Pharmacovigilance is crucial in ensuring the safety and potency of polyherbal products, as many have not been extensively evaluated for their pharmacology and toxicity. With the increasing popularity of polyherbal medications, there has been a rise in complaints of probable toxicity and adverse outcomes. This study investigates the importance of pharmacovigilance in the polyherbal sector and examines its challenges and future potential. Data was collected from various databases from 2000-2024. Pharmacovigilance has become a key domain in medicine and public health, with a significant portion of India’s population relying on Indian medical systems. The study highlights the importance of implementing pharmacovigilance procedures for polyherbal medications, promoting rational use and appropriate treatment methods. Polyherbal drugs may have negative interactions with other medications, foods, biologicals, and compounds, leading to decreased therapeutic efficacy, undesirable side effects, and severe complications. Systematic pharmacovigilance is necessary to collect accurate data and develop guidelines for safe and effective use.