The low quality of the seismic resolution of the studied Cambrian Pre-Cenomanian formations, which rest directly on the basement in the October Field in the Gulf of Suez, requires study, and the structure pattern controlling these formations is uncertain. The poor quality of the seismic data resolution in the Gulf of Suez is due to the presence of thick sequences of evaporites represented by the South Gharib and Zeit formations. Therefore, the current study used seismic reflection data integrated with well-log data to define the structural-stratigraphic setting of the pre-Cretaceous Nubian reservoir sequence. The study aims at locating and delineating zones having excellent reservoir potential within the Nubian sequence horizons (Nubian Transition, main Nubian, Nubian marker-1, and Nubia marker-2, referred to as NT, MN, M1 and M2, respectively) through the integration of the 3D static modelling and the petrophysical parameters deduced from the well-log data processing. A detailed petrophysical analysis, based on the wireline logs of some wells, was performed to determine the lithological units using two types of cross plots (Neutron-Density and M-N plots), and the different petrophysical parameters that characterize the various Nubian horizons were also computed. 3D modelling was used to visualise the lateral and vertical changes of the reservoir characteristics. The seismic mapping reveals that the Nubian structure is controlled by an NW-SE trending (Clysmic trend) of an NE-plunging asymmetrical anticlinal feature unconformably resting on a basement horst. The main structure is affected by two major normal faults, which trend NW, andis cut by two smaller sub-parallel faults that disturb the core of the structure, which is unaffected by the easterly oriented faults of the Aqaba trend. The petrophysical analyses indicate that the Nubian sandstones have intervals of good reservoir quality, with a total net-pay thickness of about 500 m, net sand ratios (60-90 %), effective porosity (10-25 %), and hydrocarbon saturation (85%), which may encourage further drilling, especially in the southeast portion. The result of this study can be extended to the other Nubia sandstones resting on the basement complex in the Gulf of Suez.