Tinea Infections Research Articles

Evaluation of Antifungal Activity of Somaraji Taila Extract & Taila in Dadru Kushta (Tinea Infections) - An Experimental Study

Dermatophytosis has become a significant health problem affecting children, adolescents, and adults worldwide. In India 5 out of 1000 people suffer from Tinea infections. The present study evaluated the antifungal activity of Somaraji Taila in Tinea (Dermatophytosis) in Invitro & Invivo model. Cultures were brought from MTCC a government body and inoculated in SDA media under aseptic condition. Later it was subjected to microscopic and macroscopic examination to identify the organism. A sensitivity test was done using SDA media by well diffusion method, with 4 different concentrations of Hydro-Methanolic extraction of Somaraji Taila ingredients. After the incubation period, the zone of inhibition was checked and was measured in mm. As the next phase of the study, animal study was also conducted to check antifungal properties & anti dermal toxicity on albino rat skin.

Diagnostic And Post-Therapeutic Histopathology Of Hansen’s Disease in a Man With Rheumatoid Arthritis

Abstract Introduction/Objective Hansen’s Disease (leprosy), caused by Mycobacterium leprae, is a chronic infectious disease primarily affecting the skin and peripheral nerves. In the United States, leprosy remains rare, with less than 200 cases per year reported to the CDC. Diagnosis is often delayed, due to low clinical suspicion and lack of experience among healthcare providers, leading to potentially severe complications and increased transmission risk. Methods/Case Report A 71-year-old man presented to dermatology with a progressive, non-tender erythematous rash involving the arms and chest. He denied any travel history, or exposure to armadillos, and had no family history of a similar rash. His medical history was significant for rheumatoid arthritis, for which he was receiving methotrexate. The clinical differential included drug eruption, tinea infection, or sarcoidosis. Skin biopsy revealed extensive infiltration of the dermis by noncaseating granulomas surrounding cutaneous nerves, and AFB stain highlighted numerous bacilli consistent with Mycobacterium leprae, leading to the diagnosis of Hansen’s disease. The WHO classification was multibacillary leprosy, and the Ridley-Jopling classification was borderline tuberculoid (BT) to perhaps mid borderline (BB), based on clinical and histologic features. He was started on triple therapy, and biopsies performed during treatment, as well as at three years follow up showed marked improvement, with some remaining disease detected in unresolved rash. Results (if a Case Study enter NA) NA Conclusion This case presents a diagnostic challenge given the absence of typical risk factors for Mycobacterium leprae transmission. The patient’s immunocompromised status due to methotrexate therapy may have predisposed him to the disease. Documented cases of Hansen’s disease have more than doubled in the southeastern states since 2013, with concern for endemic regions emerging in Florida. Early recognition, classification, and prompt treatment are essential to prevent disease progression and reduce transmission. Increased education and awareness among healthcare providers are crucial to improving diagnostic accuracy and patient outcomes in cases of leprosy.

Clinical inertia in onychomycosis treatment: results from the Illuminating Dialogues and Insights in Onychomycosis Management (IDIOM) survey.

Onychomycosis is a fungal infection of the nail that can serve as a reservoir for tinea infections in other parts of the body and can be transmitted to other individuals. As the disease progresses, it can lead to functional impairment, such as difficulties in walking, and negatively impact the psychosocial aspects of quality of life. Onychomycosis treatment, especially topical, is long-term, and adequate follow-up is essential for cure. However, the realities and issues of patient-physician communication after treatment initiation, including patients' perception of efficacy, treatment satisfaction, and reconsideration of the treatment approach, remain unclear. Therefore, this study aimed to examine the realities and issues associated with onychomycosis treatment, focusing on topical therapies, through a web-based survey of patients with onychomycosis and dermatologists. The duration of topical treatment was prolonged, with 30.5% of patients undergoing topical therapy for more than 2 years. Of these, 54.5% had not perceived clear efficacy. In addition, 93.7% of all patients with onychomycosis expressed a desire to change their treatment if it was ineffective. However, only 29.9% of patients receiving topical treatment discussed changing their treatment with their physicians, and only 7.3% ultimately changed their treatment. These findings indicate that the review of treatment strategies was insufficient. Furthermore, the satisfaction rate among patients treated with oral medications was higher than that of patients treated with topical medication. Despite dermatologists' awareness of low patient satisfaction with topical treatments, approximately 40% recommended alternative topical therapies when the initial topical treatment was ineffective. These results suggest clinical inertia in the treatment of onychomycosis stemming from a lack of appropriate intensification of treatment. In managing onychomycosis, the patient and dermatologist must share a common understanding of the importance of regular evaluation and the optimization of treatment regimens during treatment and must work side by side toward a cure.

