Research Settings Research Articles

The short Thai version of functional outcomes of sleep questionnaire (FOSQ-10T): reliability and validity in patients with sleep-disordered breathing.

The study is to evaluate reliability and validity of the short Thai version of Functional Outcome of Sleep Questionnaire (FOSQ-10T), in patients with sleep disordered breathing (SDB). Inclusion criteria were Thai patients with SDB age ≥ 18years old who had polysomnography results available. Exclusion criteria were patients unable to complete questionnaire for any reason, patients with a history of continuous antidepressant or alcohol use, and underlying disorders including unstable cardiovascular, pulmonary, or neurological conditions. All participants were asked to complete the FOSQ-10T and Epworth sleepiness scales (ESS). Of these, 38 patients were required to retake FOSQ-10T at 2-4weeks later to assess test-retest reliability, and 19 OSA patients treated with CPAP were asked to do so at 4weeks following therapy to assess questionnaire's responsiveness to treatment. There were 42 participants (24 men, 18 women), with a mean age of 48.3years. The internal consistency of the FOSQ-10T was good, as indicated by Cronbach's alpha coefficient of 0.85. The test-retest reliability was good, as indicated by intraclass correlation coefficient of 0.77. The correlation between the FOSQ-10T and ESS scores (concurrent validity) was moderate (r = - 0.41). The scores of FOSQ-10T significantly increased after receiving adequate CPAP therapy, showing an excellent responsiveness to treatment. However, there was no significant association between FOSQ-10T scores and OSA severity measured by apnea-hypopnea index. The FOSQ-10T has good reliability and validity to use as a tool to assess QOL in Thai patients with SDB. It is convenient and potentially useful in both clinical and research settings.

Elevated serum levels of soluble B-cell maturation antigen as a prognostic biomarker for multiple myeloma.

Serum B-cell maturation antigen (sBCMA) levels can serve as a sensitive biomarker in multiple myeloma (MM). In the research setting, sBCMA levels can be accurately detected by enzyme-linked immunosorbent assay (ELISA), but the approach has not been approved for clinical use. Here, we used a novel chemiluminescence method to assess sBCMA levels in 759 serum samples from 17 healthy donors and 443 patients with plasma cell (PC) diseases including AL amyloidosis, POEMS syndrome and MM. Serum BCMA levels were elevated 16.1-fold in patients with newly diagnosed MM compared to healthy donors and rare PC diseases patients. Specifically, the sBCMA levels in patients with progressive disease were 64.6-fold higher than those who showed partial response or above to treatment. The sBCMA level also correlated negatively with the response depth of MM patients. In newly diagnosed and relapsed MM patients, survival was significantly longer among those subjects whose sBCMA levels are below the median levels compared with those above the median value. We optimized the accuracy of the survival prediction further by integrating sBCMA level into the Second Revised International Staging System (R2-ISS). Our findings provide evidence that the novel chemiluminescence method is sensitive and practical for measuring sBCMA levels in clinical samples and confirm that sBCMA might serve as an independent prognostic biomarker for MM.

Exploring the symbiotic relationship between smart technologies and thermal comfort in urban environments

