Updated Review Research Articles

An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer.

Colorectal cancer is one of the most common cancer types worldwide. Since colorectal cancer takes time to develop, its incidence and mortality can be treated effectively if it is detected in its early stages. As a result, non-invasive or invasive biomarkers play an essential role in the early diagnosis of colorectal cancer. Many experimental studies have been carried out to assess genetic, epigenetic, or protein markers in feces, serum, and tissue. It may be possible to find biomarkers that will help with the diagnosis of colorectal cancer by identifying the genes, RNAs, and/or proteins indicative of cancer growth. Recent advancements in the molecular subtypes of colorectal cancer, DNA methylation, microRNAs, long noncoding RNAs, exosomes, and their involvement in colorectal cancer have led to the discovery of numerous new colorectal cancer biomarkers. In small-scale investigations, most biomarkers appear promising. However, large-scale clinical trials are required to validate their effectiveness before routine clinical implementation. Hence, this review focuses on small-scale investigations and results of big data analysis that may provide an overview of the biomarkers for the diagnosis, therapy, and prognosis of colorectal cancer.

Lower vs higher fluid volumes in adult patients with sepsis - “an updated systematic review with meta-analysis and trial sequential analysis”

Lower vs higher fluid volumes in adult patients with sepsis - “an updated systematic review with meta-analysis and trial sequential analysis”

Blended diets for tube-fed children and young people: A rapid review update

Blended diets for tube-fed children and young people: A rapid review update

An Updated Review on Self-Healing Barrier Materials with Potential Application in Contaminated Soil / Groundwater Risk Control

An Updated Review on Self-Healing Barrier Materials with Potential Application in Contaminated Soil / Groundwater Risk Control

Protocol: Reducing community violence: A systematic meta-review of what works.

This is the protocol for a Campbell Collaboration systematic review. Our objective is to synthesize what is known about the effectiveness of strategies for reducing community violence, focusing on those strategies that have been subjected to a systematic review. We aim to answer the following questions in this review: what strategies to reduce community violence have been rigorously evaluated through systematic reviews;which have sufficient evidence of effectiveness, which seem promising, and which appear ineffective; and what implications for practice and policy can be drawn from this large body of research?We anticipate categorizing the results of our review similarly to the original review by Abt and Winship (2016).That is, categorizing reviews by people-based approaches, place-based approaches, and behavior-based approaches. However, given that this is an updated review and we will be incorporating additional studies, we may find that an alternative or additional categorization is warranted and update our categorization accordingly. Implications for policy and practice as they relate to these categories will be discussed.

Isometric Exercise Training and Arterial Hypertension: An Updated Review.

Hypertension is recognised as a leading attributable risk factor for cardiovascular disease and premature mortality. Global initiatives towards the prevention and treatment of arterial hypertension are centred around non-pharmacological lifestyle modification. Exercise recommendations differ between professional and scientific organisations, but are generally unanimous on the primary role of traditional aerobic and dynamic resistance exercise. In recent years, isometric exercise training (IET) has emerged as an effective novel exercise intervention with consistent evidence of reductions in blood pressure (BP) superior to that reported from traditional guideline-recommended exercise modes. Despite a wealth of emerging new data and endorsement by select governing bodies, IET remains underutilised and is not widely prescribed in clinical practice. This expert-informed review critically examines the role of IET as a potential adjuvant tool in the future clinical management of BP. We explore the efficacy, prescription protocols, evidence quality and certainty, acute cardiovascular stimulus, and physiological mechanisms underpinning its anti-hypertensive effects. We end the review with take-home suggestions regarding the direction of future IET research.

Factors influencing nurse manager retention, intent to stay or leave and turnover: A systematic review update.

