Resistance Parameters Research Articles

Targeting of TAMs: can we be more clever than cancer cells?

АbstractWith increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disability worldwide. Principal progress in the development of new anticancer therapies, in improving the efficiency of immunotherapeutic tools, and in the personification of conventional therapies needs to consider cancer-specific and patient-specific programming of innate immunity. Intratumoral TAMs and their precursors, resident macrophages and monocytes, are principal regulators of tumor progression and therapy resistance. Our review summarizes the accumulated evidence for the subpopulations of TAMs and their increasing number of biomarkers, indicating their predictive value for the clinical parameters of carcinogenesis and therapy resistance, with a focus on solid cancers of non-infectious etiology. We present the state-of-the-art knowledge about the tumor-supporting functions of TAMs at all stages of tumor progression and highlight biomarkers, recently identified by single-cell and spatial analytical methods, that discriminate between tumor-promoting and tumor-inhibiting TAMs, where both subtypes express a combination of prototype M1 and M2 genes. Our review focuses on novel mechanisms involved in the crosstalk among epigenetic, signaling, transcriptional and metabolic pathways in TAMs. Particular attention has been given to the recently identified link between cancer cell metabolism and the epigenetic programming of TAMs by histone lactylation, which can be responsible for the unlimited protumoral programming of TAMs. Finally, we explain how TAMs interfere with currently used anticancer therapeutics and summarize the most advanced data from clinical trials, which we divide into four categories: inhibition of TAM survival and differentiation, inhibition of monocyte/TAM recruitment into tumors, functional reprogramming of TAMs, and genetic enhancement of macrophages.

Assessment of Insulin Resistance, HOMA-IR, and QUICKI Levels in Patients with Endometrial Cancer and Hyperplasia

Aim: To analyze insulin resistance and related parameters in patients with endometrial cancer and hyperplasia. Methods: The study included 102 patients in 3 groups. Group I and II included patients with a histologic diagnosis of endometrial cancer (n=41, 40.2%) and endometrial hyperplasia (n=31, 30.4%) based on the final pathology report. Group III was the control group and included patients who had undergone surgery for a benign indication other than endometrial hyperplasia (n=30, 29.4%). Age, body mass index (BMI), menarcheal age, menopausal status, gravidity, parity score, diabetes, oral contraceptive status, fasting glucose levels, insulin levels, endometrial thickness, HOMA-IR and QUICKI scores were assessed. Results: The mean age of group I was statistically higher than that of group II (55.3±9.5 vs. 48.8±7.1, p=0.002). The average BMI of the two groups was similar (p=0.076). When fasting glucose values were evaluated, group I showed significantly higher values compared to group II. The mean insulin and HOMA-IR values in the control group were significantly higher than those in group I (p

Numerical model of curved composite tiles under low-velocity impact loading

In recent years, composite structures have seen widespread application across diverse industries, including automotive and aerospace, owing to their favourable strength-to-weight ratio. However, these structures, particularly high-pressure vessels, are susceptible to extreme loadings such as impact forces, resulting in visible and latent damage, ultimately leading to catastrophic failures. Hence, it is imperative to assess such damages diligently. Given the cost implications associated with experimental investigations, numerical methodologies emerge as a potent means for conducting relevant analyses. This paper will introduce a numerical model approach to conducting virtual tests to assess curved carbon fibre composite tiles subjected to low-velocity impact. The primary focus of this study is to consider the impact-induced delamination on composite tiles through a numerical model. The composite tiles are conducted to 90J impact loading. Specifically, the study evaluates filament winding structures’ interface properties (shear resistance) variability during manufacturing. Notably, the parameter of shear resistance significantly impacts the anticipation of intralaminar damage (delamination) after impact loading. Three-point bending tests were performed to calibrate the composite material’s shear interface properties, followed by low-velocity impact tests on the curved composite tiles. The findings indicate that the shear resistance values, which ranged from 14.25 MPa to 60 MPa, play a critical role in predicting delamination, with lower shear resistance leading to increased damage areas. The results underscore the importance of accurately calibrating interface properties to enhance the predictive accuracy of numerical models for curved composite structures under impact loading.

