Scientific Research Institute Research Articles

Functional preference and spatial response of urban renewal entities in Beijing

In the process of rapid urban renewal, quantitative research on functional preferences and spatial layout norms of multi-type urban renewal entities is crucial for optimizing spatial governance and promoting orderly control of urban renewal. We investigate urban renewal in Beijing from 2006 to 2021 using directional distribution, spatial autocorrelation, and hotspot analysis. The findings are as follows: (1) The functional preference of each type of entity differs. While most private companies and other profit-oriented entities concentrate on producer services and residential functions, policy-oriented entities dominate the urban regeneration of public service activities. (2) Every entity shows a significant agglomeration characteristic, yet exhibits a differentiated spatial response pattern. Those entities with stronger leasing ability prefer the central zone while others are the opposite. (3) Diverse types of entities have differentiated spatiotemporal evolutions. The spatial directional divergence of state-owned enterprises and scientific research institutes has increased between 2006 and 2021. This is mainly influenced by the policy of relieving Beijing of nonessential functions. However, the rest entities show a balanced spatial development trend with the difference in each direction becoming smaller. Furthermore, the center of gravity of profit-oriented entities has shifted from the suburbs to the central zone due to a combination of administrative and market forces, whereas the center of gravity of policy-oriented entities tends to move outward from the central zone.

The state of psychological and immunological indicators in graduate students of a medical university

Training future doctors for professional practice usually entails building awareness and embracing the significant responsibility inherent in the field. This, in turn, leads to significant psycho-emotional stress by the time of graduation from academic institution. With the aim of identifying the correlation between homeostatic system indicators, a comparative analysis was conducted to characterize the immunological and psychological parameters of final-year medical university students, contingent upon their respective training programs. The study involved sixth-year students of the Therapeutic and Preventive Faculty [TPF] (29 individuals) and the Military Training Center [MTC] (34 individuals) of Rostov State Medical University, a Federal State Budgetary Educational Institution of Higher Education. The exclusion criteria for all participants included the presence of chronic diseases and any infectious process of any origin within three months prior to the study. The groups were similar in terms of age (23.8±1.82 and 23.9±2.2 years, respectively), gender (all male), and corresponded to health group I. Psychological evaluation was conducted employing the Spielberger–Hanin Scale to gauge levels of personal and situational anxiety. The assessment of immunological status was carried out at the Scientific Research Institute of Clinical Immunology using standard methodological approaches. Registration cards for immunopathology analysis were used to characterize health status over the year. Analysis of the obtained data from psychological questionnaires revealed that students of the Therapeutic and Preventive Faculty, compared to their counterparts from the Military Training Center, demonstrated a higher degree of situational and, particularly, personal anxiety. Differences in the immune response system between the compared groups were identified with regards to indicators that characterize both adaptive and innate immunity. These differences were expressed in a more significant number of circulating regulatory T lymphocytes, a less pronounced lytic potential of effector cells, a greater number of TLR9+ monocytes with a decrease in the proportion of cells of the monocyte series carrying HLA-DR in medical students compared to their counterparts studying in the medical service officers’ program. Thus, the period of psychological preparation in a medical university for the commencement of professional activity varies based on the characteristics of the educational process and proves to be more effective for sixth-year students of MTC. Students from the TPF exhibit more pronounced psycho-emotional stress compared to their counterparts in military medical training, leading to evident signs of immune system dysregulation. It is imperative to develop strategies for timely detection of changes in both psychological and immunological adaptive capacities.