The study's primary focus is to gather profound insights into user perceptions and preferences related to living in smart environments prioritizing thermal comfort and energy efficiency. This objective is pursued through meticulous surveys designed to capture the nuanced experiences of residents, unravelling the intricate relationship between smart technologies and their impact on daily life within these intelligent living spaces. The findings from these quantitative surveys become a valuable repository of information that sheds light on the intricate dynamics of user satisfaction and experience, providing a holistic understanding of the role played by smart technologies in shaping thermal comfort in the built environment. Additionally, the research sets out to assess the specific influence of smart technologies on thermal comfort within the urban settings of Turkey. By narrowing the focus to this geographical context, the study aims to draw region-specific insights that can be instrumental in tailoring smart living solutions to the unique needs and nuances of the Turkish urban landscape. This contextual analysis allows for a nuanced understanding of how smart technologies operate in diverse urban environments, providing a foundation for targeted interventions and improvements. A core objective of the study is to distil actionable recommendations for architects, designers, and urban planners. These recommendations are crafted with the intention of guiding the creation of user-centric spaces within the built environment that not only meet but exceed expectations in optimizing thermal comfort. By translating survey findings and regional assessments into practical suggestions, this research aims to empower professionals in the field to integrate smart technologies seamlessly into their designs, ultimately contributing to the development of intelligent, sustainable, and people-focused spaces. In summary, the study positions itself as a comprehensive exploration of the symbiotic relationship between smart technologies and thermal comfort. Through a meticulous examination of user perceptions, regional influences, and actionable recommendations, the research seeks to chart a course for a future where the built environment actively supports and enhances thermal comfort, thereby improving the overall quality of life for its residents.

Measures of Suicidal Thoughts and Behaviors in Children and Adolescents: A Systematic Review and Recommendations for Use in Clinical and Research Settings.

Empirically supported measures of suicidal thoughts and behaviors (STBs) are needed to serve as reference outcomes for suicide risk screening tools and to monitor severity and treatment progress in children and adolescents with STBs. The present paper systematically reviewed existing measures of STBs in youth and studies evaluating their psychometric properties and clinical utility. Measures were then evaluated on reliability, validity, and clinical utility. Sixteen articles (20 independent samples) were found with psychometric data with youth samples for eight measures. Interview-based measures were found to have the strongest psychometric support and clinical utility. Significant limitations exist for all self-report measures due to inherent characteristics of these measures that cannot be remedied through additional psychometric study. There is an urgent need for the development and validation of new self-report measures of STBs, particularly for preadolescent children, sexual and gender minority youth, and racial/ethnic minority youth.

Exploring X: barriers to care for eosinophilic esophagitis.

Patients with chronic diseases have increasingly turned to social media to discuss symptoms and share the challenges they face with disease management. The primary aim of this study is to use naturally occurring data from X (formerly known as Twitter) to identify barriers to care faced by individuals affected by eosinophilic esophagitis (EoE). For this qualitative study, the X application programming interface with academic research access was used to search for posts that referenced EoE between 1 January 2019 and 10 August 2022. The posts were identified as being either related to barriers to care for EoE or not. Those related to barriers to care were further categorized by the type of barrier that was expressed. A total of 8636 EoE-related posts were annotated of which 12.1% were related to barriers to care in EoE. The themes that emerged about barriers to care included: dietary challenges, limited treatment options, lack of community support, lack of physician awareness of disease, misinformation, cost of care, lack of patient belief in disease or trust in physician, and limited access to care. Saturation of themes was achieved. This study highlights barriers to care in EoE using readily accessible social media data that is not derived from a curated research setting. Identifying these obstacles is key to improving care for this chronic disease.

Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting.

We investigated autistic children's generalisation of social communication over time across three settings during a play-based assessment with different adults and explore the potential moderating effects on generalisation of age, nonverbal IQ and level of restricted and repetitive behaviours. The social communication abilities of 248 autistic children (2-11years, 21% female, 22% single parent, 60% white) from three UK sites were assessed from 1984 video interactions in three contexts with three different interaction partners (parent/home, teaching assistant/school, researcher/clinic) at baseline, midpoint (+ 7m) and endpoint (+ 12m) within the Paediatric Autism Communication Trial-Generalised (PACT-G), a parent-mediated social communication intervention. Children's midpoint social communication at home generalised to school at midpoint and to clinic at endpoint. Generalisation was stronger from home to school and clinic than school to home and clinic. Generalisation was not moderated by age, nonverbal IQ or restricted and repetitive behaviour. Broader child development did not explain the pattern of results. The current study is the largest study to date to explore generalisation with autistic children and provides novel insight into their generalisation of social communication skills. Further research is needed to gain a more comprehensive understanding of facilitators of generalisation across settings and interaction partners in order to develop targeted strategies for interventions to enhance outcomes for young autistic children.