Development of a material selection decision support system for an automotive application

This study presents the development of a material selection decision support system for an automotive rooftop tent. The system uses five parameters of material cost, formability, corrosion resistance, tensile strength and hardness to optimize material choice from a list of aluminium alloy options. This was done before production via the deep drawing process can commence. The parameters were quantified using the average market prices for each alloy, product requirements obtained from the case study and the performance data that was obtained from the uniaxial tensile and hardness tests. These inputs were combined with the developed material selection framework and then programmed into a web-based decision support system for automated, data-driven material selection. The output presents the recommendation for the optimum material that balances cost-effectiveness and performance. The decision support system was successfully used to select the optimum alloy for the rooftop tent. Results show that AA1050 is the optimum material, providing weight reduction at the minimum achievable cost without compromising the product requirements for the rooftop tent. The decision support system is also scalable, and this allows it to be used with larger datasets for different products and processes in the future.

Is there any association between vitamin D status and PCOS disease?

Introduction Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age. The current study sought to assess vitamin D status in women with PCOS compared to the control group and to describe the association between vitamin D deficiency and the features of PCOS. Material and methodology A descriptive retrospective study about 176 women of reproductive age was conducted. The sample was divided into two groups: individuals with PCOS (82 women) and healthy individuals without PCOS (94 women). Vitamin D deficiency was defined as a serum concentration less than 10 ng/ml. We used the Statistical Package for the Social Sciences (SPSS), version 21 for all analyses. Results In our study, vitamin D deficiency was observed in 40.2% PCOS patients and 24% controls. The 25(OH)D level was lower in PCOS women and the incidence of vitamin D deficiency and insufficiency were significantly higher in comparison with the control group (p < 0.05). Furthermore, PCOS women with insulin resistance or obesity had lower 25(OH)D levels in comparison with PCOS individuals without IR or obesity. Furthermore, a significant correlation was found between homeostatic model assessment for insulin resistance (HOMA-IR)/body mass index (BMI) and vitamin D status. Discussion and conclusion Vitamin D deficiency could be one of the etiological mechanisms of PCOS. In fact, the prevalence of vitamin D deficiency in PCOS women is evident, principally in those with obesity or IR. Also, the serum 25(OH)D level was correlated with parameters of insulin resistance and metabolic syndrome. Therefore, it is proposed that vitamin D supplementation may be beneficial for the management of PCOS patients.

Estimation of Undrained Shear Strength of Soil from CPTu Data

The estimation of undrained shear strength ( ) from Cone Penetration Test with pore pressure measurement (CPTu) for two sites was investigated in this research. The CPTu cone parameters: net cone resistance ( ), excess pore pressure ( ) and effective cone resistance ( ) were used to estimate the for the two sites and the values obtained were compared with the undrained shear strength in triaxial compression ( calculated from Anisotropically Consolidated Undrained Compression (CAUC) triaxial test results. For the clayey silt site, the undrained shear strength from the CAUC tests are higher compared to the values obtained from the CPTu, and the highest correlation was obtained from the effective cone resistance parameter . For the quick clay test site, the value and were relatively the same and showed stronger correlation as compared to the clayey silt site. The measured from the cone parameter had the highest correlation. It was concluded that and yields good correlation with the CAUC results for the clayey silt and quick clay test sites respectively as compared to the other con parameters.

Experimental study on mechanical and durability properties of concrete incorporating various polyvinyl alcohol fiber lengths and dosages

To inquire about the properties of concrete reinforced with polyvinyl alcohol (PVA) fiber (various fiber lengths and dosages), different experimental tests including mechanical property, cracking resistance, and chloride resistance were investigated. The overall performance of PVA fiber-reinforced concrete (FRC) was innovatively analyzed integrating mechanical indicators and crack resistance parameters. Furthermore, nuclear magnetic resonance (NMR) and scanning electron microscope (SEM) were selected to analyze the causes and mechanisms underlying the alterations in the performance of PVA-FRC. The experimental results demonstrate that the flexural strength, the crack resistance characteristic and chloride ion penetration resistance of PVA-FRC are significantly improved compared to ordinary concrete. Increasing fiber length plays a key role in flexural strength, compared with fiber dosage. Considering both mechanical properties and durability, PVA-FRC containing 0.25% volume fraction of 12 mm PVA fibers (F12-0.25) demonstrated optimal performance.

