Restricted Basis Research Articles

ON MINIMAL RESTRICTED ASYMPTOTIC BASES

AbstractLet $h \geq 2$ be a positive integer. We introduce the concept of minimal restricted asymptotic bases and obtain some examples of minimal restricted asymptotic bases of order h.

Many-particle covalency, ionicity, and atomicity revisited for a few simple example molecules

We analyze two-particle binding factors of H2, LiH, and HeH+ molecules/ions with the help of our original exact diagonalization ab initio approach. The interelectronic correlations are taken into account rigorously within the second quantization scheme for restricted basis of renormalized single-particle wave functions, i.e., with their size readjusted in the correlated state. This allows us to determine the many-particle covalency and ionicity factors in a natural and intuitive manner in terms of the microscopic single-particle and interaction parameters, also determined within our method. We discuss the limitations of those basic characteristics and introduce the concept of atomicity, corresponding to the Mott and Hubbard criterion concerning localization threshold in many-particle systems. This addition introduces an atomic ingredient into the electron states and thus removes a spurious behavior of covalency with the increasing interatomic distance, as well as provides a more complete physical interpretation of bonding.

A case for the provision of assisted dying in prisons founded on the right to self-determination: Creating equivalence between prisoners and non-prisoners?

This article makes the case for the provision of access to assisted death in prisons, founded on the right to self-determination under Article 8(1) ECHR, in order to create equivalence between prisoners and non-prisoners. It considers possible State justifications for interferences with the right under Article 8(2) and whether they would meet the Convention standards of legality and proportionality. In relation to proportionality, it is argued that the foundational basis for restrictions on assisted dying imposed on both the general and prison populations derives from the concept of human dignity, a concept which is also fundamental to prisoners’ rights. Under the banner of proportionality, from an initial presumption of equivalence of access to assisted dying, the article identifies certain conditions inherent in the prison situation that inevitably oppose human dignity and which provide a plausible basis for divergence. Ultimately, it is concluded that an absolute bar on provision of access to assisted dying in prisons cannot be justified, but that the factors that undermine dignity in prison could justify a degree of divergence from creation of equivalence between the prison and the non-prison populations in terms of such access.

The Role of the VP4 Attachment Protein in Rotavirus Host Range Restriction in an In Vivo Suckling Mouse Model.

The basis for rotavirus (RV) host range restriction (HRR) is not fully understood but is likely multigenic. RV genes encoding VP3, VP4, NSP1, NSP2, NSP3, and NSP4 have been associated with HRR in various studies. With the exception of NSP1, little is known about the relative contribution of the other RV genes to HRR. VP4 has been linked to HRR because it functions as the RV cell attachment protein, but its actual role in HRR has not been fully assessed. We generated a collection of recombinant RVs (rRVs) in an isogenic murine-like RV genetic background, harboring either heterologous or homologous VP4 genes from simian, bovine, porcine, human, and murine RV strains, and characterized these rRVs in vitro and in vivo. We found that a murine-like rRV encoding a simian VP4 was shed, spread to uninoculated littermates, and induced diarrhea comparably to rRV harboring a murine VP4. However, rRVs carrying VP4s from both bovine and porcine RVs had reduced diarrhea, but no change in fecal shedding was observed. Both diarrhea and shedding were reduced when VP4 originated from a human RV strain. rRVs harboring VP4s from human or bovine RVs did not transmit to uninoculated littermates. We also generated two rRVs harboring reciprocal chimeric murine or bovine VP4. Both chimeras replicated and caused disease as efficiently as the parental strain with a fully murine VP4. These data suggest that the genetic origin of VP4 partially modulates HRR in the suckling mouse and that both the VP8* and VP5* domains independently contribute to pathogenesis and transmission. IMPORTANCE Human group A rotaviruses (RVs) remain the most important cause of severe acute gastroenteritis among infants and young children worldwide despite the introduction of several safe and effective live attenuated vaccines. The lack of knowledge regarding fundamental aspects of RV biology, such as the genetic basis of host range restriction (HRR), has made it difficult to predictively and efficiently design improved, next-generation live attenuated rotavirus vaccines. Here, we engineered a collection of VP4 monoreassortant RVs to systematically explore the role of VP4 in replication, pathogenicity, and spread, as measures of HRR, in a suckling mouse model. The genetic and mechanistic bases of HRR have substantial clinical relevance given that this restriction forms the basis of attenuation for several replication-competent human RV vaccines. In addition, a better understanding of RV pathogenesis and the determinants of RV spread is likely to enhance our ability to improve antiviral drug and therapy development.