To understand factors influencing nurse manager retention or intention to leave, develop a preliminary theoretical model and identify strategies and interventions for workforce planning. Systematic review update of literature with integrated design of mixed research synthesis. We included peer-reviewed articles examining factors influencing retention or intention to leave for front-line, middle or patient care nurse managers. Authors independently screened articles for inclusion and assessed included articles for quality. We adhered to a convergent synthesis approach. Nine databases included MEDLINE, EMBASE, PsychINFO, CINAHL Plus with Full Text, ERIC, Health Source Nursing/Academic Edition, Scopus, ProQuest Dissertations and Theses and LILACS in January 2023. Thirty-five studies published between 1990 and 2022, 22 quantitative and 13 qualitative or mixed methods, were included. 155 factors influencing nurse manager retention, intention to stay, or turnover were reported. Job satisfaction was most frequently examined (n = 7), followed by factors such as empowerment (n = 3), decision-making (n = 3) and resilience (n = 2). We developed a preliminary theoretical model demonstrating staff relations and leadership, organizational and job characteristics, socio-demographics, personal characteristics, well-being and nurse manager relationship with work influence managers' intention to stay or to leave. Nurse managers who were empowered, satisfied with their work, received constructive feedback and found meaning in their roles showed greater intent to stay. Nurse administrators can ensure managers are provided with authority to make decisions that promote autonomy. Work cultures that allow for regular meaningful constructive feedback from staff and leaders may contribute to nurse managers feeling valued. Understanding factors that influence job retention or intention to leave may help nurse managers and their supervisors identify areas for strategy and intervention design to ensure sustainability of this workforce. PRISMA 2020 Guidelines. No patient or public contribution.

Insights into Nimbolide molecular crosstalk and its anticancer properties.

Nimbolide, one of the main ingredients constituent of Azadirachta indica (neem) leaf extract, has garnered attention for its potential as an anticancer agent. Its efficacy against various cancers and chemopreventive action has been demonstrated through numerous in vivo and in vitro studies. This updated review aims to comprehensively explore the chemopreventive and anticancer properties of nimbolide, emphasizing its molecular mechanisms of action and potential therapeutic applications in oncology. The review synthesizes evidence from various studies that examine nimbolide's roles in apoptosis induction, anti-proliferation, cell death, metastasis inhibition, angiogenesis suppression, and modulation of carcinogen-metabolizing enzymes. Nimbolide exhibits multifaceted anticancer activities, including the modulation of multiple cell signaling pathways related to inflammation, invasion, survival, growth, metastasis, and angiogenesis. However, its pharmacological development is still in the early stages, mainly due to limited pharmacokinetic and comprehensive long-term toxicological studies. Nimbolide shows promising anticancer and chemopreventive properties, but there is need for systematic preclinical pharmacokinetic and toxicological research. Such studies are essential for establishing safe dosage ranges for first-in-human clinical trials and further advancing nimbolide's development as a therapeutic agent against various cancers. The review highlights the potential of nimbolide in cancer treatment and underscores the importance of rigorous preclinical evaluation to realize its full therapeutic potential.

Herbs Used to Treat Depression: An Updated Review

Depression is a prevalent mental illness. In addition to being a substantial contribution to the overall global disease burden, depression is one of the main causes of disability worldwide. Complementary therapies are necessary because of the drawbacks of standard antidepressant therapy, including side effects, even though the former can help reduce depression symptoms and avoid relapse of the illness. Because they have fewer side effects and are less expensive than other therapies for depression, herbal medications have drawn a lot of interest recently. Compared to synthetic medications, herbal plants have fewer adverse effects and exhibit antidepressant properties. As such, they may be able to help people who are depressed. Because herbs have fewer adverse effects than conventional drugs, many people prefer them for symptom treatment. If traditional medications aren't working for you because of side effects, poor efficacy, or accessibility issues, using phytomedicine can be a good alternative. This review will concentrate on herbs that are used to cure depression. Keywords: Herbal medicines, Depression, Herb, Treatment, St. John’s Wort

Vitrification of human blastocysts for couples undergoing assisted reproduction: an updated review

Over the past 40 years there has been a worldwide critical change in the field of assisted reproduction technology (ART), leading to the increased application of single blastocyst transfer, which is extremely important to avoid the risks of multiple pregnancy and associated complications for both mother and babies. Indeed, advancements in ART over the last few decades have been obtained thanks to several improvements, including ovarian stimulation, embryo culture conditions and, of course, progress in cryopreservation methods, especially with the application of vitrification. The ability to cryopreserve human embryos has improved significantly with vitrification compared to the initially adopted slow-freezing procedures. Since the introduction of vitrification, it has become the gold standard method to effectively cryopreserve human blastocysts. However, some new protocols are now being explored, such as the short warming procedure and even shorter exposure to the equilibration solution before vitrification, which seem to provide optimal results. Therefore, the main aim of the current narrative review, will be to illustrate the benefit of vitrification as an effective method to cryopreserve the human blastocyst and to illustrate new protocols and variations which in future may increase the performance of vitrification protocols.