Examining the reliability and validity of the arabic version of the Glasgow Sleep Effort Scale (GSES).

Sleep effort refers to the cognitive and behavioral exertion involved in initiating and maintaining sleep. High sleep effort is increasingly recognized as perpetuating insomnia and poor sleep quality. Validated sleep effort scales enable the quantification of this construct in clinical and research settings. However, no Arabic version has been available. This study translated and validated the Glasgow Sleep Effort Scale (GSES) into Arabic to assess sleep effort in Arabic-speaking populations. The GSES was translated into Arabic using the forward-backward translation approach. This involved an initial Arabic translation from the source followed by a back translation into English to ensure accuracy. A total of 369 participants were recruited to assess the psychometric properties of the Arabic version of the GSES, specifically its reliability and validity. The reliability analysis included Cronbach's α, McDonald's ω, and test-retest reliability. Validity was examined using confirmatory factor analysis (CFA) to evaluate the unidimensionality of the scale and assess model fit. Convergent validity was also assessed through correlation analysis with the Athens Insomnia Scale (AIS) and the Generalized Anxiety Disorder-7 Scale (GAD-7). The Cronbach's α reliability coefficient and McDonald's ω for the scale were found to be 0.87 (95% CI: 0.85-0.89). The test-retest reliability was 0.95 (95% CI: 0.93 - 0.97) after two weeks. The one-factor model showed an acceptable fit, with a CFI of 0.96, a TLI of 0.94, and an SRMR of 0.04. Invariance analysis revealed that male and female participants conceptualized and responded to the GSES items similarly, without differences in factor loadings or scale characteristics between the sexes. The Arabic version of the GSES has good convergent validity, as shown by the significant correlation between the AIS and the GSES (r = 0.72, p < 0.001). Similarly, the GAD-7 score was significantly correlated with the GSES score (r = 0.77, p < 0.001). This is the first study in which the GSES was validated in Arabic. This allows the scale to reliably gauge sleep effort among Arabic speakers, providing new clinical and research opportunities to understand how maladaptive sleep effort may contribute to insomnia and suboptimal sleep in this demographic population.

Deconstructing hegemonic masculinities and promoting prevention altruism and antiretroviral therapy adherence among couples

Through the use of a netnography research design, this research sets out to explore plausible strategies that can be adopted for adherence to antiretroviral therapy (ART) for the management of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). The research posits that the successful management of HIV and AIDS is hindered by hegemonic masculinities, which accord power to men and subordinate women. Additionally, a number of societal beliefs linked with sociocultural masculine attitudes become repressive to men in terms of their health-seeking behaviour. This results in their disinclination towards disclosure of their HIV status and access to medicinal usage, which consequently affects the health and well-being of their female counterparts. This research acknowledges the importance of ART in managing HIV and AIDS. For HIV-positive persons, ART reduces the viral load and prolongs the timeframe between a diagnosis of the HIV and the AIDS. It prolongs the survival chances of the infected person. In order to promote adherence to ART and to minimise the risk of HIV infection for women, the research advocates for the promotion of prevention altruism as a mechanism for deconstructing hegemonic masculinities to enable the effective management of HIV and AIDS.Contribution: This research recognises the negative interface between hegemonic masculinities and adherence to ART. Hence, the research suggests the practice of prevention altruism for promoting adherence to ART as well as the effective management of HIV and AIDS in a bid to prolong longevity and to promote Sustainable Development Goal 3.

