Resource Partners Research Articles

Symbiotic association of resources and market-facing capabilities in supply chains as determinants of performance: a resource orchestration perspective

PurposeThe purpose of this study is to advance the understanding of resource orchestration in inter-firm partnerships that appropriately configure and align strategic cross-firm supply chain resources and capabilities generating synergies to deliver superior performance.Design/methodology/approachApplying the resource orchestration logic, supported by the relational view of competitive advantage, the study draws from an empirical analysis of survey data from 152 top-level executives of US manufacturing firms to investigate the effect of leveraging and coherently combining cross-firm supply chain resources with capabilities on operational performance.FindingsThe study underscores the view that appropriately orchestrated combinations of key partnership resources and capabilities as mechanisms for marketing strategy implementation, enhance performance. Specifically, research results suggest that complementary inter-firm resources and lean align, and similarly idiosyncratic resources and agility align synergistically to deliver superior operational performance outcomes. The results also accent partnership responses to intense competition, enabling enhanced operational performance. The findings thus enrich the understanding of the resource orchestration logic and strategy, making important theoretical contributions.Research limitations/implicationsAs is typical in marketing and strategy research, the study research design has a cross-sectional framework, thus limiting insights on the resource orchestration dynamics that can otherwise be generated using a longitudinal design. Also, the resource orchestration stream is still nascent. Further research is needed to delineate the orchestration mechanisms that deliver on performance outcomes, especially in supply chains.Practical implicationsA key insight for supply chain and marketing managers is that close-knit inter-firm partnerships are critical for accessing idiosyncratic and complementary resources that can be configured and symbiotically aligned with market-facing agility and lean capabilities, respectively, to deliver market value. Proactive partnerships, especially in highly competitive and disruptive environments, enable mobilizing cross-firm resources and building appropriate matching combinations with capabilities to deliver on operational performance.Originality/valueThe study, guided by theory, advances the understanding of how key cross-firm resources and capabilities deliver performance gains. The key to competitive advantage and enhanced performance outcomes may lie in acquiring, leveraging and deploying appropriately matched resource-capability combinations. The present study investigates this proposition within the context of supply chain partnerships, focusing on cross-firm resources and capabilities.

Interfirm partnership resource–lean capability association: exploring the moderating role of learning orientation and performance implications

ABSTRACT Applying the dynamic capabilities theory and the relational perspective, we examine key cross-firm supply chain resources as determinants of lean capability, the latter’s impact on operational and financial performance, and additionally, the interactive influence of learning orientation. Analyses of 152 manufacturing firms headquartered in the U.S.A. relate lean capability to operational and financial performance outcomes. Resource complementarity and resource specificity significantly associate with supply chain lean capability. A negative interaction effect of learning orientation context is indicated for the resource complementarity–lean association. However, a universality of interactive impact of learning orientation is suggested for the resource specificity-lean capability relationship. Contributions extend dynamic capability theory to supply chain contexts: key supply chain partnership resources configured into lean capability deliver superior performance, with learning orientation present in a boundary condition role. Managerial implications relate to the importance of supply chains in providing key cross-firm resources that configure into lean capabilities in a learning environment for superior performance outcomes.