Greenspace exposure and associated health outcomes: a systematic review of reviews

Background Numerous systematic reviews and meta-analyses have sought to clarify the relationship between greenspace exposure and health outcomes, but the results are inconsistent. We aimed to synthesise all relevant systematic reviews and meta-analyses on this association. Methods We searched five databases (PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and the Cochrane Database of Systematic Reviews) and conducted a manual reference search for systematic reviews and meta-analyses written in English and published in peer-reviewed journals that used clearly defined measures of greenspace exposure and reported health outcomes directly attributable to greenspace exposure. A total of 36 systematic reviews published between January 2010 and December 2020 were identified for inclusion in this systematic review of reviews (PROSPERO: CRD42021227422). An updated review is underway, and the protocol is published in PROSPERO (CRD42022383421). The methodological quality and risk of bias of included systematic reviews were evaluated using the AMSTAR-2 and ROBIS tools, respectively. Results Beneficial effects of greenspace exposure were observed for all-cause and cardiovascular disease mortality, and mental health and cognitive function. Ambivalent results were found for cardiovascular and metabolic health, general health and quality of life (QOL), and respiratory health and allergies. Most of the systematic reviews included in the current umbrella review had a low to moderate methodological quality and a high risk of bias. Conclusions This umbrella review highlights the link between greenspaces and a variety of health outcomes, emphasising the importance of preserving existing greenspaces and integrating additional vegetation into urban areas to maintain public health.

Limitations and trends on cobalt-free cathode materials development for intermediate-temperature solid oxide fuel cell- an updated technical review

Limitations and trends on cobalt-free cathode materials development for intermediate-temperature solid oxide fuel cell- an updated technical review

Myelin Oligodendrocyte Glycoprotein-Antibody Associated Disease: An Updated Review of the Clinical Spectrum, Pathogenetic Mechanisms and Therapeutic Management

Clinical syndromes associated with antibodies against myelin oligodendrocyte glycoprotein (MOG) are now recognized as a distinct neurological disease entity, and are gaining increasing attention. The pathogenic mechanisms underlying MOG-antibody disease (MOGAD) remain incompletely understood. Case series, facilitated by registries, and observational studies over the past few years have shed increasing light on the clinical aspects and therapeutic approaches of MOGAD. MOGAD may manifest with a variety of clinical syndromes, including acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis, optic neuritis (ON) and transverse myelitis (TM). MOGAD can be either monophasic or relapsing. This review aims to provide a comprehensive updated description of the clinical spectrum, paraclinical features, and prognosis of MOG-antibody disease, as well as summarize its therapeutic considerations. Randomized clinical trials, standardized diagnostic criteria and treatment guidelines are the steps forward.

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update

Idarucizumab is an antibody fragment specific for the immediate reversal of dabigatran anticoagulation effects. The use of idarucizumab is approved for dabigatran-treated patients suffering from life-threatening or uncontrolled bleeding and those in need of urgent surgery or invasive procedures. Data from randomized controlled clinical trials and real-world experience provide reassuring evidence about the efficacy and safety of idarucizmab use in patients with acute stroke. In this narrative review, we summarize the available real-world evidence and discuss the relevance and importance of idarucizumab treatment in acute stroke patients in everyday clinical practice. In addition, we also discuss special issues like prothrombin complex concentrate application as an alternative to idarucizumab, its application before endovascular therapy, sensitivity of thrombi to lysis, and necessary laboratory examinations.

