sites were at a slight risk level based on the RI. The value of IRI in the basin ranged from 11.1 to 75.5, with a mean value of 28.1. IRI differed from RI in spatial distribution due to the influence of soil adsorption. The comparative analysis between the metal contents in sediments and surrounding soils confirmed the tremendous influence of soil adsorption on ecological risks, indicating that soil adsorption should be taken into consideration in soil risk assessment.

Forecasts of the Compound Coastal Erosion Risks Based on Time-Variant Assessment: A Case Study on Yunlin Coast, Taiwan

A coastal erosion risk assessment was framed as the basis for the intervention of coastal adaptation strategies under time-variant scenarios. The framework was devised to assess the influence of coastal erosion on coastal defense, the coastal inundation induced by the erosion-induced malfunction of defense, and risks using a downscaling analysis and the mechanism of the compound hazard interaction, which are innovative and practical for the application of coastal management in Taiwan. In addition, the vulnerable socio-economy was also taken into consideration in risk assessment. The adaptive strategy is proposed in terms of the risk origins and time-variance of risk forecasts, and the risk origins were assessed based on the Fuzzy Delphi Method and the analytic hierarchy process instead of subjective consideration. Within the erosion-induced hazard and risk assessments, this study considered erosion rates, decreases in defense elevation due to land subsidence, and population development in time-variant scenario analyses to estimate risk forecasts. Furthermore, a case study of the Yunlin coastal area was undertaken to demonstrate the feasibility of the proposed method. The presented results are informative for coastal hazard reduction and the promotion of the sustainable development of coastal zones.

Whole-Genome Sequencing Reveals Germ Cell Mutagenicity of α-Endosulfan in Caenorhabditis elegans.

Endosulfan is an extensively used organochlorine pesticide around the world, which was classified as a persistent organic pollutant (POP) in 2009. Although previous studies have documented the reproductive toxicity of endosulfan in a variety of organisms, little is known about the influence of endosulfan on the genome stability of germ cells and nonexposed progeny. Here we applied whole-genome sequencing to explore the germ cell mutagenicity of α-endosulfan in Caenorhabditis elegans (C. elegans). We found that, although low doses of α-endosulfan exhibited a minor effect on the reproductive capacity of C. elegans, chronic exposure to 1 μM α-endosulfan significantly increased the mutation frequencies of nonexposed progeny. Further analysis of genome-wide mutation spectra demonstrated that α-endosulfan preferentially elicited A:T → G:C substitutions and clustered mutations. By using worms deficient in DNA damage response genes, our results suggest the involvement of translesion synthesis polymerase η in modulating α-endosulfan-induced mutations in germ cells. Together, these observations reveal the germ cell mutagenicity of α-endosulfan in C. elegans and the possible underlying mechanism. In addition, our findings implicate that germ cell mutagenicity might be a necessary consideration for the health risk assessment of environmental chemicals such as POPs.

USE OF THE GENERAL ARRIVAL DECLARATION: RESPONSIBLE ENTITIES

The article is devoted to certain aspects of submitting and applying the General declaration of arrival in Ukraine. The effectiveness of prior information depends on the defined circle of persons who can submit the General declaration of arrival and are responsible for it. The work presents the international experience of delineating the persons responsible for the submission of the general declaration of arrival. Common in different countries is the permission to submit a general declaration to persons other than the carrier who can present the cargo to the customs authority. At the same time, the responsibility for submission rests with the carrier. Recent changes in the customs legislation of Ukraine significantly expanded the list of persons who can submit a general declaration of arrival. At the same time, in contrast to international practice, Ukrainian legislation does not take into account such aspects as the need to agree on the submission of the PDP by all participants; the availability of all necessary information to the persons submitting the LDP; the possibility of an additional request from the customs authorities for additional information, which all participants must provide and be responsible for providing it. Legislative innovations also concern the conceptual apparatus. Thus, such characteristics as the importance of meeting the deadlines and the order of its submission were added to the definition of the general declaration of arrival. In addition, the term “carrier” has undergone changes, which led to the appearance of inconsistencies between European and Ukrainian legislation regarding the person responsible for submitting the LDP in case of combined transportation. The results of the study emphasized the need to introduce responsibility for non-submission, untimely submission of a tax return, or submission of incomplete or inaccurate information. It is also advisable to develop a mechanism of responsibility for all participants in the supply chain. This involves consideration for risk assessment separately for each participant. Thus, each of the participants will be interested in providing the carrier with information about each shipment.

Effect of Multi-Components Strong Motion Duration on Seismic Performance of High CFRDs Based on Fragility Analysis

ABSTRACT This paper investigates the influence of multi-components strong motion duration on seismic performance of high concrete-faced rockfill dams (CFRDs) by fragility analysis based on the method of incremental dynamic analysis (IDA). The contributions of all compositions of earthquake excitations are considered by the definition of integrated duration based on the concept of significant duration. The nonlinear finite element model of a 2D 200-m-high CFRD is established as a case study and the vertical and horizontal displacements are selected as damage measures. Fragility curves and probabilities of two sets of 23 and 25 spectrally equivalent as-recorded bi-directional long-duration and short-duration motions are determined under different failure grades and intensities. The results show that the duration of vertical component has a certain effect on correction between strong motion duration and deformation of the dam and fragility analysis indicates that the ground motions with long duration can make more risk of failure of high CFRDs than short duration motions. Therefore, the seismic performance of high CFRDs will be reformed by taking the effect of ground motion duration into seismic design and risk assessment consideration.