ECONOMIC COOPERATION IN HIGHER EDUCATION BETWEEN CHINA AND EUROPE

The article deals with the scientifically substantiated analyses of the problem of economic cooperation in the field of higher education between China and Europe based on its essential importance for the world problem of developing new innovative sides of higher education. Taking into account the scientific and innovative development of China it is necessary to conduct analyses of the problems of educational-research cooperation between universities of China and EU.
 This article examines the following analytical questions and identifies factors affecting the development of the education system in modern economic conditions. Factor analysis makes it possible to form the concept of development of economic cooperation in the established macro- and microeconomic conditions; predict educational potential using quantitative assessments and taking into account structural changes and the number of students; to combine supply and demand for highly qualified specialists in popular specialties for the innovative economy. To do this, using a factor approach, it is necessary to monitor the state of scientific and educational cooperation between Chinese and European universities according to key indicators.
 The general provisions on analysis for solving this problem are given and it is estimated that the analytical approach is the most acceptable, since it allows you to build a diagram for comparing percentage of the quantity of Chinese students in European universities and the quantity of European students at Chinese universities. It is advisable to consider the process of developing and financing the exchange programs for students as the most important factor for educational cooperation. This research paper reveals the fact that China owes its economic growth mainly to the intensive development of its innovations and investments into the education cooperating with foreign countries, using own human resources and raw materials.
 The article analyzes economists’ views on the process of solving the educational problems of cooperation in the field of education. It should be noted that various educational and scientific programs and initiatives have been established within the framework of cooperation between China and Europe in the field of higher education. One of the key benefits of collaboration is that each party can access the best practices and technologies used by the other party. In order to create an innovative economy, it is necessary to create a human resourse reserve for high-tech and knowledge-intensive industries of the future. Therefore, the task of universities is to provide education at the level of world standards.
 The research has been developed to estimate that China is a leading country in the educational sector of the economy, which include improving public funding through the creation of a system of subsidies and educational loans, attracting social partnership resources, and using distance learning. The EU and China have agreed to promote the study and teaching of Chinese and European languages, which will allow expanding contacts between people, reaffirming their commitment to multilingualism. The process of cooperation between China and European countries in the sphere of high education, which is currently unfolding, aims to facilitate the development of industrial 4.0 and technology hub in China.

E-commerce platform resources, sequence of digital strategic actions and competitive advantage: an empirical study from online tourism industry

This study examines the impact of the sequence of digital strategic actions initiated by e-commerce platform on competitive advantage in competitive interaction (DSAs). Based on the competitive repertoire theory, the configurational approach is used to analyse the secondary data of Chinese online tourism industry, the research finds out the configurations of DSAs orchestrated by digital technologies, partnership resources and competitor responses. Secondly, dynamic characteristics (including complexity and unpredictability) of DSAs sequence are calculated. Thirdly, panel regression has been applied to explore the relationship between the unpredictability and complexity of DSAs sequence and competitive performance in the competitive interaction, and the inverted U-shaped relationship between them is found. Finally, discussion of the implications for theory and practice is presented. In a nutshell, this study aims to help managers formulate and initiate sequences of competitive actions more effectively in the digital environment.

Corporate social responsibility in emerging social issues: (non)institutionalized practices in response to the global refugee crisis

PurposeCSR reporting is an institutionalized practice. However, institutionalization has been primarily examined in the context of limited social issues and largely restricted to the presence of CSR communication. The purpose of this paper is to introduce a framework to explore how institutional and organizational factors shape CSR programming in response to an emerging social issue: the global refugee crisis.Design/methodology/approachThe authors collected corporate social responsibility (CSR) reports from Global 500 Fortune corporations between 2012 and 2017. This study uses content coding and inferential analysis to examine how industry type, headquarters location, and partnership resources are related to programming in the refugee relief efforts.FindingsThe results reveal distinctive patterns from the technology sector and European corporations, with no clear patterns identified among other corporations. The findings indicate that although CSR is an institutionalized practice, CSR program reporting offers fewer insights as to how institutionalization occurs.Research limitations/implicationsResults suggest a preliminary framework for understanding how CSR programming becomes institutionalized and provide implications for how corporations may address emerging social issues.Originality/valueThis study applies an institutional, communicative approach to the context of the recent global refugee crisis, which contributes to theory development through the examination of an emerging social issue. It also extends prior research on the institutionalization of CSR by focusing on programming in response to an emerging social issue over time and suggests the limits of prior claims of institutionalized practices.

Surmounting structural barriers to tackle endemic infectious diseases.

A unique experiment in bringing academic and industrial scientists together to tackle endemic infectious diseases has proved a success. The Tres Cantos Open Lab Foundation, guided and advised by independent experts, funds extended stays of academics at the campus of a pharmaceutical company, where they access the firm's resources in partnership with company scientists. Progress in tackling tuberculosis, protozoal infections, and enteric bacterial diseases has sustained the decade-long evolution of the model, whose distinctive features complement other public-private partnerships with similar goals.

