Macroscopic mechanical response is one of the key factors in designing pressure vessel. A geometric modeling of pressure vessel was established and the mesh of this modeling then generated by using the finite element simulating methods in software ABAQUS. Loading and boundary conditions of dead weight, hydraulic and uniform internal pressure which often suffered pressure vessel were set and calculated by the finite element method. Stress/strain response of pressure vessel in all kinds of alone loading ways were obtained. The results of finite element simulating were in accordance with those of theoretical calculation which provided useful data for research on mechanical response of pressure vessel under complex loading conditions.