Review Article Research Articles

Introduction of Honeycomb (Nidus Vespae) and Some of Its Most Important Pharmacological Benefits

Background:: Nidus Vespae (honeycomb), which is a well-known traditional Chinese medicine, is the honey-comb of Polistes japonicus Saussure, Parapolybia varia Fabricius, or Polistes olivaceus (De Geer), and it is usually harvest in winter and autumn. Methods: Its chemical component is completely complex combining honey, pollen, royal jelly, and propolis and consequently has a significant number of bioactive components such as nitro compounds, flavonoids, and polyphenols. It has shown various pharmacological impacts, such as anti-inflammatory, anti-viral, anti-microbial, and anti-tumor effects. Results: In this review article, all relevant papers from various scholars and researchers were searched in Science Direct, Google Scholar, PubMed, and Scopus. Honeycomb has various activities and numerous pharmacological benefits and health advantages, and it can be considered a valuable source of nutraceuticals, and an effective natural medicine and organic product. Conclusion:: In this mini-review, we have decided to discuss the importance of traditional treatment, and the pharmacological properties of Nidus Vespae

RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment.

Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.

Point Cloud Completion: A Survey.

Point cloud completion is the task of producing a complete 3D shape given an input of a partial point cloud. It has become a vital process in 3D computer graphics, vision and applications such as autonomous driving, robotics, and augmented reality. These applications often rely on the presence of a complete 3D representation of the environment. Over the past few years, many completion algorithms have been proposed and a substantial amount of research has been carried out. However, there are not many in-depth surveys that summarise the research progress in such a way that allows users to make an informed choice of what algorithms to employ given the type of data they have, the end result they want, the challenges they may face and the possible strategies they could use. In this study, we present a comprehensive survey and classification of articles on point cloud completion untill August 2023 based on the strategies, techniques, inputs, outputs, and network architectures. We will also cover datasets, evaluation methods, and application areas in point cloud completion. Finally, we discuss challenges faced by the research community and future research directions.

Herbal Medicinal Nanoformulations for Psoriasis Treatment: Current State of Knowledge and Future Directions

Background: Psoriasis is a persistent immune system disorder that influences the skin, leading to red, flaky patches that can be painful and irritated. Objective: Traditional treatments for psoriasis, such as topical creams and oral medications, may be effective but also have potential side effects. Herbal remedies have been used for centuries to treat skin conditions, and advancements in nanotechnology have led to the development of herbal nanoformulations that offer several advantages over traditional herbal remedies, such as efficacy, safety, and targeted delivery. Methods: The studies and reviews published under the title were looked up in several databases (including PubMed, Elsevier, and Google Scholar). Results: Several herbal nanoformulations, including those containing curcumin, aloe vera, and neem, have been shown to exhibit anti-inflammatory and immunomodulatory impacts, which will be useful within the treatment of psoriasis. However, more study is required to decide the efficacy and safety of these details, as well as the optimal dosing, duration of treatment, and potential side effects. Conclusion: Overall, herbal nanoformulations represent a promising area of research for the treatment of psoriasis, and may offer a safe and effective alternative or adjunct therapy to conventional treatments. This review article summarizes the present state of information for the herbal nanoformulations role in the treatment of psoriasis and their future perspectives.

Nanoparticle-based Gene Therapy for Neurodegenerative Disorders.

Neurological disorders present a formidable challenge in modern medicine due to the intricate obstacles set for the brain and the multipart nature of genetic interventions. This review article delves into the promising realm of nanoparticle-based gene therapy as an innovative approach to addressing the intricacies of neurological disorders. Nanoparticles (NPs) provide a multipurpose podium for the conveyance of therapeutic genes, offering unique properties such as precise targeting, enhanced stability, and the potential to bypass blood-brain barrier (BBB) restrictions. This comprehensive exploration reviews the current state of nanoparticle-mediated gene therapy in neurological disorders, highlighting recent advancements and breakthroughs. The discussion encompasses the synthesis of nanoparticles from various materials and their conjugation to therapeutic genes, emphasizing the flexibility in design that contributes to specific tissue targeting. The abstract also addresses the low immunogenicity of these nanoparticles and their stability in circulation, critical factors for successful gene delivery. While the potential of NP-based gene therapy for neurological disorders is vast, challenges and gaps in knowledge persist. The lack of extensive clinical trials leaves questions about safety and potential side effects unanswered. Therefore, this abstract emphasizes the need for further research to validate the therapeutic applications of NP-mediated gene therapy and to address nanosafety concerns. In conclusion, nanoparticle-based gene therapy emerges as a promising avenue in the pursuit of effective treatments for neurological disorders. This abstract advocates for continued research efforts to bridge existing knowledge gaps, unlocking the full potential of this innovative approach and paving the way for transformative solutions in the realm of neurological health.

