Review Of Theliterature Research Articles

Towards Fostering Patriotism and Instilling Moral Values in Ghana Through Faith: The Role of The Church of Pentecost in National Development

The Church’s place in modern life has gone a lot beyond its original purpose of giving spiritual advice through religious groups. Through participant observation and a review of the literature, this paper examined how the Church, especially The Church of Pentecost (CoP), has changed over time in modern Ghana to promote patriotism and instil moral values in modern Ghana through its two flagship programmes—“National Development Conference 2023” and the “All Ministers Conference 2023”. The findings of the research revealed that morals, unity, and national growth were emphasised at these conferences. There were teachings, prayers, workshops, and the raising of the Ghanaian flag as a symbol of how important it is to work together across party lines for national growth. The study highlighted key recommendations, including employing a holistic approach, promoting patriotic songs, fostering collaboration, upholding moral values, emphasizing the national flag, and transcending partisanship. The study concluded that media influence, equality, punctuality, and unity are essential in fostering patriotism and moral values for Ghana’s growth and development. The paper contributes to the proactive role of the church in nurturing patriotism and moral values, providing valuable insights into nation-building and societal cohesion. Keywords: The Church of Pentecost, Religion, Patriotism, Moral Values, National Development

A Novel Dental and Maxillofacial Sign in Aarskog Syndrome: A Family Case and Review of the Literature

Objective: To describe a case of a novel mutation with dental and maxillofacial expression in a family with Aarskog syndrome and to conduct a literature review to determine the importance of a multidisciplinary approach in the pathology. Methods: The authors described a family of a father and mother and 7 children (5 sons affected). The first child is evaluated for multiple mandibular osteolytic lesions and dental malocclusion with eruption disorders. The patient presents facial features of Aarskog syndrome, such as hypertelorism and eyelid ptosis with epicanthal folds, but also an unusual sign of numerous comedones distributed over the body. A literature review on dental and maxillofacial signs in Aarskog syndrome was conducted on Scopus and Pubmed with specific keywords. Results: Osteolytic lesions are described as orthokeratotic keratocysts with giant cellular, foreign body type, calcifications, and bone spicules. A recurrence occurred 2 years after surgery of keratocysts. Ten articles were selected for the description of dental and maxillofacial features associated with Aarskog syndrome. Discussion: Literature has paid little attention to different phenotypic characterizations in the maxillofacial region of patients with Aarskog syndrome. It is important to determine an early diagnosis to provide the best treatments for patients. The family described has some peculiarities: (1) a new nucleotide variation, (2) the sample size, (3) features as multiple comedones of the body, and keratocysts of the jaws are never described in the literature. Conclusion: Clinical and radiological maxillofacial signs, often not evaluated in Aarskog syndrome, should be considered early to obtain an optimal treatment.

Os Trigonum Syndrome: A Cause of Posterior Ankle Pain.

Os trigonum syndrome represents a cause of posterior ankle pain that is predominantly seen in athletes. The os trigonum ossicle forms from a secondary ossification center of the talus and is located at its posterior aspect in an interval between the posterior lip of the tibial plafond and calcaneus. The os trigonum ossicle is often an incidental finding and asymptomatic. However, repetitive plantarflexion and push-off maneuvers can cause symptoms and lead a patient to pursue orthopedic care. A review of the literature was conducted using the PubMed search engine with the following keywords: "os trigonum", "os trigonum ossicle", "os trigonum syndrome", "posterior ankle impingement", and "Stieda process". The pertinent anatomy, clinical presentation, diagnostic evaluation, and treatment of os trigonum syndrome were reviewed in the literature and are extensively discussed in this article. Os trigonum syndrome represents a potential cause of posterior ankle pain that needs thorough evaluation regarding history, physical examination, and imaging. Once diagnosed, treatment ranges from conservative to surgical interventions depending on surgeon preference and specific case presentation. [Orthopedics. 2024;47(2):e67-e72.].