Volume-based selection in Pinus pinaster Aiton breeding: evaluating resistance to Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle and wood properties

Key messageGenetic parameter estimates at age 12 years for trunk volume in Pinus pinaster displayed low to moderate heritability for growth and stem form, whereas wood properties showed high heritability. No correlation was detected between resistance to the nematode Bursaphelenchus xylophilus and growth, stem form, or wood properties. However, certain families stood out, showing favorable values across all traits, including resistance to the nematode.ContextThe breeding program for Pinus pinaster should advance towards a second-generation breeding population based on volume, stem form, and resistance to Bursaphelenchus xylophilus, with the challenge of incorporating novel traits of importance.AimsWe focused on assessing the genetic parameters of growth, stem form, wood properties, and resistance to B. xylophilus as well as exploring the relationship between these traits.MethodsWe evaluated 116 half-sib families at three ages (7, 12, and 17 years) in seven progeny trials established in 2005, analyzing growth, stem form, and wood traits. Resistance to B. xylophilus was assessed in 91 of the 116 half-sib families at age 2 by artificial inoculation tests under greenhouse conditions.ResultsAdvancing the selection age to 12 years proved to be feasible for volume selection in Galician P. pinaster. All traits, including resistance to B. xylophilus, showed potential for genetic improvement. Remarkably, resistance to B. xylophilus was not correlated to any other trait.ConclusionExcluding the most susceptible families to B. xylophilus from the Galician P. pinaster breeding program would not result in a significant decrease in volume, stem form, or wood properties.

Improvement in Symptoms of Depression and Anxiety and Cardiometabolic Risk Factors in Children and Adolescents with Overweight and Obesity Following the Implementation of a Multidisciplinary Personalized Lifestyle Intervention Program

Background/Objectives: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems, which persist for a long time. The aim of the study was to assess the effect of a multidisciplinary personalized lifestyle intervention for depressive and anxiety symptoms, as evaluated by psychometric questionnaires, and their effect and association with cardiometabolic parameters in children and adolescents with overweight and obesity conditions before and after the intervention. Methods: Six hundred and eleven (n = 611) children and adolescents (mean age ± SE: 10.39 ± 0.10 years; 51.5% females, 46.6% pubertal) were studied prospectively. Subjects were classified as being obese (50.2%), overweight (33.5%), or having a normal BMI (16.2%) according to IOTF criteria. All participants entered a 1-year lifestyle intervention program; laboratory investigations were obtained at the beginning and end of the study and two psychometric questionnaires were completed, the CDI and SCARED, which evaluate symptoms of depression and anxiety, respectively. Results: Following the lifestyle intervention, a significant decrease was noted in anxiety scores in all subjects and in depression scores in youth with obesity, as well as in adolescents with obesity, while females presented a reduced response to the intervention. Insulin resistance and metabolic syndrome parameters, cortisol, PRL, and LH concentrations were positive predictors for depressive and anxiety symptoms. Conclusions: The implementation of a multidisciplinary personalized lifestyle intervention program in the management of childhood obesity is associated with a significant decrease in cardiometabolic and psychosocial comorbidities in children with and without excess adiposity. The improvement in mental health is speculated to be mediated by an improvement in energy metabolism with subsequent improvement in neuroinflammation owing to lifestyle changes.

