Rigid Framework Research Articles

Probing Cell Membrane Tension Using DNA Framework-Encoded Vibration-Induced Emission Molecular Assemblies.

Mechanosensitive fluorescent probes are valuable tools for detecting changes in cellular mechanics and viscosity. While numerous mechanosensitive probes have been developed, the construction of molecular assemblies for probing cellular mechanics remains largely unexplored, possibly due to the challenges of designing assemblies with synergistic and integrated functionalities. Here, we report the design and synthesis of mechanosensitive molecular assemblies by integrating DNA frameworks with vibration-induced emission (VIE) probes to enable live-cell membrane tension imaging. The molecular assemblies consist of a rigid tetrahedral DNA framework anchored with prescribed numbers of VIE probes. We find that VIE probes on the DNA framework retain their ratiometric fluorescence response characteristics in aqueous systems and on lipidic model membranes. Importantly, VIE assemblies exhibit distinct cell membrane targeting behaviors depending on the number of contact points between the molecular assemblies and the cell membrane. Especially, trivalent molecular assemblies can inhibit the internalization of the probes by the cells, a property absent in free VIE and mono/divalent molecular assemblies, thereby achieving targeted and prolonged retention on the cell membrane. Using the trivalent molecular assemblies, we successfully achieve ratiometric fluorescence imaging of cell membrane tension using confocal laser scanning microscopy, revealing the potential of such multifunctional mechanical-sensitive probes for live-cell applications.

Size-dependent guest-memory switching of the flexible and robust adsorption characteristics of layered metal-organic frameworks.

Flexible-robust metal-organic frameworks (MOFs), which exhibit unique hybrid nature comprising both flexible and rigid framework characteristics, exhibit high potential for hydrocarbon separations. However, no clear guidelines have been established to regulate their hybrid characteristics owing to limited understanding of their adsorption mechanism. This study investigates the effects of the particle size of a flexible-robust MOF on its adsorption and structural transition behaviors. The robust nature originates from the structural transition of a metastable guest-free structure, while its flexible nature arises from another guest-free structure. The type of guest-free structure is predominantly determined by the particle size; particles below the critical size are trapped in the metastable guest-free structure. Notably, the critical size varies with the type of guest molecule to be removed; consequently, the difference in critical size results in guest-memory characteristics, enabling guest-free structure switching. These results underscore the importance of controlling the particle size to fine-tune hybrid adsorption characteristics of flexible-robust MOFs.

Facile access to spirobifluorene-fused chiral multi-resonance materials with ultra-narrowband blue emission

Narrowband multiple resonance (MR) emitters with circularly polarized luminescence (CPL) hold significant promise for three dimension organic light-emitting diode (3D-OLED) displays. In this work, we present a simple method for developing a new type of 9,9’-spirobifluorene-based CP-MR emitters by a recrystallization resolution technology and chlorine (Cl)-directed electrophilic borylation reaction, both of which significantly enhances the efficiency and scalability for mass production. This approach allows for integrating an asymmetric 9,9’-spirobifluorene core between two MR frameworks to achieve optically active CP-MR emitters. The highly rigid spirobifluorene framework minimizes structural relaxation, and meanwhile, the introduction of a cyano (CN) group enhances the MR emission characteristics, leading to an ultra-narrowband blue emission with full width at half maximum (FWHM) of 14 nm. As a result, these molecules facilitate the assembly of narrowband blue CPL-OLEDs with a maximum external quantum efficiency (EQEmax) of 30.7% and an impressive narrow FWHM of 16 nm, representing the first instance of an FWHM below 20 nm in CPL-OLEDs.

Three-dimensionally assembled polyelectrolyte multilayers-functionalized silica nanowire membrane for highly-efficient adsorptive separation of copper ions from water

