Restricted Joint Mobility Research Articles

Total Knee Replacement as Treatment for Hemophilic Arthropathy: A Case Series.

Background and objectives Hemophilic arthropathy is a known complication of patients with hemophilia, with the knee as the commonest joint affected. Patients with this condition have severe pain and restricted joint mobility, affecting their activities of daily living. Total knee replacement can increase these patients' quality of life. Nevertheless, this surgery has a high risk of complications due to the nature of the underlying hemophilia. In this study, we present the short-term outcome of a case series of six patients with hemophilic arthropathy who underwent total knee replacement at a hospital with hematology support performed by an experienced arthroplasty surgeon. Patients and method This study reviewed and included eight consecutive total knee replacements in six patients with hemophilic arthropathy performed by a single board-certified arthroplasty surgeon from 2019 to 2023. The demographic profile of the patients, pre- and postoperative range of movement, and short-term outcome scores were summarized. Results The mean preoperative flexion contracture was 10.6° (range: 5°-30°), and it was 0.7° (range: 0°-5°) postoperatively. The mean preoperative flexion of the knee was 78.1° (range: 45°-110°) and 98.8° postoperatively. At six-month follow-up, the average Knee Society Score expectation, satisfaction, and functional scores had improved from 8.3 to 13.8 points, 20 to 38.5 points, and 42.8 to 80.5 points, respectively. Conclusion This study suggests that short-term results of total knee replacement in patients with hemophilic arthropathy are favorable, with increased range of movement and quality of life. We also conclude that surgery should be performed by an experienced surgeon with the support of a dedicated hematology unit.

EFFECTIVENESS OF PASSIVE STRETCHING IN TREATING JUVENILE IDIOPATHIC RHEUMATOID ARTHRITIS- A CASE STUDY

Background:Rheumatoid Arthritis (RA) a systemic autoimmune disease characterized by inflammatory arthritis and extra-articular involvement. It is a chronic inflammatory disease that mostly affects the synovial joints.A diverse subset of idiopathic inflammatory arthritis that affects children under 16 and lasts for six weeks or more is known as juvenile idiopathic arthritis (JIA). Methodology:A 15-year-old female had juvenile idiopathic arthritis with medical treatment, there was no reduction of pain and led to difficulties in her ADL with restricted joint mobility and reduced ROM. Whereas she was evaluated and treated with specific physiotherapeutic measures for eight months period seven days in a week with specific stretching exercises. Result:The significant difference were reported from the pre and post test values of pain and also functional improvement with regards to kartz index Conclusion: Passive stretching, when implemented as part of a comprehensive physiotherapeutic approach, can effectively alleviate the symptoms and improve the quality of life.

Diagnostic Value of Whole-Body MRI in Pediatric Patients with Suspected Rheumatic Diseases.

Background and Objectives: The diagnosis of rheumatic diseases in children is challenging and requires the use of advanced imaging examinations such as whole-body magnetic resonance imaging (MRI). Whole-body MRI allows visualization of bone marrow edema (BME), muscle edema, joint effusion and changes in the soft tissues surrounding the joints. The aim of this study was to collect and compare whole-body MRI findings, laboratory results and clinical manifestations of pediatric patients with suspected rheumatic disease. Materials and methods: In this retrospective single-center study, 33 patients who underwent whole-body MRI were included. Their age ranged from 9 to 17 years, and 24 (72.73%) of the patients were female. Patients were diagnosed as follows: juvenile idiopathic arthritis (27.27%), juvenile idiopathic inflammatory myopathies (21.21%), chronic nonbacterial osteomyelitis (21.21%) and other medical conditions (30.30%), such as arthritis associated with infection, scleroderma, Takayasu arteritis, polyarteritis nodosa and joint damage. Results: The most common symptom reported by 26 (79.79%) patients was pain. On physical examination, the limitation of joint mobility was examined in 17 (51.51%), swelling of the joints was observed in 12 (36.36%) patients and decreased muscle strength was noticed in 11 (33.33%) patients. An increase in the C-reactive protein (12%), erythrocyte sedimentation rate (9%), leukocyte count (9%) and creatine kinase (CK) (18%) was observed. Whole-body MRI revealed myositis (30%), joint effusion (27%) and BME (24%). The statistical analysis showed a significant relationship between myositis and the elevated CK level (p < 0.05). Conclusions: The most common symptom in the studied population was pain, while the limitation of joint mobility was found in more than half of patients. Myositis was the most commonly imaged lesion on the whole-body MRI and it was related to an increase in the CK level.

