Reversible Hydrogel Research Articles

Phase-changing NIPAM-AM/ATO hydrogels for thermochromic smart windows with highly adaptive solar modulation

Improving the solar regulation and reducing the response temperature of thermochromic smart windows are pivotal importance for energy-saving buildings. However, these two strategies are challenging to be integrated into one window. Herein, a novel composite hydrogel based on N-isopropylacrylamide (NIPAM) doped with antimony-doped tin oxide (ATO) nanoparticles and acrylamide (AM) was developed for producing a high-performance smart window, which successfully achieved enhanced solar energy regulation and reduced response temperature. This smart window was fabricated by combining a reversible thermoresponsive hydrogel (TAH) that acted as a thermochromic material with a ATO multilayer film that performed as a transparent heater. The as-prepared smart window could modulate solar light over a range from ultraviolet (UV) to infrared (IR) radiation and achieved active responses to high-temperature weather. The smart window showed high luminous transmittance (Tlum, 82.92 %) together with an excellent solar modulation performance (ΔTlum = 73.31 %, ΔTIR = 38.26 %, and ΔTsol = 60.74 %), and a lower critical solution temperature of 32 °C. Even after 120 high- and low-temperature cyclic durability tests, the smart windows still exhibited a high solar modulation capability. In outdoor demonstrations, the as-prepared smart window exhibited a promising temperature regulation ability under strong solar irradiation. Therefore, the present universal modification framework provided some insights for the future design of energy-saving windows.

Anti-inflammatory dressing based on hyaluronic acid and hydroxyethyl starch for wound healing

Eliminating persistent inflammation and choosing dressings that provide the best healing environment is key to promoting wound healing. Dynamic and reversible hydrogels have attracted much attention because of their capacity to adapt to irregular wound surfaces. Herein, oxidized hydroxyethyl starch (OHES) and hyaluronic acid (HA-ADH) were crosslinked via the dynamic acylhydrazone bond to form an anti-inflammatory function hydrogel (HA-ADH/OHES@XT) that could release xanthatin (XT) slowly. The HA-ADH/OHES hydrogels showed an appropriate gelation time, notable water-retaining capacity, self-healing, suitable biodegradability, and good biocompatibility for wound healing applications. In vivo experiments demonstrated that HA-ADH/OHES@XT hydrogels promoted tissue regeneration and wound healing at a rate of approximately 89.1 % on day 20 by reducing inflammation, increasing collagen deposition, and promoting re-epithelialization, indicating their great potential as a wound dressing.

A rewritable and shape memory hydrogel doped with fluorescein-functionalized ZIF-8 for information storage and fluorescent anti-counterfeiting

The emergence of stimuli-responsive fluorescence anti-counterfeiting technology has garnered increasing attention in the era of intelligent internet. Smart fluorescent hydrogels combine the characteristics of luminous materials with the unique structure of hydrogels, offering the potential for dynamic reversible erasing and multi-tiered data encryption. In this work, a fluorescent hydrogel was constructed by zeolitic imidazolate framework-8 loaded with fluorescein and then mixed with polyvinyl alcohol hydrogel, sodium carboxymethyl cellulose and borax, which could be used for image hiding in visible light. The reversible bonds cross-linked fluorescent hydrogel was stretchable and self-healing with a three-dimensional network structure. The hydrogel presented bright green fluorescence under 365 nm UV light, which was quenched by adding copper ions. Meanwhile, the imprint of the hydrogel could be cleared by L-Cysteine and repeatedly recorded information many times. The alkali-induced shape memory capability was further utilized to achieve multi-tiered data encryption by deforming it to a 3D-specific shape through splicing or folding. The rewritable and multi-dimensional encrypted hydrogel is expected to improve data security and reduce resource consumption.

Development and Geometrical Considerations of Unique Conductive and Reversible Carbon-Nanotube Hydrogel without Need for Gelators.

We propose a new type of CNT hydrogel that has unique conductive and reversible characteristics. We found in previous studies that CNT dispersions became gelatinous without any gelators when a specific CNT was combined with a specific dispersant. This hydrogel has conductive properties derived mainly from the CNTs it contains; and even after gelation, it can be returned to a liquid state by ultrasonic irradiation. Furthermore, the liquid is gelable again. In this study, we prepared several types of CNTs and several types of dispersants, experimentally verified the possibility of gelation by combining them, and geometrically investigated the gelation mechanism to determine how this unique hydrogel is formed. As a result, we found that the experimental results and the theory examined in this study were consistent with the combination of materials that actually become hydrogels. We expect that this study will allow us to anticipate whether or not an unknown combination of CNTs and dispersants will also become gelatinous.