Studying the Transmission of Height Traits in Second Generation Reciprocal Wheat Hybrids

The presented article presents the results of a study of height inheritance in reciprocal hybrid combinations of the second generation (F2) of common wheat. The research was carried out in the 2020–2021 growing season at the experimental site of the experimental base at the Scientific Research Institute of Agriculture of Azerbaijan under irrigation conditions. In the year of research, the heights of 9 local varieties (Azeri, Gobustan, Fatima, Gyrmyzy gul-1, Murov-2, Askeran, Matin, Onur and Mirbashir-128) of soft wheat were studied, which were used as the parent form and 32 reciprocal combinations of the second generation. The degree and frequency of transgression was determined. During the growing season, agrotechnical work was carried out in accordance with the accepted methodology. In terms of height, the studied samples belonged to semi-dwarf (51.0-80.0 cm) and medium-sized (81.0-110.0 cm) varieties and combinations. Plant height in parental forms ranged from 70.0-97.0 cm. In hybrid combinations, plant height ranged from 60.0-95.0 cm. 71.9% of combinations (23 pcs.) were semi-dwarf and 28.1% combinations (9 pcs.) an average increase was observed. Transgressive variability in plant height was calculated using the method of G. S. Voskresensky and V. I. Spot. According to the results of the study, negative transgression was observed in hybrid combinations of the second generation (F2), which were characterized by low dominance and heterosis in the first generation (F1). As a result of the study, it can be concluded that short-growing hybrids can be obtained by involving varieties of the same height in hybridization, and taller forms can be obtained by using short-growing varieties in hybridization. The reciprocal hybrids Askeran × Gobustan and Askeran × Murov-2 showed a negative level of transgression when using the Askeran variety as the maternal form.

80th anniversary of NIITIAG

The article is dedicated to the anniversary of the Scientific Research Institute of Theory and History of Architecture and Urban Planning (NIITIAG), which the Institute celebrates this year.

Atherosclerotic vascular lesion in the coal industry workers of average and high fatal risk groups

Introduction. Experts do not take into account the presence of subclinical atherosclerosis when stratifying risk on the SCORE scale, however, it is the main substrate for the occurrence of cardiovascular disasters. Most primary cardiovascular events occur in low cardiovascular risk groups, which requires timely detection of atherosclerosis and preventive measures to preserve the working population's ability to work and reduce the economic burden of treatment of cardiovascular diseases. The study aims to research the incidence of atherosclerosis in workers of the main professions of the coal industry in the South of Kuzbass in groups of medium and high risk of fatal events on the SCORE scale. Materials and methods. We divided the subjects into two groups using the SCORE scale: high-risk (main) — from 5 to 9%, which included 60 people, and moderate-risk group — from 2 to 4% (comparison) — 70 employees. The average age of the first was 50.98±0.43 years, the comparison group was 49.96±0.35 years (p=0.070). The scientists examined the indicators of blood pressure, lipid, carbohydrate and purine metabolism, and performed an ultrasound examination of the main arteries. Results. The incidence of atherosclerotic plaques in at least one vascular basin was 80.0% in the main group and 78.6% in the comparison group, p=0.845. The frequency of carotid artery atheromas in the high-risk group on the SCORE scale (52.7%) did not significantly differ from the comparison group (54.3%), p=0.862; a similar pattern in the arteries of the lower extremities: 80.0% vs. 70.0%, respectively, p=0.203. The frequency of carotid artery atheromas in the high-risk group on the SCORE scale (52.7%) did not significantly differ from the comparison group (54.3%), p=0.862; a similar pattern in the arteries of the lower extremities: 80.0% vs. 70.0%, respectively, p=0.203. The combination of thickening of the intima of vessels and the presence of atheromas tended to be more frequent in the main group — 83.6% compared with those in the comparison group — 70.1%, p=0.076 Limitations. The study is limited by the number of examined patients who underwent periodic medical examination at the Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases. Conclusion. The incidence of atherosclerosis among employees of coal enterprises turned out to be very high and did not statistically differ in the groups of medium and high fatal risk stratified on the SCORE scale, which requires more thorough screening and measures of enhanced angioprotective prevention, even in people with a low risk of fatal cardiovascular disasters. Ethics. All the subjects signed an informed consent to participate in the study, the Protocol of which corresponded to the requirements of the Bioethical Committee of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, executed in accordance with the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting medical research with human participation as a subject" as amended in 2013 and the "Rules of Good Clinical Practice" approved by the order Ministry of Health of the Russian Federation No. 200n dated April 1, 2016.