Banking Business Performance Evaluation Using Standard Model of Quality Management Europe – EFQM (European Foundation for Quality Management): Case Study in Bank Bjb (Jabar-Banten) Tbk.

This is paper research case study to examine application evaluating and measuring business performance banking company using concept International Quality Standard of Excellences Model European Foundation for Quality Management (EFQM - 2013) with ten (10) variables: Case study in Bank Jabar Banten Indonesia (PT. Bank Bjb Tbk). The study examines the organization productivies, effectiveness and efficiencies, and the level of company performance comply with role and regulation of banking authority. The variance was explained by extraction factor sums squared loadings of the information yielded in business performance of firms. The main of findings showed that all the two (2) variables i.e. Leadership and Partnership Resources are less influence the business performance of PT. Bank Bjb Tbk. The novelty of this research study are the understanding the excellent level of capability of business performance firms; realized the actual quality practices have significant positive effect towards business performance banking ; including the necessary improvements to be carried-out by the companies involved.

Development of student entrepreneurial competence using the resources of social partnership

The paper brings to the fore the need for developing entrepreneurial competences in school students. It describes the concept of entrepreneurial competence as an ability to put forward original ideas and innovate along with communication, organisation, project management, action planning, and risk-taking competences, receptivity, and also knowledge and skills required for starting a new business and implementing practical ideas to proceed successfully. The case is made for developing courses in entrepreneurship and the criteria of efficiency are determined as follows: clearly set objectives, balanced theoretical and practical content, focus on learning by doing, voluntary approach and motivation, social partnership involving businessmen, financial institutions, and municipal government bodies, openness of the educational environment, availability of training for teachers and contacts with businessmen, and opportunity to present the outcomes. A description is provided of the model and algorithm of creating a school business incubator using the resources of social partnership with businessmen, financial institutions, and municipal governance bodies. The outcomes in entrepreneurship education in the context of a business incubator include the defence of a business project under the supervision of a mentor conducted in a competitive form in two stages, namely, the defence of the business idea and the project itself. Various procedures are used to assess business incubator performance, such as questionnaires for students, teachers, and mentors and expert assessment of students’ entrepreneurial competence acquisition levels by teachers and mentors.

A pharmacy liaison-patient navigation intervention to reduce inpatient and emergency department utilization among primary care patients in a Medicaid accountable care organization: A pragmatic trial protocol.

ObjectiveTo determine whether employing the services of a pharmacy liaison to promote medication adherence (usual care), relative to a pharmacy liaison with training in motivational interviewing and as a patient navigator who systematically screens for health-related social needs and provides targeted navigation services to connect patients with appropriate community resources in partnership with a community-based organization (enhanced usual care), will reduce inpatient hospital admissions and emergency department visits among patients who are members of a Medicaid ACO and receive primary care at a large urban safety-net hospital. BackgroundPrior studies have demonstrated only modest effects in reducing utilization among safety-net patient populations. Interventions that address health-related social needs have the potential to reduce utilization in these populations. Design/MethodsAssignment to treatment condition is by medical record number (odd vs. even) and is unblinded (NCT03919084). Adults age 18–64 within the 3rd to 10th percentile for health care utilization and cost among Medicaid Accountable Care Organization membership attending a primary care visit in the general internal medicine practice at Boston Medical Center enrolled. DiscussionOur study will advance the field in two ways: 1) by providing evidence about the effectiveness of pharmacy liaisons who also function as patient navigators; and 2) by de-implementing patient navigators. Patients in the enhanced usual care arm will no longer receive the services of a clinic-based patient navigator. In addition, our study includes a novel collaboration with a community-based organization, and focuses on an intermediate-cost patient population, rather than the most costly patient population.

