Response Score Research Articles

Concordance of ChatGPT With American Burn Association Guidelines on Acute Burns.

Burn injuries often require immediate assistance and specialized care for optimal management and outcomes. The emergence of accessible artificial intelligence technology has just recently started being applied to healthcare decision making and patient education. However, its role in clinical recommendations is still under scrutiny. This study aims to evaluate ChatGPT's outputs and the appropriateness of its responses to commonly asked questions regarding acute burn care when compared to the American Burn Association Guidelines. Twelve commonly asked questions were formulated by a fellowship-trained burn surgeon to address the American Burn Association's recommendations on burn injuries, management, and patient referral. These questions were prompted into ChatGPT, and each response was compared with the aforementioned guidelines, the gold standard for accurate and evidence-based burn care recommendations. Three burn surgeons independently evaluated the appropriateness and comprehensiveness of each ChatGPT response based on the guidelines according to the modified Global Quality Score scale. The average score for ChatGPT-generated responses was 4.56 ± 0.65, indicating the responses were exceptional quality with the most important topics covered and in high concordance with the guidelines. This initial comparison of ChatGPT-generated responses and the American Burn Association guidelines demonstrates that ChatGPT can accurately and comprehensibly describe appropriate treatment and management plans for acute burn injuries. We foresee that ChatGPT may play a role as a complementary tool in medical decision making and patient education, having a profound impact on clinical practice, research, and education.

Maximizing effectiveness: Chemotherapy response score and homologous recombination deficiency strategies

Maximizing effectiveness: Chemotherapy response score and homologous recombination deficiency strategies

Assessment of Knowledge About High Blood Pressure Among Syrians

Hypertension, often referred to the silent killer, is a prevalent health issue that impacts more than a billion individuals worldwide. The purpose of this study was to investigate the understanding of hypertension among Syrian individuals. 104 individuals filled out surveys. Females made up 64.4% of the group that was surveyed. 28.8% of the participants in the study were between the ages of 46 and 60. More than half of the participants had a study or a work related to the medicinal field. The participants showed good medication adherence where the score of accurate responses to the questions regarding medication compliance was very high. Most participants were familiar with the normal values of blood pressure levels and were optimistic about the possibility of treating the condition. A good percentage of individuals surveyed stated that smoking and obesity are contributing factors to developing high blood pressure. Most participants believed that consuming fatty foods raises plasma cholesterol levels. Participants had a good overall understanding of high blood pressure. However, they still need improvement in medical information about high blood pressure to enhance compliance with treatments.

Development of augmented reality media based on Assemblr Edu to enhance the learning outcomes

This study focuses on the development and evaluation of augmented reality (AR) learning media based on the Assemblr Edu application, aimed at enhancing the learning experience of fifth-grade students at SDN Tambaharjo 01. The AR media covers the subject of Community Economic Conditions and Natural Resources and Supporting Factors for Community Economic Activities. The research process included designing the AR content, validating it with experts, and conducting small and large group trials. This study investigates the development and effectiveness of AR learning media based on the Assemblr Edu application to improve learning outcomes in Natural Science and Social Studies for fifth-grade students at SD Negeri Tambaharjo 01. The research employs a quantitative approach with a Research and Development (R&D) method, utilizing the ADDIE development model to create and assess the learning media. The study addresses low student performance in Natural Science and Social Studies by integrating interactive AR technology to make learning more engaging and effective.The developed AR media, which includes 3D and 2D interactive content, was validated by material and media experts, yielding a high validity score of 90.31%. Small and large group trials were conducted, showing significant improvements in student learning outcomes. Pretest and posttest results demonstrated an average score increase from 50 to 85, with a student response rate of 88.46% indicating the media's feasibility. Teachers also rated the AR media highly, with a response score of 91.34%, confirming its practical application in educational settings. The study concludes that the Assemblr Edu-based AR learning media is highly feasible and effective in enhancing student learning outcomes in Natural Science and Social Studies.

Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer.