Postoperative pain management after abdominal transplantations.

The aim of this review article is to present current recommendations as well as knowledge gaps and controversies pertaining to commonly utilized postoperative pain management after solid organ transplantation in the abdominal cavity. Postsurgical pain has been identified as one of the major challenges in recovery and treatment after solid organ transplants. Many perioperative interventions and management strategies are available for reducing and managing postoperative pain. Management should be tailored to the individual needs, taking an interdisciplinary and holistic approach and following enhanced recovery after surgery guidelines. Many centers currently utilize peripheral and neuraxial blocks during transplantation surgery, but these techniques are far from standardized practices. The utilization of these procedures is often dependent on transplantation centers' historical methods and perioperative cultures. The optimal pain management regimen has not yet been definitively established, and current scientific evidence does not yet support the endorsement of a certain analgesic approach. This objective necessitates the need for high-quality randomized controlled trials.

Air Pollution and Rheumatoid Arthritis Risk and Progression: Implications for the Mucosal Origins Hypothesis and Climate Change for RA Pathogenesis.

The goal of this review paper is to summarize the main research and findings regarding air pollution and its association with the risk and progression of rheumatoid arthritis (RA). The most studied components of air pollution included particulate matter of ≤ 2.5 microns in diameter (PM2.5), PM10, carbon monoxide (CO), nitrogen dioxide (NO2), nitric oxide (NOx), sulfur dioxide (SO2), and ozone (O3). In addition, specific occupations and occupational inhalants have been investigated for RA risk. Several studies showed that increased exposure to air pollutants increased the risk of developing RA, particularly seropositive RA. There was evidence of gene-inhalant interactions for seropositive RA risk. Fewer studies have been conducted on RA disease activity and bone erosions. Some studies suggest that patients with RA-associated interstitial lung disease may have worse outcomes if exposed to air pollution. We summarized associations between air pollution and increased RA risk, including RA-associated interstitial lung disease. Relatively few studies investigated air pollution and RA disease activity or other outcomes. These results suggest an important role of air pollution for seropositive RA development and suggest that climate change could be a driver in increasing RA incidence as air pollution increases.

Exploring the Potential of High Entropy Alloys: A Comprehensive Review on Microstructure, Properties and Applications: Part I

Over the past few years, there has been a notable surge in research interest surrounding high entropy alloys (HEAs) owing to their exceptional properties. Unlike conventional alloys, HEAs consist of five or more principal elements, which offer endless possibilities for developing new alloy systems. HEAs exhibit a high concentration of mixing elements, resulting in high disorderliness of the atomic structure within the material, known as high entropy. This unique nature provides HEAs with desirable properties, including excellent mechanical and physical properties at elevated temperatures, making them ideal for high-temperature applications like cryogenic engines and gas turbines. Moreover, HEAs have shown remarkable corrosion resistance, positioning them as viable options for applications in demanding environments such as marine settings, oil and gas pipelines and chemical processing plants. This comprehensive review paper analyses recent studies on various HEAs. Part I introduces HEAs and describes their synthesis, microstructure, hardness and strength properties.

Multi-functional Acyl Urea Compounds: A Review on Related Patents, Clinical Trials, and Synthetic Approaches

: Acyl ureas are a well-known class of organic compounds that have drawn a lot of attention recently because of their array of chemical properties and possible multi-use in medicine. The article summarizes the synthetic procedures used to produce various Acyl urea synthons and includes instances of clinical trials, patents, and commercialized medications having Acyl urea and N-acyl urea moiety. This extensive study examines and summarizes research on acyl urea derivatives conducted over the last 20 years from a variety of sources, including PubMed, Google Scholar, and Google Websites. When it comes to the discovery of new chemicals, urea derivatives still require attention compared to other acyl compounds. This review paper aims to provide a comprehensive overview of the various synthetic approaches utilized in the design of an array of acyl ureas to accomplish the same goal. This work summarizes information related to several heteroatom-fused acyl urea compounds, which fortunately will be a very useful resource for chemists and scientists who are interested in acyl urea synthesis and its applications in chemistry.