High-performance materials for heavy metal ion removal are highly demanded in environmental treatment. Membrane adsorption has the advantages of being easy to operate and avoiding secondary pollution. It remains challenging to prepare adsorption membranes with both high removal rate and high permeability. Here, we present a novel strategy for preparing poly(acrylic acid) (PAA) and polyethyleneimine (PEI) multilayer-assembled silica nanowires (SiO2 NWs) membrane with abundant, multiple functional groups on a highly porous network for Cu(II) capture. The SiO2 NWs in the hybrid membranes serve as a rigid 3D framework to improve membrane porosity and water flux, while the polyelectrolyte multilayers assembled on the SiO2 NWs provide abundant, highly accessible adsorption sites for Cu(II) uptake. The adsorption capacity of the membranes can be tuned by changing the dosage of the assembled SiO2 NWs and the PAA/PEI pair layers. The maximum adsorption capacity of the active polyelectrolyte layer for SiO2 NWs@(PAA/PEI)4 composite membrane was 272.5 mg/g toward Cu(II), outperforming the counterpart (PAA/PEI)4 membrane (97.5 mg/g) after removal of the SiO2 NWs framework. The hybrid membrane shows excellent adsorption performance for the removal of low concentrations of Cu(II) in a dynamic adsorption mode, and the removal rate is maintained at above 90% after eight recycles.

Dual-site responsive module-triggered CRISPR/Cas12a switch with enhanced reaction kinetics for specific detection of PSA

Despite advances in DNA-based nanodevices for tumor biomarker detection, the pursuit of enhanced sensitivity and specificity remains a profound challenge. In this study, we designed an integrated dual-site responsive module as the AND logic gate that responded to both prostate-specific antigen (PSA) and apurinic/apyrimidinic endonuclease 1 (APE1), triggering a tetrahedral DNA nanostructure (TDN)-accelerated CRISPR/Cas12a signal switch for PSA detection. In detail, the dual-site responsive module was a T-shaped probe comprised of three DNA strands, which contained PSA aptamer and apurinic/apyrimidinic (AP) sites, significantly improving the specificity of prostate cancer screening by orthogonal recognition of PSA and APE1. When both PSA and APE1 were present, PSA could specifically bind with the aptamer, while APE1 catalyzed and cleaved the AP sites, releasing a part of one auxiliary strand as the mimic target (MT). To enhance the trans-cleavage efficiency of the CRISPR/Cas12a signal switch, we parallelly constructed the TDN with extended non-target strands (NTS) at each vertex, which could capture the MT to form double-stranded DNA (dsDNA) activators at the TDN vertices (TDN-activators) for triggering the CRISPR/Cas12a signal switch. Benefiting from the rigid framework of TDN, the TDN-activators not only increased the local concentration of Cas12a but also enabled a dominant conformation that was more favorable for recognizing and activating the Cas12a-crRNA complex, which demonstrated a 4.06-fold increase in trans-cleavage efficiency compared to that of dsDNA-activated Cas12a. This work applies the T-shaped probes and TDN-accelerated CRISPR/Cas12a signal switch to achieve the specific and sensitive electrochemiluminescence (ECL) detection of PSA from 1.0 × 10−5 to 10 μg/mL with a low limit of detection (LOD) of 4.5 × 10−6 μg/mL, offering a promising tool for early clinical screening of prostate cancer.

Structures of hexamethyl-[1,1′-biphenyl]-4,4′-diammonium salts

The crystal structures of nine hexamethyl-[1,1′-biphenyl]-4,4′-diammonium (HMB) salts are described: the iodide (2), triiodide (3), succinate (4), fumarate (5), tetravanadate (6), hydroterephthalate (7) and perylenetetracarboxylate (8), as well as pentamethyl-[1,1′-biphenyl]-4,4′-diammonium iodide (1) and the metal–organic framework sodium diacetylenedisalicylate–HMB (9). HMB carbonate (10) has been synthesized as an important intermediate for a promising anti-metal–organic framework (`anti-MOF'). All the described compounds are characterized by high solubility in water. The results suggest that, during crystallization, crystallohydrates are formed from water. Compounds 6 and 9 are characterized by the presence of a rigid framework; compound 6 has an open framework structure filled with water molecules. Synchronous thermal analyses of compounds 2, 4, 6, 7, 8 and 10 allowed the identification of similarities in the mechanisms of thermolysis. At about 80–180°C, the loss of crystallization water molecules occurs. Between 180 and 250°C, a methyl group (methyl cation) is split off from the quaternary ammonium salt to form tetramethylbenzidinium. In the case of the iodides and salts of organic acids, the second thermolysis product is the methyl ester of this acid (methyliodide, dimethyl carbonate), which easily evaporates. In the range 240–355°C, tetramethylbenzidinium evaporates without decomposition.

Two New Coordination Polymers: Crystal Structures and Fluorescence Properties.