Checkpoint inhibitors (CPIs) have been widely applied in the treatment of patients with bladder cancer (BLCA). However, there is still unmet need to dissect response predict biomarkers. To uncover CPI response-related marker genes in cancer cells, we utilized SCISSOR, integrating single-cell RNA and bulk RNA sequencing data. Transcriptomic and clinical data from IMvigor210, UNC-108, and BCAN/HCRN datasets were collected to evaluate and validate the identified biomarkers and signatures. Additionally, we analyzed TCGA-BLCA and local-BLCA RNA-seq data to investigate alternative splicing events (ASEs). Cell viability was assessed in T24 and UMUC3 cells with RBM17 upregulation or downregulation. Through SCISSOR analysis, we discovered that the expression levels of RBM17, TAP1, and PSMB8 were significantly associated with CPI response. Since PSMB8 displayed a highly positive correlation with TAP1, we developed a CPI response score (CRS) signature based on the expression profiles of RBM17 and TAP1. The CRS demonstrated robust predictive capacity in IMvigor210, UNC-108, and BCAN/HCRN datasets and was associated with higher tumor mutational burden (TMB), PD-L1 expression, and unique genomic features. Notably, RBM17 was not linked to the clinical outcomes of BLCA patients but positively correlated with BLCA cell proliferation in vitro. In the meantime, RBM17 was correlated with higher activity in core biological pathways, including antigen processing machinery, CD8 + T effector cells, cell cycle, DNA damage repair, epithelial-mesenchymal transition, histone regulation, and immune checkpoints. Moreover, the high-RBM17 group showed enrichment of LumU/Ba/sq subtypes but fewer FGFR3 alterations. Lastly, RBM17 significantly upregulated ASEs in BLCA samples, leading to higher neoantigen levels, a more inflamed tumor microenvironment, and improved CPI response. RBM17 is associated with higher ASEs and neoantigen levels, thereby potentiating the efficacy of CPI in BLCA. The established predictive signature, utilizing only two genes, has the potential to streamline clinical applications, providing a cost-effective alternative to expensive genomic, transcriptomic, and biological feature tests.

Accuracy of natural language processors for patients seeking inguinal hernia information.

NLPs such as ChatGPT are novel sources of online healthcare information that are readily accessible and integrated into internet search tools. The accuracy of NLP-generated responses to health information questions is unknown. We queried four NLPs (ChatGPT 3.5 and 4, Bard, and Claude 2.0) for responses to simulated patient questions about inguinal hernias and their management. Responses were graded on a Likert scale (1 poor to 5 excellent) for relevance, completeness, and accuracy. Responses were compiled and scored collectively for readability using the Flesch-Kincaid score and for educational quality using the DISCERN instrument, a validated tool for evaluating patient information materials. Responses were also compared to two gold-standard educational materials provided by SAGES and the ACS. Evaluations were performed by six hernia surgeons. The average NLP response scores for relevance, completeness, and accuracy were 4.76 (95% CI 4.70-4.80), 4.11 (95% CI 4.02-4.20), and 4.14 (95% CI 4.03-4.24), respectively. ChatGPT4 received higher accuracy scores (mean 4.43 [95% CI 4.37-4.50]) than Bard (mean 4.06 [95% CI 3.88-4.26]) and Claude 2.0 (mean 3.85 [95% CI 3.63-4.08]). The ACS document received the best scores for reading ease (55.2) and grade level (9.2); however, none of the documents achieved the readibility thresholds recommended by the American Medical Association. The ACS document also received the highest DISCERN score of 63.5 (57.0-70.1), and this was significantly higher compared to ChatGPT 4 (50.8 [95% CI 46.2-55.4]) and Claude 2.0 (48 [95% CI 41.6-54.4]). The evaluated NLPs provided relevant responses of reasonable accuracy to questions about inguinal hernia. Compiled NLP responses received relatively low readability and DISCERN scores, although results may improve as NLPs evolve or with adjustments in question wording. As surgical patients expand their use of NLPs for healthcare information, surgeons should be aware of the benefits and limitations of NLPs as patient education tools.

Design and Development of Diabestfriend Application for Digital Self Care Management of Type 2 Diabetes Mellitus Patients

Objective: The availability of the results of the Android-based Diabestfriend Application for digital self-care management of type 2 diabetes mellitus patients. Theoretical Framework: The numerous interventions that come under the more general term "self-care" and are helpful in understanding the self-care suite have been categorized into three domains: self-awareness, self-testing, and self-care. Methods: The ADDIE development model is used in this study in three stages. Ten patients with type 2 diabetes who completed questionnaires, along with validators from one media expert and one material expert, comprise the implementation stage, which is the application assessment stage. The questionnaires consist of three sections: a total of 16 questions for patient application assessment, 21 questions for media expert validation, and 25 questions for material expert validation. Results and Discussion: The validation score of media experts was 83.8 with the very good category, the validation score of the material experts was 81.6 with the very good category and the response score of diabetes mellitus patients was 88.95 with the very good category. Research Implications: Further research on the efficacy of the Diabestfriend Application as a digital self-care management tool in type 2 diabetes mellitus patients will provide insight into how the use of the application affects the patients' level of self-care management. Originality/Value: The Diabestfriend Application is appropriate for use as a digital self-care management tool for patients with type 2 diabetes mellitus, according to validation from media experts, material experts, and 10 diabetes patients.