Delayed reconstruction of pharyngeal and pharyngoesophageal defects in patients with malignant neoplasms of the larynx and pharyngeopharynx after laryngectomy. Review of the literature

The aim of the study was to investigate the current surgical approaches and complications of delayed reconstruction of pharyngeal and pharyngoesophageal defects in patients with malignant neoplasms of the larynx and pharyngeopharynx after laryngectomy using different reconstructive materials. There are various classifications of pharyngoesophageal defects in the current literature, in which one should pay attention to the shape, size, and structure of the pharyngeal defect. The Blackwell and Urken classification is the most widely used in the choice of plastic material. The Blackwell and Urken classification distinguishes the following types of pharyngoesophageal defects: Type 0 - small defects that close mostly without tissue introduction; Type 1 - noncircular defects that retain a viable band of mucosa from the laryngeopharynx to the cervical esophagus; 2 type - circular defects that extend from the valleculae, that is, the depression between the root of the tongue and the lingual surface of the epiglottis, and down to the thoracic entrance; 3 type - circular defects that extend from the level of the valleculae and cranially to the oropharynx; 4 type - extensive defects that extend below the clavicles to the thoracic esophagus. The types of defects and types of plasty with the use of different plastic material depending on the type of defect are considered.
 In the delayed reconstruction of pharyngeal and pharygoesophageal defects in cancer patients various plastic materials are used: from the covering tissues, the material on the axial blood supply (deltopectoral, pectoral, thoracodorsal), free flaps (radial forearm flap, anterolateral thigh flap) and visceral flaps from fragments of the gastrointestinal tract, allowing to restore the integrity and lumen of the throat. At all types of plasty complications can develop in the postoperative period.

Can Anesthesiologists Prevent Perioperative Neurocognitive Decline? A Review of the Literature

Can Anesthesiologists Prevent Perioperative Neurocognitive Decline? A Review of the Literature

Eligibility criteria for using menopausal hormone therapy in breast cancer survivors: a safety report based on a systematic review and meta-analysis.

Menopause hormone therapy (MHT) effectively alleviates menopausal symptoms. However, it is generally not recommended for breast cancer survivors, although the scientific evidence is scarce. This study aimed to establish eligibility criteria for use of the MHT in breast cancer survivors based on a systematic review and meta-analysis of the literature. We conducted exhaustive literature searches until June 2022 in MEDLINE, The Cochrane Library, and EMBASE, using a tailored strategy with a combination of controlled vocabulary and search terms related to breast cancer survivors and MHT. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and assessed the risk of bias using the Cochrane and Risk of Bias in Non-randomized Studies - of Interventions tools. The quality of the evidence was graded according to grading quality of evidence and strength of recommendations criteria (A, high; B, moderate; C, low; and D, very low). We categorized MHT use into four levels: category 1 (no restrictions on use), category 2 (the benefits outweigh the risks), category 3 (the risks generally outweigh the benefits), and category 4 (MHT should not be used). A total of 12 studies met the eligibility criteria. Analysis of the three randomized clinical trials using combined MHT or tibolone revealed no significant differences concerning tumor recurrence (relative risk [RR], 1.46; 95% CI, 0.99-2.24). A combined analysis of randomized clinical trials, prospective, and retrospective trials found no elevated risk of recurrence (RR, 0.85; 95% CI, 0.54-1.33) or death (RR, 0.91; 95% CI, 0.38-2.19). The eligibility criteria for patients with hormone receptor (HR)-positive tumors fell into categories 3B and 3C for combined MHT or estrogen alone and 4A for tibolone. For HR-negative tumors, the category was 2B and 2C. Our findings suggest that MHT could be a viable treatment alternative for breast cancer survivors experiencing menopausal symptoms, especially those with HR-negative tumors. Personalized management is recommended for each peri/postmenopausal woman facing a diminished quality of life because of menopause symptoms. Further randomized trials are needed before considering changes to current standards of care.