An Assessment of the Evolution of Executive Functions

Cognitive evolution, as the core subject of fields like paleoanthropology, cognitive archeology, and neuropsychology, has begun to gain more interest in psychology in recent years. Executive functions are viewed from the perspective of cognitive evolution as basic advancements that are crucial to the evolution of language and contemporary cognition. As a metaphor, executive functions refer to advanced cognitive processes (working memory, inhibition, organization, cognitive flexibility, etc.) in the context of complex goal-directed behaviors. Sophisticated cognitive traits like executive functions emerged because of solutions to adaptive issues (survival, reproduction, and social group life) that human ancestors confronted over millions of years and passed them on to their offspring. Although it is accepted that Homo sapiens owes its evolutionary success to Paleolithic living conditions, explaining this process has not always been easy. In this review article, general information about executive functions is presented, followed by a review of scientific explanations about the evolution of executive functions. Evaluations have shown that these alternative scientific explanations based on archaeological, anthropological, and neuropsychological evidence for the evolutionary origins of executive functions do not fit all the pieces of the puzzle. It is believed that novel research models will clarify which of these alternative explanations are proximate causes and which are ultimate causes.

Digital health in your hands: A narrative review of exploring Ayushman Bharat's digital revolution

Background: “The Ayushman Bharat Digital Mission (ABDM)” is a revolutionary initiative started in India in September 2021 that aims to digitalize the country's healthcare industry. Initiatives like Ayushman Bharat Digital Mission, CoWIN App, Aarogya Setu, e-Sanjeevani, and e-Hospital provide healthcare services and facilities that reach every corner of India. This narrative review focuses on the mission's goals, objectives, innovations, significant features, progress, and worldwide scenery for digital health practices—India's healthcare scene by delivering universal health coverage and improving health outcomes. The assessment finds that ABDM is an important step toward a digitalized healthcare system that requires attention and assistance to overcome obstacles and reach its full potential. Methods: The research utilized various databases including Research Gate, PubMed, Google Scholar, and government portals to conduct a comprehensive literature review. This review article provides a critical analysis and offers essential suggestions, ideas, and recommendations for the effective and rapid implementation of the Ayushman Bharat Program. Furthermore, it includes information about the program's ability to transform India's healthcare sector and achieve universal health coverage. Conclusion: The revolutionary Ayushman Bharat Digital Mission (ABDM) aims to digitalize India's healthcare industry. It has made major achievements in improving healthcare access, increasing system effectiveness, improving care quality, and promoting teamwork amongst stakeholders in the healthcare system. By implementing strong data privacy and security protocols and developing infrastructure for India's diverse population, ABDM can play a key role in achieving national health coverage and improving health outcomes. ABDM may be vital in attaining national health coverage and greatly enhancing health outcomes with persistent work and strategic assistance.

Radiation therapy systems using linear accelerator, importance of its components and their development

Given the importance of devices used in the field of medicine in terms of diagnosis and treatment, and the great importance of this topic in accelerating early diagnosis and saving the lives of the largest possible number of people, we decided to study one of these devices to better define its components and review some of the difficulties. Many linear accelerators for hybrid magnetic resonance imaging have been developed as a result of the need to profit from directed images of tissues and various body sections during radiation therapy (linear accelerators). There are now a number of linear accelerators for magnetic resonance imaging that cover both low and high magnetic field strengths as well as two directions of the beam field; these systems have the potential to be beneficial. This technology has only recently been used in clinical trials. However, its continued usage as a routine radiation therapy procedure is certain. The majority of the key elements and difficulties encountered in the creation of such technology as well as its present state are outlined in this review article.

Impact of Calcium Aluminate Based Cement and Ceramic Waste Aggregate on the Strength Aspect of Concrete

A new race of development has been launched as quickly as possible in many countries and nations in this modern globe and era of development, but it has been noted that all of them are encountering a variety of issues in reaching their objective. Their development has been reported to be hindered by a lack of resources, and among the issues they encounter are the absence and scarcity of a variety of high-quality, environmentally friendly building materials. The lack of building materials is one of the main issues that these developing countries are dealing with. This review paper goes into great detail about the issue at hand and makes some recommendations based on a number of earlier research findings. The major materials discussed are both waste material and those with very good constructional properties.

The Impact of Educational Technologies on Modern Education: Navigating Opportunities and Challenges

The integration of technology into modern education has profoundly transformed traditional learning environments and offered unprecedented opportunities. This review article explores the multifaceted impact of technology on education, focusing on its role in enhancing access to information, personalizing learning experiences, and fostering collaboration among students and educators. Technological advancements, such as online learning platforms, educational software, and digital resources, have democratized education, making it accessible to a broader audience. However, challenges such as the digital divide, data privacy concerns, and potential exacerbation of educational inequalities persist. The article also examines shifts in pedagogical approaches, particularly the adoption of blended and hybrid learning models, and their implications for teacher-student interactions and curriculum development. By reviewing existing literature and case studies, this article provides a balanced overview of how technology is reshaping education and emphasizes the need for thoughtful integration and equitable access to ensure all students benefit from these advancements.