The effects of bioactive glass hydrogel coated with hyaluronic acid-Pluronic F-127 conjugates containing silver nanoparticles for accelerating of infected wounds healing

Antimicrobial resistance has forced researchers to produce new dressings for the treatment of infected wounds. Tissue engineering based on biomaterials is used to accelerate the wound healing process. The purpose of this study was to examine the effects of bioactive glass (BG) hydrogel coated with hyaluronic acid (HA)-Pluronic F-127 (PLF-127) conjugates containing silver nanoparticles (AgNPs) for healing the infected wounds. HA/BG, PL&HA/BG and PL&HA/BG-AgNPs formulations were designed and their properties were evaluated for application in the wound healing process. Safety and antibacterial properties of formulations were also evaluated. These were applied for the treatment of infected wounds and their efficiencies were assessed by measuring wound contraction, total bacterial count, pathological parameters and the expression of positive cells of cyclin-D1, c-Myc, WNT-1, B-Catenin, and COL-1A. The synthesized thermally reversible hydrogels demonstrated sol-gel transition, indicating the gels’ potential as injectable hydrogels. These exhibited antibacterial properties and safety. The PL&HA/BG-AgNPs, PL&HA/BG and HA/BG hydrogels showed greatest wound healing activities, respectively and could compete with Polysporin® due to their effects on total bacterial count and modulation in increasing the expressions of B-Catenin, COL-1A, cyclin-D1 and c-Myc. In sum, PL&HA/BG-AgNP hydrogels are good candidate for accelerating the wound healing process and as alternatives for antibiotics in the treatment of infected wounds.

Enhanced Stability-Based Hydroxymethyl Cellulose/Polyacrylamide Interpenetrating Dual Network Hydrogel Electrolyte for Flexible Yarn Zinc-Ion Batteries

As the field of wearable electronics continues to boom, the demand for flexible energy storage devices continues to grow. However, the development of soft energy supply devices with excellent stability is still a challenging task. Traditional hydrogel electrolytes are prone to mechanical deformation, which makes it difficult to maintain the functional stability of flexible yarn due to its short battery life and low wear resistance. Here, we developed a reversible energy-dissipating dual-network hydrogel electrolyte. The hydroxymethyl cellulose (CMC)/polyacrylamide (PAM) hydrogel electrolyte has a tensile deformation of 2700% and a high ionic conductivity of 6.37 × 10−2 S cm−1. The specific capacity of the assembled CMC/PAM-based yarn cell was 170 μAh cm−1 at 1 mA cm−1 and 73.14% after 100 cycles. The excellent performance is attributed to the crosslinked double network structure, in which the introduction of carboxyl groups is conducive to the improvement of hydrophilicity and ionic conductivity. The hydrogen bond and reversible CMC macromolecular chain can be restored after stress relief, which greatly improves the toughness of the material. Even under different bending angles and repeated bending conditions, zinc yarn batteries still have outstanding mechanical properties and cycle stability (71.28% specific capacity after 100 cycles), showing broad application prospects in wearable smart textiles.

A wearable microneedle patch incorporating reversible FRET-based hydrogel sensors for continuous glucose monitoring

Continuous glucose monitors are crucial for diabetes management, but invasive sampling, signal drift and frequent calibrations restrict their widespread usage. Microneedle sensors are emerging as a minimally-invasive platform for real-time monitoring of clinical parameters in interstitial fluid. Herein, a painless and flexible microneedle sensing patch is constructed by a mechanically-strong microneedle base and a thin layer of fluorescent hydrogel sensor for on-site, accurate, and continuous glucose monitoring. The Förster resonance energy transfer (FRET)-based hydrogel sensors are fabricated by facile photopolymerizations of acryloylated FRET pairs and glucose-specific phenylboronic acid. The optimized hydrogel sensor enables quantification of glucose with reversibility, high selectivity, and signal stability against photobleaching. Poly (ethylene glycol diacrylate)-co-polyacrylamide hydrogel is utilized as the microneedle base, facilitating effective skin piercing and biofluid extraction. The integrated microneedle sensor patch displays a sensitivity of 0.029 mM−1 in the (patho)physiological range, a low detection limit of 0.193 mM, and a response time of 7.7 min in human serum. Hypoglycemia, euglycemia and hyperglycemia are continuously monitored over 6 h simulated meal and rest activities in a porcine skin model. This microneedle sensor with high transdermal analytical performance offers a powerful tool for continuous diabetes monitoring at point-of-care settings.

