The rigorous safety requirements in the nuclear industry have necessitated the development of accident tolerant fuels, with FeCrAl-UN/U3Si2 being one of the latest innovations in this field. To comprehensively evaluate the performance of this fuel type under accident scenarios, the best estimate plus uncertainty method is employed to conduct a realistic safety assessment of a large break loss-of-coolant accident in the HPR-1000 nuclear power plant using FeCrAl-UN/U3Si2 fuel. The peak cladding temperature and peak pellet temperature are selected as figures of merit, while the uncertainties of key performance models for the FeCrAl cladding and UN/U3Si2 pellet are quantified. The upper tolerance limits of the two figures of merit are determined through uncertainty propagation calculations, and the key influencing parameters are also identified based on the sensitivity analysis. Results demonstrate that the FeCrAl-UN/U3Si2 fuel type owns larger safety margin than the conventional Zr-UO2 fuel type and effectively reduces the cladding temperature while significantly reducing oxidation and hydrogen production during the accident.