Efficacy of Biofeedback Therapy for Giggle Incontinence in Children: How Many Sessions Are Required?

Giggle incontinence (GI) is characterized by the sudden and involuntary expulsion of urine coinciding with episodes of laughter. The underlying pathophysiology of this condition remains unclear, and various treatment approaches are employed. The objective of this study is to assess the effectiveness of biofeedback (BF) therapy in treating GI and ascertain the requisite number of therapy sessions needed for efficacy. Medical records of children treated with BF therapy for GI between November 2022 and November 2023 were retrospectively analyzed. The success of treatment was assessed after four and eight sessions, as well as following three maintenance sessions. Treatment outcomes were evaluated using the scoring system recommended by the International Children's Continence Society (ICCS), which categorizes responses into three levels: no response (Score 0), partial response (Score 1), and complete response (Score 2). Thirteen patients were initially diagnosed with GI. Of these, 10 patients were included in the study as three discontinued treatments. The cohort comprised an equal gender distribution with five females (50.0%) and five males (50.0%). The mean age of patients was 8.9 ± 3.3 (range 5-16) years. Two out of ten patients had a history of previous treatment for overactive bladder, while three had received treatment for primary monosymptomatic nocturnal enuresis. Following the completion of all BF sessions, the rate of complete response was observed at 80.0% (n = 8), while the partial response rate accounted for 10.0% (n = 1). Statistical analysis revealed significant differences in response scores after four and eight sessions (p < 0.01) as well as between the results after eight sessions and the completion of maintenance sessions (p < 0.01). BF therapy demonstrates a high success rate in managing GI. Completion of at least eight BF therapy sessions enhances the probability of a successful outcome in the treatment of GI. Additionally, it has been observed that maintenance sessions contribute to the increased efficacy of the treatment.

Elevated temperature increases the susceptibility of D. magna to environmental mixtures of carbamazepine, tramadol and citalopram

The joint risks assessment of thermal stress and rising loads of pharmaceuticals (PhACs) in surface waters is a relevant topic in aquatic ecotoxicology. This study investigated the relevance of increased water temperature to alter the acute toxicity of environmentally relevant carbamazepine (CBZ), citalopram (CIT) and tramadol (TRA) concentrations as mixtures (ECs) and delayed outcomes in Daphnia magna. Responses of detoxification and antioxidant pathways in premature daphnids post an acute 24 h (pulsed) exposure to the PhACs mixtures and delayed responses as the reproductive output over 14 days recovery were investigated under 21- and 26 °C incubation. Biphasic modulation in glutathione S-transferase (GST) activity and significant inhibition of superoxide dismutase (SOD) activity were observed in both thermal regimes with significant shift in effective thresholds from 10-fold ECs at 21 °C to ECs at 26 °C incubation. Significant induction in catalase (CAT) activity and oxidative stress development were recorded at elevated temperatures from the 10-fold ECs dose onward. Pulsed exposures at 26 °C also led to significant decrease in the reproduction of daphnids above the 10-fold ECs of PhACs. The Integrated Biomarker Response scoring (IBRv2) approach outlined a 1.8-fold increase in alterations of daphnids exposed to 100-fold ECs of PhACs at 26 °C.