An Analysis of The Constructs Influencing Public and Private Hospitals' Level of Service Quality: A Study in Context of Nepal

This research study examines the significance of the data collected as well as the service quality provided by hospitals in Nepal through a systematic review and analysis of the literature. Given the swift growth of the healthcare sector in Nepal, evaluating the caliber of hospital services is essential. The project's objectives are to compile all of the available data, pinpoint knowledge gaps, and offer wise counsel to academics, policymakers, and medical professionals. Using pre-established keywords linked to Nepali hospital service quality, a comprehensive search was carried out across several electronic databases, including PubMed, Scopus, and Web of Science. Studies released between January 2000 and April 2023 were taken into consideration. The systematic review comprised thirteen studies in all, including both qualitative and quantitative research methods. The systematic study's findings brought to light several essential elements of high-quality services, including tangibles, assurance, responsiveness, empathy, infrastructure, and assurance. An exploratory factor analysis technique was used to identify the contributing factors that are primarily responsible for the disparities in services offered between public and private sector hospitals in Nepal, based on the 600 valid responses to the survey that was conducted among the general public regarding private and public hospitals.
 Methods: To obtain an overall picture, a reliable data set was chosen from the sample data gathered from patient parties and administrative staffs throughout public and private sector hospitals using systematic statistical procedures.
 Results: The study's findings contribute to our understanding of the standard of hospital treatment in Nepal and could eventually raise public and professional awareness of the disparity in quality between hospital care in Nepal.
 Discussions: The impact of hospital services on the people who use them is determined in this study, and it is a major aspect in assessing the standard of healthcare provided by the various sectors.

The cost-utility of intraoperative tranexamic acid in adult spinal deformity patients undergoing long posterior spinal fusion.

This study aims to evaluate the cost-utility of intraoperative tranexamic acid (TXA) in adult spinal deformity (ASD) patients undergoing long posterior (≥ 5 vertebral levels) spinal fusion. A decision-analysis model was built for a hypothetical 60-year-old adult patient with spinal deformity undergoing long posterior spinal fusion. A comprehensive review of the literature was performed to obtain event probabilities, costs and health utilities at each node. Health utilities were utilized to calculate Quality-Adjusted Life Years (QALYs). A base-case analysis was carried out to obtain the incremental cost and effectiveness of intraoperative TXA. Probabilistic sensitivity analysis was performed to evaluate uncertainty in our model and obtain mean incremental costs, effectiveness, and net monetary benefits. One-way sensitivity analyses were also performed to identify the variables with the most impact on our model. Use of intraoperative TXA was the favored strategy in 88% of the iterations. The mean incremental utility ratio for using intraoperative TXA demonstrated higher benefit and lower cost while being lower than the willingness-to-pay threshold set at $50,000 per quality adjusted life years. Use of intraoperative TXA was associated with a mean incremental net monetary benefit (INMB) of $3743 (95% CI 3492-3995). One-way sensitivity analysis reported cost of blood transfusions due to post-operative anemia to be a major driver of cost-utility analysis. Use of intraoperative TXAs is a cost-effective strategy to reduce overall perioperative costs related to post-operative blood transfusions. Administration of intraoperative TXA should be considered for long fusions in ASD population when not explicitly contra-indicated due to patient factors.

Acetabular custom implants in the management of severe acetabular bone defects in revision total hip arthroplasty: a systematic review of the literature

Acetabular custom implants in the management of severe acetabular bone defects in revision total hip arthroplasty: a systematic review of the literature

Production Choices and Food Security: A Review of Studies Based on a Micro-Diversity Perspective.

Given the 'subsistence' character of smallholder production, agricultural production diversification is often seen as an effective strategy for smallholders to improve their diets' diversity and nutritional status, yet the existing evidence remains inadequate. The study applies bibliometric data from the "Web of Science" database to synthesize 46 papers from developing countries to explore the relationship between production diversity, dietary diversity, and nutrition in smallholder households. The study identifies the most influential journals, authors, organizations, and countries and reveals research themes related to agricultural production and food security. This data analysis can help researchers target potential collaborators and access influential literature in agricultural production diversity and dietary diversity research. In addition, the results showed that agricultural production diversity potentially influences households' dietary diversity, with mixed results: Agricultural production diversification is the primary way to improve food and nutritional security among smallholder families with low socio-economic status, inaccessible transportation, and poverty; market access and trade have more potential to improve dietary diversity among smallholder households with well-developed markets and higher income levels; the significant measures of agricultural production diversity include Crop Counts, FGPD, SI, and SWDI; the significant measures of dietary diversity include HDDS and IDDS. This paper provides a roadmap for agricultural production and food security researchers by conducting a systematic review of the literature, summarizing some research methods and perspectives applicable to local socio-economic development.