Efficacy of soothing cream gel in the range of motion and chronic pain at the shoulder and elbow: protocol of a double-blinded, randomised, placebo-controlled trial

IntroductionUpper limb problems have a significant impact on the global population leading to pain and restricted joint mobility, ultimately impacting their quality of life. Traditional treatments, such as non-steroidal anti-inflammatory...

Calcinosis Prevalence in Autoimmune Connective Tissue Diseases-A Retrospective Study.

Background/Objectives: Calcinosis cutis is the deposition of insoluble calcium salts, which may cause inflammation, ulceration, pain, and restricted joint mobility. It rarely develops in damaged tissues (dystrophic subtype), most frequently in autoimmune connective tissue diseases (CTDs), but there is very limited data on the prevalence. Also, therapy remains an unsolved issue. In this study, we aimed to collect data on the prevalence of calcinosis in CTD patients to highlight that it is a considerable problem. Methods: A retrospective study was conducted in our department to assess the epidemiology of dystrophic calcinosis in CTDs between January 2003 and January 2024. Results: A total of 839 CTD patients were identified, of whom 56 had calcinosis (6.67%). The mean age of the calcinosis patients at diagnosis of underlying CTD was 41.16 ± 19.47 years. The mean time interval from the onset of calcinosis was 5.96 ± 8.62 years. Systemic sclerosis was the most common CTD complicated by calcinosis (n = 22). Conclusions: Our results are comparable to those reported previously in the literature. Although calcinosis is rare in the overall population, it is a present and unsolved problem in CTD patients. Therefore, further studies are needed on the factors involved in the development and progression of calcinosis as well as its treatment.

Analysis of congenital Zika syndrome clinicopathologic findings reported in the 8 years since the Brazilian outbreak

Aim: A Zika virus outbreak that began in Brazil, developed into an international public health emergency that extended from February 2015 until November 2016. Zika-infected pregnant women gave birth to a cohort of infants with congenital Zika syndrome (CZS) originally defined by severe microcephaly, retinal scarring, joint deformities, and hypertonia. This study examines the nature, extent, and severity of all CZS clinicopathologic findings described to date, compiled and analyzed by system. It reviews studies monitoring disease progression and proposing classification schemes for CZS stages. The teratogenic cellular and molecular mechanisms implicated in CZS pathogenesis are also discussed. Methods: A systematic review was conducted by literature search through WorldCat.org and ProQuest Central databases to identify studies on case series from the 2015–2016 CZS outbreak. Results: Twenty-six reports were included describing radiologic, ophthalmologic, audiologic, orthopedic, and laboratory test results in CZS cases including stillborns between 2016 and 2023. CZS neuropathology included prenatal and postnatal microcephaly, cerebral calcifications, quadriparesis, epilepsy, ventriculomegaly, reduced cerebral parenchyma, malformation of cortical development, and sleep electroencephalogram disturbances. Visual deficits were due to retinal and optic nerve lesions. Conductive and sensorineural hearing deficits were stable. Hypertonia, hypotonia, and spasticity with foot, hip, knee, and shoulder deformities resulted in arthrogryposis and restricted joint mobility. There was enlargement of immune organs, increased leukocyte counts, and cytokine dysregulation. Oro-craniofacial deformities affected the midface and caused dental eruption delay. Additional studies proposed that these systemic teratogenic effects could be attributable to transplacental Zika virus infection of multiple fetal progenitor cell lineages. Conclusions: The CZS-associated impairments in brain, eye, musculoskeletal, and immunologic functions caused disabilities that varied from moderate to severe, and significantly increased age-specific mortality rates. Further research is warranted to assess progression, classify stages, elucidate the precise molecular mechanisms mediating Zika teratogenicity, develop suitable therapeutic strategies, and design supportive social policies.