Flexibilizing Mechanisms of Spinel-, Hercynite-, Galaxite-, and Chromite-Containing Basic Refractories for Cement Rotary Kilns

Background: Refractory linings of cement rotary kilns are subjected to severe thermomechanical stresses of cranking, ovality, tyre hooping/migration, and uneven thermal distribution. An insistent demand is to discover the significance of spinel, hercynite, galaxite, and chromite in magnesia refractories, as well as their flexibilizing mechanisms. Objectives: The objectives are to compare the fracture behavior of magnesia–spinel, – hercynite, -galaxite, and -chromite refractories and to unveil the flexibilizing mechanisms of different spinels. Methods: The wedge-splitting test is carried out to produce various fracture parameters. Their flexibilizing mechanisms are unveiled by performing microstructural observations and analyses. Results: Various fracture parameters are obtained, including specific fracture energy, brittleness number, characteristic crack length, and thermal-shock resistance parameter. Generally, magnesia–hercynite bricks and magnesia–galaxite bricks have demonstrated the obvious advantages of fracture resistance, which are more flexible than magnesia–spinel bricks and magnesia–chromite bricks. Conclusion: The flexibility of magnesia–spinel bricks is attributed to microcracks generated from the thermal mismatch between spinel grains and surrounding periclase, which is recognized as the thermal-expansion mismatch mechanism. In magnesia–hercynite and magnesia-galaxite refractories, the active-ion-diffusion mechanism is predominant beyond similar microcracks, to drive the flexibility by the continuous diffusion of Fe2+, Mn2+, and Mg2+ during high-temperature processes. In magnesia–chromite bricks, the pore rims contribute to the flexibility as a silicate-migration mechanism, after silicate envelopes first arise around chromite grains and then vanish into the surrounding magnesia by the suction of capillary force during the burning process.

Interaction and combined effect of triglyceride-glucose index and hypertension ontype 2 diabetesindividuals'peripheral arterial disease risk.

The interaction and combined effect of the triglyceride-glucose (TyG) index, an alternative parameter of insulin resistance, along with hypertension (HT), on the risk of peripheral arterial disease (PAD), a specific type of atherosclerotic cardiovascular disease, in individuals with type 2 diabetes (T2D) seems straightforward. However, specific research on this topic remains scarce. In this cross-sectional study, 2027 adult participants with T2D were devided into four groups based on the mean values of TyG index and various blood pressure parameters along with its category. Binary logistic regression, interaction analysis, combined effect size, and goodness-of-fit of the constructed models were performed. The TyG index's individual effect and it's combined effect with HT, or higher systolic blood pressure (SBP) or higher mean arterial pressure in patients with T2D correlated with a higher PAD risk respectively (odds ratio [OR], 0.50, [95% confidence interval {CI} 0.28-0.89]; OR, 0.32, [95% CI 0.12-0.90]; OR, 0.35, [95% CI 0.13-0.94]; OR, 0.35, [95% CI 0.12-0.98], respectively). Only an interaction effect exists between the TyG index and SBP (multiplicative interaction{INTM}: 1.02 [1.002, 1.038]). Combining them can significantly improve the accuracy of predicting PAD (area under the receiver operating characteristic curve {AUC}MAX = 0.7, AUCModel3 + TyG index + SBP-AUCModel3 = 0.027). All P values were < 0.05. This study suggested that TyG index and hypertension, as well as their combined and interaction effect were significantly correlated with the risk of PAD in T2D individuals.

Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice

Polyhexamethylene guanidine phosphate (PHMG-p), a major ingredient of humidifier disinfectants, is known to induce inflammation, interstitial pneumonitis, and fibrosis in the lungs. While its histopathologic toxicities have been studied in rodents, research on pulmonary function test (PFT) changes following PHMG-p exposure is limited. This study aimed to investigate the acute and chronic effects, as well as the dose and time response, of PHMG-p on the lungs in mice using PFT and histopathologic examinations. In the single instillation model, mice received PHMG-p and were sacrificed at 2, 4, and 8 weeks. In the five-time instillation model, PHMG-p was administered five times at one-week intervals, and mice were sacrificed 10 weeks after the first instillation. Results showed that PHMG-p exposure reduced lung volume, increased resistance, and decreased compliance, indicating a restrictive ventilation defect. Histopathologic examination showed increases in lung inflammation and fibrosis scores. Changes in several lung volume and compliance parameters, as well as histopathology, were dose-dependent. Lung resistance and compliance parameters had significant correlations with lung inflammation and fibrosis scores. PHMG-p exposure in mice resulted in a restrictive ventilation defect with altered lung resistance and compliance, along with histopathologic lung inflammation and fibrosis.