Accessibility and Disability-Inclusive Urban Planning in Kathmandu Metropolitan City

This research aims to explore the importance of accessibility and disability-inclusive urban planning. For this, it analyzes the problems of disabled people, especially physically disabled people, living in Kathmandu Metropolitan City. The review of the literature shows that people with disabilities face a widespread lack of accessibility to build environments, from roads and housing to public buildings and spaces and basic urban services such as sanitation and water, health, education, transportation, and emergency response and resilience programs. Particularly, one of the main problems in Kathmandu Metropolitan City is the inaccessibility of urban public spaces such as sidewalks, bus stops, pedestrian crossings, etc. for people with all kinds of abilities. Persons with disability (PWDs), often struggle with the complexities of the built environment in urban areas that hinder their equal participation in daily activities. So, there is a need for accessibility and disability-inclusive urban planning in Kathmandu metropolitan city.

Abstract IA004: Universal tumor screening for Lynch syndrome versus germline multi-gene panel testing for all endometrial cancer patients

Abstract Introduction: Implementation of universal tumor screening for Lynch syndrome has been adopted more slowly for endometrial cancer patients than colorectal cancer patients yet the data is very similar. Recent guidelines have suggested doing both universal tumor screening and considering multi-gene panel testing for all colorectal cancer patients and so the data in endometrial cancer patients was reviewed to determine if the same recommendation could be made for endometrial cancer. Methods: Review of the literature found 4 large studies of universal tumor screening for Lynch syndrome among and 6 large studies of universal multi-gene panel testing among large cohorts of endometrial cancer patients. Results were reviewed and a meta-analysis performed. Results: Four large studies have looked at universal tumor screening among all endometrial cancer patients. They found that 23-26.7% of endometrial cancers are MSI-high or dMMR. The majority of these dMMR endometrial cancers are caused by MLH1 promoter hypermethylation which is present in 14-20.2% of all EC cases (60.3-75.8% of dMMR cases). Lynch syndrome was ultimately diagnosed in 2.5-3.3% of all endometrial cancer patients. The mutation distribution among Lynch syndrome patient diagnosed through universal tumor screening was 53.1% MSH6, 24.5% MSH2, 12.2% MLH1, and 10.2% PMS2. IHC was better at identifying Lynch syndrome cases than MSI among endometrial cancers (mainly due to MSH6 tumors not always being MSI-high). Multi-gene panel testing (MGPT) for all endometrial cancer patients has been reported in 6 studies of endometrial cancer patients (3 high risk and 3 unselected). MGPT studies found that 10 – 14% of unselected and 9 - 15% of selected endometrial cancer patients have a pathogenic variant in a cancer susceptibility gene. Patients diagnosed under age 50 were not significantly more likely to test positive. In the three selected cohorts, the prevalence of Lynch syndrome was 8.1% (575/7095). In the three unselected cohorts, the prevalence of Lynch syndrome was 2.7% (73/2742). Conclusions: Tumor screening with MSI or MMR IHC for all endometrial cancers will only identify Lynch syndrome (as intended). It will miss patiesporadicny other hereditary cancer syndrome and some patients with Lynch syndrome who have a sporadic endometrial cancer. However, it is now necessary for treatment purposes (Immune Checkpoint Blockade therapy). Universal germline MGPT testing for all endometrial cancers will identify some Lynch syndrome cases who have normal tumor screening and will identify many non-Lynch syndrome cases that would be completely missed by tumor screening. Citation Format: Heather Hampel. Universal tumor screening for Lynch syndrome versus germline multi-gene panel testing for all endometrial cancer patients [abstract]. In: Proceedings of the AACR Special Conference on Endometrial Cancer: Transforming Care through Science; 2023 Nov 16-18; Boston, Massachusetts. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(5_Suppl):Abstract nr IA004.

Mediators of change in psychological interventions for adult offenders with personality disorders: A scoping review of the literature.