Effects of simulation problem-based learning based on Peplau's Interpersonal Relationship Model for cesarean section maternity nursing on communication skills, communication attitudes and team efficacy

BackgroundIn the coronavirus disease-impacted era, many medical institutions have not permitted clinical practice at hospitals or have operated their training on a restricted basis. The effective strategy for improving therapeutic communication and team cooperation as a nursing core competency is required. ObjectivesThe study aimed to verify the effects of simulation problem-based learning on nursing students' communication skills, communication attitudes, and team efficacy. DesignNon-equivalent control group pretest-posttest design. SettingsA university in South Korea. ParticipantsNursing students who were classified as advanced beginners were randomly allocated to the control group (n = 46) or the experimental group (n = 47). MethodsThe experimental group's students participated in the simulation problem-based learning for cesarean section maternity nursing. The control group's students participated in a conventional type of maternity nursing clinical practice. The communication skills, communication attitudes, and team efficacy were measured by using a self-reported questionnaire. ResultsAs compared with the pretest, the communication attitudes increased significantly (t = 2.41, p = .020) in the posttest for the experimental group. The communication skills (t = 1.47, p = .150) and team efficacy (F = 3.30, p = .073) were not statistically significant. ConclusionsThe simulation problem-based learning in clinical practice is recommended to improve communication attitudes for nursing students and to apply the learned knowledge in simulated nursing situations through experiential learning. Future research is particularly needed the standardized educational program to identify the long-term effects in various cases and settings.

A Stage-Specific OTX2 Regulatory Network and Maturation-Associated Gene Programs Are Inherent Barriers to RPE Neural Competency.

The retinal pigment epithelium (RPE) exhibits a diverse range of plasticity across vertebrates and is a potential source of cells for the regeneration of retinal neurons. Embryonic amniotes possess a transitory ability to regenerate neural retina through the reprogramming of RPE cells in an FGF-dependent manner. Chicken RPE can regenerate neural retina at embryonic day 4 (E4), but RPE neural competence is lost by embryonic day 5 (E5). To identify mechanisms that underlie loss of regenerative competence, we performed RNA and ATAC sequencing using E4 and E5 chicken RPE, as well as at both stages following retinectomy and FGF2 treatment. We find that genes associated with neural retina fate remain FGF2-inducible in the non-regenerative E5 RPE. Coinciding with fate restriction, RPE cells stably exit the cell cycle and dampen the expression of cell cycle progression genes normally expressed during regeneration, including E2F1. E5 RPE exhibits progressive activation of gene pathways associated with mature function independently of retinectomy or FGF2 treatment, including retinal metabolism, pigmentation synthesis, and ion transport. Moreover, the E5 RPE fails to efficiently repress OTX2 expression in response to FGF2. Predicted OTX2 binding motifs undergo robust accessibility increases in E5 RPE, many of which coincide with putative regulatory elements for genes known to facilitate RPE differentiation and maturation. Together, these results uncover widespread alterations in gene regulation that culminate in the loss of RPE neural competence and implicate OTX2 as a key determinant in solidifying the RPE fate. These results yield valuable insight to the basis of RPE lineage restriction during early development and will be of importance in understanding the varying capacities for RPE-derived retinal regeneration observed among vertebrates.