Overview of Key Technologies in Surgical Robots and Optimization Discussions

Surgical robot is the national strategic diagnostic and therapeutic equipment research focus, get a number of scientific research institutes, colleges and universities and enterprises pay extensive attention to the design and development of a variety of surgical robots, and registration declaration. This article explores the critical technologies of surgical robots and key areas for optimizing their performance, including kinematic positioning errors, pose errors, feedback model errors, image recognition positioning errors, path planning, and safety aspects. The findings not only provide a scientific basis for future standardization research on surgical robots but also offer significant theoretical and practical references for the research, manufacturing, and registration processes in the medical robotics industry.

Assessing the built environment through photographs and its association with obesity in 21 countries: the PURE Study

The built environment can influence human health, but the available evidence is modest and almost entirely from urban communities in high-income countries. Here we aimed to analyse built environment characteristics and their associations with obesity in urban and rural communities in 21 countries at different development levels participating in the Prospective Urban and Rural Epidemiology (PURE) Study. Photographs were acquired with a standardised approach. We used the previously validated Environmental Profile of a Community's Health photo instrument to evaluate photos for safety, walkability, neighbourhood beautification, and community disorder. An integrated built environment score (ie, a minimum of 0 and a maximum of 20) was used to summarise this evaluation across built environment domains. Associations between built environment characteristics, separately and combined in the integrated built environment score, and obesity (ie, a BMI >30kg/m2) were assessed using multilevel regression models, adjusting for individual, household, and community confounding factors. Attenuation in the associations due to walking was examined. Analyses include 143 338 participants from 530 communities. The mean integrated built environment score was higher in high-income countries (13·3, SD 2·8) compared with other regions (10·1, 2·5) and urban communities (11·2, 3·0). More than 60% of high-income country communities had pedestrian safety features (eg, crosswalks, sidewalks, and traffic signals). Urban communities outside high-income countries had higher rates of sidewalks (176 [84%] of 209) than rural communities (59 [28%] of 209). 15 (5%) of 290 urban communities had bike lanes. Litter and graffiti were present in 372 (70%) of 530 communities, and poorly maintained buildings were present in 103 (19%) of 530. The integrated built environment score was significantly associated with reduced obesity overall (relative risk [RR] 0·58, 95% CI 0·35-0·93; p=0·025) for high compared with low scores and for increasing trend (0·85, 0·78-0·91; p<0·0001). The trends were statistically significant in urban (0·85, 0·77-0·93; p=0·0007) and rural (0·87, 0·78-0·97; p=0·015) communities. Some built environment features were associated with a lower prevalence of obesity: community beautification RR 0·75 (95% CI 0·61-0·92; p=0·0066); bike lanes RR 0·58 (0·45-0·73; p<0·0001); pedestrian safety RR 0·75 (0·62-0·90; p=0·0018); and traffic signals RR 0·68 (0·52-0·89; p=0·0055). Community disorder was associated with a higher prevalence of obesity (RR 1·48, 95% CI 1·17-1·86; p=0·0010). Community built environment features recorded in photographs, including bike lanes, pedestrian safety measures, beautification, traffic density, and disorder, were related to obesity after adjusting for confounders, and stronger associations were found in urban than rural communities. The method presents a novel way of assessing the built environment's potential effect on health. Population Health Research Institute, Hamilton Health Sciences Research Institute, Heart and Stroke Foundation of Ontario, Canadian Institutes of Health Research's Strategy for Patient Oriented Research, Ontario Support Unit, Ontario Ministry of Health and Long-Term Care, AstraZeneca, Sanofi-Aventis, Boehringer Ingelheim, Servier, and GlaxoSmithKline.