Correlation between Bilateral Muscle Loading Asymmetry and Neck Pain - A Prospective Cross-Sectional Study

Background: Neck discomfort is a common musculoskeletal disorder which often manifests into scapular asymmetry, muscle imbalances, and restricted joint mobility. This study attempts to establish the correlation between asymmetries of the posterior chain muscles and individuals with neck pain. Method: 85 subjects, 36 male and 49 female, were required for this study. A biomechanical postural evaluation using a Postural bench and Neck Disability Index (NDI) score was taken for further analysis in this study. Result: The relationship between the NDI, scapular asymmetry and pelvis asymmetry was highly significant. A significant relationship was seen between lumbar asymmetry and NDI whereas no relationship was found between NDI and total body asymmetry. Conclusion: It is concluded that the neck disability was significantly related to scapular and pelvis load asymmetry, however, the total body asymmetry was not significantly related.

LIMITED JOINT MOBILITY OF THE HAND: COULD IT BE THE AGING HAND?

Background: The progressive diminution of manual dexterity and functional capacity in the hands is an inherent aspect of the aging process. However, when assessing hand dysfunction and limitations in elderly individuals, it is imperative to exclude alternative etiologies before attributing such manifestations solely to age-related deterioration.&#x0D; Case Report: This report presents the case of a 65-year-old female patient exhibiting skin thickening and restricted joint mobility in both hands. Subsequent comprehensive evaluation led to a diagnosis of diabetic cheiroarthropathy, commonly known as limited joint mobility syndrome.&#x0D; Conclusion: The observed decline in hand function among elderly individuals with diabetes mellitus may be attributable to diabetic cheiroarthropathy. This underscores the importance of considering diabetes-related musculoskeletal disorders in the differential diagnosis of age-associated functional deterioration in the hands.

Systemic Sodium Thiosulfate as an Adjunct Treatment in Calcinosis: A Retrospective Study.

(1) Background: Calcinosis of the skin mainly appears in connective tissue disorders (dystrophic subtype). It may cause inflammation, ulceration, pain, and restricted joint mobility. Management is difficult; sodium thiosulfate is one potential therapeutic agent with promising data on intralesional and topical formulation for smaller calcified lesions. There are very limited data on systemic administration. (2) Methods: A retrospective study was conducted at our department to assess the efficacy of oral and intravenous sodium thiosulfate in dystrophic calcinosis between 2003 and 2023. (3) Results: Seven patients were identified, who received systemic sodium thiosulfate (intravenous or oral). The mean duration of calcinosis at the time of administration was 3.8 ± 4 years (range 0-11). Intravenous sodium thiosulfate was administered in doses of 12.5-25 g two or three times during one week of the month for 4.5 ± 3.9 months on average. Orally, 1-8 g was administered daily for 29.1 ± 40.9 months on average. Four of seven patients had a partial response (57.1%). Despite no complete response, pain, ulceration and inflammation frequency decreased, and sodium thiosulfate prevented further progression in responsive patients. (4) Conclusions: Based on our experience and literature data, systemic sodium thiosulfate may be a potential adjunct therapy in calcinosis, especially if inflamed or ulcerating.

Evaluating the Efficacy of a Thermoresponsive Hydrogel for Delivering Anti-Collagen Antibodies to Reduce Posttraumatic Scarring in Orthopedic Tissues.

Excessive posttraumatic scarring in orthopedic tissues, such as joint capsules, ligaments, tendons, muscles, and peripheral nerves, presents a significant medical problem, resulting in pain, restricted joint mobility, and impaired musculoskeletal function. Current treatments for excessive scarring are often ineffective and require the surgical removal of fibrotic tissue, which can aggravate the problem. The primary component of orthopedic scars is collagen I-rich fibrils. Our research team has developed a monoclonal anti-collagen antibody (ACA) that alleviates posttraumatic scarring by inhibiting collagen fibril formation. We previously established the safety and efficacy of ACA in a rabbit-based arthrofibrosis model. In this study, we evaluate the utility of a well-characterized thermoresponsive hydrogel (THG) as a delivery vehicle for ACA to injury sites. Crucial components of the hydrogel included N-isopropylacrylamide, poly(ethylene glycol) diacrylate, and hyaluronic acid. Our investigation focused on in vitro ACA release kinetics, stability, and activity. Additionally, we examined the antigen-binding characteristics of ACA post-release from the THG in an in vivo context. Our preliminary findings suggest that the THG construct exhibits promise as a delivery platform for antibody-based therapeutics to reduce excessive scarring in orthopedic tissues.