Offenders with personality disorder cause disproportionate harm to society and pose significant challenges for those responsible for their care and rehabilitation. Personality disorders are heterogeneous in terms of symptoms, as well as their pathways to offending behaviour. Thus, there is limited evidence regarding effective interventions. One solution might be to focus on how interventions are delivered as well as what is delivered. Within the non-offender personality disorder literature, the identification of potential mediators of change has enabled interventions to focus on 'how' they are delivered (e.g., therapeutic alliance) rather than the intervention itself. We explore the evidence and present a scoping review of the available literature on the mechanisms of change in psychological treatments for offenders with personality disorder. Only one study was found in the scoping review, highlighting a significant gap in the evidence base. We discuss the implications of this finding and potential future directions.

The Use of Lexical Bundles in English Language Academic Writing among University Learners: A Systematic Literature Review

Lexical bundles have been widely studied in English academic writing, but not as extensive in university learners’ academic writing. This study conducted a systematic review of the literature on lexical bundles in academic writing among university learners from 2017 to 2022 to describe the directions of and limitations of recent studies on how lexical bundles influence the fluency and coherence of academic writing among university learners. The review relied on two major databases, Scopus and Web of Science, and adhered to the PRISMA 2020 guidelines. The study analyzed 28 articles them based on three content-based themes: the research context, the research contents, and the research objectives. Recent research on lexical bundles in academic writing among university students 1) lacks an in-depth analysis of specific functions, such as text-oriented bundles, which predominate and play an important coherence role in more advanced academic writing; 2) addressing the analysis of lexical bundles solely through a phraseological lens fails to account for their genre-specific characteristics. It is crucial to merge insights from both genre and phraseology for a thorough analysis; 3) comparing the academic writing of native English-speaking learners, that of university learners in East Asia and the Middle East are unevenly distributed and limited in scope. There is limited research on academic writing at higher academic levels, university learners in Southeast Asia, and cross-regional comparative studies.

Combined knee osteotomy and cartilage procedure for varus knees: friend or foe? A narrative review of the literature.

Varus knees with associated cartilage pathologies are not uncommon scenarios that present to orthopaedic surgeons. There is no agreement on the ideal management of varus knees with concomitant cartilage pathology. Through a literature review, the authors tried to answer three main questions: On October 2022, OVID MEDLINE, EMBASE, and COCHRANE databases were searched. Clinical studies reporting on clinical, radiologic, or macroscopic cartilage regeneration following either isolated knee osteotomy or concomitant osteotomy and a cartilage procedure were reviewed. Despite controversies, the literature demonstrated favourable outcomes of combined knee osteotomy and a cartilage procedure in patients with substantial deformity and cartilage defects. Isolated high tibial osteotomy may induce cartilage regeneration in several scenarios and severities of concomitant malalignment and cartilage defects. There are recommendations that knee osteotomy should be added to a cartilage procedure when an extra-articular deformity of > 5° is detected. Some studies report good outcomes for combining a knee osteotomy with cartilage grafting, but they lack a control group of isolated osteotomy. There is still scarce of evidence on the influence of osteotomies on cartilage regeneration and the outcomes of concomitant osteotomy and different cartilage procedures vs isolated osteotomies. With advanced statistical evaluation (artificial intelligence, machine learning) of big datasets, more answers and better results will be delivered.

The relationship between cultural variables and resilience to psychological trauma: A systematic review of the literature.

The relationship between cultural variables and resilience to psychological trauma: A systematic review of the literature.

How Precise are Nanomedicines in Overcoming the Blood-Brain Barrier? A Comprehensive Review of the Literature.

