Bioplant is a liquid soil conditioner that contains a consortium of beneficial fungi and bacteria manufactured by Artemis and Angel Company Limited in Bangkok. Bioplant is purported to stimulate beneficial microbial activity in soil and hence increase crop yield. However, the efficacy of Bioplant has not been evaluated on Ghanaian soils. A screen house trial was consequently conducted to evaluate the efficacy or otherwise of Bioplant on the yield of lettuce in a Rhodic Kandiustalf amended with or without compost. The soil was mixed with compost at 20 parts soil to 80 parts compost and 60 parts soil to 40 parts compost (v/v) and potted in 1.7-L pots. There was another potted soil with no compost amendment. To each of these potted soils, Bioplant was applied at four rates, viz., zero, half the manufacturer's recommended rate, the manufacturer's recommended rate, and twice the manufacturer's recommended rate, and allowed to equilibrate for 2 weeks. Seedlings of lettuce of the variety Eden were transplanted into the pots, and the treatments kept at 80% field capacity. The treatments were replicated four times in a completely randomized design. At physiological maturity, the lettuce was harvested, and fresh and dry matter yields were taken. The C and N contents and N uptake in the harvested plants were also determined. Results indicate that conditioning the soil with Bioplant at half and the manufacturer's recommended rates increased N uptake, resulting in higher carbon accumulation with concomitant increases in both fresh and dry matter yields. The results also show that amending the Rhodic Kandiustalf with Bioplant at twice the manufacturer's rate suppressed yield. Application of Bioplant at the manufacturer's recommended rate in combination with compost amended at 40 parts to 60 parts soil (v/v) saw a 47 and 90% respective significant yield increases in fresh weight and dry matter when only Bioplant was applied at the manufacturer's recommended rate. It is therefore recommended for Bioplant to be applied at the manufacturer's recommended rate of 825 mL/ha in combination with 40 parts of compost to 60 parts of soil (v/v).