A new Ni (II) metal-organic frameworks with the formula [Ni2(HL)2(H2O)4]∙3H2O (1) and a novel phenoxo-O bridged rare-earth dinuclear Schiff base complex with the formula [La2(dbm)4L·CH3OH] (2), where the HL2- is the partial deprotonated of the organic ligand H3L, and H2L is a bis-Schiff foundation ligand (H3L = 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid, H2L = N, N'-bis (2-hydroxy-3-methoxybenzylidene) -propane-1,2-diamine, Hdbm = dibenzoylmethane), have been successfully generated under the solvothermal condition. The targeted product sample of 1 and 2 has been fully characterized by single-crystal X-ray data, elemental analysis, FT-IR, powder X-ray diffraction, and thermogravimetric analysis. Furthermore, fluorescence performance testing of the complexes revealed that in complex 1, H3L forms a rigid chain through coordination with Ni2+ ions and further forms a highly rigid three-dimensional framework within the hydrogen bond network, resulting in fluorescence enhancement of up to 13.7-fold, displaying deep blue fluorescence with CIE coordinates of (0.1626, 0.1375). In contrast, complex 2 forms only discrete zero-dimensional molecules and exhibits light blue fluorescence with CIE coordinates of (0.1744, 0.2306). This demonstrates their potential as fluorescent materials.

Nitrogen-Oxidized Tröger's Base Macrocyclic Arenes: Unprecedented Enantioselective Recognition in Water.

Achieving high enantioselectivity with synthetic receptors, particularly in water, remains a significant challenge despite the success seen in natural biological systems. In this study, we introduce a facile synthesis of Tröger's base (TB)-containing macrocyclic arenes (TBn), where TB units are linked via methylene bridges, providing the macrocycles with a rigid framework. Oxidation of enantiopure TBn yields corresponding chiral nitrogen oxides (TBnNO) with excellent water solubility, attributed to the high polarity of the N-O bond, surpassing the pH limitations of traditional ion-functionalized approaches. Remarkably, TBnNO exhibits exceptional enantioselective recognition toward a wide range of chiral guests in aqueous solution, achieving enantioselectivities as high as 41.0. The underlying mechanism involves a combination of hydrophobic interactions and steric effects caused by rigid chiral cavities. These findings highlight the potential of nitrogen-oxidized macrocycles as a transformative tool for supramolecular application in water.

Nitrogen‐Oxidized Tröger's Base Macrocyclic Arenes: Unprecedented Enantioselective Recognition in Water

AbstractAchieving high enantioselectivity with synthetic receptors, particularly in water, remains a significant challenge despite the success seen in natural biological systems. In this study, we introduce a facile synthesis of Tröger's base (TB)‐containing macrocyclic arenes (TBn), where TB units are linked via methylene bridges, providing the macrocycles with a rigid framework. Oxidation of enantiopure TBn yields corresponding chiral nitrogen oxides (TBnNO) with excellent water solubility, attributed to the high polarity of the N−O bond, surpassing the pH limitations of traditional ion‐functionalized approaches. Remarkably, TBnNO exhibits exceptional enantioselective recognition toward a wide range of chiral guests in aqueous solution, achieving enantioselectivities as high as 41.0. The underlying mechanism involves a combination of hydrophobic interactions and steric effects caused by rigid chiral cavities. These findings highlight the potential of nitrogen‐oxidized macrocycles as a transformative tool for supramolecular application in water.

Decoding Public Policy: How Cultural Dynamics Shape Decision-Making in Indonesia’s Political Landscape

This study explores how cultural dynamics shape public policy in Indonesia, focusing on the influence of cultural dimensions on policy-making processes and outcomes. The purpose is to understand the impacts of Indonesian cultural values on various policy sectors, including education, health, environment, and economic development. Employing a qualitative research approach, the study relies exclusively on secondary data from academic literature, government reports, and media sources to examine these cultural influences. Findings reveal that high power distance leads to centralized decision-making, while collectivism shapes policies toward community welfare. High uncertainty avoidance results in rigid regulatory frameworks, and traditional gender roles affect gender-related policies. Sector-specific analyses highlight the integration of traditional knowledge in environmental policies and the challenges of balancing modernization with cultural heritage in economic policies. The implications of these findings suggest that policymakers should incorporate cultural considerations into policy design to enhance effectiveness and inclusivity. This research contributes original insights into the intersection of culture and policy, emphasizing the need for culturally sensitive approaches in diverse governance contexts. By shedding light on how cultural factors impact policy formulation and implementation, the study offers valuable guidance for developing culturally relevant and effective policies addressing societal needs.

