Retroperitoneal Teratoma Research Articles

903 Risk-adapted treatment of clinical stage 1 (CS1) nonseminoma testis cancer (NSTC)

246 patients (pts) with CSI NSTC were included into a prospective multicenter protocol during 1990–94 and treated according to 3 risk strata: Pts without tumor cell invasion of vascular structures in the testis (VASC–) and elevated serum AFP levels (AFP+) at orchiectomy were considered low risk (LR) and surveilled only. VASC– & AFP– or VASC+ & AFP+ pts were presumed intermediate risk (IR) and path. staged (PS) by retroperitoneal lymph node dissection (RPLND). VASC+ & AFP− pts were regarded as high risk (HR) and received adjuvant chemotherapy (BEP × 3) Preliminary results at a median obs, time of 32 months: Crude survival of all 246 pts are 100% and all relapsing pts are in remission. Of 225 fully evaluable pts: Relapse rate in the 99 LR pts are 23% and 76% had elevated serum tumor markers at relapse. One of 32 (3%) HR pts relapsed (resectable retroperitoneal mature teratoma). Of 94 IR pts 38% had either PS2 at RPLND or relapsed despite PSI. AFP status at orchiectomy had no real predictive value for subclinical metastases in this study, but may indicate increased safety during surveillance by early warning of relapse. 246 patients (pts) with CSI NSTC were included into a prospective multicenter protocol during 1990–94 and treated according to 3 risk strata: Pts without tumor cell invasion of vascular structures in the testis (VASC–) and elevated serum AFP levels (AFP+) at orchiectomy were considered low risk (LR) and surveilled only. VASC– & AFP– or VASC+ & AFP+ pts were presumed intermediate risk (IR) and path. staged (PS) by retroperitoneal lymph node dissection (RPLND). VASC+ & AFP− pts were regarded as high risk (HR) and received adjuvant chemotherapy (BEP × 3) Preliminary results at a median obs, time of 32 months: Crude survival of all 246 pts are 100% and all relapsing pts are in remission. Of 225 fully evaluable pts: Relapse rate in the 99 LR pts are 23% and 76% had elevated serum tumor markers at relapse. One of 32 (3%) HR pts relapsed (resectable retroperitoneal mature teratoma). Of 94 IR pts 38% had either PS2 at RPLND or relapsed despite PSI. AFP status at orchiectomy had no real predictive value for subclinical metastases in this study, but may indicate increased safety during surveillance by early warning of relapse.

Retroperitoneal Teratoma Associated with Renovascular Hypertension and Secondary Hyperaldosteronism

Retroperitoneal Teratoma Associated with Renovascular Hypertension and Secondary Hyperaldosteronism

A CASE OF A HUGE ADULT RETROPERITONEAL TERATOMA

Retroperitoneal teratoma commonly occurs in children but rare in adults. This paper presents a case of retroperitoneal teratom in an adult with a review of the literature. A 28-year-old man visited a nearby hospital because of right hypochondralgia, and was found to have a huge tumor in the retroperitoneum. the patient was referred to the hospital for close examination and operation. On admission an elastic-hard and infant's head-sized tumor was palpated in the right hypochondrium with a dull pain when it was strongly pressed. Diagnostic imagings such as abdominal ultrasonography, CT, and MRI revealed a tumor with calcification and its content suggestive of liquid fat. Retroperitoneal teratoma was strongly suspected, but a possibility of myelolipoma was also considered because of its site of occurrence. Operation was performed. Resected specimen disclosed a cystic tumor with smooth surface, skin-like internal wall, and a portion with calcification which seemed like the bone marrow. Histopathologically the appendages of the skin was confirmed, and hence it was diagnosed as matured retroperitoneal teratoma.

A CASE OF RETROPERITONEAL TERATOMA WHICH WAS BEEN DIAGNOSED 32 YEARS PREVIOUSLY, RESOLVED TO EXTIRPATE BY GALLSTONE ATTACK

This paper describes a case of amusing retroperitoneal teratoma, with a review of the pertinent literature. A 35-year-old female, who had been diagnosed as having a retroperitoneal tumor when she was 3 years old, was seen at the hospital because of severe epigastralgia caused by cholecystolithiasis. She had been refused to extirpate the tumor by various reasons for a long time. Plain roentgenogram of the abdomen revealed a large right lateral abdominal mass containing osseous structure. In computed tomography, the tumor was detected as multiloculated and cystic mass including colorful content as bone and adipose tissue in the cyst, locating anterior to the right kidney. Preoperative diagnosis was benign retroperitoneal teratoma, and she resolved to undergo extirpation of the tumor with cholecystectomy at last. At laparotomy, the tumor was displaced the adjacent organs (right kidney, pancreas head, duodenum and inferior vena cava), and adhered to them besides. Gross findings of the specimen included encapsulated, multiloculated and cystic tumor containing sebaceous like material and yellowish fat including hair and bone in the cyst, with 15.3×10.8×7.9cm in size and 570g in weight. Histologically, the tumor revealed matured benign teratoma of all three germ layers. The patient has been in good health without a sign of recurrence for 2 years and 4 months after the operation.