3D printed micro-structured hydrogel device with transmittance-changeable soft ‘armor’ camouflage for dual-encryption

Hydrogel-based physical dual-encryption typically relies on the reversible shape-deformation of polymer chains for the decryption. However, the stored information is confronted by indecipherability at the microscale because the intrinsic relaxation of polymer chains would disrupt the fidelity of encoded information. Inspired by female Doryteuthis opalescens squid’s camouflage strategy (i.e., switching a stripe on its mantle from nearly transparent to opaque white), we devised a reversible transmittance-changeable hydrogel layer to fully cover the mono-encrypted information layer for dual-encryption. The micro-structured hydrogel was manufactured via 3D printing to encode the information, which can be decoded by UV-induced fluorescent emission. Then, the white camouflage hydrogel was constructed to conceal the mono-encrypted layer, which will not affect the information encoding layer during the reversible polymer chain mobility. The information can be decoded with alkaline solution and UV irradiation in a rapid speed, i.e., in 4 min, with good reusability. Moreover, the information was accurately unveiled even at microscale resolution, holding great promise for high-level encryption at the device level.

Strong and Thermo-Switchable Gel Adhesion Based on UCST-Type Phase Transition in Deep Eutectic Solvent.

It remains a great challenge to achieve strong and reversible hydrogel adhesion. Hydrogel adhesives also suffer from poor environmental stability due to dehydration. To overcome these problems, here reversible adhesive gels are designed using a new switching mechanism and new solvent. For the first time, the study observes UCST (upper critical solution temperature)-type thermosensitive behaviors of poly(benzyl acrylate) (PBnA) polymer and gel in menthol:thymol deep eutectic solvents (DESs). The temperature-induced phase transition allows adjusting cohesive force, and hence adhesion strength of PBnA gels by temperature. To further improve the mechanical and adhesion properties, a peptide crosslinker is used to allow energy dissipation when deforming. The resulting eutectogel exhibits thermal reversible adhesion with a high switching ratio of 14.0. The adhesion strength at attachment state reaches 0.627MPa, which is much higher than most reversible adhesive hydrogels reported before. The low vapor pressure of DES endows the gel excellent environmental stability. More importantly, the gel can be repeatedly switched between attachment and detachment states. The strong and reversible gel adhesive is successfully used to design soft gripper for the transport of heavy cargos and climbing robot capable of moving on vertical and inverted surface in a manner similar to gecko.

Reversible color-changing polymer hydrogels mediated by urea-urease clock reaction for temporary information display

Inspired by the natural world's fascinating capacity for color change, researchers have developed various responsive hydrogels that shift colors. Among these, hydrogels that react to pH changes are particularly notable for their unique properties. The urea-urease autocatalytic reaction, a key pH clock reaction, is especially effective in temporarily adjusting these hydrogels' properties and enabling color changes in response to stimuli. In this study, we synergize the urea-urease clock reaction with the pH-sensitive color transformation of neutral red (NR), thereby establishing an NR-urea-urease clock reaction system. This system exhibits a dynamic color cycle from yellow to red and back to yellow. By incorporating this color transition mechanism into polymer hydrogels, we successfully initiate a pH change within the system. This innovation paves the way for a smart material capable of displaying temporary information through enzymatic reactions. The temporal variation in information display is finely tuned by adjusting the urea and urease concentrations. Such reversible color-changing hydrogels hold promising prospects for applications in secure information transmission and dynamic camouflage, marking a significant step forward in systems chemistry and materials science.