A Learning Model for Explanation Text Literacy Using Flipbook Applications in SMP/MTS

This research aims to develop an explanatory text literacy learning model using the flipbook application as media in SMP/MTS. The background to this problem 1) How is the planning for an explanatory text literacy learning model using the flipbook application as a medium in class VIII SMP/MTS? 2) How to implement an explanatory text literacy learning model using the flipbook application as a medium in class VIII SMP/MTS? 3) What is the effectiveness of the explanatory text literacy learning model using the flipbook application as a medium in class VIII SMP/MTS? This research uses the Research and Development (R&amp;D) research and development method with the ADDIE (Analyze, Design, Development, Implementation, and Evaluation) model. The steps of this research consist of, needs analysis, learning model design, learning model development, implementation of learning model products, evaluation of learning model products. Data collection in this research was by collecting data from the results of expert validation questionnaires and questionnaires from student assessments. The data obtained was analyzed descriptively using a Likert scale. The results of the validation test by media experts obtained a score of 77.94%, the validation test by language experts obtained a score of 81.25%, the Indonesian language teacher's response score obtained a score of 97.33%, and the average student response obtained a score of 82.13%. The conclusion of this research is that the explanatory text literacy learning model using the flipbook application media in SMP/MTS meets the appropriate criteria to be used as a learning model by students or teachers in Indonesian language subjects with explanatory text material in class VIII SMP/ MTS students.

Prognostic Significance of Chemotherapy Response Score in Patients Undergoing Interval Debulking Surgery and Attained Complete Cytoreduction for High-Grade Serous Tubal and Ovarian Carcinoma

Objectives The chemotherapy response score (CRS) has been described to assess the pathological response to chemotherapy in patients with high-grade serous tubal and ovarian carcinoma. The main aim of this study was to assess the prognostic significance of CRS in patients who underwent interval debulking surgery and attained complete cytoreduction. Materials and Methods A retrospective study was conducted on patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage IIIC and IV high-grade serous tubal and ovarian carcinomas who had undergone surgery after three to four cycles of neoadjuvant chemotherapy and attained complete cytoreduction from January 2015 to July 2018. Results A total of 125 patients were included in the study. The median age of the patients was 52 years. There were 21 patients (16.8%) with a CRS of 1, 53 patients (42.4%) with a CRS of 2, and 51 (40.8%) patients with a CRS of 3. The median follow-up period was 77 months. The CRS applied on the omental samples showed significant correlation with progression-free survival (PFS; CRS of 1 vs. 2: median PFS, 17 vs. 22 months; hazard ratio, 1.73; and CRS of 2 vs. 3: median PFS, 22 vs. 54 months; hazard ratio, 2.32) and overall survival (OS; CRS of 1 vs. 2: median OS, 19 vs. 40 months; hazard ratio, 2.13; CRS of 2 vs. 3: median OS, 40 months vs. not reached; hazard ratio, 2.19). Conclusion Our study confirms that the omental CRS is significantly associated with PFS and OS in patients who attained complete cytoreduction during interval debulking surgery.

EzySCR: A free and easy tool for scoring event-related skin conductance responses in the first, second, and third interval latency windows.

Skin conductance is a commonly used physiological measure during psychology experiments, such as during fear conditioning. Methods for scoring skin conductance responses (SCRs) are highly heterogeneous, though most researchers agree that manually inspected scores provide the highest quality data when compared to most available fully automated scoring methods. However, manual scoring is extremely time-consuming. We developed a semi-automated scoring program that reduces the time required to process SCR data at a level of quality akin to manual scoring. In contrast to all previous scoring programs, our program enables scoring of first interval response (FIR), second interval response (SIR), and third interval response (TIR) SCRs. Using interclass correlation coefficients (ICCs), Bland-Altman plots and Pareto analysis, we show here that our method is highly reliable and produces data that are almost identical to data that are manually scored and scored using LEDALAB. This software is very easy to use and is freely available to download and modify. We expect that this software will be helpful in reducing the time required to produce high quality FIR, SIR, and TIR skin conductance data for psychology researchers around the world.

The association of the chemotherapy response score and homologous recombination deficiency in patients undergoing interval tumor reductive surgery following neoadjuvant chemotherapy

ObjectivesIn patients undergoing interval tumor reductive surgery, a good response to neoadjuvant chemotherapy may limit available tumor for homologous recombination deficiency testing. The objective of this study was to assess...

Prognostic impact of microscopic residual disease after neoadjuvant chemotherapy in patients undergoing interval debulking surgery for advanced ovarian cancer.