Conceptual framework for enhancing front-end web performance: Strategies and best practices

This review paper presents a conceptual framework for optimizing front-end web performance, emphasizing the critical strategies of code splitting, lazy loading, caching, and other optimization techniques such as minification and image optimization. The paper explores the importance of front-end performance in enhancing user experience, reducing load times, and increasing user engagement, which is vital for driving the digital economy forward. Through a detailed analysis of key performance metrics and the challenges in optimizing front-end performance, the paper underscores how integrating multiple strategies can lead to comprehensive optimization. The discussion includes practical guidelines for prioritizing and implementing these strategies based on specific project needs, ensuring a holistic approach to performance. Furthermore, the paper examines the economic impact of optimized front-end performance, showcasing real-world examples and future trends, such as progressive web apps and machine learning, shaping the next generation of web development.

Cortisol Stress Hormones as a Psychobiological Mechanism in Coronary Artery Disease: A Critical Review

Coronary artery disease (CAD) is the most common type of heart disease and affects the lives of 1 in 20 adults. CAD-associated healthcare costs are estimated to exceed $200 Billion annually in the United States alone. Psychosocial stress, mental distress, depression, and fatigue are all linked to CAD. While the underlying mechanisms are not fully understood, the involvement of cortisol in inflammation in the pathophysiological process in CAD has been demonstrated. The literature has documented some modifiable risk factors for CAD, such as diet and exercise; however, the scope of information on stress as a modifiable risk factor is limited. This critical review paper analyzed four empirical studies published between 2019 and 2023, all of which reviewed the role of cortisol stress hormones in CAD. The results of all four studies revealed that cortisol levels are associated with CAD, though the direction and magnitude of the relationship varied between studies. An overview of each study is provided, including a review of the methodology used, a summary of the main findings, and a discussion of limitations.

Effectiveness of social engineering awareness training in mitigating spear phishing risks in financial institutions from a cybersecurity perspective

Spear phishing remains a critical cybersecurity threat to financial institutions, where attackers exploit human vulnerabilities to breach sensitive systems. This review paper explores the effectiveness of social engineering awareness training programs in reducing spear phishing risks within the financial sector from a cybersecurity perspective. By analyzing existing research, the paper assesses various training approaches, focusing on elements such as content relevance, delivery methods, and employee engagement. The review highlights how targeted awareness programs can enhance employees' ability to recognize and respond to phishing attempts, thereby strengthening overall cybersecurity defenses. The findings emphasize the importance of continuous, specialized training in fostering a proactive security culture and offer recommendations for optimizing awareness strategies to bolster cybersecurity resilience in financial institutions.

Assessing the influence of dietary patterns on preeclampsia and obesity among pregnant women in the United States

This review paper examines the influence of dietary patterns on preeclampsia and obesity among pregnant women in the United States, aiming to elucidate the connection between nutrition and maternal health outcomes. The paper explores common dietary patterns, their impact on pregnancy complications, and the potential mechanisms through which nutrition affects maternal and fetal health. By synthesizing existing research, the review highlights the critical role of personalized dietary counseling and lifestyle interventions in improving pregnancy outcomes. It also emphasizes the need for comprehensive policy initiatives and future research directions to enhance maternal health through optimal nutrition and lifestyle modifications. Through a detailed analysis, the review underscores the importance of adopting healthy dietary patterns to mitigate risks and promote positive health outcomes for both mothers and their children.

The impact of workforce analytics on HR strategies for customer service excellence

This review paper explores the transformative role of workforce analytics in enhancing human resources (HR) strategies to achieve customer service excellence. By examining employee performance and customer satisfaction, the paper highlights how data-driven insights can inform HR strategies, including identifying skills gaps, developing targeted training programs, and aligning workforce management with customer service goals. The paper also addresses the challenges organizations face in implementing workforce analytics, such as data quality, analytical skills gaps, and resistance to change. Furthermore, it considers the future of workforce analytics in HR, emphasizing the integration of advanced technologies like artificial intelligence and the importance of ethical considerations. The paper concludes with practical recommendations for organizations looking to adopt workforce analytics, ensuring they can fully leverage its potential to drive employee engagement and customer satisfaction.

Global Impact of New Media in Public Relations: A Review

The present study examines new media platforms and public relations from different journals related to Public Relations and articles from Google Scholar. The initial sample consisted of 23 articles, of which 15 met the criteria and were analyzed. The study's findings show that the current research is in the exploratory phase with both quantitative and qualitative studies which explores the dominance of the use of technology by practitioners. The study suggests that public relations practitioners use technology to sustain a positive relationship with their audience. Furthermore, this review paper compiles major findings from previous research to improve overall awareness of current and future problems that new media particularly social media pose to public relations. It's not clear if present theoretical frameworks can effectively incorporate the new media, and data proposes that many public relations professionals are grappling with the influence of new media, specifically, the Internet at their workplaces.