Analysis of hybrid potato populations in the conditions of the Magadan region

The priority direction in potato breeding in the Magadan region, given the short growing season and heat shortage, is the creation of predominantly early-ripening potato varieties. The article presents the results of the evaluation of potato breeding samples in terms of productivity and ripeness. Over two years, about three thousand samples of 67 hybrid combinations have been studied. The research was carried out in 2022–2023 on the experimental field of the Magadan Scientific Research Institute of Agriculture on floodplain, sod-alluvial, pebble-sandy loam soils. More than two thousand samples represented by 25 hybrid combinations were studied in the nursery of seedlings. Hybrid combinations characterized by a high frequency of selection of promising forms are identified, such as Arctica × Elbeida, Udacha × Bellarosa, Krone × Bellarosa, Charoite × Bellarosa, Krone × Labadia, Arctica × Gala. In these hybrid combinations, from 7.6 to 17.9% of the samples from the total number of the seedlings planted in the field were selected as clones. The samples with high productivity indicators were selected in the nursery of hybrids of the 1st year. The maximum weight of tubers of one plant was noted in the populations of Columba × Krepysh – 2010, Udacha × Bellarosa – 1820, Arctica × Elbeida – 1825, Charoite × Bellarosa – 1800. In the nursery of hybrids of the 2nd year, hybrids with productivity exceeding 1000 g/bush, such as Columba × Krepysh (2700 g/bush), Udacha × Bellarosa (1950 g/bush), Arctica × Krepysh (1670 g/bush), were identified in terms of yield and economically valuable characteristics. The frequency of selection of productive clones here exceeded 50%. These hybrid combinations are recommended for breeding research in the conditions of the Magadan region.

Первые педологи Чувашской Республики и их опыт исследования чувашских детей

The article is devoted to the study of the activities of pedologists of the Chuvash ASSR and aims to analyze the historically first study devoted to the intelligence of Chuvash children. The study is based on the publications of the first pedologists from Chuvashia F. P. Petrov and M. E. Efimov. In accordance with the historical and psychological methods described by V. A. Koltsova, the work uses problematic and source study methods. The study is written in the aspect of the history of pedagogy. A graduate student of the Kazan Oriental Pedagogical Institute, F. P. Petrov with a team of students, for the first time carried out a comprehensive study of the intellectual development of Chuvash children using the Binet-Simon test method, widely known among Soviet pedologists. At first, pedologists took the test method in Russian, then it was translated into the Chuvash language with appropriate text changes in relation to the everyday and speech characteristics of the Chuvash. The result of the study was the book published in Cheboksary, &amp;quot;The experience of studying the intellectual development of Chuvash children using the Binet-Simon method&amp;quot;, published in 1928. The book caused serious objections from the head of the pedological office at the Chuvash Scientific Research Institute M. E. Efimov; he believed that the author was biased against Chuvash children and violated the methodological principle of making tests. The correspondence polemic between two Chuvash pedologists about the measurement of children’s intelligence, along with similar cases in the country’s republics, prompted L. S. Vygotsky to call for an understanding of the problems of national pedology, with its leading problem – the measurement of intelligence.

К истории открытия и изучения феномена Окло

The paper dwells on the brief history of the discovery and studies of the Oklo uranium deposit, a natural nuclear reactor, is considered. It was shown by French specialists in 1972. The discovery was made by studying the isotope ratio 235U§238U in ore. Several years earlier, such research was carried out at the All-Union Scientific Research Institute of Mineral Raw Materials (VIMS). Unfortunately, the application for the discovery of domestic scientists was rejected.

Drought-stress tolerance potential in plum and prune rootstocks and cultivars (Prunus spp.) based on physiological and photosynthetical parameters