A CASE OF ENTERIC CYST ARISED IN THE RETROPERITONEUM

A very rare case of enteric cyst arising in the retroperitoneum is described here, with some discussion on the relevant literature.A 21-year-old Philippine woman was seen at the hospital because of an enlarging tumor of the right upper abdomen with right hypochondralgia. The tumor had been pointed out 5 years before, but she asked for no treatment. The patient was suspected to have a hepatic tumor and was admitted to the hospital. Echography revealed an infant-head sized, multilobular cystic mass extending from the subhepatic space to anterior aspect of the right kidney. CT also visualized a low density mass in the same part. Angiography revealed no vessels of the tumor coming from the hepatic artery, but showed only an opressed figure. Malposition of the inferior vena cava to the left was found. The tumor enucleation was performed under a diagnosis of retroperitoneal teratoma. The excised tumor was a cyst weight 2200 g. Histopathologically it was an enteric cyst consisting of adenocytes similar to intestinal epithelial cells presenting with PAS-positive, no malignant picture being seen.Retroperitoneal enteric cyst is so rate that only 4 cases can be seen in the Japanese literature.

General diagnosis case of the day. Primary retroperitoneal teratoma.

General diagnosis case of the day. Primary retroperitoneal teratoma.

A CASE OF RUPTURED RETROPERITONEAL TERATOMA BY A BLUNT ABDOMINAL TRAUMA

We experienced a case of ruptured retroperitoneal teratoma due to a blunt abdominal trauma which presented with peritonitis symptoms demanding emergency operation.A 15-year-old boy, who had been suffering from severe upper abdominal pain for about 24 hours which developed immediately after he was kicked the site, was referred to our hospital for the manifestations of panperitonitis.Signs and symptoms of acute panperitonitis, including a calcified mass on a plain abdominal X-ray films, suggested a ruptured tetratoma. Laparotomy disclosed a ruptured firm cystic mass directly behind the stomach. The contents of the cyst had already allowed to pour out into the abdominal cavity. Pathological examination of resected specimen revealed a benign matured teratoma.Analysis of the literature permits a suggestion that this case is the first showing perforative panperitonitis in a case of retroperitoneal teratoma.

Primary retroperitoneal teratoma in the adult: Correlation of MRI features with CT and pathology

Primary benign teratoma of the retroperitoneum is a rare tumor in the adult population. Only one case with an MRI examination has been reported in the English literature. This paper describes the CT and MRI features of a retroperitoneal teratoma in a 24-year-old male and discusses the value of MRI in the diagnosis and the preoperative imaging of such a tumor.

Peritonitis due to rupture of retroperitoneal teratoma: Computed tomography diagnosis

Retroperitoneal benign cystic teratoma is relatively rare in adults. We report a case of traumatic rupture of primary retroperitoneal teratoma into peritoneum that produced chemical peritonitis. It was demonstrated by computed tomography, which showed fat-fluid levels in the peritoneum. We suggest that the demonstration of fat-fluid levels in the peritoneum could be a reliable sign of intraperitoneal rupture of abdominal teratoma and subsequent chemical peritonitis.

RETROPERITONEAL DERMOID PRESENTING AS AN INFECTED PANCREATIC CYST

Bacteroides fragilis infection of a juxtapancreatic benign cystic retroperitoneal teratoma in a 28 year old Chinese male is reported. Preliminary drainage was followed by excision. The radiological and pathological findings of this rare tumour are reported with emphasis on the differential diagnosis which includes inflammatory and neoplastic pancreatic cysts.

Retroperitoneal teratoma with predominance of nephroblastic elements: a case report

The morphological features of a retroperitoneal teratoma in a 10-month-old girl are reported. Unlike the usual pattern of the teratoma, this tumor was composed predominantly of nephroblastomatous tissue. Histologically, glomeruloid and tubular structures were identified in nests of undifferentiated blastemal elements. Hyaline cartilage, adipose tissue, glial tissue and glands lined by mucin-secreting columnar epithelium were minor elements. A focal cystic structure lined by thin flattened epithelium was also noted. Retroperitoneal teratoma with predominance of nephroblastic elements is of interest not only because of its rarity but also because it needs to be differentiated from extrarenal Wilms' tumor, since both of these tumors have different origins.