To determine the prognostic impact of microscopic residual disease after neoadjuvant chemotherapy (NACT) in patients undergoing interval debulking surgery (IDS) for advanced epithelial ovarian cancer (AEOC). Patients affected by FIGO stage IIIC-IV ovarian cancer undergoing IDS between October 2010 and April 2016 were selected. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier analysis. In total, 98 patients were identified. Four patients (4.1%) were considered inoperable. Overall, 67 patients (out of 94; 71.3%) had macroscopic disease, equating Chemotherapy Response Score (CRS) 1 and 2, 7 (7.4%) had microscopic residuals, equating CRS3, rare CRS2, while 20 (21.3%) had both microscopic and macroscopic disease. Median OS and PFS were, respectively, 44 and 14months in patients with no macroscopic residual disease (RD = 0) compared to 25 and 6months, in patients with RD > 0 (OS: p = 0.001; PFS: p = 0.002). The median PFS was 9months compared to 14months for patients with more or less than 3 areas of microscopic disease at final pathologic evaluation (p = 0.04). The serum Ca125 dosage after NACT was higher in patients with RD > 0 compared to those without residue (986.31 ± 2240.7µg/mL vs 215.72 ± 349.5µg/mL; p = 0.01). Even in the absence of macroscopic disease after NACT, the persistence of microscopic residuals predicts a poorer prognosis among AEOC patients undergoing IDS, with a trend towards worse PFS for patients with more than three affected areas. Removing all fibrotic residuals eventually hiding microscopic disease during IDS represents the key to improving the prognosis of these patients.

What Is the Prognostic Value of the Pathologic Response after Neoadjuvant Radiotherapy in Soft Tissue Sarcoma? An Institutional Study Using the EORTC-STBSG Response Score.

Background/Objectives: The relationship between pathologic findings in soft tissue sarcoma (STS) after neoadjuvant treatment and oncological outcomes remains uncertain due to varying evaluation methods and cut-off values. This study aims to assess pathologic findings after neoadjuvant radiotherapy in STS using the EORTC-STBSG response score and evaluate its prognostic value. Methods: Clinical and outcome data from 44 patients were reviewed. Resected specimens were re-evaluated to measure viable cells, necrosis, fibrosis, and hyalinization. Local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS) were analyzed using Kaplan-Meier survival analysis. Cox proportional hazards regression was used for univariate and multivariate analyses to correlate outcomes with pathologic response. Results: The median percentages of viable cells, necrosis, and fibrosis/hyalinization were 20%, 11%, and 40%, respectively. A pathologic complete response (pCR), defined as ≤5% viable cells, was achieved in 25% of cases. Local recurrence occurred in 33% of cases, with a significantly higher rate of 64% after R1 resection compared to 22% after R0 resection. Distant metastases were observed in 42% of patients, primarily in the lungs. The 3-year rates for LRFS, DMFS, and OS were 65%, 54%, and 67%, respectively. A correlation between outcomes and tumor size, grade and histological subtype was observed. Classifying pathologic response by the EORTC-STBSG score failed to show an association with outcomes. Patients achieving pCR showed lower risk of LR and improved OS. Conclusions: While the EORTC-STBSG score did not show a prognostic value, resection specimens with ≤5% viable cells were linked to improved LRFS and OS.

The Ramp protocol: Uncovering individual differences in walking to an auditory beat using TeensyStep

Intentionally walking to the beat of an auditory stimulus seems effortless for most humans. However, studies have revealed significant individual differences in the spontaneous tendency to synchronize. Some individuals tend to adapt their walking pace to the beat, while others show little or no adjustment. To fill this gap we introduce the Ramp protocol, which measures spontaneous adaptation to a change in an auditory rhythmic stimulus in a gait task. First, participants walk at their preferred cadence without stimulation. After several steps, a metronome is presented, timed to match the participant’s heel-strike. Then, the metronome tempo progressively departs from the participant’s cadence by either accelerating or decelerating. The implementation of the Ramp protocol required real-time detection of heel-strike and auditory stimuli aligned with participants’ preferred cadence. To achieve this, we developed the TeensyStep device, which we validated compared to a gold standard for step detection. We also demonstrated the sensitivity of the Ramp protocol to individual differences in the spontaneous response to a tempo-changing rhythmic stimulus by introducing a new measure: the Response Score. This new method and quantification of spontaneous response to rhythmic stimuli holds promise for highlighting and distinguishing different profiles of adaptation in a gait task.

Association of psychological and physical stress response with weight gain in university employees in Japan: a retrospective cohort study.