How CEOs can Increase Public Engagement via Microblogs: The Role of CEO Gender and Content Orientation

AbstractIn the social media era, Chief Executive Officers (CEOs) are increasingly using microblogging sites to communicate with the public. Drawing on schema‐congruity theory and gender egalitarianism, we investigate how CEO gender and work–life content orientation interact to influence public engagement with CEOs on microblogs. Using China as our research setting, we conduct a content analysis of data collected from 63 high‐profile CEOs’ microblogs and four laboratory studies with some 2000 respondents. Our results show that for female CEOs, work‐related content leads to greater engagement than life‐related content; for male CEOs, the effect is reversed. We find that such outcomes are driven by the incongruity between stereotypical gender roles and content orientation, which enhances perceived novelty and audience interest, thus leading to greater engagement. This effect diminishes when the audience has a very high or very low perception of gender equality in their society; or when the audience supports male privilege values personally. Our research provides new theoretical insights for online leadership communication, public engagement and gender research. It also offers useful managerial guidance for executives to effectively leverage the capabilities of social media in engaging with the public.

Validation of spectral sleep scoring with polysomnography using forehead EEG device

IntroductionVisual scoring of sleep electroencephalography (EEG) has long been considered the gold standard for sleep staging. However, it has several drawbacks, including high cost, time-intensiveness, vulnerability to human variability, discomfort to patients, lack of visualization to validate the hypnogram, and no acknowledgment of differences between delta and slow oscillation deep sleep. This report highlights a spectral scoring approach that addresses all these shortcomings of visual scoring. Past algorithms have used spectral information to help classify traditional visual stages. The current method used the clearly visible spectral patterns to develop new spectral stages, which are similar to but not the same as visual stages. Importantly, spectral scoring delivers both a hypnogram and a whole-night spectrogram, which can be visually inspected to ensure accurate scoring.MethodsThis study compared traditional visual scoring of 32-channel polysomnography with forehead-only spectral scoring from an EEG patch worn concurrently. The PSG was visually scored by trained technicians and the forehead patch was scored spectrally. Because non-rapid eye movement (NREM) stage divisions in spectral scoring are not based on visual NREM stages, the agreements are not expected to be as high as other automated sleep scoring algorithms. Rather, they are a guide to understanding spectral stages as they relate to the more widely understood visual stages and to emphasize reasons for the differences.ResultsThe results showed that visual REM was highly recognized as spectral REM (89%). Visual wake was only scored as spectral Wake 47% of the time, partly because of excessive visual scoring of wake during Light and REM sleep. The majority of spectral Light (predominance of spindle power) was scored as N2 (74%), while less N2 was scored as Light (65%), mostly because of incorrect visual staging of Lo Deep sleep due to high-pass filtering. N3 was scored as both Hi Deep (13 Hz power, 42%) and Lo Deep (0–1 Hz power, 39%), constituting a total of 81% of N3.DiscussionThe results show that spectral scoring better identifies clinically relevant physiology at a substantially lower cost and in a more reproducible fashion than visual scoring, supporting further work exploring its use in clinical and research settings.

AAPM Task Group Report 267: A joint AAPM GEC-ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy.

Brachytherapy utilizes a multitude of radioactive sources and treatment techniques that often exhibit widely different spatial and temporal dose delivery patterns. Biophysical models, capable of modeling the key interacting effects of dose delivery patterns with the underlying cellular processes of the irradiated tissues, can be a potentially useful tool for elucidating the radiobiological effects of complex brachytherapy dose delivery patterns and for comparing their relative clinical effectiveness. While the biophysical models have been used largely in research settings by experts, it has also been used increasingly by clinical medical physicists over the last two decades. A good understanding of the potentials and limitations of the biophysical models and their intended use is critically important in the widespread use of these models. To facilitate meaningful and consistent use of biophysical models in brachytherapy, Task Group 267 (TG-267) was formed jointly with the American Association of Physics in Medicine (AAPM) and The Groupe Européen de Curiethérapie and the European Society for Radiotherapy & Oncology (GEC-ESTRO) to review the existing biophysical models, model parameters, and their use in selected brachytherapy modalities and to develop practice guidelines for clinical medical physicists regarding the selection, use, and interpretation of biophysical models. The report provides an overview of the clinical background and the rationale for the development of biophysical models in radiation oncology and, particularly, in brachytherapy; a summary of the results of literature review of the existing biophysical models that have been used in brachytherapy; a focused discussion of the applications of relevant biophysical models for five selected brachytherapy modalities; and the task group recommendations on the use, reporting, and implementation of biophysical models for brachytherapy treatment planning and evaluation. The report concludes with discussions on the challenges and opportunities in using biophysical models for brachytherapy and with an outlook for future developments.