New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from drug designers. The treatment of neurological conditions, including brain tumors, stroke, Parkinson's Disease (PD), and Alzheimer's disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration have demonstrated the effective application of nanomaterials in the treatment of brain illnesses. Nanocarriers (NCs) have made it easier to deliver drugs precisely to where they are needed. Thus, the most effective use of nanomaterials is in the treatment of various brain diseases, as this amplifies the overall impact of medication and emphasizes the significance of nanotherapeutics through gene therapy, enzyme replacement therapy, and blood-barrier mechanisms. Recent advances in nanotechnology have led to the development of multifunctional nanotherapeutic agents, a promising treatment for brain disorders. This novel method reduces the side effects and improves treatment outcomes. This review critically assesses efficient nano-based systems in light of obstacles and outstanding achievements. Nanocarriers that transfer medications across the blood-brain barrier and nano-assisted therapies, including nano-immunotherapy, nano-gene therapy, nano enzyme replacement therapy, scaffolds, and 3D to 6D printing, have been widely explored for the treatment of brain disorders. This study aimed to evaluate existing literature regarding the use of nanotechnology in the development of drug delivery systems that can penetrate the blood-brain barrier (BBB) and deliver therapeutic agents to treat various brain disorders.

Sleep related bruxism—comprehensive review of the literature based on a rare case presentation

Davis C. Thomas, Jaimin Patel, Sanjana Santhosh Kumar, Janani Dakshinamoorthy, Yonatan Greenstein, Harita Kamalam Ravindran, Priyanka Kodaganallur Pitchumani

Relationship of herpes simplex virus and stage IV periodontitis: A systematic review of the literature

Objetivo: El presente trabajo tiene como propósito determinar, mediante una revisión sistemática de literatura, la relación entre el Virus del Herpes Simple (VHS) y la periodontitis estadio IV, con el fin de orientar la terapéutica para el tratamiento de esta entidad. Materiales y Métodos: Revisión sistemática de literatura en las bases de datos PubMed, Elsevier, Science Direct y Scielo, empleando la lista de comprobación PRISMA. Se incluyeron revisiones sistemáticas y meta análisis sobre diseños de estudios experimentales, estudios de biología molecular y estudios in vivo humanos acerca de la relación del herpes virus simple tipo 1 y la periodontitis estadio IV, publicados entre el 2017 y 2022, en español e inglés, en una búsqueda que se realizó entre el 8 y el 22 de abril del 2022. Tres artículos resultaron elegibles, aplicando los criterios de inclusión y exclusión, de un total inicial de 1.797. Resultados: Las revisiones examinadas comprueban una relación más convincente del virus del herpes humano, aumentada por su presencia y asociación con la enfermedad periodontal en estadios avanzados, como la periodontitis estadio IV, en comparación con pacientes sanos y con gingivitis. Conclusiones: El manejo farmacológico coadyuvante de la terapia periodontal en pacientes con periodontitis estadio IV, acompañado de terapia antibiótica y antiviral, puede reducir o erradicar el herpes simple en sitios con enfermedad periodontal.

The first Iranian patient with You-Hoover-Fong syndrome and a review of the literature on 27 cases: expanding the genotypic and phenotypic spectrum.

The ultra-rare autosomal recessive genetic disorder, You-Hoover-Fong Syndrome (YHFS), is caused by defects in the TELO2 gene and is characterized by intellectual disability, developmental delay, and ocular impairments. This study aims to contribute to a better understanding of YHFS by reviewing previous cases and introducing a novel variant in a new case. Whole exome sequencing (WES) was conducted on the proband to identify genetic variants, and Sanger sequencing was used to confirm variants within the family. This article presents a comprehensive collection of reported cases of YHFS, incorporating both molecular and clinical data, through an extensive literature search and analysis of English-language studies published until June 2023. Using WES, a novel homozygous missense variant, c.1799A > G (p. Tyr600Cys), was identified in the TELO2 gene in a 4-year-old Iranian male patient. Novel clinical features, including choanal atresia and clubfoot, were also identified. A comprehensive literature review identified 27 patients with YHFS, with 20 variants in the TELO2 gene. Missense pathogenic variants were the most common type of pathogenic variant, and the most common features were microcephaly and intellectual impairment. This study presents the first case of pathogenic variants in TELO2 genein Iran, expands the genotypic and phenotypic spectrum of YHFS and contributes to the growing body of literature pertaining to YHFS. Furthermore, our findings highlight the importance of genetic testing for non-consanguineous carrier screening, as compound heterozygosity may be a significant factor in the development of YHFS. Further research is needed to clarify the molecular mechanisms underlying YHFS pathogenesis.