To clarify the association of job stressor score (A score), psychological and physical stress response score (B score), and social support (C score), with the incidence of ≥10% weight gain. This study included 10,036 university employees who completed the brief job stress questionnaire (BJSQ) and annual health checkups between 2016 and 2021. The incidence of ≥10% weight gain from baseline weight was measured. Participants were classified into four categories based on their BJSQ dimension scores. B score was significantly associated with the incidence of weight gain, whereas A and C scores were not. Participants of Q75-89, and Q90-100 categories of B score were at significantly high risk of the incidence of ≥10% weight gain. Psychological and physical stress response had an increasing risk of weight gain.

The role of visual aids in the clinical success of posterior restorations: Randomized controlled clinical trial

ObjectiveThis clinical study aimed to assess the impact of utilizing loupes and dental operating microscopes (DOM) with varying magnifications on the success of class II direct composite restorations. MethodsA total of 130 class II, moderately deep caries teeth from 85 patients were randomly assigned to four groups: naked eye, ×3 loupe, ×5 loupe, and ×8.5 DOM. Cavities were restored with or without magnification. The restorations were evaluated according to World Dental Federation criteria at 1, 6, and 12-month intervals by previously calibrated evaluators. Cochran's Q test was used to compare paired scores across three or more time points within groups, while the Friedman test was employed to compare scores at three or more time points. Multiple comparisons were adjusted using the Bonferroni correction. The significance level was set at p < 0.05. ResultsStatistical analysis revealed no significant differences among the groups at the 1-, 6-, and 12-month follow-up periods (p > 0.05). Although not statistically significant, the magnified groups exhibited higher scores in aesthetic anatomical form, proximal form, postoperative sensitivity, periodontal response, and adjacent mucosalcriteria compared to the naked eye group. ConclusionAlthough no statistically significant difference was observed at the 12-month follow-up between restorations performed with and without magnification, the groups using magnification showed higher scores.

Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Initially Treated with Baricitinib 4-mg: Week 152 data from BRAVE-AA2

BackgroundBaricitinib, an oral selective Janus kinase inhibitor, is approved to treat adults with severe alopecia areata (AA). ObjectiveTo report the Week 152 efficacy results from the Phase 3 trial BRAVE-AA2 down-titration sub-study. MethodsBRAVE-AA2 enrolled 546 adults with severe AA (Severity of Alopecia Tool [SALT] score ≥50). Baricitinib 4-mg treated patients achieving a clinical response (SALT score ≤20) at Week 52 were rerandomized 1:1 to stay on 4-mg or down-titrate to 2-mg. Last observation carried forward was used to impute missing or censored data. ResultsAt Week 52, 86/234 (36.8%) baricitinib 4-mg treated patients were eligible for down-titration; 44 remained on 4-mg while 42 down-titrated to 2-mg. At Week 152, 39/44 (88.6%) 4-mg treated patients had maintained clinical response, compared to 24/41 (58.5%) down-titrated patients. Among down-titrated patients, loss of treatment benefit was less frequent in those with sustained response and SALT score ≤5 at Week 52. LimitationsMethod and timing of down-titration were pre-specified in the protocol based on Week 52 responder status and not on other clinical factors. ConclusionMore than half of down-titrated patients maintained response. Sustained treatment response and/or near-total regrowth may be associated with a greater likelihood of response maintenance after down-titration.

THE ROLE OF INFLAMMATORY PARAMETERS AND SCORING SYSTEMS IN PREDICTING COMPLICATED ACUTE APPENDICITIS

Aim: To assess the complications associated with acute appendicitis (AA) and to evaluate how specific routine patient parameters influence disease severity. Materials and Methods: A retrospective study was carried out on patients diagnosed with AA who presented to the emergency department (ED) between January 1, 2019, and December 31, 2020. Data collected included demographic details, blood test results, and specific scoring systems utilized in the ED. Results: Of the 223 patients studied, 63.7% were male with a mean age of 37.5 ± 16.8 years. Patients with complicated appendicitis (CA) showed significantly elevated hematological parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP), systemic immune inflammation index (SII), white blood cell count (WBC), and neutrophil levels. Conversely, decreased lymphocyte/C-reactive protein ratio (LCRP) and lymphocyte levels were noted. Furthermore, CA cases exhibited significantly greater Appendicitis Inflammatory Response (AIR) and Alvarado scores. In the context of diagnosing CA, the AIR score had a sensitivity of 85.9% and a specificity of 47.9% with a cut-off value of ≥6 (95% CI 0.675-0.821, Area Under the Curve (AUC): 0.748; p