Assessment of morphophysiological parameters of resistance of various varieties of winter rye to chloride salinity in laboratory conditions

Determining the tolerance of cultivated plants to salts is considered important and necessary in breeding practice in areas with primary and secondary soil salinization. This article examines the effect of salinity (NaCl) in laboratory conditions on the growth and development of plants of three varieties of winter rye (Chusovaya, Yantarnaya, Alisa) and the effectiveness of early diagnosis on resistance to the stress factor. The purpose of the study was to determine the resistance of winter rye varieties to chloride salinity based on the variability of morphophysiological characteristics under simulated conditions. Based on the identified differences in indicators characterizing the growth processes of plants in vegetation vessels in the control and on the substrate with NaCl, the varieties according to resistance to salt stress are distributed in the following order: Chusovaya, Yantarnaya, Alisa. The data obtained indicate the specificity of the response of varieties to a stress factor. It is shown that for a more objective characterization of genotypes for salt tolerance, a comprehensive study of traits (seed germination, morphometric parameters of shoots and roots, chlorophyll content in leaves, plant biomass) is necessary. The results of the study can be used in the selection of initial forms for the selection of winter rye, as well as in the cultivation of the studied varieties in different agro-ecological conditions.

Experimental Study on Horizontal Resistance Parameter of Gravelly Soil Considering Slope Gradient Factor

Horizontal resistance can be significantly different for gravelly soil slope sites with different gradients. The impact of slope gradient on the horizontal resistance of soil based on a three-dimensional physical simulation test has been investigated, and the displacement of the pile top and soil pressure for four piles under various gradients (slope gradient 0–45°) was analyzed. The research reveals that ① The soil resistance exhibits a linear increase stage, non-linear steep increase stage, and gradually stabilizing stage with the increase in load. ② The ultimate soil resistance is significantly affected by depth and displacement, and hyperbolic variation characteristics related to the displacement stage. It has a slope weakening effect, and the steeper the slope gradient, the lower the ultimate soil resistance of the pile sides, which effect is negligible when the depth exceeds 0.6–0.7 times that of the pile buried depth. ③ Based on the characteristics of horizontal ultimate resistance-displacement-depth variation in soil, a gradient factor, which is only related to the slope gradient, was used to describe the impact of gradient on the soil resistance modulus (kini) and ultimate resistance (pu). kini is reduced close to the ground surface and gradually increases with depth until it becomes equal to the value of level ground. The ratio between pu in slope ground and level ground was determined for slope angles. The above horizontal resistance parameters were expressed as a function based on the test data to calculate the lateral ultimate bearing capacity of gravelly soil considering the slope gradient factor. The research results developed the theory of foundation design for building structures, promoting the reliability evaluation of pile soil systems towards a more scientific and rigorous direction.

Analysis of the Physiological Parameters of Cold Resistance in Core Winter and Spring Wheat Cultivars

We selected 46 core winter–spring wheat cultivars from China’s main wheat-producing areas as experimental materials to clarify the differences in the physiological parameters of their cold resistance and provide a theoretical basis and high-quality germplasm for cold resistance breeding. We investigated differences in their cold resistance under field conditions for two consecutive years, and determined the physiological parameters of the cold resistance, yield, and quality indicators of different winter–spring wheat cultivars. Our results showed that the cold resistance of winter wheat cultivars was higher than that of spring wheat cultivars. The chlorophyll (Chl), soluble sugar (SS), soluble protein (SP), and free proline (Pro) contents of different winter–spring wheat cultivars were positively correlated with cold resistance, and malondialdehyde (MDA) content was negatively correlated with cold resistance. The five physiological parameters can be used as physiological indicators for the breeding of cold-resistant cultivars. The cold resistance, yield, and quality indicators of different spring and winter wheat cultivars were comprehensively evaluated by using the average membership value and comprehensive score. It was found that the average membership value and comprehensive score of winter wheat cultivars were higher than those of spring wheat cultivars. Through classification using the K-means method, the cold-resistant, high-yield, and high-quality cultivars were screened out, namely, Jimai23 (JM23), Jimai44 (JM44), Shannong57 (SN57), and Jinmai 919 (JM919).

