Research Award Research Articles

IMLS Early Career Research: A Dialogue with Program Officers and Awardees

External funding presents an opportunity for early career scholars to jumpstart their research agenda post-PhD. One funding opportunity available in the library and information science (LIS) field is the Institute of Museum and Library Services (IMLS) Laura Bush 21st Century Librarian (LB21) Early Career Research award. What is the IMLS LB21 Early Career Research (EC) award? Learn more in this 90-minute interactive session that will include five primary activities: IMLS Funding Overview, Panelist Presentations, Attendee Breakout Discussion, Panel Discussion, and Reporting Back. Attendees will gain a better understanding of the EC funding opportunity available at IMLS; learn about first-hand experiences from EC awardees; reflect on their own career trajectories with peers; and evaluate potential next steps for funding their research agenda.

SBIR mills and the U.S. Department of Defense

AbstractMultiple winners of Small Business Innovation Research (SBIR) awards have come under scrutiny by some in the public sector who claim that so-called SBIR mills fail to commercialize from their funded research. We examine this issue using data on a sample of SBIR awards awarded between 1992 and 2001. Consistent with the critique, we find a negative association between the overall number of previous SBIR awards and commercialization from a current SBIR-funded project. However, when we consider the number of previous SBIR awards related to the current project’s technology, we find a positive association thus suggesting previous technologically related awards increase the probability of commercialization. We extend the analysis beyond commercialization to patents and scientific publications related to the current award and find similar patterns of results. Our results also reinforce the finding of others that multiple SBIR awards are a heterogeneous metric.

American College of Surgeons: Owen H Wangensteen Scientific Forum Excellence in Research Awards 2024

American College of Surgeons: Owen H Wangensteen Scientific Forum Excellence in Research Awards 2024

Darren A. Lytle Honored With 2024 A.P. Black Research Award

Darren A. Lytle Honored With 2024 A.P. Black Research Award

Success and opportunities of the American Academy of Pediatrics Marshall Klaus research grant program in neonatal-perinatal medicine.

Physician-scientists are a crucial link between clinical practice and research. The American Academy of Pediatrics (AAP) initiated the Marshall Klaus Perinatal Research Award to enhance the development of research skills among physicians training in Neonatal-Perinatal Medicine. In this study, we sought to identify trends in funding along with geographical and demographic variables of the applicants and mentees and assess the applicants' scholarly productivity and funding from the National Institutes of Health (NIH). We reviewed the data of applicants and awardees from 2015-2024. We found that basic science applications had a higher funding likelihood than clinical/translational applications. The geographical distribution of awardees is skewed. There was a significant association between awardee status and K08 or K23 funding attainment. Future efforts should support more equitable award distribution and a diverse research landscape in neonatal-perinatal medicine.

Seismic Local Buckling Limits for Hollow Structural Section and Built-Up Box Columns

Recently completed research on seismic local buckling limits for steel hollow structural section (HSS) and built-up box columns is featured. These National Center for Research on Earthquake Engineering (NCREE) studies are led by Dr. Chung-Che Chou and Dr. Tung-Yu Wu in the Department of Civil Engineering at National Taiwan University (NTU). Dr. Chou also serves as the NCREE Director. Dr. Chou’s research has focused on seismic testing, analysis, and design for steel and post-tensioned self-centering structures. Some recent work includes studies on hybrid simulation of a full-scale steel moment frame, a post-tensioned self-centering brace, novel prediction models for early earthquake warnings, and earthquake reconnaissance work in eastern Taiwan. Dr. Chou’s numerous accolades include the Awards for Excellent Research and Technology Transfers for his leadership on a research team developing a sandwiched buckling-restrained brace and a self-centering brace. Dr. Wu’s research interests include collapse behavior of cold-formed HSS columns under seismic loading, subwavelength seismic metamaterial structures, crack growth in railway crossings under high wheel-rail impacts, and seismic resilience of steel buildings. In addition to multiple scholarships and fellowships, Dr. Wu’s honors include the Raymond C. Reese Research Prize, awarded by the American Society of Civil Engineers (ASCE) for papers representing notable achievements in research with impact on design. The National Science and Technology Council is supporting this research on seismic local buckling limits for HSS and built-up box columns. Selected highlights from both projects are presented, along with a preview of future research tasks.

Congratulations to the 2024 Excellence in Research and Presidential Scholar Award Winners

Congratulations to the 2024 Excellence in Research and Presidential Scholar Award Winners

S827 Global Insights: Glucagon-Like Peptide-1 Receptor Agonists are Linked to Gastrointestinal Functional Disorders ACG Outstanding Research Award in the Functional Bowel Disease Category (Trainee)

S827 Global Insights: Glucagon-Like Peptide-1 Receptor Agonists are Linked to Gastrointestinal Functional Disorders ACG Outstanding Research Award in the Functional Bowel Disease Category (Trainee)

S2088 Racial and Ethnic Disparities and Their Association With Obesity Phenotypes: A Prospective Single-Center Registry ACG Outstanding Research Award in the Obesity Category (Trainee)

S2088 Racial and Ethnic Disparities and Their Association With Obesity Phenotypes: A Prospective Single-Center Registry ACG Outstanding Research Award in the Obesity Category (Trainee)

S1603 Endoscopic Ultrasound Functionality for a Standard Upper Endoscope: Initial U.S. Experience ACG Outstanding Research Award in the Interventional Endoscopy Category

S1603 Endoscopic Ultrasound Functionality for a Standard Upper Endoscope: Initial U.S. Experience ACG Outstanding Research Award in the Interventional Endoscopy Category

T cell responses and clinical symptoms among infants with congenital cytomegalovirus infection.

