Stimulated by the enhancing requirements for system safety as well as process reliability in complex industrial processes, this paper investigates a data-driven fault detection and fault-tolerant control scheme for large-scale systems. To this end, a pair-wise decomposition approach is first presented based on the inclusion principle, which expands the original large-scale system into a set of disjointed pair-wise subsystems. Then, for the pair-wise subsystems, the observer-based residual generators and observer-based state feedback controllers for fault detection and fault-tolerant control purpose are further developed in a decentralized way. On this basis, the fault-tolerant controller for the original large-scale system is obtained by the coordination and contraction of the decentralized observer-based state feedback controllers. Finally, the feasibility and effectiveness of the proposed scheme are demonstrated through the case study on a multi-area interconnected power system.