Definition of diaphragmatic sleep disordered breathing and clinical meaning in Duchenne muscular dystrophy

BackgroundDiaphragmatic sleep disordered breathing (dSDB) has been recently identified as sleep dysfunction secondary to diaphragmatic weakness in Duchenne muscular dystrophy (DMD). However, scoring criteria for the identification of dSDB are...

PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application.

This study aims to develop and validate an end-to-end software platform, PyHFO, that streamlines the application of deep learning methodologies in detecting neurophysiological biomarkers for epileptogenic zones from EEG recordings.&#xD;&#xD;Methods: We introduced PyHFO, which enables time-efficient HFO detection algorithms like short-term energy (STE) and Montreal Neurological Institute and Hospital (MNI) detectors. It incorporates deep learning models for artifact and HFO with spike classification, designed to operate efficiently on standard computer hardware. &#xD;&#xD;Main results: The validation of PyHFO was conducted on three separate datasets: the first comprised solely of grid/strip electrodes, the second a combination of grid/strip and depth electrodes, and the third derived from rodent studies, which sampled the neocortex and hippocampus using depth electrodes. PyHFO demonstrated an ability to handle datasets efficiently, with optimization techniques enabling it to achieve speeds up to 50 times faster than traditional HFO detection applications. Users have the flexibility to employ our pre-trained deep learning model or use their EEG data for custom model training.&#xD;&#xD;Significance: PyHFO successfully bridges the computational challenge faced in applying deep learning techniques to EEG data analysis in epilepsy studies, presenting a feasible solution for both clinical and research settings. By offering a user-friendly and computationally efficient platform, PyHFO paves the way for broader adoption of advanced EEG data analysis tools in clinical practice and fosters potential for large-scale research collaborations.

Advances in DNA Extraction Techniques: A Comprehensive Review of Methods and Applications

The extraction of DNA is a fundamental process in molecular biology, underpinning a wide range of applications from genetic research to forensic science and medical diagnostics. This review aims to explore the latest advancements in DNA extraction techniques, highlighting their principles, applications, and suitability for various types of biological samples. Traditional DNA extraction methods, such as phenol-chloroform and ethanol precipitation, have served as the backbone of DNA isolation for decades. However, these techniques often involve hazardous chemicals and can be time-consuming. Recent advancements have focused on developing safer, faster, and more efficient methods, with a focus on automation and scalability. Innovations such as magnetic bead-based extraction, silica column purification, and specialized kits have greatly simplified the process, allowing for high-throughput applications in clinical and research settings. In addition to these technical improvements, new approaches have emerged to address specific challenges, such as extracting DNA from degraded or trace samples, as seen in forensic investigations, or isolating cell-free DNA for non-invasive prenatal testing and cancer diagnostics. Moreover, microfluidic devices and lab-on-a-chip technologies are transforming the landscape by enabling DNA extraction from minute samples with minimal reagent consumption. This review discusses the principles underlying these advanced techniques, their benefits and limitations, and the specific contexts in which they excel. It also considers future trends, including further automation, integration with sequencing platforms, and the potential for point-of-care applications. By examining the current state of DNA extraction technology, this review aims to provide researchers and practitioners with a comprehensive guide to the best methods for their specific needs.