To evaluate histopathological changes in placenta of IUGR

The present study entitled “To evaluate Histopathological changes in Placenta of IUGR” was conducted in the Department of Obstetrics and Gynaecology. A total of 400 patients were studied. Out of them 200 were normal patients without IUGR and 200 with IUGR. These patients were evaluated with the help of semistructured proforma consisting of various socio-demographic and clinical variables.Number of LSCS deliveries in IUGR patients (59) is significantly more than control group (33).The number of syncytial knot formation (>10) in IUGR is 169 compared to 153 of control and hence is statistically insignificant. Cytotrophoblastic proliferation (>10) in IUGR (126) is significantly more than (92) in the control group. Number Of area fibrinoid necrosis in villi > 5 in IUGR group is 57 compared to control group (29) (significantly higher) No. of hylinized areas (> 5) in IUGR (101) is significantly higher than in control group (68). Histopathological findings in low power field like syncytial knot formation, cytotrophoblastic cellular proliferation, calcification and hyalinisation of villi are also found as normal aging changes in placenta but it occur early and more frequently per low power field in IUGR group. To conclude, these morphological & histological findings of placenta are the etiological basis for Intra uterine growth restriction.

Deep Learning Base Face Anti Spoofing -Convolutional Restricted Basis Neural Network Technique

Face anti-spoofing is the practice of using an authorized person's face to escape false face verification with a picture, video, mask, or another substitute. Latest innovations in face recognition and deep learning technology have made it possible to identify people from a distance using images acquired by a camera. The existing methods used different training sets and classifiers to recognize the face, which was difficult to classify and increase the time. A novel technology 3D Convolutional Restricted Basis Neural Network (CRBNN) is proposed in this paper to overcome this drawback. The proposed system is initialized by testing based on cross-entropy loss with augmented facial samples and further reinforced with an explicitly built generalization loss. The 3D-Convolutional layer is used for mapping the feature of the input image. Next, the Boltzmann technique is used for translation to form the reconstructed parameters. The Radial Basis Function Network (RBFN) is used to obtain an accurate classification. The experimental result proved the proposed CRBNN is given a better accuracy rate, less Equal Error Rate, and less time duration than existing methods. Our method is compared with spatial pyramid coding micro-texture (SPMT), Convolutional Neural Network (CNN), and radial basis function network (RBFN) and outperformed.

Metabolomics analysis reveals the physiological mechanism underlying growth restriction in maize roots under continuous negative pressure and stable water supply

Metabolomics analysis was used to elucidate the mechanism underlying response of the maize root system to continuous negative pressure and stable water supply. Results showed a significant reduction in continuous negative pressure and stable water supply (NPI) relative to intermittent positive pressure water supply (DI), maize root dry matter accumulation and root shoot ratio in NPI was 20.22%, 34.15% and lower than DI, respectively, yield was 44.10% higher than DI, and superoxide anion, malonic dialdehyde, osmotic adjustment substance content, and antioxidant enzyme activity was reduced. Next, we applied liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, and nuclear magnetic resonance to perform non-targeted metabolomics analysis with the aim of elucidating the physiological basis of root redundant growth restriction. Results revealed presence of 33 different metabolites in NPI, belonging to different categories, including organic acids and their derivatives, nucleosides, nucleotides and their corresponding analogues, lipids and lipid-like molecules, as well as organic oxygen compounds. Moreover, all these were enriched in 44 metabolic pathways, relative to DI. Notably, metabolic pathways, biosynthesis of secondary metabolites, starch and sucrose metabolism, plant hormones biosynthesis, and biosynthesis of plant secondary metabolites might restrict maize roots growth. In NPI was, Trehalose, 2’-deoxyadenosine, isoleucine and ajmaline were 0.34-, 0.05-, 0.004- and 0.17-fold lower than DI, whereas glutamic acid, glutamine and zeatin were 4.62,4.26,4.06 times higher than DI. This might inhibit root redundant growth. In summary, continuous negative pressure and stable water supply inhibited maize root redundant growth restriction by suppressing sugar metabolism and protein synthesis via genetic information transmission.