Three-dimensional PDC-SiBCN network in MA-SiBCN ceramics: Toughening-reinforcing effect and oxidation barrier

A three-dimensional (3D) precursor-derived (PDC) SiBCN network was incorporated into mechanical alloying-derived (MA) SiBCN (MA@PDC-SiBCN) ceramic through a novel hybrid organic-inorganic method, enhancing densification while providing significant reinforcement and toughening effects. The PDC-SiBCN network's submicron continuity and uniformity enable efficient load transfer between under-sintered MA-SiBCN particles, increasing strength by 130%, compared to MA-SiBCN ceramics of the same density. Additionally, as cracks penetrate the PDC-SiBCN network, crack tip deflection and bifurcation result in 57% and 352% increases in fracture toughness respectively, compared to fully sintered and under-sintered MA-SiBCN ceramics of the same density. Besides, due to synergistic oxidation characteristics, the three-dimensional PDC-SiBCN network acts as an oxidation barrier, inhibiting the heterogeneous oxidation of the encapsulated MA-SiBCN component, especially limiting the consumption of BN(C) phase at lower temperatures. The residual PDC-SiBCN network in the oxide layer serves as a rigid framework, preventing bubble growth in the molten oxide layer thereby forming a dense protective oxide layer.

Crip Time Travels Through the Membrane and Vortex: An Autoethnographic Inquiry of Neurodivergent Student Temporality in Higher Art Education

AbstractCrip time is a fluid term with various definitions that pertain to the ways that disabled people experience time. In one sense, the effects of crip time can be constraining, particularly when it results in an encounter with ableist institutional and societal barriers. But crip time can also take on a liberatory form as a mode of resistance and a catalyst for structural change. This autoethnographic inquiry explores these various manifestations of crip time and will take form as a kind of crip time travel endeavour that recounts my experiences of temporality as a neurodivergent university art student. Framed through the mental imagery of the membrane and the vortex, I discuss the ways in which my neurodivergent student temporality collided and conflicted with the rigid temporal frameworks of neoliberal higher art education (HAE). I particularly focus on how HAE segments its programming into academic and artistic curricular time. I detail my difficulties keeping up with the academic curricular time to such an extent that the studio time and community time of artistic curricular time became lost or displaced time. Based on this crip time travel inquiry, I will acknowledge and move beyond a confining conception of crip time to offer insights into the liberatory potential of crip time towards reimagining temporal relations, reconceiving student success and opening time for neurodivergent students for critical making and thinking among a community of artist peers and mentors in HAE.

Physically crosslinked hydrogel based on silver nanowires with a discontinuous rigid framework for robust, sensitive, antibacterial, and biocompatible flexible sensors

Conductive hydrogels as flexible sensors fulfill the essential requirements of realtime monitoring and sensitive transmission in the fields of human-machine interaction. However, it is still a great challenge to integrate satisfying mechanical properties, sensitivity, antibacterial efficacy, and biocompatibility into one hydrogel sensor while ensuring a precise output signal. Herein, ultrathin silver nanowires (AgNWs) were prepared by controlling the growth of Ag atoms in (111) crystal planes within the Ethylene Glycol-Polyvinylpyrrolidone (EG-PVP) reduction system. Then, multifunctional hydrogel (SA-SH-AgNWs/PVA) was developed by physically crosslinking polyvinyl alcohol (PVA) and thiol-modified sodium alginate (SA-SH) in AgNWs aqueous solution through freeze-thaw circulation and Ca2+ crosslink. The AgNWs were adsorbed onto sodium alginate (SA) chains through electrostatic adsorption with thiol groups (-SH), forming a discontinuous rigid framework structure with a 278 % increase in tensile strength. The uniform dispersion of AgNWs within the hydrogel offers good sensing performance: gauge factor (GF) of 2.40 and sensitivity (S) of 3.24 × 10−2 kPa−1, and satisfying antibacterial abilities. What’s more, the obtained hydrogel can serve as stretching or compressing sensors to detect tiny yet intricate changes of human bodies. Therefore, the hydrogel is a great inspiration for the development of portable, intelligent, and highly flexible sensors.