African women migration researchers and the question of reflexivity

Reflexivity has received a lot of attention in recent years, but there is little on how to initiate reflexivity amongst those who are not familiar with it. This paper explores how to initiate reflexivity work and what difference it can make to the initiates in how we research and what we write about, and how this work can be done collaboratively between women in different locales. It breaks new ground by drawing on duo-reflexivity between three African women migration researchers reflecting on their role in collaborative research. In doing so, it unravels the complexities of insider-outsider status in global-North/South research and shows the importance of intersectional reflexivity, which addresses gender, social class, nationality, research setting, and discipline as we researched migration and inclusive growth in Africa. The paper unpacks gender as a category and how we approach it, how we experience it as part of our daily researching lives, and as a research topic in Ghana, Kenya, and Nigeria. Furthermore, we throw a global South perspective on taken for granted categories such as income to show how reflexivity is important when researching migrants and non-migrants for a global audience. The paper ends with some thoughts on our experience of undertaking this reflexivity exercise. We offer this as an invitation to researchers, especially those from the global South, who may also be new to reflexivity.

Teleworking and commuting mode choice in the post-COVID-19 era as a challenge for organisations

PurposeThis empirical research aims to provide organisations with useful information on how teleworking has affected employee commuting, allowing organisations to adapt working conditions to the new social context. This research sets out to provide evidence on the behaviour of teleworkers in terms of the mode of transport chosen when commuting to work physically.Design/methodology/approachThis research is based on a survey conducted in Madrid based on a theoretical approach grounded in the theory of planned behaviour (TPB) and discrete choice models. Exploratory factor analysis (EFA) and discriminant analysis have been used to determine the variables that influence the mode of transport chosen by teleworkers when commuting in person.FindingsThe results indicate the prevalence of private car use by teleworkers when working at the office, finding that attitudes and satisfaction with modes of transport significantly influence their choice. The characteristics and frequency of teleworking, however, are not significant, which indicates that teleworkers attach greater importance to their preferred mode of transport, regardless of the disadvantages.Originality/valueThis research provides empirical evidence using an inductive approach to understand the challenges that organisations are facing with regard to teleworking since commuting behaviour has changed for teleworkers. This requires organisations to give significant reconsideration to the issue of commuting as an important component of working time that could condition employee satisfaction and, therefore, the retention or recruitment of talent. Furthermore, residence and mobility changes afford organisations better access for recruitment, notwithstanding urban planning implications.

From love to betrayal? When your team’s sponsor decides to also sponsor your rival

PurposeThe aim of this research was to investigate fans’ responses toward a sponsor that has had a long-standing sponsorship deal with a club and decided also to sponsor the club’s rival.Design/methodology/approachA long-term sponsorship deal between a retsina wine company and a popular football club and a newly established deal between the company and the main rival club were selected as the research setting. Data were collected from a total sample of 302 participants, fans of the two teams, using an online survey and PLS-SEM was employed to test the relationships of the proposed structural model.FindingsThe results provided evidence for the importance of the inclusion of perceptions of fit for both teams to the model as it impacted the responses in the joint sponsorship. Team identification emerged significant for improving fans perceptions of fit between the sponsor and their favorite club but also led fans of the long-term sponsored club to feel betrayed from the sponsor. The sense of betrayal impacted the level of fit, the rejection of sponsorship but did not emerge significant for driving negative responses toward the sponsor’s brand. The same held for the rejection of the joint sponsorship.Originality/valueThis is the very first study that incorporated the effects of the perceptions of fit of two rival clubs to test the effect of sponsorship for a sponsor brand of a deal that includes a longtime sponsored football club and its rival as a newly sponsored one. It is also one of the first attempts that explores relationships between perceptions of fit, sense of betrayal and rejection of a joint sport sponsorship in a rivalry context, highlighting the importance of preventing fans' betrayal.

Partnering with consumers and practising clinicians to establish research priorities for public hospital maternity services.