Does Restricted Ankle Joint Mobility Influence Hamstring Muscle Strength, Work and Power in Football Players after ACL Reconstruction and Non-Injured Players?

This study was aimed at observing how the limitation of ankle dorsiflexion ROM affects hamstring muscle Peak Torque/BW (%), Average Power (W), and Total Work (J), and whether this effect is similar in football players after ACL rupture and reconstruction and in those without injuries. The study included 47 professional football players who were divided into two groups: Group 1 (n = 24) after ACL reconstruction and Group 2 (n = 23) without injuries in the past 3 years. Based on the Weight-Bearing Lunge Test (WBLT), the following subgroups in Groups 1 and 2 were distinguished: N (normal ankle joint dorsiflexion) and R (restricted ankle joint dorsiflexion). The concentric isokinetic test (10 knee flexions and extensions at 60°/s) was performed on both limbs. Significantly lower values of Peak Torque/BW and Average Power were observed in Group 1 compared to Group 2, as well as in subjects with normal and restricted ankle dorsiflexion. However, no significant differences were noted for either group in any of the strength variables comparing subjects with normal and restricted ankle dorsiflexion. A poor and non-significant correlation was exhibited between the ankle joint range of dorsiflexion and all the strength variables. The area under the ROC curve (AUC) for all the evaluated variables in both groups was below 0.5, or very close to this value, indicating that ankle dorsiflexion ROM has no diagnostic accuracy for hamstring muscle strength. Based on the obtained results, it can be assumed that ankle dorsiflexion limitation, which is common in football players, is not a factor in weakening hamstring muscle strength, either in football players after ACL reconstruction or among those without injuries. However, some authors have reported that limited mobility of the ankle joint can have a destructive effect on the work of the lower limbs and may also be a factor in increasing the risk of football injuries in this area. Therefore, we have suggested that hamstring muscle weakness and increased risk of injury may occur due to factors other than limited ankle mobility. These observations may be of great importance in the selection of prevention methods by including a broad spectrum of physical techniques, not just exercises that focus on the improvement of mobility or stability of the lower limbs.

CYP26B1-related disorder: expanding the ends of the spectrum through clinical and molecular evidence.

CYP26B1 metabolizes retinoic acid in the developing embryo to regulate its levels. A limited number of individuals with pathogenic variants in CYP26B1 have been documented with a varied phenotypic spectrum, spanning from a severe manifestation involving skull anomalies, craniosynostosis, encephalocele, radio-humeral fusion, oligodactyly, and a narrow thorax, to a milder presentation characterized by craniosynostosis, restricted radio-humeral joint mobility, hearing loss, and intellectual disability. Here, we report two families with CYP26B1-related phenotypes and describe the data obtained from functional studies of the variants. Exome and Sanger sequencing were used for variant identification in family 1 and family 2, respectively. Family 1 reflects a mild phenotype, which includes craniofacial dysmorphism with brachycephaly (without craniosynostosis), arachnodactyly, reduced radioulnar joint movement, conductive hearing loss, learning disability-and compound heterozygous CYP26B1 variants: (p.[(Pro118Leu)];[(Arg234Gln)]) were found. In family 2, a stillborn fetus presented a lethal phenotype with spina bifida occulta, hydrocephalus, poor skeletal mineralization, synostosis, limb defects, and a synonymous homozygous variant in CYP26B1: c.1083C > A. A minigene assay revealed that the synonymous variant created a new splice site, removing part of exon 5 (p.Val361_Asp382del). Enzymatic activity was assessed using a luciferase assay, demonstrating a notable reduction in exogenous retinoic acid metabolism for the variant p.Val361_Asp382del. (~ 3.5 × decrease compared to wild-type); comparatively, the variants p.(Pro118Leu) and p.(Arg234Gln) demonstrated a partial loss of metabolism (1.7× and 2.3× reduction, respectively). A proximity-dependent biotin identification assay reaffirmed previously reported ER-resident protein interactions. Additional work into these interactions is critical to determine if CYP26B1 is involved with other biological events on the ER. Immunofluorescence assay suggests that mutant CYP26B1 is still localized in the endoplasmic reticulum. These results indicate that novel pathogenic variants in CYP26B1 result in varying levels of enzymatic activity that impact retinoic acid metabolism and relate to the distinct phenotypes observed.

