Aims: the aim of the current study is to assess the quantity of sorption and solubility seen in the soft denture liner with herbal (neem) and commercially (clinsodent) available denture cleanser.
 Materials and Methods: The cross sectional study was carried out in the Department of Prosthodontics at Sharad Pawar Dental College And Hospital between February 2021 and July 2021. 52 samples of heat cured acrylic resin of circular shape were prepared using a stainless steel mould. The resilient liner was applied to all the samples using a denture adhesive. All samples will then be desiccated for 24 hours to get a stable or conditioned weight W1. The samples will then be divided into 2 groups namely: Group A (clinsodent group) and the Group B (herbal denture cleanser group). All the samples were immersed daily in cleanser for 8 hour and then transferred to artificial saliva for rest 16 hours of the day. Solutions of artificial saliva and denture cleanser was changed daily for the entire period of study that is 7 days. Later, all the test samples were removed from saliva, wiped dry, weighed for saturated weight W2. - After desiccating again for 24 hours the samples were again assessed for renovated weight that is W3.
 Results: With respect to sorption and solubility it was found that the clinsodent group exhibited greater percentage of sorption when compared to the neem denture cleanser group after a period of 7 days, p-values of 0.0001,S.
 Conclusion: It can be established that the solubility and sorption values of clinsodent group were higher when compared to the herbal denture cleanser group. Overall, neem in the form of denture cleanser performed better than clinsodent.