The permeability coefficient of landslide mass, a key parameter in the study of reservoir landslides, is commonly obtained through in situ and laboratory tests; however, the tests are costly and subject to high variability, leading to potential biases. In this paper, a new method was proposed to inversely estimate the permeability coefficient of landslide layers using monitoring data of groundwater level (GWL). First, the landslide transient seepage simulation was conducted to generate sample data for permeability coefficients and GWL during a reservoir operation cycle. Second, using GWL data as input and permeability coefficient data as output, the least-square support vector machine (LSSVM) was trained with two optimization algorithms, the particle swarm optimization (PSO) algorithm and the whale optimization algorithm (WOA), to construct the nonlinear mapping relationship between simulated GWL and permeability coefficients. Third, the accurate permeability coefficients for landslide seepage simulation were inverted or predicted based on the monitored GWL. Finally, using the inverted permeability coefficients for landslide seepage simulation, we compared simulation results with actual monitored GWL and achieved good consistency. In addition, this paper compared the inversion effects of three different algorithms: the standard LSSVM, PSO-LSSVM, and WOA-LSSVM. This study showed that these three algorithms had good nonlinear fitting effects in studying landslide seepage fields. Among them, using the inversion values from PSO-LSSVM for landslide seepage simulation resulted in the smallest relative error compared to actual monitoring data. Within a single reservoir operation cycle, the simulated water level changes were also largely consistent with the monitored water level changes. The results could provide a reference to determine landslide permeability coefficients and seepage.