Psychische Belastung und Resilienz im Rahmen schwerer körperlicher Erkrankungen: eine Analyse dyadischer Zusammenhänge

In this article, we present 3 studies examining patients with current or previous severe physical illness and their partners with respect to dyadic concordance, gender and role differences in mental distress and resilience. Study 1 included 55 patients and their partners on average 4.5 years after severe sepsis. Study 2 involved 49 patients with lung cancer, predominantly in advanced stage with metastases, and their partners. In study 3, 69 cancer patients with various tumor entities and tumor stages undergoing additional outpatient homeopathic treatment as well as their partners were examined. All studies used the Hospital Anxiety and Depression Scale (HADS) to measure mental distress and the short version of the Resilience Scale RS-13 to assess resilience as a personality trait. Results were meta-analytically pooled across the 3 studies. We found dyadic concordances between patient and partner in anxiety (r=0.29 [0.06; 0.48], I2=55%) and depression (r=0.44 [0.31; 0.55], I2=0%), but not in resilience. Gender differences emerged consistently across all three studies, both female patients and partners showed more severe anxiety symptoms than males (d=0.58 [0.26; 0.91], I2=0% for patients; d=0.53 [- 0.06; 1.12], I2=69% for partners). Results were heterogeneous for gender differences in depression and for role differences. Higher resilience scores were associated with lower mental distress both in patients and partners. There is some evidence that resilience has a protective effect for mental distress of the spouse. Based on the results on dyadic concordance between patients and partners in mental distress somatic diseases should always be considered from a systemic perspective. Mental distress of both patients and partners requires special attention in psychosocial support, and partnership resources should be taken into account for coping with the disease.

“It’s a ripple effect”: the role of intergroup contact within an inner-city youth sport for development and peace program

ABSTRACTRationale: Positive contact between divided groups experiencing conflict may not only change intergroup attitudes, but may also promote positive relationship development and other community development outcomes.Purpose: The study draws on SDP literature and contact theory to investigate factors that facilitate positive intergroup contact within an inner-city youth SDP soccer program developed within the public sector. A secondary purpose is to examine the impact that contact has on program stakeholders including youth and authority figures within a community plagued with issues of youth deviance.Method: Semi-structured interviews were conducted with thirteen program stakeholders in one municipality in Ontario, Canada.Findings: Relevant programing, understanding others’ perspectives, having champions of youth development, and human, financial, and partnership resources all play a critical role in facilitating contact within an inner-city youth SDP program. Intergroup contact also had many positive impacts on program stakeholders as trusting relationships were developed, youth behavior changed, and community pride was established.Practical Implications: Managers and policy makers can consider these factors when facilitating contact between diverse groups.Research Contribution: The study offers new insight into the role of public sector actors in SDP practice.

Developing a model for supply chain agility and innovativeness to enhance firms’ competitive advantage

Purpose Developing agility and innovativeness as dynamic capabilities are important for firms to sustain their competitive advantage in today’s global economy. The purpose of this paper is to develop and empirically test a framework to investigate how the supply chain agility and innovativeness are achieved through IT integration and trust in members of supply chain and how these, in turn, can enhance firms’ competitive advantage. Design/methodology/approach This research employs a survey method and data are collected from senior managers working in the supply chain or IT area. The model and hypotheses are tested utilizing data from 204 usable Taiwan manufacturing firms via structural equations modeling methodology. Findings The study demonstrates that both IT integration and trust in supply chain members significantly enhance supply chain agility and innovativeness, which in turn positively affect firm’s competitive advantage. The results indicate that IT integration and trust are antecedents and major joint partnership resources for improving supply chain agility and innovativeness. Research limitations/implications Data are collected from manufacturing industry in Taiwan and single respondent from each firm, the generalizability of current findings to other industries or countries should require additional investigation. Practical implications The study suggests that a firm should focus on IT integration and trust in supply chain members to achieve supply chain agility and innovativeness. To take advantage of supply chain agility and innovativeness, through maximizing firm’s competitive advantage, firms should continually adapt to the fast changing business environment and search for creative ways to satisfy new market needs. Originality/value Given the attention paid to supply chain agility and innovativeness in terms of importance to responding to business uncertainty and competitiveness, and more recently, as important capabilities in managing supply chain management, this paper investigates how IT integration and trust can contribute to supply chain agility and innovativeness. Provide evidence regarding the impact of IT integration and trust on agility of supply chains, innovativeness and competitive advantage.