Unforeseen consequence: heterotopic ossification following traumatic brain injury and acetabulum fracture-a case report

Heterotopic ossification (HO) is a rare pathological condition characterized by the formation of bone in soft tissues outside the normal skeletal system. HO can result in restricted joint mobility, nerve compression, and pain. We present a case report of a 34-year-old male who developed HO. There is a history of neurological injury and fracture acetabulum (left). Imaging studies revealed extensive HO with complete bony bridging of the hip joint, leading to severe functional impairment and chronic pain. The patient had previously undergone multiple medical treatments with non-steroidal anti-inflammatory drugs, and physiotherapy with limited success. Ultimately, he underwent a complex surgical intervention involving resection of HO, release of joint contractures, resulting in significant improvement in joint mobility and pain control. Here we discuss a rare and debilitating presentation of HO and the treatment options available for such patients. Clinicians should be aware of this challenging condition and manage patients through a multidisciplinary approach.

A rare case of smear positive tuberculous arthritis

TB arthritis is a very rare extrapulmonary presentation in an immunocompetent host. It is usually the result of direct hematogenous spread from the primary focus. Our patient presented with pain and swelling of the right knee for 6 months. The blood investigations and CT chest revealed findings consistent with active tuberculosis. Synovial fluid was positive for acid-fast bacilli (AFB) which is a very rare finding. Cartridge-based nucleic acid amplification test (CBNAAT) revealed Mycobacterium tuberculosis and sensitivity to rifampicin. Establishing the diagnosis of Mycobacterium tuberculosis beyond doubt is very important, and early initiation of antitubercular treatment (ATT) is important as delay in treatment may lead to irreversible damage to the joint and restriction of joint mobility.

Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis

Category: Midfoot/Forefoot; Other Introduction/Purpose: Hallux Rigidus (HR) can cause pain with motion, enlarged joint, decreased joint space, subchondral sclerosis, osteophyte formation and restricted joint mobility, limiting patient physical activity. A modern technique for the treatment of HR is 1st MTP hemiarthroplasty with the use of a Cartiva synthetic cartilage implant. The Cartiva implant is designed to imitate natural cartilage; this allows patients to maintain motion in the 1st MTP joint. Current scientific literature reporting early outcomes of the procedure is sparse and mixed. This discrepancy and the overall scarcity of data indicates the need for further analysis. The purpose of this study is to compare improvement in VAS with 1st MTP hemiarthroplasty with the Cartiva implant, allograft interposition arthroplasty and fusion in patients who failed conservative management or cheilectomy. Methods: This study evaluated subjects who underwent interpositional arthroplasty, arthrodesis, or hemiarthroplasty with the Cartiva implant from January 2008 to April 2020, with a minimum of one year documented follow-up. All subjects were 18 years of age and older, diagnosed Hallux rigidus with pain, had a decrease in 1st MTP motion, and had X-ray findings consistent with decreased joint space. Patient data collected includes age, gender, ethnicity, occupation, height, weight, BMI, diabetes status, rheumatoid arthritis status, smoking, co-morbid conditions, medication, activity of choice, duration of symptoms, and operative data. Pre-operative and post- operative Visual Analog Scale (VAS) pain scores were compared between groups. Pain, function, and alignment between groups were also evaluated, pre-operatively and post- operatively, using the AOFAS Midfoot Scale. Secondary objectives evaluated include surgical complications, surgical revision, and X-rays. Results: One hundred patients with 12 months of post-operative follow-up were included in this study: 52 hemiarthroplasty with Cartiva implant patients (Group A), 24 arthrodesis patients (Group B), and 24 interpositional arthroplasty patients (Group C). The mean age of patients was 57.12 years (range 35-95). Average VAS pain scores for Group A was 3.78 (0-9), for Group B was 2.71 (0-10), and Group C was 3.67 (0-8). The average AOFAS score for Group A was 63.36 (30-95), for Group B was 60.98 (32- 83), and Group C was 60.13 (31-83). Pre-operative average VAS pain scores were 4.86 (Group A), 2.32 (Group B), and 5.58 (Group C). Post-operative average VAS pain scores were 2.69 (Group A), 0.91 (Group B), and 1.75 (Group C). Pre-operative average AOFAS scores were 59.52 (Group A), 48 (Group B), and 47.25 (Group C). Post-operative average AOFAS scores were 67.20 (Group A), 73.96 (Group B), and 73 (Group C). Conclusion: Preliminary data shows the greatest reduction in VAS pain scores in the interpositional arthroplasty group. The greatest improvement in derived AOFAS score was seen in the arthrodesis and interpositional arthroplasty groups, indicating a better overall combination of post-operative pain, function, and alignment when compared to patients who underwent hemiarthroplasty with Cartiva implant. While this study is not yet complete, it appears that hemiarthroplasty with Cartiva implant may allow patients to maintain motion in the 1st MTP joint, but at the cost of increased post-operative pain.