Restrictions of Human Rights on the Basis of Public Welfare

One of the basic principles of Japanese Constitution is respect for human rights. However, the Constitution stipulates “public welfare” in 4 Articles, and recognizes restrictions on human rights. From its text, it appears that human rights restrictions are widely recognized. The debate over public welfare has gone through several stages, and understanding has changed. The aim of this article is to introduce the meaning of “public welfare” in Japanese Constitution, and how it works. After introducing the flow of the theory, this article will examine how it functions as a basis for restrictions on human rights.

About system legislative viruses and social foundations of creating a new system of the Criminal Code of Ukraine

The article contains critical remarks about the draft of the new system of the Criminal Code of Ukraine, which is presented for discussion by its developers and is characterized by the presence of many new provisions. It is established that this system has significant shortcomings, which are associated with the incorrect reflection in the content of criminal law norms of the essential social features of crimes.
 To identify such shortcomings in the system of criminal law, the concept of "system legislative viruses" is highlighted and the need to have protection against such viruses in the system is substantiated. The necessity to distinguish between the legislative virus, the negative consequences of which in the form of human rights violations are local in nature, and the system legislative virus, the negative consequences of which are large-scale, is substantiated. Legislative viruses that result in violation of the principle of proportionality between punishment and social characteristics of acts are analyzed.
 Proposals for improving the system of the Criminal Code of Ukraine have been formulated. In particular, they concern the use of the category "public danger", which must perform a human rights function in the system of the Criminal Code of Ukraine. It is proposed to classify crimes using the social values ​​they encroach on and the extent of the damage that has been or may be caused. Emphasis is placed on the need to allocate at the law enforcement level the severity (danger) of the crime: 1) with particularly mitigating circumstances, 2) with mitigating circumstances, 3) without mitigating and aggravating circumstances, 4) with aggravating circumstances and 6) with especially aggravating circumstances. The court must impose penalties based on these degrees and the legal restrictions associated with them.
 The necessity of providing legal certainty on the social basis of criminal liability and restriction of rights for committing a crime, as well as on the legislative assessment of cases of simultaneous commission of several crimes and the rules of their qualification is substantiated.
 It is proposed to supplement the Criminal Code of Ukraine with Article 2-1 "Rule of Law", which will ensure justice in cases of errors made by the legislator and in other cases where there is a discrepancy between formal legal requirements and social characteristics of the crime.

The abuse potential of prolintane in rodents: Behavioral pharmacology approaches

Prolintane (1-Phenyl-2-pyrrolidinylpentane), a synthetic central nervous system (CNS) stimulant, is structurally similar to amphetamine but pharmacologically acts as a dopamine reuptake inhibitor like cocaine. While several case studies reported adverse effects and recreational use of prolintane, the abuse potential of the drug has not been systemically examined yet. In the present study, we evaluated the behavioral effects of prolintane regarding its abuse liability in rodents using locomotor activity, conditioned place preference (CPP), self-administration (SA), and drug discrimination paradigms, as well as in-vivo microdialysis experiment. First, acute prolintane (10 and 20 mg/kg, intraperitoneal injection) increased locomotor activity (distance traveled, cm) in mice but to a lesser degree than methamphetamine (as a positive control). We also found that a single and solitary injection of prolintane (20 mg/kg, IP) significantly increased extracellular dopamine in the striatum. The following result suggests that its stimulatory effects might be associated with the mesolimbic dopaminergic pathway. Further, prolintane produced a significant drug-paired place preference at doses of both 10 and 20 mg/kg. In the SA experiment, the mice that self-administered prolintane intravenously (4 mg/kg/inf) showed a higher infusion and active lever responses but not inactive lever responses. Additionally, cumulative doses of prolintane partially elicited cocaine-appropriate lever responses (38.57% at doses up to 10 mg/kg) in rats. These results implied that prolintane has not only rewarding and reinforcing effects but also interoceptive stimulus properties, which are similar to cocaine at a moderate level. Taken together, this study was the first to show, to our knowledge, that prolintane has a certain level of abuse potential and should be considered carefully as a valuable basis for legal restrictions on use.This article is part of the special Issue on ‘Stress, Addiction and Plasticity'.

