Review Of Current Results Research Articles

Leibniz algebras: a brief review of current results

Let $L$ be an algebra over a field $F$ with the binary operations $+$ and $[\cdot,\cdot]$. Then $L$ is called a left Leibniz algebra if it satisfies the left Leibniz identity $[[a,b],c]=[a,[b,c]]-[b,[a, c]]$ for all $a,b,c\in L$. This paper is a brief review of some current results, which related to finite-dimensional and infinite-dimensional Leibniz algebras.

HIV pre‐exposure prophylaxis for people who inject drugs: a review of current results and an agenda for future research

IntroductionStudies examining the use of pre-exposure prophylaxis (PrEP) to prevent HIV transmission among people who inject drugs (PWIDs) have not been adequately summarized. Recently, the Bangkok Tenofovir Study has shown that PrEP may be effective at reducing new HIV infections among this high-risk group. This randomized controlled trial was the first study to specifically examine the efficacy of PrEP among PWIDs. In this review, we present the current state of evidence regarding the use of PrEP to prevent HIV infection in PWID populations, and set an agenda for future research to inform the most effective implementation of PrEP in the context of existing evidence-based HIV prevention strategies.DiscussionDespite positive trial results confirming that PrEP may prevent HIV transmission among PWIDs, there remain many questions regarding the interpretation of these results, as well as obstacles to the implementation of PrEP regimens within highly diverse drug-using communities. Aside from the Bangkok Tenofovir Study, we identified only one other published study that has collected empirical data to inform the use of PrEP among PWIDs. The large gap in research regarding the use and implementation of PrEP for PWIDs signals the need for further research and attention.ConclusionsWe recommend that future research efforts focus on elucidating the generalizability of the Bangkok Tenofovir Study results in other injection drug–using populations, examining the willingness of PWIDs to use PrEP in diverse contexts, identifying barriers to adherence to PrEP regimens and determining the most effective ways to implement PrEP programmes within the context of existing evidence-based prevention strategies, including opioid substitution therapy and needle and syringe distribution programmes.

Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

Transarterial chemoembolization (TACE) involves the emulsification of a chemotherapeutic agent in a viscous drug carrier, delivered intra-arterially to liver tumor for maximum effect. TACE reduces arterial inflow, diminishes washout of the chemotherapeutic agent, and decreases systemic exposure. Despite evidence of some clinical success with TACE, a new type of microspheres with drug-eluting capabilities may offer a precisely controlled and sustainable release of the chemotherapeutic agent into the tumor bed. In animal trials tumor necrosis (approaching 100%) was greatest at 7 days, with significantly lower plasma concentrations of doxorubicin than in control animals treated with doxorubicin intra-arterially. Clinically, drug-eluting microspheres loaded with doxorubicin, either at 75 mg/m(2) or at a fixed dose of 150 mg, were used recently and no severe disorders of the hepatic function were observed postprocedure, while a substantial reduction of the fetoprotein levels occurred. An interim analysis of the first 15 patients from the Hong Kong group at 3 months showed an objective response rate of 61.54% and 53.84% according to EASL criteria and RECIST criteria, respectively, and a survival rate of 93.3%. In this paper we present how to use microspheres loaded with doxorubicin and review their clinical value and preliminary performance for treatment of unresectable liver cancer.

Prognostic value of deoxyribonucleic acid content in prostate cancer: a review of current results.

A total of 115 articles on prostate cancer were reviewed for data on the prognostic value of DNA content in the tumor cells. In 44 series, data pertinent to this review were found. There was no consensus in the literature with respect to methods of analysis of DNA content or definitions of subclasses of DNA content such as categories of ploidy. The DNA content of prostate cancer cells was strongly related to tumor grade and stage. When analyzed as a single parameter in univariate analyses, the DNA content had a prognostic value with respect to overall or disease-specific survival. In multivariate analyses the additional prognostic value of the DNA content was less convincing when analysed with tumor grade and stage. The prognostic data from univariate and multivariate analyses available in the literature were mainly derived from patients with advanced disease and data on localized, potentially curable disease were scanty and conflicting.

The Archaean gneiss complex of northern Labrador A review of current results, ideas and problems

1. The early Archaean rocks in northern Labrador can be subdivided into the ea. 3.78 Ga Nulliak supracrus­tal association, the migmatitic Uivak I gneisses, the dominant phase of which was emplaced at ea. 3.73 Ga, and the Uivak II augen gneiss. Inherited low-U rounded inclusions within igneous zircons in the Uivak I gneisses have ages between 3.73 and 3.86 Ga and are more likely to have been derived from a pre-existing high-grade metamorphic gneiss complex than from the Nulliak association. In the early Archaean there were probably several rapid cycles of sedimentary deposition and volcanism followed by emplacement of major plutons. Mid Archaean gneisses are more abundant in northern Labrador than previously realised. The late Archaean metamorphic history of these gneisses is different from the history of the early Archaean gneisses. Whereas an important part of the mid Archaean suite was emplaced in granulite facies and retrogressed at the time of granitoid veining at ea. 2.99 Ga, the major part of the early Archaean rocks were reworked under granulite facies conditions in a sequence of closely spaced events between 2. 7 and 2.8 Ga. The two groups of gneisses had different metamorphic histories until ea. 2.7 Ga, but late and post-tectonic granites of 2.5- 2. 7 Ga age cut across both. It is suggested that the terrane model in southern West Greenland can be extended to Labrador and that tectonic intercalation of early and mid Archaean gneisses took place around 2.7 Ga. Correlation between the Maggo gneisses around Hopedale, mid Archaean gneisses in northernmost Labrador and gneisses from the Akia terrane in West Greenland is suggested. Like the Malene supracrustals in West Greenland the Upernavik supracrustals in Labrador are composite associations, the youngest of which are thought to have been deposited around 2. 7 Ga.