The relationship between the state of cerebral blood flow and volemic status in patients with ischemic stroke in the acute period

The objective was to assess the relationship between the state of cerebral blood flow and volemic status in patients with acute ischemic stroke using the laboratory and instrumental parameters.Materials and methods. 51 patients with newly diagnosed ischemic stroke confirmed by MSCT/MRI of the brain were examined within less than 24 hours from the onset of the disease, and 20 practically healthy individuals (control group). To determine cerebral blood flow, the hemodynamic parameters of transcranial Doppler imaging were used: blood flow rates (maximum systolic, diastolic, averaged over time), Gosling’s pulsatility index and Purcelo’s index of peripheral resistance in the anterior, posterior, middle and main cerebral arteries from the affected and intact sides. Volemic status was assessed using laboratory (serum sodium and brain natriuretic peptide NT-pro-BNP) and instrumental parameters (echocardiography – end-diastolic volume of the left ventricle, left ventricular ejection fraction, diameter and degree of collapse on inhalation of the inferior vena cava).Results. Deterioration of the state of cerebral blood flow by speed indicators and an increase in the resistance parameters of the vascular wall was noted in the studied affected and intact arteries against the background of violations of the volemic status by the level of brain natriuretic peptide, end-diastolic volume of the left ventricle, diameter of the inferior vena cava, left ventricular ejection fraction and degree of collapse of the inferior vena cava. There is a correlation of vascular wall resistance parameters with laboratory and instrumental indicators of volemia, since both the development of deficiency and volume overload negatively affect cerebral perfusion.Conclusions. The cerebral blood flow parameters are correlated with the volemic status of patients with ischemic stroke in the acute period.

Visceral adipose tissue, epicardial fat, and hepatic steatosis in polycystic ovary syndrome: a study of ectopic fat stores and metabolic dysfunction.

In polycystic ovary syndrome (PCOS), ectopic fat accumulation remains debatable. Therefore, intra-abdominal, hepatic, and epicardial fat were compared between PCOS women and body mass index (BMI)-matched controls and their associations with metabolic and hormonal parameters were explored. Furthermore, the performance of echocardiographic epicardial adipose tissue thickness (EATT) and hepatic steatosis measurement using transient elastography-based controlled attenuation parameter (TE-CAP) in screening abdominal visceral adipose tissue (VAT) was originally evaluated. Women aged 18-39 years with BMI < 35 kg/m² were recruited. PCOS was defined by the Rotterdam criteria. All participants underwent clinical and laboratory exams, dual-energy X-ray absorptiometry (DXA), TE-CAP, and echocardiography. A receiver operating characteristic curve was applied to evaluate the accuracy and optimal cutoff values of TE-CAP and EATT in predicting DXA-measured VAT. The study included 35 women with PCOS and 37 controls. PCOS women exhibited higher levels of androgens, insulin resistance (IR) parameters, LDL-cholesterol, triglycerides, VAT, and EATT. VAT correlated with IR and triglycerides, whereas EATT correlated with HDL-cholesterol. In PCOS women aged 18-29, the cutoff values of CAP and EATT for VAT were 198.0 and 3.07, respectively, with CAP showing higher area under the curves (AUC). In PCOS women aged 30-39, the cutoff values were 209.5 and 3.36, respectively, with EATT showing higher AUC. VAT correlates with more metabolic parameters in PCOS than TE-CAP or EATT. TE-CAP is useful for VAT screening in PCOS patients aged 18-39 years, whereas EATT is effective and outperforms CAP in those aged 30-39 years.