Protection from domestic violence in the Republic of Kosovo

The paper analyzes and elaborates the protection from domestic violence, the subjects protected by law, the protection measures provided by law such as: lawsuit, court order, shelter of the victim, issuance of protection order, investigation, identification and responsibilities of the police on the basis of the law on the protection of victims of domestic violence. The paper will also analyze the measures taken to prevent domestic violence, strategies and efforts. Mutual police communications with the public through press releases, leaflets, leaflets, targeting negative phenomena in society, transparency on all taboo topics in the public interest but understood on the basis of legal restrictions. The paper also included research by various authors from both national and international perspectives on domestic violence. The paper uses inductive and deductive research methods, as well as analytical and comparative methods. This paper contributes to the existing scientific literature, especially the legal, criminological and victimological literature. Furthermore, this paper is likely to contribute to the work of NGOs that deal with providing victims of domestic violence, but also to the work of state bodies for the prevention of domestic violence, which is and remains a national challenge.

Prohibition of Discrimination on Grounds of Nationality in the Freedom of Movement of Persons within the EU in the Light of Case Law of the Court of Justice of the European Union

Prohibition of Discrimination on Grounds of Nationality in the Freedom of Movement of Persons within the EU in the Light of Case Law of the Court of Justice of the European Union

The essence and role of environmentally friendly agricultural land use in agriculture

The article deals with the relationship between economic development and environmental security.With regard to agricultural land use, ensuring environmental security involves optimizing the organization of land use and land use process on the basis of environmental restrictions on environmental pollution and agricultural products. First of all, according to environmental constraints, the possibilities of exploitation of natural resources and taking into account the peculiarities of agroecosystems (natural and climatic conditions, water resources, terrain, land and soil structure, land erosion, etc.) are determined to address food security. On their basis, ecologically balanced operation of agroecosystems is carried out through the formation of ecologically safe land uses, which provide for the optimization of economic activity of agricultural producers, taking into account environmental constraints. The article clarifies the essence and significance of ecologically safe agricultural land use in agriculture, proposes an approach to defining the essence of ecologically safe agricultural land use as a process of land use in the agricultural sector of the economy, which prevents the danger to human health, degradation of land resources, as well as their resilience to environmental threats and risks. The role of ecologically safe agrarian land use in ensuring sustainable development of rural areas and directions of influence of interaction of ecological and economic components of safety of agrarian land use are defined.

Corrosion Behavior of LENS Deposited CoCrMo Alloy Using Bayesian Regularization-Based Artificial Neural Network (BRANN)

The well-known fact of metallurgy is that the lifetime of a metal structure depends on the material's corrosion rate. Therefore, applying an appropriate prediction of corrosion process for the manufactured metals or alloys trigger an extended life of the product. At present, the current prediction models for additive manufactured alloys are either complicated or built on a restricted basis towards corrosion depletion. This paper presents a novel approach to estimate the corrosion rate and corrosion potential prediction by considering significant major parameters such as solution time, aging time, aging temperature, and corrosion test time. The Laser Engineered Net Shaping (LENS), which is an additive manufacturing process used in the manufacturing of health care equipment, was investigated in the present research. All the accumulated information used to manufacture the LENS-based Cobalt-Chromium-Molybdenum (CoCrMo) alloy was considered from previous literature. They enabled to create a robust Bayesian Regularization (BR)-based Artificial Neural Network (ANN) in order to predict with accuracy the material best corrosion properties. The achieved data were validated by investigating its experimental behavior. It was found a very good agreement between the predicted values generated with the BRANN model and experimental values. The robustness of the proposed approach allows to implement the manufactured materials successfully in the biomedical implants.