Simulation of double-leg stance in conditions of limited hip mobility

Hip osteoarthritis is one of the most common and disabling conditions affecting the elderly. Coxarthrosis is accompanied by impairment of the amortization properties of cartilage, its thinning and destruction, the appearance of pain syndrome, impaired motor functions due to a decrease in muscle strength and the development of stable flexion-adduction contractures, which change congenital motor programs, and, with a prolonged course of degenerative disease, lead to the formation of pathological habits. Objective: to determine the required strength of the muscles of the lower limb in conditions of limited hip mobility to support an upright posture in double-leg stance. Materials and methods. The work of the muscles of the lower extremities under conditions of restricted hip mobility was simulated using the OpenSim 4.0 software. It is based on the ToyLandingModel, which has contact geometry objects to fix the model on the support area. Four models were created: norm (without limitation of joint mobility), model 2 — adduction of 5°, model 3 — adduction of 7°, flexion of 10°, model 4 — adduction of 10°, flexion of 20°, shortening of the femur bones by 2 cm. Results. It was found that with insignificant adduction contractures of the hip joint, the work of the muscles of the lower limb changes slightly during double-leg stance. With flexion-adduction contractures, changes are observed in almost all muscles of the lower limb. There are some peculiarities in the work of muscles under contractures. All the muscles around the thigh reduce the strength necessary to maintain balance, while the lower leg muscles, on the contrary, increase the required strength several times. For example, m.medial gastrocnemius with flexion-adduction contracture and limb shortening develops10 times higher compensatory force (200 N) than in normal conditions (20 N), and although muscle resources are 1500 N, it is very demanding to maintain an upright posture. Similarly, m.tibialis posterior require an increase in strength (threefold), but the antagonist muscle m.tibialis anterior, on the contrary, reduces the force of contraction by an average of 100 N. Conclusions. According to the data of the conducted modeling of double-leg stance with limited hip mobility, it was proved that an increase in limited movements changes the nature of muscle contraction of the entire lower limb and pelvis. The analysis of the obtained results showed that restriction of movements reduces the required force of muscle stabilization around the hip joint, and increases the required force of contraction of the leg muscles. That is, there is an imbalance in the muscles.

Senolytics alleviate the degenerative disorders of temporomandibular joint in old age.