ObjectiveAn innovative approach by two Queensland health services was taken to establish a shared maternity services' research agenda by partnering with consumers and clinicians. The objective was to set the top five research priorities to ensure that the future direction of maternity research was relevant to end-user and organisational needs.MethodsA modified James Lind Alliance (JLA) methodology was applied between August 2022 and February 2023 across two south-east Queensland Health Services which included five participating maternity units and involved partnership with consumers, healthcare professionals and clinician researchers. The reporting guideline for priority setting of health research (REPRISE) was followed.ResultsThere were 192 respondents to the initial harvesting survey, generating 461 research suggestions. These were aggregated into 122 unique questions and further summarised into a list of 44 research questions. The 157 eligible interim prioritisation survey respondents short-listed 27 questions ready for ranking at a final consensus workshop. The top five question themes were: (1) maternity care experience, engagement and outcomes of priority populations; (2) increasing spontaneous vaginal birth; (3) experiences and perceptions of woman/person-centred care; (4) best practice care during the 'fourth' trimester; and (5) antibiotic use during labour and birth.ConclusionApplying an adapted JLA framework can successfully shape and establish a research agenda within Australian health services, through partnership with consumers and practicing clinicians. This is a transparent process that strengthens the legitimacy and credibility of research agendas, and it can form a replicable framework for other settings.

The Impact of Online Informal Learning Of English (OILE) Through Fandom Participation

This research set out to explore the role that online fandom participation had in the language learning process of pre-graduate English teachers in Mexico. To this end, the data were collected by means of five individual interviews with students, who had previously identified themselves as former participants of online fandom and who claimed that they significantly developed their English skills as a result of this fandom participation. The evidence indicates that by becoming invested in fan communities of predominantly English-speaking media, the participants became fluent in the target language, mostly by themselves. This learning took place outside the language classroom in an engaging and stress-free environment; regardless of whether the participants were conscious of it or not. This study’s implications suggest as technology and education move forward, alternatives to incorporate extra-curricular tools aligned with the learners’ interest and in the benefit of their language learning process, should be sought.

Conceptualising TMD symptom burden in youths: Symptom duration, frequency, intensity and interference.

This study aimed to conceptualise Temporomandibular disorder (TMD) symptom burden and severity and explored their interrelationships with somatic symptoms and psychological distress. Participants were recruited from a local polytechnic. The quintessential five TMD symptoms (5Ts) of the Diagnostic Criteria for TMDs (DC/TMD) were appraised and extended to evaluate the duration, frequency, intensity and interference of discrete TMD symptoms. Global TMD severity (GS) was computed by totaling the points for all TMD symptoms and dimensions. TMD (TS) and somatic symptom (SS) burden were assessed based on the Somatic Symptoms Scale-8, while psychological distress was measured with the Depression, Anxiety and Stress Scales-21. Statistical analyses were performed using Kruskal-Wallis/Dunn tests and Spearman's correlation (α = .05). Of the 366 eligible participants (mean age 19.1 ± 2.3 years), 51.4% were 5Ts-negative and 48.6% were 5Ts-positive. Among the 5Ts-positive individuals, 25.3%/64.0% were 'bothered a little' whereas 4.5%/10.7% were 'bothered a lot' by TMD pain/headache. Correspondingly, 32.6%/12.4%/5.1% were 'bothered a little' while 2.8%/2.8%/1.1% were 'bothered a lot' by TMJ sounds/closed/open locking. TS burden was moderate-to-strongly correlated to aggregate symptom duration, frequency, intensity, interference, GS and SS burden (rs = .50-.88). While TS burden and GS were weakly associated with psychological distress (rs = .18-.36), SS burden was moderately related to depression, anxiety and stress (rs = .47-.53). TS burden can serve as a proxy for global TMD severity and may be more meaningful than the mere presence of TMD symptoms in clinical and research settings.