A simple and safe method to diagnose ringworm infection in children

A simple and safe method to diagnose ringworm infection in children

Tinea capitis with kerion complicated by keloid formation in a 34-year-old man: A case report

A kerion, also known as a dermatophyte, is a type of inflammatory tinea capitis caused by an exaggerated immune response to a fungal ringworm infection primarily affecting the scalp. A keloid is an abnormal scar tissue proliferation occurring at the site of tissue injury or spontaneously. It occurs more commonly in darker-skinned individuals. The coexistence of kerion and keloid is rare. This case involves a 34-year-old man who presented with a four-year history of scalp swelling, itching, and occasional fluid discharge. There is a history of keloids in multiple parts of the body. Examination revealed multiple keloids on the scalp alongside a purulent, oozing rash with satellite nodules. Skin scraping for KOH microscopy was positive for fungal spores and hyphae. This case highlights the rare complication of keloid formation in kerion which can hinder effective treatment of the underlying fungal infection.

Argemone Mexicana is a Plant with Anti-Cancer & Anti-Inflammatory Properties. A Review of its Traditional uses & Scientific Evidence

Argemonea Mexicana, generally known as the Mexican prickly poppy of the family Papavaraceae, is a plant that's well known for its medicinal quality. The plant is set up in tropical regions and is used in Ayurvedic, Unani, Siddha and Homeopathic drug practies, Each part of the plant contains bioactive composites that help in treating a variety of affections similar as' HIV', malaria, ringworm infection, fungal Infections & cancer. The plant has been studied in vivo & in vitro the results have been positive. The Plant also contains composites like berberine, argemonine & protopine, which are known for their restorative action. It's considerably used traditionally for the treatment of multitudinous conditions.Aregmone Mexicana is reported to have antimicrobial exertion, crack mending capacity in rats, larvicidal and chemosterilant exertion, and Nematicidal & allelopathic eventuality. In Mexico Infusion of the upstanding part of the plant is used as hypoglycemic. Chemical disquisition of the plant has revealed the presence of alkaloids, amino acids, phenolics, & adipose acids. The upstanding corridor of the plant contain" Isoquinoline" and" Benzylisoquinoline ” alkaloids. Medicinal plant are extensively used in the treatment of habitual conditions, metabolic conditions, and cancer. Argemone Mexicana L.(A. mexicana), substantially set up in the remains of Marathwada( Maharashtra, India), has been used in the treatment of speech diseases. In this research, cold water, and methanolic extricates were arranged from the Argemone mexicana stem and taken off. These extricates were tried for their antifungal and anticancer exercises. The antifungal action was tried exercising the Agar well dispersion strategy, whereas the anticancer motion against eternalized cell lines was examined by the Erythrosin blue experiment.

What Do Clinicians Mean When Submitting a Biopsy as “Rule Out Eczema”

Background: “Eczema” encompasses many dermatological conditions and usually manifests with spongiosis histologically. Dermatopathologists often receive biopsy specimens with requests to “rule out eczema.” However, this broad term is limiting and lacks the necessary clinical context for precise diagnoses. Objective: This study explored the conditions implied by “rule out eczema” when rendered by clinicians and whether they regard it as synonymous with atopic dermatitis or other spongiotic conditions. Understanding this distinction is vital for guiding appropriate treatment which differs among disparate conditions appearing similar histologically. Method: 63 clinicians (54 dermatologists, 5 physician assistants, 4 nurse practitioners) completed a web-based questionnaire. Participants identified conditions considered when requesting to “rule out eczema,” who completed requisition forms, and whether they modify automated EMR phrases to specify these conditions. Results: 83% (52/63) included atopic dermatitis in the differential diagnosis, with “rule out eczema” also referencing nummular eczema (65%), dyshidrotic eczema (54%), contact dermatitis (51%), neurodermatitis (22%), and seborrheic dermatitis (14%). Other conditions included mycosis fungoides, psoriasis, and tinea infections. Most forms were completed by medical assistants (51%) or dermatologists (43%). 81% were modified from the suggested EMR diagnosis before submission. Conclusion: Because “rule out eczema” is nonspecific and conditions may not be readily distinguished with histology alone, it’s recommended that the phrase be discarded in favor of specifying which disorder the clinician is presumptively diagnosing clinically. Because nonspecific phrases such as “dermatitis unspecified” generated by EMR programs are of limited value, it is not recommended to provide these options for clinicians when submitting biopsy specimens.