Performance implications of lean in supply chains: Exploring the role of learning orientation and relational resources

The study enhances understanding of the contribution of learning orientation and supply chain partnership resources in building lean capability, and its impact on operational performance. Using the resource-based view, the relational view and organizational learning, the study develops a conceptual model of relationships to empirically understand how a learning culture enables firms to leverage critical cross-firm resources to engender lean. Additionally, the study investigates the mediating influences of partnership resources. Findings from the empirical analysis of survey data from top managers in manufacturing firms support the conventional wisdom relating supply chain collaboration to lean, and its contribution to enhance operational performance. The importance of learning orientation for mobilizing relational resources - essential ingredients for lean capabilities – is a highlight of the study. The results provide a framework for managers to understand the criticality of a learning culture in supply chains to exploit partnership resources to build market-responsive capabilities that give them the competitive edge. Along with the discussion of the implications, the study suggests future research directions.

"Waging Peace!": An Art Museum as a Resource for Partnerships

"Waging Peace!": An Art Museum as a Resource for Partnerships

FINANCIAL METHODS IN THE STRUCTURE OF FINANCIAL MECHANISM OF STATE-PRIVATE PARTNERSHIP: SCIENTIFIC ASPECTS OF RESEARCH

Introduction. An essential condition for the functioning of the financial mechanism of public-private partnership is the formation of effective financial methods. At the same time there is no single approach in the economic literature to finding out the essence of financial methods and their types, that needs activation of scientific efforts, noted questions directed on research. Methods. We use methods of dialectical analysis and synthesis, as well as methods of logical generalization, comparison and formalization. Results. The article outlines the essence of financial methods as a manifestation of the financial mechanism of public-private partnership. Under them it is necessary to understand the totality of financial procedures used in the joint activity of the state and economic entities for the performance of their functions. It was singled out their types, in particular: financial planning, financial support, financial regulation, financial accounting, analysis, evaluation of the effectiveness and efficiency of the mechanism, financial control. The objective necessity of effective development and effective use of financial methods is exposed for the sphere of realization of partner relations between the state and business is revealed. After all, with the help of them, strategic and tactical vectors of activity are created, the mobilization of the necessary financial resources and rational distribution of them are carried out, the tasks of the partners of the partnership are fulfilled. It is noted that the relevance of these issues caused considerable interest and attention of scientists to the study of financial methods. It noted the versatility of the coverage of this concept in the scientific literature, and as a consequence, the lack of a terminological basis of his knowledge in the field of selected research. Conclusions. Financial methods occupy an important place in the structure of the financial mechanism of public-private partnership. After all, they allow to rationally plan the sources of formation and directions of the use of financial resources of public-private partnership, to effectively monitor the flow of financial flows, to monitor the status of payments and settlements with suppliers and customers, to evaluate the results of financial and economic activities of the partners. Consequently, the effectiveness, efficiency and effectiveness of the mechanism are ensured.

Specifics of organising supplementary education in rural areas

The article presents the factors that help to improve the accessibility and quality of supplementary education of rural schoolchildren, defines the objectives of supplementary education and describes the pedagogic means of solving the most topical problems. Special attention is paid to the ways of satisfying individual interests and wants of children, to the analysis of the results of supplementary education of rural children, to the usage of the rural community resources and to the social partnership development. The article shows the social environment potential and social partnership resources in creating the supplementary education municipal network. The authors suggest the variants of the interaction of the school with other rural subjects, the content and forms of participation of the organisations and local people in children's supplementary education (CSE). The article emphasises the role of parents (legal representatives) in the CSE, proposes the ways of informing parents of supplementary education and their involvement in organising the CSE.

\u2018Victim-Offenders\u2019: a Third Category in Police Targeting of Harm Reduction