Drought stress and water crisis is a great limiting factor for the production of horticultural crops. The present study was carried out during 2021 and 2022 at Horticultural Science Research Institute, Kamalshahr, Karaj, Iran to identify the effect of drought stress in physiological and photosynthetic characteristics of Prunus spp. rootstocks and varieties of 4-year old Prunus spp. The factorial experiment was conducted in a completely randomized block design (CRBD) having 3 factors and 3 replications. Factors included 8 rootstocks, viz. Myrobalan 29C, Penta, Tetra, St. Julien, Mariana 2624, GF 677, GN 15 and Seedling as the first factor; 4 cultivars, viz. Greengage, Simka, NO 16 and Zochelo as the second factor; and drought stress conditions in two levels namely with interruption of irrigation for 14 days and without interruption of irrigation as the third factor. Drought stress decreased relative water content of leaves, stomatal conductance, transpiration, CO2 content in substomatal chamber, and water use efficiency. Zuchelo and Greengage varieties and GN 15 rootstock had the highest and Simka variety and Mariana 2624 and Myrobalan 29C rootstocks had the lowest stomatal exchanges and photosynthesis, respectively. Among the rootstocks; GN 15, GF 677 and Mariana 2624 showed better physiological stability under stress, and the most tolerant variety against drought stress was NO 16. Totally, grafting combination of cv. NO 16 and rootstock GN 15 has been identified as the most tolerant to drought stress.

Hagnýting menntunar meðal háskólamenntaðs starfsfólks einkarekinna fyrirtækja og opinberra stofnana

Markmið greinarinnar er að kanna hvort munur sé á hagnýtingu þekkingar meðal háskólamenntaðs fólks sem vinnur annars vegar í einkareknum fyrirtækjum og í opinberum stofnunum hins vegar. Úrtak rannsóknarinnar byggðist á tilviljunarúrtaki úr þjóðskrá sem Þjóðmálakönnun Félagsvísindastofnunar Háskóla Íslands framkvæmdi 9. mars til 9. apríl 2016. Könnunin náði til 2.001 einstaklings á aldrinum 18 ára og eldri á landinu öllu og svöruðu 1.210 þeirra könnuninni. Í þessari rannsókn var aðeins litið til þeirra þátttakenda í úrtakinu sem höfðu lokið háskólanámi og voru í launaðri vinnu á Íslandi hjá hinu opinbera eða í einkafyrirtæki. Eftir hreinsun gagna voru þátttakendur 374, þar af voru 178 karlar og 196 konur. Niðurstöður rannsóknar sýndu að 20,3% þátttakenda voru ofmenntuð. Meirihluti kvenna vinnur hjá hinu opinbera en meirihluti karla hjá einkafyrirtækjum. Vanmenntaðir starfsmenn eru líklegri til að starfa hjá hinu opinbera á meðan ofmenntaðir eru líklegri til að starfa hjá einkafyrirtækjum (sá munur skýrist af van- eða ofmenntun kvenna). Hjá opinberum fyrirtækjum starfa frekar þeir sem lokið hafa námi á sviði mennta- og heilbrigðisvísinda meðan starfsfólk af verk- og náttúruvísindasviði er helst hjá einkafyrirtækjum. Laun eru hærri hjá einkafyrirtækjum.

ACHIEVED RESULTS AND PERSPECTIVES FOR FURTHER DEVELOPMENT OF SMALL AND MEDIUM-SIZED ENTERPRISES: STATISTICAL FINDINGS AND ANALYSIS

Small and medium-sized enterprises are a key part of every national economy and represent a factor of economic and social stability. In particular, entrepreneurial organizations are recognized as drivers of economic development, because they encourage the introduction of new technologies and have a direct impact on the level of investments and aggregate demand in terms of macroeconomic indicators. Also, this type of organizations contributes to solving the problem of unemployment and unequal distribution of wages. The need for strategic support and development of small and medium enterprises at the state level is permanent. In the past, these entities have been hit by the pandemic caused by the Covid-19 virus, inflation and digitization. The subject of the paper is the results review of the small and medium-sized enterprises development in Serbia, as well as the perspective of their further growth. Taking into account the effect of quality standards on business results, the connection of small and medium-sized enterprises with scientific and research institutions, but also the connection between the same organizations on the market, the authors propose certain improvements for their development. The key elements are based on the adequate and correct diagnosis of the mentioned connections. The research sample was purposive, which included companies in each of the 5 regions of the Republic of Serbia (n=112). The importance of quality standards and cooperation with faculties and scientific research institutions was established. It has been proven that the biggest obstacles in the development of the business of small and medium-sized enterprises are administrative procedures, as well as fiscal appropriation, and that the biggest impact on future business prospects is the adopted quality standard, investment in modern equipment, innovation, new knowledge and the introduction of new production lines.