Full‐Color Tunability Room Temperature Phosphorescence from Inorganic Crystal Frameworks

AbstractRoom temperature afterglow (RTA) materials have aroused prodigious research interests owing to their unique long‐life luminescent properties. However, it is rare for RTA materials to be reported with full‐color afterglow emission. Herein, a universal strategy is designed to activate full‐color tunability RTA based on phenylboronic acid derivatives (BOH) and boric acid (BA) via an ingenious solvent‐free solid‐phase heating. As the conjugation degrees of aromatic groups of the guest molecule expanded, the BOH/BA composites showed tunable afterglow colors ranging from blue to red after ultraviolet (UV) irradiation. This strategy is to firmly anchor the guest molecule in a rigid framework of the inorganic metaboric acid matrix by abundant hydrogen‐bonding interactions between the host and guest, suppressing molecular motion and promoting the intersystem crossing (ISC) rate between the singlet and triplet excited states for enhanced afterglow emission. In addition, through mixing in multiple guest molecules into BA simultaneously, the obtained composite can be modulated in a wide excitation range from blue to red. This fascinating study provides a simple and universal method to fabricate full‐color tunability RTA composites, making them a promising candidate for applications in advanced information security and multi‐level encryption.

Total Synthesis of the Humulene‐Derived Sesquiterpenoid (‐)‐Integrifolian‐1,5‐dione

AbstractThe oxygenated sesquiterpenoid (‐)‐integrifolian‐1,5‐dione, which originates from a plant that finds widespread use in South American traditional medicine, is distinguished by a rigid bicyclic framework consisting of a cyclopropane that is cis‐annulated to a cyclodecane ring. The first total synthesis of this demanding target is described, which relies on a highly selective cyclopropanation reaction of an α‐stannylated‐α‐diazoester catalyzed by a heteroleptic dirhodium paddlewheel complex, followed by an unprecedented Stille‐type cross coupling of the resulting stannylated cyclopropane with methyl iodide as the electrophilic partner to form the all‐carbon quaternary stereocenter at one of the bridgehead positions. Equally decisive was the bicyclization strategy based on lactonization/ring expansion that ultimately allowed the strained ten‐membered carbocycle to be forged.

Carbon Dot-Based Composite with Color Excitation-Dependent Room-Temperature Phosphorescence for Advanced Optical Encryption and Anticounterfeiting.

The phenomenon of multicolor afterglow emission has attracted considerable attention in information encryption, bioimaging, and sensing. Consequently, there is a growing demand for the development of multicolor afterglow and phosphorescence switching methods utilizing carbon dot (CD) materials. Herein, multicolor room-temperature phosphorescence (RTP) emission in CD-based materials (PM-CD@BA composite) was achieved by developing multiple emission centers and tuning the excitation wavelength. The color of the afterglow observed in this composite covered from the deep-blue to the green region. The experimental results reveal that under heating treatment, the CDs embedded in inorganic boric acid/B2O3 matrix materials and a rigid framework generated in the composite system effectively suppressed the nonradiative transition and promoted the RTP emission. Finally, high-resolution multilevel RTP 2D code data encryption was realized by inkjet printing technology. The developed concepts of information encryption and anticounterfeiting exhibit the significant potential of CD-based afterglow materials applied in advanced optical applications.

Highly Conductive Supramolecular Salt Gel Electrolyte for Flexible Supercapacitors.

Conductive gels have greatly facilitated the development of flexible energy storage devices, including supercapacitors, batteries, and triboelectric nanogenerators. However, it is challenging for gel electrolytes to tackle the trade-off issues between mechanical properties and conductivity. Herein, a strategy of all inorganic salt-driven supramolecular networks is presented to construct gel electrolytes with high conductivity and reliable mechanical performance for flexible supercapacitors. The salt gel is successfully fabricated by combining a salt supramolecular network constructed by NH4Mo7O24·4H2O and FeCl3·6H2O and a polymer network of poly(vinyl alcohol). The inorganic salt supramolecular network serves as a rigid self-supporting framework in the hydrogel system for improving the mechanical properties and providing abundant active sites for accelerating ion transport. Furthermore, the salt gel-enabled supercapacitors are equipped and exhibit a high specific capacitance (199.4 mF cm-2) and excellent energy density (27.69 μWh cm-2). Moreover, the flexible supercapacitors not only present remarkable cyclic stability after 3000 charging/discharging cycles but also exhibit good electrochemical stability even under severe deformation conditions. The strategy of salt-gel-driven flexible supercapacitors would provide fresh thinking for the development of advanced flexible energy storage fields.

