Objectives: The objective of the present study was to evaluate the cyclic fatigue strength of clockwise cutting rotary endodontic instruments when subjected to two different kinematics: continuous clockwise rotation and clockwise reciprocation movement under optimum torque reverse (OTR) motion. Methods: New ProTaper Next X1 (n = 20) and X2 (n = 20) instruments were randomly divided into two subgroups (n = 10) based on kinematics (continuous rotation or OTR). The specimens were tested using a custom-made device with a non-tapered stainless-steel artificial canal measuring 19 mm in length, featuring a 6 mm radius and an 86-degree curvature. All instruments were tested with a lubricant at room temperature until a fracture occurred. The time to fracture and the length of the separated fragment were recorded. Subsequently, the fractured instruments were inspected under a scanning electron microscope for signs of cyclic fatigue failure, plastic deformation, and/or crack propagation. The subgroup comparisons for time to fracture and instrument length were performed using the independent samples t-test, with the level of statistical significance set at 0.05. Results: When using OTR movement, the ProTaper Next X1 increased the time to fracture from 52.9 to 125.8 s (p < 0.001), while the ProTaper Next X2 increased from 45.4 to 66.0 s (p < 0.001). No subgroup exhibited plastic deformations, but both showed dimpling marks indicative of cyclic fatigue as the primary mode of failure. Additionally, OTR movement resulted in more metal alloy microcracks. Conclusions: The use of OTR motion extended the lifespan of the tested instruments and resulted in a higher number of metal microcracks. This suggests that OTR motion helped to distribute the mechanical stress more evenly across the instrument, thereby relieving localized tension. As a result, it delayed the formation of a single catastrophic crack, enhancing the overall performance of the instruments during the experimental procedures.
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