Research QuestionTo what extent do people classified by police as ‘offenders’ and those they classify as ‘victims’ overlap, thus creating a third category of individual targets for crime and harm reduction called ‘victim-offenders’?DataLeicestershire police records in the 3-year period 2014–2016 were compiled on all 117,766 individuals who were identified as either victims or offenders in all 159,702 crimes in which one or more individual victims were named. A 730-day-at-risk tracking period after individuals’ initial appearance in the data set was examined for the tracked cohort of 42,916 individuals who entered the data set in 2014 only and were ultimately identified in 62,336 individual-victim crimes.MethodsEach individual who entered the data set from 2014 to 2016 was classified as (only) a victim, (only) an offender, or (both) victim and offender in separate events. We designate the latter category as victim-offenders. The total count of criminal events and total recommended days of imprisonment value of the Cambridge Crime Harm Index (CHI) were calculated for each individual, both for crimes committed and victimizations experienced. Individuals who entered the data set in 2014 were tracked for 730 days from their first recorded offence or victimization. All individuals were ranked, by both crime counts and CHI values, from highest to lowest.FindingsFrom 2014 to 2016, victims comprised 89.9% of the 117,766 individuals ever appearing as victims or offenders, offenders comprised 7.9% and victim-offenders were 3.2%. In 2014, all 38,318 individual victims and 4598 offenders were placed into the 730-day tracking period in which 1825 individuals became victim-offenders, or 4.2%. Initial offenders were seven times as likely to become victims (17.9%) as initial victims were to become offenders (2.6%). Victim-offenders had 74.5% higher average harm scores and 68% higher average crime counts than the overall 2014 entry cohort, with 65% of victim-offenders’ harm a result of their victimisation. Only 417 ‘high harm-high volume’ individuals experience or cause the most crime harm as well as the most crime, of whom 49.9% (208/417) are victim-offenders, 33.3% (139/417) victims and 16.7% (70/417) offenders.ConclusionOpportunities to reduce crime and harm through targeting police and partnership resources on the ‘power few’ (Sherman, Journal of Experimental Criminology, 3(4), 299–321, 2007) can be enhanced by identification of victim-offenders and testing prevention strategies appropriate to this third category of people.

Abstract 986: The National Cancer Institute's patient-derived models repository (PDMR)

Abstract The National Cancer Institute (NCI) has developed a Patient-Derived Models Repository (PDMR) comprised of quality-controlled, early-passage, clinically-annotated patient-derived xenografts (PDXs) to serve as a resource for public-private partnerships and academic drug discovery efforts. These models are offered to the extramural community for research use (https://pdmr.cancer.gov/), along with clinical annotation and molecular information (whole exome sequence, RNASeq), which is available in a publicly accessible database. The PDMR was established by NCI at the Frederick National Laboratory for Cancer Research (FNLCR) in direct response to discussions with academia and industry; the oncology community's highest priority need was preclinical models that more faithfully reflect the patient's tumor and are associated with the patient's treatment history. NCI has focused on generating models to complement existing PDX collections and address unmet needs in the preclinical model space. The PDMR generates the majority of its PDXs by subcutaneous implantation except for those histologies having better success rates in either orthotopic or alternate implant sites. All SOPs and quality-control standards developed by the PDMR as well as those shared by collaborators are posted to a public web site that houses the PDMR database. In May 2017, the public website (https://pdmr.cancer.gov/) went live with its first 100 models from histologies including pancreatic, colorectal, renal, head and neck, and lung squamous cell cancers as well as melanoma and adult soft tissue sarcomas. In early 2018, the PDMR will begin releasing models from gynecological cancers, small cell lung cancer, chondro/osteo sarcomas, lung adenocarcinoma, and squamous cell skin and Merkel cell carcinomas. In addition, wherever available germline sequence and somatic variant calls will be added to the existing molecular characterization data for each model. NCI has also increased its focus on creating PDXs from racial and ethnic minorities through several funding opportunities. The overall goal of NCI is to create a long-term home for at least 1000 models such that sufficient biological and clinical diversity is represented to allow researchers to ask questions regarding the impact of tumor heterogeneity on target qualification or clinical response, whether PDXs more faithfully represent the human tumor for pharmacodynamic assay and predictive marker development, or if adequately powered preclinical PDX clinical trials can lead to better evaluation of therapies for future clinical use. Moving forward the PDMR plans to distribute in vitro, early-passage tumor cell cultures and cancer-associated fibroblasts as well as releasing PDX drug response data for a panel of FNA-approved therapeutic agents. Funded by NCI Contract No. HHSN261200800001E Citation Format: Yvonne A. Evrard, Michelle M. Gottholm Ahalt, Sergio . Y. Alcoser, Kaitlyn Arthur, Mariah Baldwin, Linda L. Blumenauer, Carrie Bonomi, Suzanne Borgel, Elizabeth Bradtke, Corinne Camalier, John Carter, Tiffanie Chase, Alice Chen, Lily Chen, Donna W. Coakley, Nicole E. Craig, Biswajit Das, Vivekananda Datta, Jordyn Davidson, Margaret R. DeFreytas, Emily Delaney, Michelle A. Eugeni, Raymond Divelbiss, Palmer Fliss, Thomas Forbes, Marion Gibson, Tara Grinnage-Pulley, Sierra Hoffman, Lilia Ileva, Paula Jacobs, Franklyn Jimenez, Joseph Kalen, Catherine Karangwa, Chris Karlovich, Candace Mallow, Chelsea McGlynn, Jenna E. Moyer, Michael Mullendore, Dianne L. Newton, Nimit Patel, Rajesh Patidar, Kevin Plater, Marianne Radzyminski, Lisa Riffle, Larry Rubinstein, Luke H. Stockwin, Mickey Williams, Melinda G. Hollingshead, James H. Doroshow. The National Cancer Institute's patient-derived models repository (PDMR) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 986.