Корневая гниль яровой пшеницы в условиях Зауралья, варианты оперативной защиты

Abstract. Root rot is a harmful and widespread disease of cereal crops. In the conditions of the Urals, Siberia, and Northern Kazakhstan, its causative agents are various species of fungi of the genus Fusarium and the fungus Bipolaris sorokiniana. The purpose of this study was to comparatively determine the effectiveness of microbiological, chemical and combined protection of spring wheat seeds. Field experiments were carried out on the experimental field of the Kurgan Scientific Research Institute of Agriculture – branch of the Ural Federal Agrarian Scientific Research Centre of the Ural Branch of the Russian Academy of Sciences (Kurgan SRIA – branch of FSBSI UrFASRC, UrB of RAS) in 2019, 2021, 2022. Scientific novelty lies in the determining the competitiveness of various methods of protecting spring wheat seeds in the conditions of the Trans-Urals within the framework of modern cultivation technology. The methods used are generally accepted in the Russian Federation. Results. In conditions of almost annual occurrence of negative natural phenomena for the growth and development of plants (droughts, frosts, sudden changes in temperature, dry winds, etc.), the use of seed treaters can be an additional stress for plants; the presence of the effect of shortening the underground internode can negatively affect field germination culture. To reduce these risks, as well as the pesticide load, we recommend using a combined method of seed protection. It involves the use of a mixture of a bacterial fungicide based on Bacillus subtilis with a chemical disinfectant at half the consumption rate. At the same time, the level of control of phytopathogens is maintained, there is no retardant effect, and economic efficiency is not inferior to the level of using a two-component chemical seed protectant (113–114 %). Chemical protection of seeds reduced the development of root rot pathogens by 63–72 %. The use of combined protection provided good control of phytopathogens, including the dominant fungi Fusarium. The predominant species from the genus Fusarium were the highly dangerous F. oxysporum, F. graminearum, F. sporotrichioides.

The humic acids influence on the quantity and quality of table grape varieties under the Absheron peninsula conditions

Humates are widely used in viticulture, including ecological viticulture. Humic stuffs benefit the qualitative and quantitative indicators of the grape harvest and can reduce the use of synthetic fertilizers and pesticides. This article presents the results of tests on the foliar application of various doses of the “Rostok” fertilizer in the conditions of the Absheron zone of Azerbaijan on local varieties of table grapes – traditional Tabrizi and a selection variety of Scientific Research Institute of Viticulture and Wine-making Ganjavi, grown in the Ampelographic collection of the institute, located on the Absheron peninsula. Fertilizer was applied in three doses – 0.5; 1.0 and 1.5 liter per hectar. Under the influence of the fertilizer, such elements of yield as the vigor of shoot growth, the number of opened buds, fruitful shoots, the number of berries in a bunch, the weight of a bunch, as well as the sugar content of berry juice increased. Fertilizer application had a positive effect on eliminating signs of leaf chlorosis. No toxic effect on the vegetative organs of the grape plant, on its development, or on the beneficial insect fauna of the vineyard was noted. Based on the data obtained, as well as calculations of economic efficiency, a four-fold application of fertilizer (twice before flowering, once after, once during veraison) at the rate of 1 liter per hectare was recommended for widespread use in wine-growing farms.

INVESTIGATING THE KEY LIMITATIONS AND IMPROVEMENTS INFLUENCING THE COMPETITIVE SUCCESS OF SOUTH AFRICA’S ORANGER EXPORTERS.