A PHARMACOLOGICAL REVIEW OF PUTIKADI LEPA FOR DADRU

The reported prevalence of fungal infection is about 40 million people in developing and underdeveloped countries. The incidence of fungal infection is found to be more during summer and rainy seasons. Local Dermatophytosis / tinea infection i.e. severe itching and annular erythematous scaly patches are the symptoms.As per classical texts, the clinical expression of Tinea infection can be closely related with Dadru. Acharya Charak has explained it in Kshudra Kushtha while Acharya Sushruta in Mahakushtha. Its symptoms include Kandu(itching), Raga(redness), Atasipushpvat Pidika (macular rashes similar to flax flower). For the management of Dadru, Putikadi Lepa is an effective poly herbal formulation. It consists of Putik, Ark, Aragvadh, Snuhi, Jati and its local application with Gomutra. It has Kusthagna, Kandughna properties. Many research studies have demonstrated that these drugs possess antifungal, antimicrobial, anti-bacterial properties. The Gomutra used for the application of Putikadi Lepa contains various elements which hydrates the skin and improves the activity of Lepa. Thus, this article deals with the pharmacological action of the ingredients of Putikadi Lepa.

Dermatophytosis Caused by Trichophyton indotineae (Trichophyton mentagrophytes ITS Genotype VIII) in Sri Lanka.

Over the past few years, a recalcitrant dermatophytosis has been observed on the Indian subcontinent, including Sri Lanka, which has caused a major public health issue in the region. An emerging species, Trichophyton indotineae, first described as Trichophyton mentagrophytes ITS genotype VIII, is thought to be responsible for this fast-spreading, mostly terbinafine-resistant dermatophytosis. Recalcitrant dermatophytosis is a challenge to dermatologists, and knowing the causative species and antifungal sensitivity in the earlier stage of management would be invaluable. We report a case series of patients with dermatophytosis caused by T. indotineae in Sri Lanka. This is the first detection of this highly terbinafine-resistant strain in Sri Lanka, and existence of this species should be taken seriously by dermatologists and healthcare policymakers for better management of tinea infections and antifungal stewardship in the country.

Hubungan Personal Hygiene Dan Obesitas Terhadap Kejadian Tinea Cruris Pada Pasien di Klinik Amanda Medika Tahun 2023

The incidence of tinea cruris in children varies around the world. It is estimated that about 10-20% of children will experience tinea cruris as in Singapore 13.5%, and and Saudi Arabia 15.1%, in a study in Saudi Arabia tinea cruris is the second most common tinea infection in children. According to PERDOKSI in 2022, Indonesia does not yet have adequate demographic data on the skin condition of Indonesians, in addition to functioning as a form of skin disease surveillance, research on skin conditions is also needed so that handling skin problems can be done more precisely. This study aims to determine the relationship of personal hygiene and obesity to the incidence of tinea cruris in patients at The Amanda Medika Clinic in 2023. This study is a type of quantitative research using case control design. The sampling technique used in this study is Simple Random Sampling with 108 respondents. The results showed that based on The Chi square analysis can be concluded that based on the chi square test above shows the value of Asy Sig (2-tailed) shows the value of 0.048 if < 0.05 means there is a relationship of personal hygiene to the incidence of tinea cruris in patients Amanda Medika Clinic. Based on the chi square test above shows the value of Asy Sig (2-tailed) shows a value of 0.025 if < 0.05 there is a relationship of obesity to the incidence of tinea cruris in patients Amanda Medika Clinic.

Household Transmission of Tinea Infections: Analysis of a Large Commercial Health Insurance Claims Database, United States, 2021.

Among 207 914 multimember households with a tinea case, a secondary case was diagnosed in another household member in 8.5%. Excluding same-day diagnoses (20%), the median time from index case to first secondary case was 138 days. To prevent household tinea transmission, appropriate treatment and strategies to reduce environmental contamination are needed.

Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of Trichophyton indotineae

Trichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on infections with T indotineae are sparse and could improve treatment practices and medical understanding of transmission. To correlate clinical features of T indotineae infections with in vitro antifungal susceptibility testing results, squalene epoxidase gene sequence variations, and isolate relatedness using whole-genome sequencing. This retrospective cohort study of patients with T indotineae infections in New York City spanned May 2022 to May 2023. Patients with confirmed T indotineae infections were recruited from 6 New York City medical centers. Improvement or resolution at the last follow-up assessment. Among 11 patients with T indotineae (6 male and 5 female patients; median [range] age, 39 [10-65] years), 2 were pregnant; 1 had lymphoma; and the remainder were immunocompetent. Nine patients reported previous travel to Bangladesh. All had widespread lesions with variable scale and inflammation, topical antifungal monotherapy failure, and diagnostic delays (range, 3-42 months). Terbinafine treatment failed in 7 patients at standard doses (250 mg daily) for prolonged duration; these patients also had isolates with amino acid substitutions at positions 393 (L393S) or 397 (F397L) in squalene epoxidase that correlated with elevated terbinafine minimum inhibitory concentrations of 0.5 μg/mL or higher. Patients who were treated with fluconazole and griseofulvin improved in 2 of 4 and 2 of 5 instances, respectively, without correlation between outcomes and antifungal minimum inhibitory concentrations. Furthermore, 5 of 7 patients treated with itraconazole cleared or had improvement at the last follow-up, and 2 of 7 were lost to follow-up or stopped treatment. Based on whole-genome sequencing analysis, US isolates formed a cluster distinct from Indian isolates. The results of this case series suggest that disease severity, diagnostic delays, and lack of response to typically used doses and durations of antifungals for tinea were common in this primarily immunocompetent patient cohort with T indotineae, consistent with published data. Itraconazole was generally effective, and the acquisition of infection was likely in Bangladesh.

Recalcitrant dermatophyte infections: identification and risk factors.

Recalcitrant dermatophytosis is an emerging phenomenon that occurs worldwide, and Trichophyton indotineae is currently the prominent cause. Skin specimens from patients with tinea infection were obtained by scrubbing and then sectioned into three fragments. Two fragments were subjected to direct microscopic examination and culture, while the third portion was utilized in the PCR method. Isolates were morphologically identified as Trichophyton mentagrophytes/interdigitale complex (n = 60 [83.33%]), Microsporum canis (n = 8 [11.11%]), Trichophyton rubrum (n = 3 [4.16%]), and Epidermophyton floccosum (n = 1 [1.38%]). Among 60 T. mentagrophytes complex isolates, 53 (88.33%) were classified as T. indotineae and seven as T. interdigitale genotype II. The disease duration was longer in the T. indotineae group (P = 0.035). Both Gradient PCR and skin-sampling methods yield similar results in terms of positive and negative cases (P = 1.0000). The time patients stopped their medication did not impact the positive case numbers (P = 0.803). Gender had no effects on the frequency (P = 0.699). Familial contamination, dermatologic disorder, and other underlying conditions did not differ in the two group infections (P > 0.05). Steroid usage is strongly associated with the emergence of tinea infection (P < 0.04). The duration of antifungal administration had a substantial effect on the emergence of resistant organisms (P = 0.05). Steroid usage, T. indotineae involvement, and prolonged exposure to antifungals were the solid and influential factors in recalcitrant involvement. Regarding quick and suitable diagnosis and treatment, which is essential in preventing recalcitrant cases, we suggest that direct skin sample PCR can meet the demands.

WhatsApp Usage during COVID-19 in Sudan for Diagnosis, Management and Follow-up of Severe Tinea Infection of Upper and Lower Extremities: Clinical Case: Severe Bilateral Tinea Pedis, Followed by Severe Bilateral Tinea Manuum

WhatsApp Usage during COVID-19 in Sudan for Diagnosis, Management and Follow-up of Severe Tinea Infection of Upper and Lower Extremities: Clinical Case: Severe Bilateral Tinea Pedis, Followed by Severe Bilateral Tinea Manuum

When cat rescue fails — Part 1. Lion-clip shaving, enilconazole bathing and oral itraconazole treatment failed to control an iatrogenic Microsporum canis outbreak in a shelter: but a novel ophytrium-chlorhexidine shampoo and mousse treatment succeeded in the home