Aging is one of the major risk factors for degenerative joint disorders, including those involving the temporomandibular joint (TMJ). TMJ degeneration occurs primarily in the population over 65, significantly increasing the risk of joint discomfort, restricted joint mobility, and reduced quality of life. Unfortunately, there is currently no effective mechanism‐based treatment available in the clinic to alleviate TMJ degeneration with aging. We now demonstrate that intermittent administration of senolytics, drugs which can selectively clear senescent cells, preserved mandibular condylar cartilage thickness, improved subchondral bone volume and turnover, and reduced Osteoarthritis Research Society International (OARSI) histopathological score in both 23‐ to 24‐month‐old male and female mice. Senolytics had little effect on 4 months old young mice, indicating age‐specific benefits. Our study provides proof‐of‐concept evidence that age‐related TMJ degeneration can be alleviated by pharmaceutical intervention targeting cellular senescence. Since the senolytics used in this study have been proven relatively safe in recent human studies, our findings may help justify future clinical trials addressing TMJ degeneration in old age.

A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.

Osteoarthritis is characterized by degeneration of joint structure over time, resulting in limitation of joint mobility. There is growing evidence that curcumin has anti-inflammatory properties and could be a potential therapeutic option for chronic inflammatory diseases. Hence, curcumin could potentially have a positive impact on osteoarthritis symptoms. This systematic review aimed to estimate the effects of curcumin on osteoarthritis. We systematically searched PubMed, ISI, Scopus, and Google Scholar up to March 4, 2020 to identify randomized controlled trials that evaluated the effects of consumption of all types of curcumin compounds in the treatment of osteoarthritis, especially in patients with knee osteoarthritis. Seventeen trials were identified. The duration of the included studies varied from 4weeks to 8months. Across all trials, 13 studies involved screening using Western Ontario and McMaster Universities (WOMAC) scores and 11 studies used visual analog scales (VAS) for recording pain from baseline to post-intervention. There was a significant improvement in VAS and overall WOMAC scores with oral administration of various types of curcumin formulations with no severe adverse effects. In conclusion, different types of curcumin compounds may be beneficial as an alternative or complementary agent for the management of osteoarthritis. Moreover, certain curcumin compounds with higher bioavailability tended to show more positive effects.

Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment.

Elderly people perform more slowly movements of everyday life as rising from a chair, walking, and climbing stairs. This is in the first place due to the loss of muscle contractile force which is even more pronounced than the loss of muscle mass. In addition, a secondary, but not negligible, component is the rigidity or increased stiffness which requires greater effort to produce the same movement and limits the range of motion of the joints. In this short review, we discuss the possible determinants of the limitations of joint mobility in healthy elderly, starting with the age-dependent alterations of the articular structure and focusing on the increased stiffness of the skeletal muscles. Thereafter, the possible mechanisms of the increased stiffness of the muscle-tendon complex are considered, among them changes in the muscle fibers, alterations of the connective tissue components, i.e., extracellular matrix (ECM), aponeurosis, tendon and fascia, and remodeling of the neural pattern of muscle activation that increases antagonist co-activation.

Wireless Motion Sensors-Useful in Assessing the Effectiveness of Physiotherapeutic Methods Used in Patients with Knee Osteoarthritis-Preliminary Report.

Osteoarthritis of the knee (OAK) is characterized by pain, limitation of joint mobility, and significant deterioration of proprioception resulting in functional decline. This study assessed proprioception in OAK patients following two ten-day rehabilitation programs using the Orthyo® system. Fifty-four study participants with clinical symptoms and radiological signs of OAK were randomly divided into an exercise group (n = 27) or a manual therapy group (n = 27). The control group consisted of 27 volunteers with radiological signs of OAK, but with no clinical symptoms or prior history of rehabilitation. The following parameters were assessed: knee proprioception using inertial sensors and a mobile application, patients’ function using Western Ontario and McMaster Universities osteoarthritis index (WOMAC), and pain intensity using the visual analog scale (VAS). Following rehabilitation, knee proprioception tests did not improve in either study group. Both study groups showed significant improvement of the WOMAC-assessed function (exercise group: p < 0.01, manual therapy group: p = 0.01) and a significant decrease (p < 0.01) of VAS-assessed pain following rehabilitation, but the post-therapy results did not differ significantly between the aforementioned groups. The Orthyo® system provided a quick and accurate assessment of the knee joint position sense. There was no direct relationship between functionality, pain, and proprioception threshold in the knee joint.