Abstract IA21: NCI's Patient-Derived Models Repository: Generating models from racial and ethnic minorities

Abstract The National Cancer Institute (NCI) has developed a Patient-Derived Models Repository (PDMR) comprising quality-controlled, early-passage, clinically annotated patient-derived xenografts (PDXs) to serve as a resource for public-private partnerships and for academic drug discovery efforts. The first 100 models were released in May 2017, are clinically annotated with pathologic and molecular information available in a publicly accessible database, and are available to the extramural community for research use (pdmr.cancer.gov). The PDMR was established by NCI at the Frederick National Laboratory for Cancer Research (FNLCR) in direct response to discussions with academia and industry; the oncology community's highest-priority need was identified as better preclinical models that more faithfully reflect the patient's tumor and are associated with the patient's treatment history. NCI has focused on collecting specimens from patients with cancers that are under-represented in many other PDX collections such as head and neck, pancreatic, bladder and gynecologic cancers, melanomas, and sarcomas. Recently, NCI has also increased its focus on generation of PDXs from racial and ethnic minorities through new funding opportunities. The initial goal is to have 20-25% of the models in the PDMR from racial and ethnic minorities in diagnoses that are most pertinent to cancer health disparities. The overall goal of NCI is to create a long-term home for at least 1,000 models such that sufficient biologic, clinical, and population diversity is represented to allow researchers to ask questions such as: what is the impact of tumor heterogeneity on target qualification or clinical response; do PDXs more faithfully represent the human tumor for pharmacodynamic assay and predictive marker development; or can an adequately powered preclinical PDX clinical trial lead to better evaluation of therapies for future clinical use? Grant Support: This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. Citation Format: Yvonne A. Evrard. NCI's Patient-Derived Models Repository: Generating models from racial and ethnic minorities [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr IA21.

Study protocol: responding to the needs of patients with IgA nephropathy, a social media approach.

BackgroundIgA nephropathy is the most common cause of glomerulonephritis in the Western world and predominantly affects young adults. Demographically these patients are the biggest users of social media. With increasing numbers of patients turning to social media to seek information and support in dealing with their disease, analysis of social media streams is an attractive modern strategy for understanding and responding to unmet patient need.MethodsTo identify unmet patient need in this population, a framework analysis will be undertaken of prospectively acquired social media posts from patients with IgA nephropathy, acquired from a range of different social media platforms. In collaboration with patients and members of the clinical multidisciplinary team, resources will be created to bridge gaps in patient knowledge and education identified through social media analysis and returned to patients via social media channels and bespoke websites. Analysis of the impact of these resources will be undertaken with further social media analysis, surveys and focus groups.ConclusionsPatients with chronic diseases are increasingly using social networking channels to connect with others with similar diseases and to search for information to help them understand their condition. This project is a 21st century digital solution to understanding patient need and developing resources in partnership with patients, and has wide applicability as a future model for understanding patient needs in a variety of conditions.