Cellulose nanofiber-mediated manifold dynamic synergy enabling adhesive and photo-detachable hydrogel for self-powered E-skin

Self-powered skin attachable and detachable electronics are under intense development to enable the internet of everything and everyone in new and useful ways. Existing on-demand separation strategies rely on complicated pretreatments and physical properties of the adherends, achieving detachable-on-demand in a facile, rapid, and universal way remains challenging. To overcome this challenge, an ingenious cellulose nanofiber-mediated manifold dynamic synergy strategy is developed to construct a supramolecular hydrogel with both reversible tough adhesion and easy photodetachment. The cellulose nanofiber-reinforced network and the coordination between Fe ions and polymer chains endow the dynamic reconfiguration of supramolecular networks and the adhesion behavior of the hydrogel. This strategy enables the simple and rapid fabrication of strong yet reversible hydrogels with tunable toughness ((Valuemax-Valuemin)/Valuemax of up to 86%), on-demand adhesion energy ((Valuemax-Valuemin)/Valuemax of up to 93%), and stable conductivity up to 12 mS cm−1. We further extend this strategy to fabricate different cellulose nanofiber/Fe3+-based hydrogels from various biomacromolecules and petroleum polymers, and shed light on exploration of fundamental dynamic supramolecular network reconfiguration. Simultaneously, we prepare an adhesive-detachable triboelectric nanogenerator as a human-machine interface for a self-powered wireless monitoring system based on this strategy, which can acquire the real-time, self-powered monitoring, and wireless whole-body movement signal, opening up possibilities for diversifying potential applications in electronic skins and intelligent devices.

Impact of Peptide Length and Solution Conditions on Tetrameric Coiled Coil Formation.

Unlike naturally derived peptides, computationally designed sequences offer programmed self-assembly and charge display. Herein, new tetrameric, coiled coil-forming peptides were computationally designed ranging from 8 to 29 amino acids in length. Experimental investigations revealed that only the sequences having three or more heptads (i.e., 21 or more amino acids) exhibited coiled coil behavior. The shortest stable coiled coil sequence had a melting temperature (Tm) of approximately 58 ± 1 °C, making it ideal for thermoreversible assembly over moderate temperatures. Effects of pH and monovalent salt were examined, revealing structural stability over a pH range of 4 to 11 and an enhancement in Tm with the addition of salt. The incorporation of the coiled coil as a hydrogel cross-linker results in a thermally and mechanically reversible hydrogel. A subsequent demonstration of the hydrogel printed through a syringe illustrated one of many potential uses from 3D printing to injectable hydrogel drug delivery.

Background-Free and Reversible Upconversion Hydrogel Sensing Platform for Visual Monitoring of Sulfite.

Excessive sulfite usage in food and pharmaceutical production causes respiratory and neurological diseases, underscoring the need for a sensitive and rapid quantification strategy. The portable sensing platform based on a luminescent hydrogel sensor is a powerful tool for the on-site, real-time detection of sulfite ions. However, the lack of recyclability in almost all reaction-based hydrogel sensors increases the application cost. This study constructed a reversible and upconversion nanoprobe combining upconversion nanoparticles (UCNPs) and pararosaniline (PAR) for sulfite detection. The upconversion nanoprobe was further encapsulated in a three-dimensional polyacrylamide hydrogel matrix to create a background-free, reversible hydrogel sensor. The near-infrared excitation of UCNPs avoids the autofluorescence in the hydrogel and real samples. Meanwhile, PAR serves as a specific recognition unit for sulfite ions. After the addition of sulfites, a specific reaction occurs between PAR and sulfites, leading to the recovery of characteristic emission at 540 nm, achieving sensitive detection of sulfite ions. Importantly, this specific reaction is reversible under thermal treatment, allowing the hydrogel sensor to return to its initial state and thus enabling reversible detection of sulfite ions. Furthermore, a portable sensing platform is developed to realize point-of-care, real-time quantitative detection of sulfite ions. The proposed upconversion reversible hydrogel sensor provides a new sensing strategy for the detection of hazardous substances in food and offers new insights into the preparation of reversible, highly sensitive hydrogel sensors.

A thermally reversible injectable adhesive for intestinal tissue repair and anti-postoperative adhesion.