An Investigation into the Approximations Used in Wave Packet Molecular Dynamics for the Study of Warm Dense Matter

Wave packet molecular dynamics (WPMD) has recently received a lot of attention as a computationally fast tool with which to study dynamical processes in warm dense matter beyond the Born–Oppenheimer approximation. These techniques, typically, employ many approximations to achieve computational efficiency while implementing semi-empirical scaling parameters to retain accuracy. We investigated three of the main approximations ubiquitous to WPMD: a restricted basis set, approximations to exchange, and the lack of correlation. We examined each of these approximations in regard to atomic and molecular hydrogen in addition to a dense hydrogen plasma. We found that the biggest improvement to WPMD comes from combining a two-Gaussian basis with a semi-empirical correction based on the valence-bond wave function. A single parameter scales this correction to match experimental pressures of dense hydrogen. Ultimately, we found that semi-empirical scaling parameters are necessary to correct for the main approximations in WPMD. However, reducing the scaling parameters for more ab-initio terms gives more accurate results and displays the underlying physics more readily.

Pharmacy Regulatory Innovation Index: Benchmarking the regulatory environment in 10 western states

BackgroundPharmacy is among the most regulated of health professions on the basis of both word count and restrictions. State-level restrictions limit the ability of pharmacists to be fully engaged as members of the health care team. ObjectiveThis paper aimed to create a simple benchmark—the Pharmacy Regulatory Innovation Index (PRII)—that takes into account the scope-of-practice allowances that a state provides to pharmacists and the overall regulatory burden for the pharmacy profession using 10 western states as a sample. MethodsA scorecard was developed on the basis of the activities reported as necessary for pharmacists to fully engage in the Pharmacists’ Patient Care Process (PPCP). The laws and regulations of 10 western states were analyzed using plain-text interpretation. ResultsThe 10 western states fall into 3 of 4 distinct quadrants. Three states appear in the highly regulated, low-innovation quadrant (Oregon, California, and Nevada), and 2 states appear in the low-regulated, high-innovation quadrant (Idaho and Washington). The remaining 5 states fall in the low-regulated, low-innovation quadrant (Alaska, Hawaii, Montana, Utah, and Wyoming). ConclusionThe PRII has been created to assess a state’s regulatory burden and its scope-of-practice allowances, using the PPCP as a guide for innovation. States can use the PRII tool to benchmark their regulations in comparison with those of peer states and identify opportunities for improvement.

Reprint: Drawing conclusions from structural vector autoregressions identified on the basis of sign restrictions

This paper discusses the problems associated with using information about the signs of certain magnitudes as a basis for drawing structural conclusions in vector autoregressions. We also review available tools to solve these problems. For illustration we use Dahlhaus and Vasishtha’s (2019) study of the effects of a U.S. monetary contraction on capital flows to emerging markets. We explain why sign restrictions alone are not enough to allow us to answer the question and suggest alternative approaches that could be used.

A single-center cost analysis assessing a change in vasopressin formulation.

Cost savings achieved at an academic medical center by reformulating the institution's standard vasopressin infusions to reduce waste are described. After a retrospective review of vasopressin utilization over a 4-month period revealed that only approximately 40% of dispensed vasopressin units were actually administered to patients, pharmacy leaders determined that the institution's standard vasopressin concentration for continuous infusions (100 units in 100 mL of sodium chloride 0.9% injection) was resulting in substantial waste, as many infusion preparations were not needed within the 18- to 24-hour expiration window. A concentration of 20 units/100 mL was adopted as the new standard formulation for vasopressin continuous infusions, with use of alternative concentrations allowed on a restricted basis. A pre-post study to assess the impact of the formulation change indicated a 38.7% decrease in vasopressin utilization (from 21,900 to 8,480 units) relative to utilization in a retrospective sample of patients who received vasopressin infusions prior to the formulation change. This reduced utilization equated to a cost decrease of $55,656.20 (as calculated on the basis of 2017 cost estimates) or $77,214.23 (as calculated on the basis of 2019 cost estimates) for the time period collected. It was estimated that the new formulations could yield annual cost savings ranging from $222,625 to $308,857. To our knowledge, this is the first description of cost savings following a change in formulation of vasopressin for continuous infusions. Other institutions could consider employing a similar approach in addition to the previously reported cost-saving interventions, such as lower vasopressin starting doses and vasopressin restriction policies.