BACKGROUNDCongenital cytomegalovirus (cCMV) infection can cause developmental impairment and sensorineural hearing loss (SNHL). To determine the relationship between immune responses to cCMV infection and neurologic sequelae, T cell responses were compared for their connection to clinical symptoms at birth and neurodevelopmental outcomes.METHODSThirty cCMV-infected and 15 uninfected infants were enrolled in a single-center prospective observational case-control study. T cell pp65-specific cytokine responses; CD57, CD28, and PD-1 expression; and memory subsets were compared.RESULTSInfected neonates (73% symptomatic at birth) lacked pp65-specific cytokine-secreting T cells, with elevated frequencies of CD57+, CD28-, and PD-1+CD8+ T cells and effector memory subsets. Though frequencies overlapped between cCMV symptom groups, asymptomatic infants had higher frequencies of CD57+PD-1+CD8+ T cells. Neonates with subsequent developmental delay lacked detectable CMV-specific T cell responses, with patterns resembling those of uninfected infants. Two children with progressive SNHL had high frequencies of PD-1+CD8+ T cells over the first year compared with children without progressive SNHL.CONCLUSIONSimilar to published reports, neonatal viral antigen-specific cytokine-secreting T cell responses were not detected, but overall patterns indicate that globally differentiated memory CD8+ T cell populations were induced by cCMV infection, with higher frequencies of terminally differentiated PD-1+CD8+ T cells potentially associated with asymptomatic infection. In this cohort, a lack of in utero T cell differentiation was associated with developmental delay, and high frequencies of PD-1+CD8+ T cells persisted only in children with progressive SNHL. Further work is needed to define the specificity of these T cells and their mechanistic connection to these outcomes.FUNDINGThis study was funded through an intramural research award at Nationwide Children's Hospital, the Pediatric Infectious Disease Society Fellowship Award funded by Stanley and Susan Plotkin and Sanofi Pasteur, the Abigail Wexner Research Institute at Nationwide Children's Hospital, and the Pichichero Family Foundation Vaccines for Children Initiative Research Award from the Pediatric Infectious Diseases Society Foundation.

MLA 2024 Annual Meeting and JMLA Biannual Research Caucus Research Awards

The MLA Research Caucus is pleased to announce the winners for best research papers and posters presented at the MLA 2024 Portland annual meeting.

Report on Selection of 6th Young Researcher Award

Report on Selection of 6th Young Researcher Award

Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation

In this Viewpoint, 2024 Albert Lasker Basic Medical Research Award winner Zhijian J. Chen describes his discovery of cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), a DNA-sensing enzyme that triggers inflammation.

Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity

In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Svetlana Mojsov describes her discovery of GLP-1 (7-37), the biologically active incretin that led to development of effective GLP-1 analogues for treating diabetes and obesity.

The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity

The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity. Each of the three had a distinct set of skills that made this advance possible; Habener is an endocrinologist and molecular biologist, Mojsov is a peptide chemist, and Knudsen is a pharmaceutical scientist. Their collective efforts have done what few thought possible—the development of highly effective medicines for reducing weight. Their research has also solved a mystery that began more than a century ago.

GLP-1 for Treating Obesity—Origin, History, and Evolution

In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Lotte Bjerre Knudsen describes her discovery of glucagon-like peptide-1 for the treatment of patients with obesity.

Hunting down the elusive cytosolic-DNA sensor

The 2024 Albert Lasker Basic Medical Research Award was attributed to Zhijian (James) Chen for “the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” Bringing to bear an ingenious in vitro complementation system, an astute insight, and superlative biochemistry, Chen and colleagues identified cGAS (cGAMP synthase) as both the molecule that perceives cytosolic DNA in infected, stressed, or dying cells and the enzyme that catalyzes the synthesis of cGAMP (cyclic GMP-AMP), a critical second messenger along the route to inflammatory cytokine production. These findings cleared up the reigning confusion surrounding a major mechanism of inciting the innate immune system, with therapeutic implications for fighting infections, containing tumors, and extinguishing autoimmune and inflammatory diseases.

The ODE Undergraduate Research Award Competition Sponsored by Omicron Delta Epsilon International Honor Society in Economics

The ODE Undergraduate Research Award Competition Sponsored by Omicron Delta Epsilon International Honor Society in Economics

The ODE Graduate Research Award Competition Sponsored by Omicron Delta Epsilon International Honor Society in Economics

The ODE Graduate Research Award Competition Sponsored by Omicron Delta Epsilon International Honor Society in Economics