Intestine damage is an acute abdominal disease that usually requires emergency sealing. However, traditional surgical suture not only causes secondary damage to the injured tissue, but also results in adhesion with other tissues in the abdominal cavity. To this end, a thermally reversible injectable gelatin-based hydrogel adhesive (GTPC) is constructed by introducing transglutaminase (TGase) and proanthocyanidins (PCs) into a gelatin system. By reducing the catalytic activity of TGase, the density of covalent and hydrogen bond crosslinking in the hydrogel can be regulated to tune the sol-gel transition temperature of gelatin-based hydrogels above the physiological temperature (42 °C) without introducing any synthetic small molecules. The GTPC hydrogel exhibits good tissue adhesion, antioxidant, and antibacterial properties, which can effectively seal damaged intestinal tissues and regulate the microenvironment of the damaged site, promoting tissue repair and regeneration. Intriguingly, temperature-induced hydrogen bond disruption and reformation confer the hydrogel with asymmetric adhesion properties, preventing tissue adhesion when applied in vivo. Animal experiment outcomes reveal that the GTPC hydrogel can seal the damaged intestinal tissue firmly, accelerate tissue healing, and efficiently prevent postoperative adhesion.

Temporary Consolidation of Marine Artifact Based on Polyvinyl Alcohol/Tannic Acid Reversible Hydrogel.

Underwater artefacts are vulnerable to damage and loss of archaeological information during the extraction process. To solve this problem, it is necessary to apply temporary consolidation materials to fix the position of marine artifacts. A cross-linked network hydrogel composed of polyvinyl alcohol (PVA), tannic acid (TA), borax, and calcium chloride has been created. Four hydrogels with varying concentrations of tannic acid were selected to evaluate the effect. The hydrogel exhibited exceptional strength, high adhesion, easy removal, and minimal residue. The PVA/TA hydrogel and epoxy resin were combined to extract waterlogged wooden artifacts and marine archaeological ceramics from a 0.4 m deep tank. This experiment demonstrates the feasibility of using hydrogel for the extraction of marine artifacts.

Thermally reversible hydrogels printing of customizable bio-channels with curvature

Replicating intricate bio-channels, akin to expansive vascular networks, offers numerous advantages including self-repair, replacing damaged bio-channels, testing drugs, and biomedical devices. But, crafting multi-sized, editable bio-channels with specific curvatures, particularly using natural polymer-based bio-inks, poses a significant challenge. To address this, this study introduces a temperature-driven indirect printing method, exemplified by the diploic vein. Here, K-carrageenan (kca)-silk fiber (SF)-hyaluronic acid (HA)/hFOB 1.19 (SV40 transfection of human osteoblasts) and kca-collagen-HA/HUVECs (human umbilical vein endothelial cells) are employed to fabricate vascular-like walls and lumens, utilizing their thermoreversible properties to create multi-stage bifurcated lumens. Precise spatial curvature was generated by heating the vascular network wrapped in poly(N-isopropyl acrylamide) (PNIPAAm)-poly(ethylene glycol) diacrylate (PEGDA). Since temperature is specific to the thermal material carrying the cells, the rheological properties of bioinks, modeling temperature parameters, and their impact on printing size was explored. Additionally, mechanical properties and curvature response were characterized to determine the necessary process parameters for achieving the desired size. Ultimately, in vitro bioprinting experiments involving HUVECs and hFOB 1.19 demonstrate cell viability, adhesion, proliferation, and migration within the intraluminal hydrogel scaffold. This approach allows for customizing bio-channel content and controlling curvature programming, providing new prospects for in vitro biochannel production, with potential benefits for pathology research.

A Dual Reversible Cross-Linked Hydrogel with Enhanced Mechanical Property and Capable of Proangiogenic and Osteogenic Activities for Bone Defect Repair.

The clinical treatment of bone defects presents ongoing challenges. One promising approach is bone tissue engineering (BTE), wherein hydrogels have garnered significant attention. However, the application of hydrogels in BTE is severely limited due to their poor mechanical properties, as well as their inferior proangiogenic and osteogenic activities. To address these limitations, our develop a dual cross-linked alendronate (ALN)-Ca2+ /Mg2+ -doped sulfated hyaluronic acid (SHA@CM) hydrogel, using a one-step mixing injection molding method known as "three-in-one" approach. This approach enabled the simultaneous formation of Schiff-Base crosslinking and electric attraction-based crosslinking within the hydrogel. The Schiff-Base crosslinking contributed to the majority of the hydrogel's mechanical strength, while the electric attraction-based crosslinking served as a release reservoir for Ca2+ /Mg2+ and ALN, promoting enhanced osteogenic activities and providing additional mechanical reinforcement to the hydrogel. These experimental data demonstrates several favorable properties of the SHA@CM hydrogel, including satisfactory injectability, rapid gelation, self-healing capacity, and excellent cytocompatibility. Moreover, the presence of sulfated groups and Mg2+ within the SHA@CM hydrogel exhibited pro-angiogenic effects, while the controlled release of nanoparticles formed by Ca2+ /Mg2+ and ALN further enhanced the osteogenesis of the hydrogel. Overall, these results indicate that the SHA@CM hydrogel holds significant potential for the clinical translation of BTE.