OBJECTIVE: To identify the reason(s) for failure to prevent repeated nosocomial dermatophyte infection of shelter cats and to present alternative strategies which are less stressful to the cats and humans involved. ANIMALS: The Dorset branch of the Royal Society for the Prevention of Cruelty to Animals (RSPCA) seized 30 of 32 Persian cats from a cat breeder on the 2nd of August 2019 and put them into Ashley Heath RSPCA shelter. Two cats and three dogs were left at home. All 30 cats were returned to their guardian in July 2020. Three cats died between 2020 and 2022, leaving 29 cats which were seized on the 8th of March 2022 and put into two RSPCA shelters. The dogs were not seized. Four cats were later euthanased. METHODS: RSPCA Animal Treatment Reports along with photographs used for evidence in the court case against the breeder and the veterinary records of their primary veterinary surgeon were retrospectively reviewed. RESULTS: Clinical signs of dermatophytosis occurred on the index_ _case one week after dematting with clippers in August 2019. _Microsporum canis_ (_M. canis) _was cultured from 27 of 30 (90%)_ _cats on the 39th day of the Ashley Heath shelter stay in 2019. _M. canis_ infection could only have been acquired while in RSPCA care because the incubation period from infection to development of clinical signs for _M. canis_ is one to three weeks, and there was no history of ringworm in their home. Efforts to control the ringworm outbreak in the shelter included lion clipping, weekly enilconazole bathing and oral itraconazole (EI treatment) for five or seven weeks until culture negative. Six cats became culture positive again in 2020. Cats were housed in pairs in 2019 to 2020 and singly in 2022, therefore transmission was indirect (i.e. via fomites). Two cats remained positive when the cats were returned to their guardian in 2020, all 30 were treated with a single ophytrium-chlorhexidine (Douxo S3 Pyo) shampoo followed by ophytrium-chlorhexidine mousse rubbed into their fur for three weeks. It was reasonable to conclude that the ophytrium-chlorhexidine treatment had cleared the _M. canis_ infection for the following six reasons: first no cat developed clinical signs of dermatophytosis during the 20 months in their home. Second, no obvious ringworm lesions were seen on the photographs taken for evidence and third, no veterinary surgeon noted in the records any lesions suspicious of dermatophytosis during the examination of the cats within days of them being seized again in March 2022. Fourth: no positive dermatophyte results were produced as evidence during the trial (ringworm charges against the owner were dropped). Fifth: three of four dermatophyte tests performed on EI untreated cats were negative and samples from the positive cat were after three months in the shelter. Sixth: no EI treatment was administered until the cats had been in the shelters again for two and a half months. Nevertheless, shelter staff assumed ringworm infection from the arrival of the cats in 2022 and again subjected them to the stressful shaving/bathing/itraconazole protocol. CLINICAL RELEVANCE AND CONCLUSIONS: This is the first report of ophytrium-chlorhexidine for treatment and prevention of _M. canis _in cats. We recommend shelter staff be trained in basic barrier nursing and be educated regarding the difference between true dermatophyte infection versus fomite carriage.

Management of Tinea incognito with Unani medicine: A case report

Tinea infections are one of the most commonly occurring skin infections creating a threat to the public health scenario in India. With the excessive and unsupervised use of over-the-counter steroid formulations, the condition is becoming more severe, leading to chronic relapse of the disease with modified skin lesions, termed as tinea incognito. This condition is usually difficult to treat, but Unani medicines can provide satisfactory results in such cases. Here is a case report of a middle-aged male patient suffering from tinea incognito. On treating the patient with Unani medicines for 30 days, there was a significant reduction in the subjective symptoms, i.e. erythema, pruritus, and scaling, along with a reduction in the Physician’s Global Assessment Score. The microscopic examination of the lesions on the potassium hydroxide mount was found to be negative for fungal hyphae after the treatment. Through this case report, it can be inferred that tinea incognito can be effectively managed with the administration of Unani medicines.

Clinicomycological Study of Dermatophyte Infections in Patients Attending Dermatology Outpatient Department in a Tertiary Care Hospital

Context: Dermatophytosis is a fungal disease characterized by the infection of skin, hair, and nails. There is an upsurge of complicated superficial dermatophytosis and an increase in the incidence of chronic, relapsing, recurrent cases in India that are also often unresponsive to conventional doses of drugs. Aims: The aim of this study was to study the prevalence of dermatophyte species in the particular study area and it is susceptibility to itraconazole, terbinafine, and fluconazole. Settings and Design: All dermatophytes isolates obtained were subjected to 10% KOH mount, fungal culture, and antifungal sensitivity testing for fluconazole, itraconazole, and terbinafine. Materials and Methods: Newly diagnosed cases of dermatophytosis without treatment for the past 3 months were included in the study. KOH preparation was observed and subjected to fungal culture. Then, the susceptibility of the dermatophytes to oral antifungals (itraconazole, terbinafine, and fluconazole) was done. Results: Out of 28 patients with tinea, 14 males and 12 females were tested KOH positive. Out of them, 23 patients showed positive for dermatophyte growth. In them, 15 isolates were Trichophyton mentagrophytes and 8 isolates were Trichophyton rubrum. Antifungal drug susceptibility testing data indicated that, for the two species, MIC of itraconazole ranged between 0.03 and 16 μg/ml, terbinafine between 0.03 and 16 μg/ml, and fluconazole between 0.25 and 64 μg/ml. Conclusions: The study provided information regarding the prevalent species of dermatophyte in our study area and it is high sensitivity to itraconazole compared to terbinafine and the lowest for fluconazole. This gives us guidance as to which antifungal to use empirically in our clinical practice to treat tinea infection.