OPTIMIZING PROCESSOR WORKLOADS AND SYSTEM EFFICIENCY THROUGH GAME-THEORETIC MODELS IN DISTRIBUTED SYSTEMS

The primary goal of this research is to examine how different strategic behaviors adopted by processors affect the workload management and overall efficiency of the system. Specifically, the study focuses on the attainment of a pure strategy Nash Equilibrium and explores its implications on system performance. In this context, Nash Equilibrium is considered as a state where no player has anything to gain by changing only their own strategy unilaterally, suggesting a stable, yet not necessarily optimal, configuration under strategic interactions. The paper rigorously develops a formal mathematical model and employs extensive simulations to validate the theoretical findings, thus ensuring the reliability of the proposed model. Additionally, adaptive algorithms for dynamic task allocation are proposed, aimed at enhancing system flexibility and efficiency in real-time processing environments. Key results from this study highlight that while Nash Equilibrium fosters stability within the system, the adoption of optimal cooperative strategies significantly improves operational efficiency and minimizes transaction costs. These findings are illustrated through detailed 3D plots and tabulated results, which provide a detailed examination of how strategic decisions influence system performance under varying conditions, such as fluctuating system loads and migration costs. The analysis also examines the balance between individual processor job satisfaction and overall system performance, highlighting the effect of rigid task reallocation frameworks. Through this study, the paper not only improves our understanding of strategic interactions within computational systems but also provides key ideas that could guide the development of more efficient computational frameworks for various applications.

Modulation of p-Block Electron Orbits in Metal-Organic Frameworks for CO2 Capture and Electrochemical Reduction.

Developing catalysts with excellent CO2 capture capability and electrochemical CO2 reduction reaction (CO2RR) at a wide potential range simultaneously is significant but remains a formidable challenge. Here, two novel InMg defective trinuclear cluster-based MOFs (SNNU-41 and SNNU-42) with abundant p-block unsaturated coordinated sites were reported and exhibited good CO2 capture and CO2RR performance simultaneously. Due to the suitable micropores, SNNU-41 showed higher CO2 capture ability at different adsorption pressure conditions. On account of the rigid framework and the closer p band center to Fermi level, SNNU-42 accelerated the conversion of CO2 molecule to C1 efficiency. Notably, via adjusting the ratio of p-block metal (In) in the SNNU-42 framework, the performance of the CO2RR was promoted drastically. SNNU-42 with the InMg (1:1.8) mixed cluster delivered an excellent Faradaic efficiency of 91.3% for C1 products and high selectivity of 72.0% for HCOOH at -2.5 V (vs Ag/Ag+) with a total current density of 77.2 mA cm-2. This work provides a possibility for efficient CO2 capture and CO2RR electrocatalysts through the modulation of electronic structures and composition in MOFs.

Advances in Chiral Pincer Complexes: Insights and Applications in Catalytic Asymmetric Reactions.

Chiral pincer complexes, characterized by their rigid tridentate coordination framework, have emerged as powerful catalysts in asymmetric synthesis. This review provides a comprehensive overview of recent advancements in the development of chiral pincer-type ligands and their corresponding transition metal complexes. We highlight the latest progress in their application across a range of catalytic asymmetric reactions, including the (transfer) hydrogenation of polar and non-polar bonds, hydrophosphination, alkynylation, Friedel-Crafts reactions, enantioselective reductive cyclization of alkynyl-tethered cyclohexadienones, enantioselective hydrosilylation, as well as Aza-Morita-Baylis-Hillman reactions. The structural rigidity and tunability of chiral pincer complexes enable precise control over stereoselectivity, resulting in high enantioselectivity and efficiency in complex molecular transformations. As the field advances, innovations in ligand design and the exploration of new metal centers are expected to expand the scope and utility of these catalysts, bearing significant implications for the synthesis of enantioenriched compounds in pharmaceuticals, materials science, and beyond.