Dynamic reversible disulfide bonds hydrogel of thiolated galactoglucomannan/cellulose nanofibril with self-healing property for protein release

In the context of sustainability transition to effectively utilize renewable biopolymers in building functional materials, we report a dynamic reversible nanocomposite hydrogel via thiolated galactoglucomannan (GGMSH) and TEMPO-oxidized cellulose nanofibrils (T-CNF) by deploying a UV-triggered thiol-disulfide exchange reaction. By adjusting the compositional content of GGMSH, the viscoelastic properties of the hydrogel precursors are tuneable and the crosslinking degree of disulfide bonds in these hydrogels dictates their mechanical properties upon UV irradiation. The nanocomposite hydrogels of GGMSH/T-CNF demonstrate robust self-healing properties, attributed to the dynamically reversible disulfide bonds and strong hydrogen bonds between T-CNF and GGMSH. For the hydrogel system of GGMSH/T-CNF/bovine serum albumin (BSA), the swelling behaviour of nanocomposite hydrogels largely dominated the release of BSA out of the hydrogels, suppressing the effect of redox-responsive stimuli with the addition of glutathione. Still, the cytotoxicity test proved a low cytotoxicity of the nanocomposite hydrogel and provided promising reference value to exploit this class of natural polymer-based hydrogel systems in biomedical applications.

MPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

Non-invasive drug delivery offers a safe treatment while improving patient compliance. However, due to the particular physiological structure of the ocular, long-term retention and sustained drug release of the drug delivery system is crucial. Herein, this study aimed to design mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels (mPEG-CS-FL-TSG) for the delivery of astragaloside IV (AS-IV) and tetramethylpyrazine (TMP) to treat age-related macular degeneration. In vitro biological properties of mPEG-CS-FL and mPEG-CS-FL-TSG showed that they could be successfully taken up by ARPE-19 cells, and the uptake rate of mPEG-CS-FL-TSG was higher. Not only that, the release rate of mPEG-CS-FL-TSG was slower. More significantly, the results showed that the cytotoxicity of mPEG-CS-FL-TSG was lower than that of mPEG-CS-FL. In vivo result revealed that the drug delivery system could prominently enhance the ocular bioavailability of AS-IV and TMP, which is the enhanced synergism of well-permeable liposome and slow-releasing hydrogel. In summary, the mPEG-CS-FL-TSG can compensate for the short retention time and sudden release of liposome, as well as the low drug penetration of hydrogel, in order to show great promise in the non-invasive delivery of multiple drugs for the treatment of posterior ocular diseases.

Ecofriendly polysaccharide-based alginate/pluronic F127 semi-IPN hydrogel with magnetic collectability for precise release of pesticides and sustained pest control

Controlled-release systems are crucial for efficient pesticide utilization and environmental protection in agricultural production. The utilization of polysaccharide-based materials derived from biopolymers as carriers for controlling pesticide release holds significant potential. In this work, a reversible near infrared-responsive polysaccharide-based hydrogel (RNPH) was fabricated by employing a semi-interpenetrating polymer network (alginate-FeIII/pluronic F127) as a carrier to encapsulate Fe3O4@polydopamine (FP) and emamectin benzoate (EB)-loaded hollow mesoporous silica. The incorporation of FP into the RNPH introduced a photothermal effect, enabling the precise release of EB through reversible shrinkage of the hydrogel upon NIR irradiation. Additionally, the presence of magnetic Fe3O4 in the system facilitated the rapid removal of remaining RNPH from the environment using a magnet, reducing EB residue. Importantly, RNPH exhibited exceptional controlled-release performance and could be reused for at least 4 cycles. Furthermore, the anti-photolysis ability of EB protected by RNPH was enhanced by 4.8 times compared to EB alone. Moreover, RNPH significantly improved the adhesion of EB to foliar surfaces, thereby reducing the loss of EB while ensuring crop safety. Therefore, the polysaccharide-based hydrogel holds promise as a versatile carrier for the precise release of EB, offering valuable applications in enhancing pesticide bioavailability and promoting environmental safety.