The objective of identifying constraining factors is to reveal that the key obstacles affecting the competitiveness of South Africa's domestic orange industry include issues such as the "quality of unskilled labor," "trust in the honesty of politicians," "electricity suppliers," "health," "South Africa’s land reform policy," "South Africa’s BEE policy," and "crime." Additionally, challenges related to the lack of quality infrastructure, bilateral agreements with trading countries, and poor performance of ports relative to their global counterparts have been identified. The constraining factors were ranked, with the top issues aligning closely with the industry's current challenges. In contrast, enhancing factors play a crucial role in boosting industry competitiveness in both domestic and international markets. The key elements contributing positively include the availability of unskilled labor, local input suppliers, scientific research institutions, technological quality, the cost of unskilled labor, soil conditions, and the sustainability of local input suppliers. Attention to maintaining and improving these factors is crucial for the sustained competitiveness of the South African orange sector.

Peptidergic and adenosinergic drugs administration to comatose patients caused by alcohol consumption on early hospital period

Introduction. Medical care for patients diagnosed with the toxic effect of ethanol (according to ICD-10 code T51.0) it turns out to be in specialized toxicological centers or in emergency departments of multidisciplinary hospitals. The purpose of this study was to study the effectiveness of the drug моликсан® (molixаn) at different levels of medical care for patients diagnosed with the toxic effect of ethanol. Material and method. 128 patients were included in the study, of which 76 patients were taken to the emergency department of St. Petersburg State Medical Institution "Alexandrovskaya Hospital" and 52 patients were taken to the intensive care unit No. 11 of the St. Petersburg Scientific Research Institute of Emergency Medicine named after I.I. Dzhanelidze. All patients met the inclusion criteria: age 18–60 years; impaired consciousness of alcoholic genesis 21–30 points on the Glasgow–Pittsburgh coma scale (PBSS: Pittsburg Brain Stem Score, Kelsey S.F., et al. 1991); ethanol concentration in the blood is more than 2.5%. 72 patients were included in the моликсан® group, 56 patients in the Placebo group. Results. The use of the drug моликсан® has a positive effect on the dynamics of restoring the level of consciousness, which is reflected in higher values of the Glasgow–Pittsburgh scale after 1, 3 and 6 hours from the start of therapy (p&lt;0.01), reducing the period of stay of the patient in a coma from 150 [75; 178] minutes to 60 [50; 161.5] minutes (p&lt;0.05) and restoration of consciousness to a clear level after 3.5± 0.3 hours (p&lt;0.05).It was also revealed, that in the group of patients using моликсан®, normalization of heart rate (p&lt;0.05) and a decrease in the frequency and severity of tremor (p&lt;0.05) were noted. The hepatoprotective efficacy of моликсан® was shown, which manifested itself in a decrease in ALT, AST, GGTP, alkaline phosphatase, total and direct bilirubin (p&lt;0.001). Limitations. The clinical efficacy of моликсан® in the toxic effects of severe ethanol was carried out in patients with depression of consciousness and elevated levels of ALT, AST, GGTP, alkaline phosphatase, total and direct bilirubin, which indicated the presence of alcoholic hepatopathy. Conclusion. The conducted study showed the expediency of using моликсан® at a dosage of 3.0 mg/kg intravenously with the toxic effect of ethanol of moderate and severe severity of the disease.

The analysis of the stock of the Republican scientific-technical library

Nowadays, the investigation of the questions of the scientific management of library stocks has gained great urgency (increased in importance). The tasks of increasing the efficiency of the formation and usage of library stocks highlight the necessity for systematic research into their peculiarities and tendencies of development. This article analyzes the peculiarities and tendencies of the development of the stocks of the Republican Scientific-Technical Library of Lithuania's Scientific-Research Institute of Scientific-Technical Information and Technical-Economic Research. The multifaceted research of the stocks should enable the improvement of library processes and information-bibliography services. The research carried out allows for the following conclusions: The Republican Scientific-Technical Library, by volume of stocks, is the largest library among scientific libraries of the republic. Its stocks total 40.4 percent of the whole stock of the United Republican Information Stock (URIS). The library is the main library in URIS, which organizes the stocks of special documentation and literature. A peculiarity of the stock is that special technical documentation and literature have predominated in the stock since 1970, totaling approximately 90.1 percent of the entire stock. The basic stocks are in the Republican Scientific-Technical Library in Vilnius, which total 87.6 percent of the entire stock. The superextensive growth of the special technical documentation and literature during 1967-1970 is accounted for by the organization of the departments of patents and technical documentation (as per the decision of the Council of Ministers of Lithuania). At present, the growth of the stock has stabilized. Every year during 1975-1982, the library received an average of 850.2 thousand documents. The growth of the quantity of the stocks, completion on the whole, and the growth of the stocks of special kinds of scientific-technical literature and documentation may be defined by a mathematical curve, which shows that from a certain moment, the speed of the growth of the volume of the stocks slows down due to limited resources.

