To evaluate the flexural and fatigue properties of a polyester disk material used in milled resin clasps of removable partial dentures, experimental polyester disk (mPE), injection-molded polyester (iPE), and polymethyl methacrylate disk (mPMMA) were examined by three-point bending tests and cyclic fatigue tests at 0.75 or 1.50 mm deflection. The mPE exhibited significantly higher flexural strength than the iPE (p<0.05). Meanwhile, the mPMMA displayed higher flexural modulus and strength than the polyesters. The mPE exhibited a significantly lower residual strain than the iPE at the cyclic 0.75 mm deflection (p<0.05); however, microcracks were observed in the mPE at the 1.50 mm deflection. The mPMMA showed a high residual strain at the 0.75 mm deflection and fractured within 1,000 cycles at the 1.5 mm deflection. The higher flexural strength and lower residual strain of the mPE compared with the iPE suggest the advantages of milled resin clasps within a limited deflection.