Upland rice (Oryza sativa L.) is a staple food crop that produces rice, which is important in meeting Indonesia's food needs. This research aims to improve growth and increase the production of upland rice plants by providing biological fertilizer and inorganic fertilizer and getting the right combination dose for upland rice plants. This research was carried out at the experimental garden of the Faculty of Agriculture, Riau University, Bina Widya campus km 12.5, Pekanbaru. This research used a factorial completely randomized design (CRD) consisting of two factors the first factor was biological fertilizer consisting of four levels, namely: H0 : Control, H1 : 0.18 g of Agrimeth fertilizer, H2 :0.41 g Kayabio fertilizer, H3: 0.45 g Petro Biofertil fertilizer; The second factor is Phonska NPK fertilizer consisting of four levels, P0 : control, P1 : 1,4 g, P2: 2 g, P3 : 2.7 g per plant. The results showed that the interaction between the application of biological fertilizer and NPK Phonska fertilizer affected the number of grainy grains per panicle and the weight of milled dry grain. Providing biological fertilizer affects plant height, root dry weight, shoot dry weight, maximum number of tillers, number of productive tillers, number of grainy grains per panicle, percentage of grainy grains and weight of milled dry grains. Application of NPK Phonska fertilizer affects plant height, shoot dry weight, root dry weight, maximum number of tillers, number of productive tillers, number of grainy grains per panicle, percentage of grainy grains and weight of milled dry grains. The correct dose to improve the growth and production of upland rice plants of the Inpago 12 variety can be 0.45 g Petro Biofertil Biofertilizer with 2.7 g Phonska NPK per plant