Improper Use of Topical Corticosteroids in Tinea Infections in a Tertiary Care Hospital.

N/A.

Ustekinumab for pyoderma gangrenosum–like skin ulcerations in late-onset leukocyte adhesion deficiency

BackgroundLeukocyte adhesion deficiency type 1 (LAD-1) is a congenital immunodeficiency leading to impaired trafficking of neutrophils to inflammation sites. Solitary or multiple pyoderma-gangrenosum (PG)-like skin ulcers (PGLU) have been reported previously in 13 children (aged 0.5-19 years) with LAD-1. ObjectiveTo report the case of a 10-year-old boy presenting with PGLU as the first manifestation of LAD-1, treated with ustekinumab. MethodsIn-situ cytokine profiles. ResultsPGLU was triggered by cutaneous ringworm infection (Trichophyton tonsurans). Skin biopsies showed increased intralesional expression of interleukins 17A, 23 and 1β as compared with healthy controls. After an unsuccessful attempt with oral methylprednisolone, ustekinumab induced regression of the ulcerations, associated with complete normalization of the cytokine profile. ConclusionsPG-like skin ulcers, triggered by ringworm infection, can be a late harbinger of LAD-1. Ustekinumab is a safe and effective therapeutic option for LAD-1-patients with PGLU whilst bridging the time until stem-cell transplantation.

Efficacy and Safety of Combination Treatment of Oral Terbinafine and Itraconazole in Patients with Extensive Superficial Dermatophytes

Background: Dermatophytosis, a prevalent fungal infection, is instigated by species like Trichophyton, Epidermophytonand Microsporum. The current approach for treating dermatophytosis involves a blend of systemic and topical antifungal therapies, applicable to all patients except those with localized, untreated Tinea. Notably, there is a growing incidence of inadequate response to the standard treatment regimen in recent times. Objective: To evaluate the efficacy andsafety of combination treatment of oralterbinafine anditraconazole in patients with extensive superficial dermatophytes. Materials and Methods: This research comprised a randomized clinical trial involving 50 individuals diagnosed with extensive superficial dermatophytosis. Study conducted at the Department of Dermatology and Venereology, Combined Military HospitalCumilla, the study spanned from July 2022 to June 2023. During the six-week duration, patients underwent treatment with terbinafine and itraconazole, with follow-up examinations every two weeks, including relevant investigations. Evaluation of treatment outcomes occurred at both four and six weeks. Statistical analysis was performed using version 25 of the Statistical Package for the Social Sciences (SPSS). Results: This study shows the majority of the participants within the age range of 16-30 years (56.0%) and the average age of the participants is 31.74±11.77 years. In terms of gender, the majority are male (78.0%). The most prevalent diagnosis is Tinea corporis (68.0%), followed by Tinea cruris (36.0%), Tinea faciei (28.0%), and Tinea incognito (12.0%). The majority of participants (85.0%) have had the disease for 12 months or less. The most common sites are the trunk (35.0%), whole body (26.0%), and crural area (24.0%). The majority of participants experience severe itching (56.0%), followed by moderate itching (34.0%), and a smaller percentage report mild itching (10.0%). The majority of participants showed improvement, with percentages increasing from 66.0% after 2 weeks to 84.0% after 4 weeks.The percentage of cured individuals also increased over time, reaching a substantial 90.0% after 6 weeks. Conclusion: The amalgamation of terbinafine and itraconazole demonstrates a superior clinical cure rate compared to use of single systemic antifungals. However, the observed clinical cure rate percentage is lower when juxtaposed with findings from previous studies. Notably, neither combination of systemic antifungals has exhibited efficacy against tinea infections previously treated with formulations containing topical steroids