Retroperitoneal Immature Teratoma Producing Alpha-Fetoprotein

An alpha-fetoprotein producing retroperitoneal immature teratoma is demonstrated and the aetiology of AFP arising probably from small island of hepatoid cells or various tubular epithelial cells in the immature teratoma is discussed.

Teratoma in children under 7 years of age: analysis of 65 cases

This report concerns 65 children under 7 years of age treated during the last 10 years. Sacrococcygeal and ovarian teratomas were most common, but the incidence of retroperitoneal, cervical, and gastric teratomas was far greater than that published in other series (Table 1). Malignancy occurred in 18 cases (26%). Complete excision of benign tumors was curative although there was mortality due to the poor general condition of small patients with large tumors. Survival of the patients with malignant tumors was poor even after postoperative chemotherapy.

後腹膜奇形腫を合併した原発性肝カルチノイドの１例

後腹膜奇形腫を合併した原発性肝カルチノイドの１例

Pattern of abdominal masses.

Two hundred and sixty cases of abdominal masses in children below 12 years at Kalawati Saran Children Hospital, New Delhi, are reviewed. More than two-third masses (71.5%) were benign. Males were affected more often than females (2.4:1). Most common mass was renal (53.5%) followed by G.I. T. (22.3%), hepatobiliary (7.7%) and genital tract (2.7%). Miscellaneous group (including neuroblastoma, tretroperitoneal secondaries, retroperitoneal teratoma etc) constituted 13.8%. Amongst renal masses, hydronephrosis (56.8%) and Wilm’s tumour (27.4%) were the commonest. Appendicular masses (27.0%) dominated gastrointestinal system. Most common mode of presentation of hepatobiliary masses was liver abscess (50.0%). Abdominal masses were associated with a high mortality (26.2%); 80.0% due to malignant tumours.

Primary retroperitoneal teratoma and crossed fused renal ectopia with Turner's syndrome: a case report

Primary retroperitoneal teratoma and crossed fused renal ectopia with Turner's syndrome: a case report

Immunocytochemical and Ultrastructural Findings in a Mature Retroperitoneal Teratoma

Report is made of a mature retroperitoneal teratoma in a 32-year-old man. Investigation of the tumor revealed cells immunoreactive for ACTH, Met-enkephalin, beta-LPH, serotonin, FSH, BPP, S100, Neuron-specific-enolase. These cells were mainly present in the glandular epithelium, lining the cysts of the tumor. Ultrastructurally, neuro-secretory granules were demonstrated in the cytoplasm of the tumoral endocrine cells. At no time did the patient display endocrine symptoms.

Immunocytochemical and Ultrastructural Findings in a Mature Retroperitoneal Teratoma

Report is made of a mature tetroperitoneal teratoma in a 32-year-old man. Investigation of the tumor revealed cells immunoreactive for ACTH, Met-enkephalin, β-LPH, serotonin, FSH, BPP, S100, Neuron-specific-enolase. These cells were mainly present in the glandular epithelium, lining the cysts of the tumor. Ultrastructurally, neuro-secretory granules were demonstrated in the cytoplasm of the tumoral endocrine cells. At no time did the patient display endocrine symptoms.

Primary retroperitoneal teratoma in adults

We report on a case of primary monodermal retroperitoneal teratoma composed solely of thyroid tissue. The CT scan appearance of such a tumor is presented.

Karyotyping and DNA flow cytometry of mature residual teratoma after intensive chemotherapy of disseminated nonseminomatous germ cell tumor of the testis: A report of two cases

Karyotyping and DNA flow cytometry was performed on mature residual teratoma cells following intensive chemotherapy of disseminated nonseminomatous germ cell tumor of the testis to study its biology. We report herein a successful method for short-term tissue culture and karyotyping of retroperitoneal residual mature teratoma in two cases. In vitro morphology confirmed that the cultured cells were nonembryonal carcinoma cells. Both mature residual teratomas were highly aneuploid and possessed the i(12p) marker characteristic of testicular germ cell tumors. A clone in the retroperitoneal residual lesion of one of the patients showed a DNA-index different from the primary tumor and might represent a clone unmasked by chemotherapy. In view of these data, which are in agreement with recent reports on secondary non-germ cell malignancies arising in mature residual teratoma, agressive surgery of mature residual lesions seems justified.