Impacts of Waste Rubber Products on the Structure and Properties of Modified Asphalt Binder: Part II-Rubber Reclaim.

The issue of forming a reliable and stable structure of a crumb-rubber-modified binder is an important scientific and technical task. The authors supplemented existing concepts of the mechanism of effective interaction with rubber crumb by introducing a preliminary first stage: controlled partial physical destruction of rubber crumb-producing rubber reclaim. Proposed physical methods of rubber crumb destruction include high shear force (roll mills), high temperature, and a plasticizing medium. The controllability and degree of devulcanization of rubber were determined by acetone-chloroform extraction in different time intervals. The degree of devulcanization of rubber in the rubber reclaim was found to be 22 ± 0.24%, with stability over 14 days. It was found that the size of the particles of the rubber reclaim in the bitumen is less than 2 µm. The properties of the structure of the binder modified with rubber reclaim, characterizing the stability and sustainability, have been studied and established. The developed modified binders are stable in storage. Rheological parameters of the structure characterizing intermolecular interaction, such as shear stability for original and RTFOT-aged, modified bitumen, meet requirements of the state standard at test temperature 64 °C. The elastic structural component of the crumb-rubber-modified binder, as indicated by the relative irreversible deformation parameter J3,2, does not exceed 2.6 kPa (<4.5 kPa) at 64 °C. Additionally, it was determined that the rheological structural parameter for fatigue resistance, which characterizes the durability of road pavement under intensive operational conditions, does not exceed 4699 kPa (<5000 kPa) at 16 °C. The use of 10% rubber reclaim combined with waste frying oil provided the opportunity to obtain a modified binder with a stable and sustainable structure without the introduction of additional stabilizers and agents. Test results showed that the overall performance characteristics of the modified binder meet the 64(S)-40 grade standards.

Comprehensive assessment of adaptability, stability and stress resistance of diploid winter rye varieties under conditions of Western Siberia

Currently, the adaptability and stability of the trait under study, i.e., the ability of a variety to maintain the optimal level of the trait in different soil and climatic conditions, is of particular importance in the breeding process. A research was conducted to comprehensively study the parameters of adaptability, stability and stress resistance in terms of yield of diploid winter rye varieties of different ecological and geographical origins in the conditions of Western Siberia. The experimental part of the study was carried out during 2019–2021, at the experimental site of SibNIIRS - a branch of the ICG SB RAS, located in the West Siberian region. The material for the research was: 6 varieties of winter rye from of the FRC «N.I. Vavilov All-Russian Research Institute of Plant Genetic Resources» (Korotkostebelnaya 69, Sibirskaya 87, Chulpan, Pamyati Kunakbaeva, Sinilga, Alisa) and 8 varieties from the Republican unitary enterprise «Research and Practical Center of National Academy of Sciences of the Republic of Belarus for Arable Farming» (Lota, Kalinka, Golubka, Vostok, Verdun, Talisman, Zubrovka, Yubileinaya). According to the results of two-factor analysis of variance, the yield was influenced by genotypic differences between varieties - 77.34% (P &lt; 0.05) and the prevailing growing conditions in different years of research - 11.98% (P &lt; 0.05). The varieties Sibirskaya 87 (689.0 g/m2) and Yubileinaya (706.0 g/m2) were characterized by productivity at the level or higher than the standard Korotkostebelnaya 69 (650 g/m2). As a result of a comprehensive assessment using ranking for adaptability, stability and stress resistance, the following winter rye varieties were identified: Yubileynaya (102), Korotkostelnaya 69 (97), Sibirskaya 87 (87), Zubrovka (79), Alisa (77), Talisman (74). The selected varieties are capable of producing relatively high yields in the contrasting conditions of Western Siberia.

Copper biomarkers and their relationship with parameters of insulin resistance in obese women.

Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case-control clinical study involving 203 women aged between 20 and 50years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.