Sustainable Affordable Housing: State-of-the-Art and Future Perspectives

Nowadays, there are many studies with a significant focus on affordable housing. The relevance of this theme, which is usually the central object of public housing policies, requires an updated review of the problems and challenges to be overcome, especially in terms of sustainability, in favor of an improvement in the quality of products delivered to beneficiaries. This research concentrates on applying the sustainability concept to affordable housing, emphasizing technical, social, and governance aspects. A novel classification framework is introduced, encompassing these aspects in the context of sustainability integrated with affordable housing. A systematic literature review is conducted and more than 100 articles are examined based on bibliometric and bibliographic analyses to highlight the main dimensions and topics involved in the housing public policy sphere. The study has been elaborated based on collecting relevant materials, building a descriptive analysis of the literature examined, highlighting the classification structure that categorizes the studies examined, and evaluating the material identified based on the classification structure. The outcomes aim to spotlight the diverse dimensions of sustainable affordable housing and associated research themes. Furthermore, the research outlines deficiencies in current approaches and outlines a future research agenda for implementing sustainability in affordable housing. It establishes a strong connection between technical, social, and governance aspects of affordable housing and sustainability, considering anticipated approaches, techniques, and challenges.

Role of phytochemicals isolated from Cirsium japonicum in neurological disorders

Phytochemicals are richest source of medicines since human history. Cirsium japonicum (Asteraceae), along with other members in the genus are a rich source of flavonoids, polyacetylenes, acetylenes, phenolic acids, phenylpropanoids, sterols, terpenoids and numerous other compounds. Current study aimed to describe an updated review of the literature on the hidden potential of the C. japonicum extracts and its active biological components on neurological disorders. Among various active phytochemicals in C. japonicum includes luteolin, hispidulin, cirsimaritin, acacetin, apigenin, diosmetin, linarin, pectolinarin, and silybin B. Flora of China has been reported around 50 Cirsium species, of which 13 species are reported to be used for treatment of stopping bleedings, removing blood stasis, reducing swelling, treating bleeding syndrome and neurodegenerative disorders like Alzheimer disease (AD). In addition, C. japonicum enhances antioxidant and anticancer activities at cellular level. Moreover, antidepressant potential of ethanol extracts of C. japonicum has also been well described are primarily due to positive modulatory impacts on GABAA receptor (GABAAR) complex. The presence of huge number of active ingredients report in multiple plant species altogether in C. japonicum, appealing for extensive studies for indepth examination of mechanisms and ultimately their usage in clinical trials.

Herbs as Skeletal Muscle Relaxant: An Updated Review

When compared to modern drugs, herbal medicines are usually accepted by doctors and patients for having greater therapeutic efficacy and fewer adverse effects.A diverse class of drugs known as skeletal muscle relaxants is frequently used to treat two distinct underlying disorders: spasticity resulting from upper motor neuron syndromes and muscular pain or spasms resulting from peripheral musculoskeletal problems. Skeletal muscle (SM) controls insulin sensitivity, glucose uptake, and blood glucose homeostasis, all of which are essential for energy and glucose metabolism. A progressive and widespread loss of skeletal muscle mass and strength that results in physical handicap, a low quality of life, and perhaps death is known as sarcopenia. Herbs are a valuable tool for illness prevention. These all have dysregulated skeletal muscle and sarcopenia. These medicinal herbs are being used over recent years. In this Review article we will keep an eye on an updated review on herbs as skeletal muscle relaxant. We will discuss about musculoskeletal disorders, phytochemicals role in disorders. Herbs like aloe barbedensis, curcuma longa, zingiber officinale,citrus aurantium,chamaemelum nobile,hibiscus rosa sinensis etc. will be studied for their role in skeletal muscle relaxation. Keywords: Skeletal muscle relaxant, sarcopenia, herbal medicines, herbs, skeletal muscles, myopathy

Repurposing simvastatin in cancer treatment: an updated review on pharmacological and nanotechnological aspects.