A Review of the Research on the Influencing Factors of Enterprise Key Core Technology Breakthrough

The breakthrough of key core technology is a theoretical and practical strategic issue to realize the rise of the country. This paper analyzes the concept of key core technology and its breakthrough and analyzes its characteristics. Based on the perspective of participants, this paper summarizes the influencing factors of key core technology breakthroughs in enterprises: internal and external enterprises, universities and scientific research institutions, and government. This paper expands the relevant research on key core technology breakthroughs and provides inspiration for enterprises to carry out key core technology research and breakthrough practices.

The effect of intellectual property rights on firm performance in service firms: the role of process and organizational innovation

PurposeThis paper aims to examine the effects of intellectual property rights (IPRs) on firm performance, considering the mediating effect of process innovation and the moderating effect of organizational innovation. Additionally, this study investigates both the direct and indirect effects of IPRs on firm performance.Design/methodology/approachWe employed partial least squares structural equation modeling (PLS-SEM) to examine proposed hypotheses. Our analysis attempted to analyze 3,750 Korean firms sourced from the Science and Technology Policy Research Institute (STEPI).FindingsProcess innovation mediates the relationship between IPRs and firm performance, and organizational innovation moderates the relationship between IPRs and process innovation. As a result, process and organizational innovation positively and indirectly affect firms’ financial performance. Also, IPRs can be regarded as a crucial resource for service firms, contributing to enhancing their performance.Research limitations/implicationsThe results of this study imply that IPRs can act as valuable intellectual resources for firms, improving financial performance. The mediating role of process innovation in the relationship between IPRs and firm performance highlights the significance of process innovation as a principal resource applicable to both the service and the manufacturing industries. Additionally, this study reveals that organizational innovation plays a vital role in determining firm performance by moderating the relationship between IPRs and process innovation. For the limitation of this study, it is important to acknowledge that the research primarily focuses on examining firms’ internal resources, while innovation activities can be significantly influenced by external knowledge resources as well. To address this limitation, future research should consider integrating the influence of external knowledge resources to provide a more well-rounded perspective on the relationship between IPRs, innovation, and firm performance.Practical implicationsThis study holds two significant practical implications. First, from a corporate management perspective, service firms can improve their financial performance by developing or improving process innovations. This underscores the importance of investing in and fostering process innovation within an organization to achieve better financial outcomes. Second, from the corporate managers’ perspective, organizational innovation is crucial in improving firm performance, particularly when combined with IPRs and process innovation. This suggests that a holistic approach to innovation, encompassing both organizational and process-oriented initiatives, can lead to more substantial positive effects on firm performance. Finally, managers should proactively manage and regulate IPRs at various organizational levels, especially in the rapidly evolving digital landscape. By safeguarding and strategically leveraging their IPRs, companies can position themselves advantageously and capitalize on the opportunities presented in the digital realm.Originality/valueThis study shows that firm innovations can dynamically shape the relationship between IPRs and firms’ performance. This highlights the significant potential for firms to leverage their intellectual resources strategically to create novel and competitive products or services. Adopting a resource-based view, this study suggests that firms can enhance their competitive advantage and overall performance by effectively utilizing and collaborating with IPRs and innovations.