Management of cancer is challenging due to non-targeting and high side effect issues. Drug repurposing is an innovative method for employing medications for other disease therapy in addition to their original use. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor, is a lipid-lowering drug that is being studied for the treatment of cancer in various in vitro and in vivo models. Nanotechnology offers a potential platform for incorporation of drugs with enhanced pharmaceutical (solubility, release characteristics, stability, etc.) and biological characteristics (targeting, pharmacokinetic, pharmacodynamic). Utilizing a variety of resources such as Scopus, Springer, Web of Science, Elsevier, Bentham Science, Taylor & Francis, and PubMed, a thorough literature search was carried out by looking through electronic records published between 2003 and 2024. The keywords used were simvastatin, drug repurposing, anti-cancer simvastatin, pharmaceutical properties of simvastatin, simvastatin nanoformulations, simvastatin patents, clinical trials, etc. Numerous articles were looked for, filtered, checked out, and incorporated. Pure simvastatin has been researched as a repurposed medication for the treatment of cancer in several in vitro and in vivo models, such as carcinoma of the lung, colon, liver, prostate, breast, and skin. Simvastatin also incorporated into different nanocarriers (nanosuspensions, microparticles/nanoparticles, liposomes, and nanostructured lipid carriers) and showed improvement in solubility, bioavailability, drug loading, release kinetics, and targeting. Clinical trial and patent reports suggest potential of simvastatin in cancer therapy. The preclinical studies of pure simvastatin in in vitro and in vivo models showed the potential for its ability to inhibit cancer cell growth and further incorporation into nanoformulations strengthened its preclinical and pharmaceutical characteristics.

Examining the Intersection of Sociopolitical Development and Transformative Social and Emotional Learning Outcomes: An Integrated Approach in Youth Participatory Action Research

Young people need opportunities that support their well-being while enabling them to take meaningful action. There has been strong interest in youth participatory action research (YPAR) as a form of sociopolitical action for marginalized youth seeking to address inequities that undermine individual and community well-being. The rapid growth of the YPAR literature in the last decade has involved studies analyzing the impact of YPAR on dimensions of youth empowerment, sociopolitical development (SPD), and well-being. The relatively new framework of Transformative Social Emotional Learning (tSEL) is potentially fruitful in identifying relevant constructs, skills, and strategies to support well-being during the YPAR process. This article seeks to advance our integrative conceptualization and analysis of the impact of YPAR by (1) considering the overlapping and unique dimensions of SPD and tSEL: agency, belonging, collaborative problem solving, curiosity, identity, societal involvement, and worldview and social analysis; and (2) applying this integrative lens to the analysis of novel data from an updated systematic review of U.S. and international YPAR studies (2015–2022). We summarize youth outcomes reported in 25 studies to assess the evidence for YPAR as an approach for promoting youth SPD and tSEL outcomes, identifying limitations and next steps for advancing our understanding of these impacts.

The prevalence of chronic pain in children and adolescents: a systematic review update and meta-analysis.

Chronic pain, defined as persistent or recurring pain or pain lasting longer than 3 months, is a common childhood problem. The objective of this study was to conduct an updated systematic review and meta-analysis on the prevalence of chronic pain (ie, overall, headache, abdominal pain, back pain, musculoskeletal pain, multisite/general pain, and other) in children and adolescents. EMBASE, PubMed, CINAHL, and PsycINFO were searched for publications between January 1, 2009, and June 30, 2023. Studies reporting population-based estimates of chronic nondisease related pain prevalence in children or adolescents (age ≤ 19 years) were included. Two independent reviewers screened articles based on a priori protocol. One hundred nineteen studies with a total of 1,043,878 children (52.0% female, mean age 13.4 years [SD 2.4]) were included. Seventy different countries were represented, with the highest number of data points of prevalence estimates coming from Finland and Germany (n = 19 each, 4.3%). The overall prevalence of chronic pain in children and adolescents was 20.8%, with the highest prevalence for headache and musculoskeletal pain (25.7%). Overall, and for all types of pain except for back pain and musculoskeletal pain, there were significant differences in the prevalence between boys and girls, with girls having a higher prevalence of pain. There was high heterogeneity (I 2 99.9%). Overall risk of bias was low to moderate. In summary, approximately 1 in 5 children and adolescents experience chronic pain and prevalence varies by pain type; for most types, there is higher pain prevalence among girls than among boys. Findings echo and expand upon the systematic review conducted in 2011.